This volume in the "Advances in Immunology" series presents recent findings related to the roles of proteasomes in the MHC class I-restricted antigen processing pathway and discusses recent observations and insights on V(D)J recombination. It also examines the structure, function and mechanisms of regulation of mammalian Ets transcription factors and the processes of b2m assembly and peptide loading and the involving molecules. Current concepts and enigmas of lymphocyte homing as well as a description of plasmacytomagenesis in mice and insights into the cellular and molecular biology of human plasma cell dyscrasias are included. In addition, the work provides a summary of the rationale for anti TNFa antibody therapy and its clinical effects.
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Key Features * Recent findings related to the roles of proteasomes in the MHC class I-restricted antigen processing pathway * New observations and insights on V(D)J recombination * Structure, function, and mechanisms of regulation of mammalian Ets transcription factors * Processes of B2m assembly and peptide loading and the involving molecules * Current concepts and enigmas of lymphocyte homing * Description of plasmacytomagenesis in mice and insights into the cellular and molecular biology of human plasma cell dyscrasias * Summary of the rationale for anti TNF antibody therapy and its clinical effects
CONTRIBUTORS ix Proteasomes and Antigen Processing 1(38) KEIJI TANAKA NOBUYUKI TANAHASHI CHIZUKO TSURUMI KIN-YA YOKOTA NAOKI SHIMBARA I. Introduction 1(3) II. The TAP System 4(1) III. The Ubiquitin System 5(3) IV. The Proteasome System 8(18) V. Model for Generation of MHC Class I-Associated Peptides 26(5) VI. Perspectives 31(1) References 32(7) Recent Advances in Understanding V(D)J Recombination 39(26) MARTIN GELLERT I. Introduction 39(1) II. Basic Properties 39(3) III. Broken DNA Molecules in V(D)J Recombination 42(2) IV. Factors Involved in V(D)J Recombination 44(7) V. Biochemistry of the First Steps of V(D)J Recombination 51(8) VI. Biological Consequences 59(2) References 61(4) The Role of Ets Transcription Factors in the Development and Function of the Mammalian Immune System 65(40) ALEXANDER G. BASSUK JEFFREY M. LEIDEN I. Introduction 65(1) II. Structure of the Ets DNA-Binding Domain 66(2) III. Ets Binding Sites in Immune Immune-Related Genes 68(6) IV. Individual Ets Proteins and Immune Function 74(20) V. Conclusions and Future Directions 94(2) References 96(9) Mechanism of Class I Assembly with XXX(2) Microglobin and Loading with Peptide 105(34) TED H. HANSEN DAVID R. LEE I. Background 105(1) II. Proteasome 105(2) III. Calnexin 107(5) IV. TAP 112(7) V. Proposed Function of Tap Versus Calnexin: Might TAP Be the Predominant Class I Chaperone? 119(2) VI. ER versus Cytosolic Processing 121(3) VII. Peptide Anchoring 124(4) VIII. Final Remarks 128(1) IX. Note Added in Proof 128(1) References 129(10) How Do Lymphocytes Know Where to Go: Current Concepts and Enigmas of Lymphocyte Homing 139(80) MARKO SALMI SIRPA JALKANEN I. Introduction 139(1) II. Lymphocyte-Endothelial Cell Interactions: Historical Aspects and the Conceptual Framework 140(3) III. Molecules and Signals Mediating Lymphocyte-Endothelial Cell Interactions 143(20) IV. Regulation of Adhesion Molecule Expression and Function 163(11) V. Regulation of Tissue-Selective Homing 174(14) VI. Lymphocyte Homing and Inflammation 188(5) VII. Adhesion Deficiencies 193(3) VIII. Antiadhension and Proadhesion Therapy 196(1) IX. Concluding Remarks 197(2) References 199(20) Plasma Cell Dyscrasias 219(64) NORIHIRO NISHIMOTO SACHIKO SUEMATSU TADAMITSU KISHIMOTO I. Introduction 219(2) II. Plasmacytoma in Mouse 221(21) III. Human Plasma Cell Dyscrasias 242(21) IV. Conclusion 263(1) References 263(20) Anti-Tumor Necrosis Factor-XXX 283(68) MARC FELDMANN MICHAEL J. ELLIOTT JAMES N. WOODY RAVINDER N. MAINI I. Introduction 283(7) II. Rationale for Anti-TNFXXX Antibody Therapy 290(9) III. Clinical Studies with Anti-TNFXXX 299(12) IV. Mechanisms of Action of Anti-TNFXXX 311(12) V. Potential Problems 323(7) VI. Prospects for the Future 330(4) VII. Concluding Remarks 334(1) References 335(16) INDEX 351(12) CONTENTS OF RECENT VOLUMES 363
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