| Preface |
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viii | |
| Contributors |
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ix | |
| Acknowledgements |
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xi | |
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1 Structure and Function of the Genome |
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1 | (70) |
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1 | (1) |
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Gene Structure and Function |
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2 | (1) |
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The Central Dogma of Molecular Biology |
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3 | (2) |
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5 | (1) |
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5 | (1) |
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5 | (2) |
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Molecular Biology Techniques |
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7 | (1) |
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8 | (1) |
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The Molecular Basis of Inherited Disease - DNA Mutations |
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9 | (62) |
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71 | |
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11 | (5) |
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16 | (4) |
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Multifactorial Inheritance |
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20 | (1) |
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Genetic Testing and Interpretation of a Genetic Result |
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20 | (4) |
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24 | (21) |
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Oogenesis and Spermatogenesis |
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24 | (10) |
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Development of the Genital Organs |
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34 | (4) |
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Development of the Placenta |
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38 | (3) |
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Development of Membranes and Formation of Amniotic Fluid |
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41 | (4) |
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4 Fetal and Placental Physiology |
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45 | (9) |
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45 | (1) |
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Fetal Development and Preparation for Birth |
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45 | (6) |
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Placental Growth and Development |
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51 | (1) |
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Fetal Growth and Growth Restriction |
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52 | (2) |
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54 | (34) |
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55 | (1) |
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55 | (1) |
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56 | (3) |
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59 | (1) |
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59 | (1) |
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60 | (1) |
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61 | (1) |
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61 | (1) |
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The Musculoskeletal System |
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62 | (2) |
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64 | (1) |
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Relevant Regional Anatomy of the Thorax |
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65 | (1) |
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66 | (5) |
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71 | (1) |
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71 | (3) |
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74 | (1) |
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74 | (2) |
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76 | (2) |
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78 | (1) |
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The Ischiorectal Fossae (Fig. 5.25) |
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78 | (2) |
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80 | (1) |
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81 | (4) |
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85 | (1) |
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85 | (1) |
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85 | (1) |
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86 | (2) |
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88 | (9) |
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General Pathological Principles |
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88 | (1) |
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Cellular Injury and Death |
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88 | (3) |
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Pathology of Gynaecological Tumours |
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91 | (1) |
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Pathology of Miscarriage and Gestational Trophoblastic Disease |
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92 | (1) |
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Pathology of Common Congenital Abnormalities and Teratogenesis |
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93 | (1) |
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Pathology of the Placenta |
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94 | (3) |
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7 Microbiology and Virology |
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97 | (19) |
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Bacteriology, Mycology and Parasitology |
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97 | (1) |
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97 | (3) |
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Laboratory Identification |
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100 | (1) |
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101 | (4) |
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105 | (2) |
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107 | (1) |
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108 | (1) |
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109 | (1) |
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109 | (1) |
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109 | (1) |
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Viruses of Importance in Obstetrics and Gynaecology |
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110 | (6) |
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116 | (10) |
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116 | (1) |
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116 | (1) |
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117 | (4) |
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Cells of the Innate Immune System |
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121 | (1) |
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Regulation of the Immune System |
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122 | (1) |
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The Fetus as an Allograft |
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123 | (2) |
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125 | (1) |
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126 | (26) |
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Structure and Function of the Normal Cell |
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126 | (3) |
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Proteins, Peptides and Amino Acids |
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129 | (5) |
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134 | (5) |
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139 | (1) |
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139 | (3) |
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Cell Signalling and Second Messaging |
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142 | (8) |
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150 | (2) |
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152 | (50) |
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153 | (1) |
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Distribution of Water and Electrolytes |
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154 | (1) |
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Cellular Transport Mechanisms |
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155 | (2) |
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157 | (3) |
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160 | (7) |
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167 | (4) |
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171 | (5) |
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176 | (5) |
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181 | (5) |
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186 | (3) |
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189 | (4) |
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193 | (9) |
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202 | (23) |
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203 | (1) |
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Mechanisms of Hormone Action and Second Messenger Systems |
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203 | (2) |
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205 | (1) |
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Hypothalamus and Pituitary |
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206 | (3) |
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209 | (1) |
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210 | (2) |
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212 | (1) |
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213 | (2) |
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215 | (2) |
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217 | (1) |
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217 | (1) |
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217 | (1) |
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218 | (3) |
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221 | (2) |
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223 | (2) |
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12 Drugs and Drug Therapy |
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225 | (16) |
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226 | (1) |
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Language of Clinical Pharmacy |
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226 | (2) |
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Factors That Influence Drug Action |
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228 | (1) |
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Physiological Changes That Affect Drug Metabolism in Pregnancy |
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229 | (1) |
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229 | (1) |
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229 | (10) |
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Mechanism of Action of the Combined Pill |
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239 | (1) |
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Drugs of Choice in Breastfeeding |
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240 | (1) |
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240 | (1) |
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13 Physics in Obstetrics and Gynaecology |
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241 | (10) |
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241 | (1) |
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241 | (2) |
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243 | (1) |
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244 | (1) |
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245 | (2) |
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247 | (1) |
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248 | (3) |
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14 Statistics and Evidence-Based Healthcare |
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251 | (14) |
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251 | (1) |
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Some Basic Statistical Principles |
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251 | (2) |
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Data Types, Distribution Assumptions and Parametric Tests |
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253 | (3) |
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Data Collection and Presentation |
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256 | (2) |
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Measures of Outcome, Exposure and Effect |
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258 | (5) |
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Equations for Basic Power Calculations |
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263 | (2) |
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15 Clinical Research Methodology |
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265 | (13) |
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265 | (1) |
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Types of Clinical Investigation |
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265 | (2) |
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The Clinical Research Process |
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267 | (2) |
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269 | (2) |
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271 | (2) |
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Consent, Information and Sponsors |
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273 | (1) |
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Trial Steering Committees and Data Monitoring and Ethics Committees |
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274 | (1) |
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274 | (1) |
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274 | (1) |
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Promoting and Maintaining a Trial |
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275 | (1) |
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Common Statistical Terms Used in Clinical Trials |
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276 | (2) |
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278 | (1) |
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Chapter 1 Structure and Function of the Genome |
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278 | (1) |
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Chapter 2 Clinical Genetics |
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279 | (1) |
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280 | (1) |
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Chapter 4 Fetal and Placental Physiology |
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281 | (1) |
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Chapter 5 Applied Anatomy |
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281 | (2) |
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283 | (1) |
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Chapter 7 Microbiology and Virology |
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283 | (1) |
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284 | (1) |
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285 | (1) |
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286 | (1) |
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286 | (1) |
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Chapter 12 Drugs and Drug Therapy |
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287 | (1) |
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Chapter 13 Physics in Obstetrics and Gynaecology |
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288 | (1) |
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Chapter 14 Statistics and Evidence-Based Health Care |
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289 | (1) |
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Chapter 15 Clinical Research Methodology |
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290 | (1) |
| Mock Exam Papers |
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291 | (11) |
| Answers |
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302 | (3) |
| Index |
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305 | |
Lisainfo e-raamatute kohta