This is essential reading for researchers and healthcare professionals involved in making medical decisions, including physicians, midlevel practitioners, pharmacists, nurses, and other allied health professionals. This is a thorough review of evidence-based medicine concepts and comparative effectiveness research that is easy to understand and offers a framework to support readers in determining how these concepts can be incorporated into their decision making methods in a practical and purposeful way. (Valerie D. Barnes, Doody's Book Reviews, September, 2016)