Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.
- Covers different aspects of anti-aging research, from foundational knowledge to future perspectives
- Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs
- Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others
Arvustused
"This is a highly useful book that describes the modern theories of the aging process and its impact at a cellular and organ level. The book provides comprehensive discussion on the different hallmarks of aging and the strategies of anti-aging drug development with a focus on recent advances that slow or reverse the aging process including telomerase reactivation, clearance of senescent cells, and stem cell-based therapy among others. The book meets the objectives as it provides valuable information on anti-aging drug discovery on the basis of the hallmarks of aging. [ It] has several high-quality colored illustrations, which make the subject matter easy to understand and more enjoyable.... This is an excellent book that discusses the modern theories of aging, the different hallmarks of aging, and the various anti-aging strategies. I am quite hopeful this book will be of great value in supporting the multidisciplinary efforts to understand the aging process. [ A] unique [ book] that addresses the hallmarks of aging on which anti-aging drug discovery is based." -- ©Doodys Review Service, 2022, Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)
1. The aging: introduction, theories, principles and future prospective Shabnam Shabir, Mahendra Pratap Singh 2. Brief description of aging in different levels as cellular, tissues, and organs Anuradha Venkatakrishnan Chimata, Prajakta Deshpande, Amit Singh 3. Brief about hallmarks of aging Josephine Esposto and Vyshnavy Balendra 4. Overview of various anti-aging strategies Dhiraj Kumar and Faiyaz Ahmad 5. Elimination of damaged cells-dependent anti-aging strategy Rayees Ahmad Naik, Vinodinee Dubey, Roshni Rajpoot, Debabrata Dash, Nidhi Gupta and Raj Kumar Koiri 6. Telomerase reactivation for anti-aging TS Gopenath, Shreya Shreshtha and Kanthesh M. Basalingapa 7. Epigenetic drugs based on anti-aging approach Tarun Minocha, Namrata Dwivedi, Chetan Panda, Anamika Misra, Barsha Baisakhi Nayak, Sanjeev Kumar Yadav, Hareram Birla and Sandeep K. Singh 8. Activation of chaperons and proteolytic system: emerging methods for anti-aging drug development Neha Gogia, Victor Olmos, Fatema Haidery, Kimberly Luttik, Leon Tejwani, Janghoo Lim 9. Dietary restriction and mTOR and IIS inhibition: the potential to anti-aging drug approach Sing-Hua Tsou 10. Anti-Aging Drugs, Candidates, and Food Supplements- The journey so far Yodhaanjali JR, Rithwick Surya, Sumukha KC, Harini G, Gouri Deshpande, Chandan S,Raghu Ram Achar 11. Role of AMPK and Sirtuins as anti-aging proteins Manjula Ramu, Sonali Vishal and Neha Gogia 12. Mitophagy and Mitohormetics: promising anti- aging strategy Chih Li Lin 13. Clearance of senescent cells: potent anti-aging approach Jacques Ferreira and Alex Deamer 14. Stem cell-based therapy as antiaging prospective Sumaira Yusuf, Mahendra P. Singh 15. Anti-inflammatory therapy as a game changer towards anti-aging Dr. Naveen Shivavedi, Anshul Shakya, Bedanta Bhattacharjee and Bhargab Deka 16. Invertebrate model organisms for aging research Arvind Kumar Shukla, Andrew Scott and Edward Giniger
Assistant Professor in Department of Medical Biotechnology at the All India Institute of Medical Sciences, Nagpur. He is researcher and neuroscientist with a strong background in Biochemistry and Biomedicine. His research interests are in neurodegenerative diseases and has ~12 years of experience. Hes a member of editorial boards of several international journals related to neuroscience and member of several scientific societies. Dr. Singh has been appointed as Bentham Ambassador by Bentham Science Publisher (USA). He is a speaker at several scientific national and international conferences/symposium/workshops in India and abroad.
Chih-Li Lin is a Professor and Research Fellow of Chung Shan Medical University and Hospital, Taiwan. He obtained his Ph. D. degree in the Institute of Biochemistry and Molecular Biology from National Taiwan University Medical College in 2007. Lin completed his postdoctoral research on the dementia & Alzheimers disease in National Taiwan University Hospital, and then moved to Institute of Medicine, Chung Shan Medical University (Taiwan) in 2008 and has been promoted to Full Professor in 2019. His major interests are to understand the pathophysiological connections between brain aging and Alzheimers dementia, particularly studying molecular mechanisms of amyloid beta (A)-induced neurotoxicity, and applications of induced pluripotent stem (iPS) cell technology. He is currently working to demonstrate that brain insulin resistance may play roles in neuronal aging features and contribute to pathogenesis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), and type 2 diabetes-associated dementia. Shailendra Kumar Mishra is co-founder of Indian Scientific Education and Technology (ISET) Foundation, a non-profit/non-governmental organization that persuades toward the science promotion. He is Molecular Human Genetics postgraduate, skilled in DNA Sequencing, Polymerase Chain Reaction (PCR), DNA & Plasmid isolation, Gel electrophoresis, Molecular hybridization, DNA elution from agarose gel, bacterial transformation, quantitation of DNA, DNA sequencing technique and versed in various diagnostic techniques. He did Master of Science in Molecular and Human Genetics from Jiwaji University, India, and research project from Banaras Hindu University, India. He has published his articles in some international and national journals such as Journal of Alzheimers Disease and Parkinsonism and Nature India. His major interest is to understand the aging process through molecular basis that could be beneficial to cure age-related diseases.
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