Offers in-depth insights into molecular mechanisms that can inhibit viral/host protein targets of SARS-CoV-2. Highlights the action of marine bioactive compounds based on advanced bioinformatics tools. Proposes their potential role in COVID-19 management. Discusses the role of marine bioactive compounds for combating SARS-CoV-2 infection.
This unique volume summarizes emerging approaches based on in silico, in vitro, in vivo, and clinical studies to uncover the potential and the underlying mechanisms of diverse marine bioactive compounds to inhibit SARS-CoV-2 and its variants and, hence, pave the way for drug discovery devoted to the management of COVID-19.
Investigating a range of natural compounds for their anti-SARS-CoV-2 activity, this volume offers in-depth insights into molecular mechanisms that can inhibit viral/host protein targets of SARS-CoV-2. It highlights the action of marine bioactive compounds based on advanced bioinformatics tools such as molecular docking, computer simulation, and systems pharmacology, as well as multiple omics and high-throughput technologies. Chapters discuss the modes of action by selected marine polysaccharides, terpenoids, astaxanthin, and an indole-alkaloid (holyrine A) for combating SARS-CoV-2, and propose their potential role in COVID-19 management. Finally, a chapter discusses the role of marine bioactive compounds that include some traditional remedies from Southeast Asia for combating SARS-CoV-2 infection.
Providing valuable knowledge based on state-of-the-art literature that highlights the anti-SARS-CoV-2 activity of marine bioactive compounds, this work will be an important resource for researchers, professors, and experts in diverse sub-fields of life sciences, such as virology, pharmaceutical science and drug discovery, medical research, biochemistry, bioinformatics, biomedical science, computational biology, epidemiology, and other areas. The book presents approaches that are potentially useful for the management of global public health and can support the goal of establishing "Good Health and Well-Being," which is one of the "Sustainable Development Goals (SDGs) 2030" of the United Nations.
1. Marine Bioactive Compounds as Efficient Antiviral Agents Against
SARS-CoV-2: An Overview
2. Marine Bioactive Compounds for Combating
SARS-CoV-2 Variants in the Post-Epidemic Era: A Molecular Insight and
Prospects
3. Marine Bioactive Compounds as Potential Anti-COVID-19
Medications
4. Marine Polysaccharides as Broad-Spectrum Drugs Against
Coronaviruses
5. Anti-SARS-CoV-2 Activity of Marine Terpenoids: The Mode of
Action on Protein Targets
6. Anti-SARS-CoV-2 Activity of Marine
Bacteria-Derived Compounds: The Mode of Action
7. The Role of Marine
Bacteria-Derived Bioactive Compounds in COVID-19 Management
8.
Anti-SARS-CoV-2 Potential of Marine Fungi-Derived Compounds and Their Roles
in COVID-19 Treatment
9. Algae-Derived Marine Bioactive Compounds Against
COVID-19
10. The Potential Role of Marine Seaweeds in the Management of
COVID-19
11. The Role of Marine Sponge-Derived Bioactive Compounds in
COVID-19 Management
12. Anti-SARS-CoV2 Bioactive Compounds Derived from
Marine Sponges: A Mechanistic Insight into Their Inhibitory Action on Protein
Targets
13. Astaxanthin and Its Effect on SARS-CoV-2
14. Holyrine A, a Marine
Indole-Alkaloid with Promising Pan-Inhibition Activity Against SARS-CoV-2
15.
A Marine Bioactive Compound Fistularin-3 Against SARS-CoV-2 and the
Underlying Mechanism
16. Potential Role of Marine Bioactive Compounds Against
the Main Protease and RNA-Dependent RNA Polymerase of SARS-CoV-2
17. Marine
Natural Products with anti-SARS-CoV-2 Activity in Southeast Asia
Jen-Tsung Chen, PhD, is a Professor of Cell Biology at the National University of Kaohsiung in Taiwan, where he teaches genomics, proteomics, plant physiology, and plant biotechnology. Dr. Chen's research interests include bioactive compounds, chromatography techniques, plant molecular biology, plant biotechnology, bioinformatics, and systems pharmacology. He is an active editor of academic books and journals in an effort to advance the exploration of multidisciplinary knowledge involving plant physiology, plant biotechnology, nanotechnology, ethnopharmacology, systems biology, and drug discovery. He serves as an editorial board member and a guest editor for several reputed journals. Dr. Chen has published books in collaboration with international publishers on diverse topics such as drug discovery, herbal medicine, medicinal biotechnology, nanotechnology, bioengineering, plant functional genomics, plant speed breeding, CRISPR-based plant genome editing, and artificial intelligence. He has been included in the list of the World's Top 2% Scientists 2023 by Stanford University.
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