| Preface to the First Edition |
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xxi | |
| Preface to the Second Edition |
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xxiii | |
| Preface to the Third Edition |
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xxiv | |
| Preface to the Fourth Edition |
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xxv | |
| Acknowledgments |
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xxvii | |
| Part I Virology And Viral Disease |
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1 | (64) |
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Chapter 1 Introduction - The Impact of Viruses on Our View of Life |
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3 | (12) |
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3 | (11) |
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The effect of virus infections on the host organism and populations - viral pathogenesis, virulence, and epidemiology |
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4 | (2) |
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The interaction between viruses and their hosts |
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6 | (1) |
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7 | (1) |
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Examples of the impact of viral disease on human history |
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8 | (1) |
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Examples of the evolutionary impact of the virus-host interaction |
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9 | (1) |
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9 | (3) |
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Viruses have a constructive as well as destructive impact on society |
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12 | (1) |
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Viruses are not the smallest self-replicating pathogens |
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13 | (1) |
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14 | (1) |
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Chapter 2 An Outline of Virus Replication and Viral Pathogenesis |
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15 | (12) |
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15 | (4) |
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Stages of virus replication in the cell |
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17 | (2) |
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Pathogenesis of Viral Infection |
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19 | (6) |
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Stages of virus-induced pathology |
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19 | (8) |
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Initial stages of infection - entry of the virus into the host |
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20 | (1) |
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The incubation period and spread of virus through the host |
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21 | (2) |
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Multiplication of virus to high levels - occurrence of disease symptoms |
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23 | (1) |
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Later stages of infection - changes in the cell |
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23 | (1) |
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The later stages of infection - the immune response |
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24 | (1) |
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The later stages of infection - virus spread to the next individual |
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25 | (1) |
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The later stages of infection - fate of the host |
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25 | (1) |
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25 | (2) |
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Chapter 3 Virus Disease in Populations and Individual Animals |
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27 | (16) |
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The Nature of Virus Reservoirs |
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27 | (4) |
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Some viruses with human reservoirs |
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28 | (2) |
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Some viruses with vertebrate reservoirs |
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30 | (1) |
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31 | (3) |
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Viral epidemiology in small and large populations |
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31 | (3) |
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Factors affecting the control of viral disease in populations |
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34 | (1) |
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Animal Models to Study Viral Pathogenesis |
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34 | (7) |
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A mouse model for studying poxvirus infection and spread |
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36 | (1) |
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Rabies: where is the virus during its long incubation period? |
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37 | (2) |
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Herpes simplex virus latency |
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39 | (5) |
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39 | (1) |
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39 | (1) |
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40 | (1) |
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41 | (2) |
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Chapter 4 Patterns of Some Viral Diseases of Humans |
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43 | (18) |
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The Dynamics of Human-Virus Interactions |
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44 | (7) |
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The stable association of viruses with their natural host places specific constraints on the nature of viral disease and mode of persistence |
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44 | (2) |
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Classification of human disease-causing viruses according to virus-host dynamics |
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46 | (5) |
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Viral diseases leading to persistence of the virus in the host are generally associated with viruses having long associations with human populations |
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46 | (4) |
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Viral diseases associated with acute, severe infection are suggestive of zoonoses |
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50 | (1) |
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Patterns of Specific Viral Diseases of Humans |
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51 | (5) |
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Acute infections followed by virus clearing |
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51 | (1) |
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Colds and respiratory infections |
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51 | (1) |
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51 | (1) |
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51 | (1) |
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Infection of an "accidental" target tissue leading to permanent damage despite efficient clearing |
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52 | (1) |
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Persistent viral infections |
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52 | (3) |
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Papilloma and polyomavirus infections |
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54 | (1) |
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Herpesvirus infections and latency |
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54 | (1) |
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Other complications arising from persistent infections |
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54 | (1) |
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Viral and subviral diseases with long incubation periods |
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55 | (1) |
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55 | (1) |
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56 | (1) |
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56 | (1) |
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Some Viral Infections Targeting Specific Organ Systems |
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56 | (4) |
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Viral infections of nerve tissue |
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57 | (1) |
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Examples of viral encephalitis with grave prognosis |
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57 | (1) |
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57 | (1) |
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58 | (1) |
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Viral encephalitis with favorable prognosis for recovery |
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58 | (1) |
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Viral infections of the liver (viral hepatitis) |
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59 | (8) |
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59 | (1) |
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59 | (1) |
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59 | (1) |
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60 | (1) |
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60 | (1) |
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60 | (1) |
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61 | (2) |
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Additional Reading for Part I |
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63 | (2) |
| Part II Basic Properties Of Viruses And Virus-Cell Interaction |
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65 | (88) |
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Chapter 5 Virus Structure and Classification |
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67 | (18) |
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67 | (12) |
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75 | (1) |
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76 | (1) |
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76 | (3) |
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79 | (1) |
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The Baltimore scheme of virus classification |
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79 | (1) |
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Disease-based classification schemes for viruses |
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80 | (1) |
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80 | (3) |
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83 | (1) |
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83 | (2) |
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Chapter 6 The Beginning and End of the Virus Replication Cycle |
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85 | (20) |
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Outline of the Virus Replication Cycle |
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85 | (1) |
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86 | (9) |
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Animal virus entry into cells - the role of the cellular receptor |
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86 | (3) |
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Mechanisms of entry of nonenveloped viruses |
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89 | (1) |
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Entry of enveloped viruses |
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90 | (1) |
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Entry of virus into plant cells |
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91 | (2) |
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The injection of bacteriophage DNA into Escherichia coli |
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93 | (2) |
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Nonspecific methods of introducing viral genomes into cells |
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95 | (1) |
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Late Events in Viral Infection: Capsid Assembly and Virion Release |
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95 | (8) |
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Assembly of helical capsids |
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95 | (3) |
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Assembly of icosahedral capsids |
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98 | (1) |
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Generation of the virion envelope and egress of the enveloped virion |
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99 | (4) |
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103 | (2) |
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Chapter 7 The Innate Immune Response: Early Defense Against Pathogens |
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105 | (26) |
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Host Cell-Based Defenses Against Virus Replication |
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106 | (6) |
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106 | (1) |
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107 | (1) |
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108 | (3) |
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108 | (1) |
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109 | (1) |
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Measurement of interferon activity |
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110 | (1) |
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Other cellular defenses against viral infection |
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111 | (1) |
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111 | (1) |
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The Adaptive Immune Response and the Lymphatic System |
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112 | (8) |
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Two pathways of helper T response: the fork in the road |
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113 | (1) |
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The immunological structure of a protein |
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114 | (2) |
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Role of the antigen-presenting cell in initiation of the immune response |
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116 | (4) |
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Clonal selection of immune-reactive lymphocytes |
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119 | (1) |
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120 | (1) |
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Complement-mediated cell lysis |
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120 | (1) |
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Control and Dysfunction of Immunity |
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120 | (4) |
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Specific viral responses to host immunity |
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121 | (3) |
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Passive evasion of immunity - antigenic drift |
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122 | (1) |
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Passive evasion of immunity - internal sanctuaries for infectious virus |
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122 | (1) |
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Passive evasion of immunity - immune tolerance |
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122 | (1) |
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Active evasion of immunity - immunosuppression |
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123 | (1) |
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Active evasion of immunity - blockage of MHC antigen presentation |
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123 | (1) |
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Consequences of immune suppression to virus infections |
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124 | (1) |
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Measurement of the Immune Reaction |
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124 | (5) |
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Measurement of cell-mediated (T-cell) immunity |
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124 | (1) |
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T-cell proliferation assay |
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124 | (1) |
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124 | (1) |
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Measurement of antiviral antibody |
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125 | (7) |
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Enzyme-linked immunosorbent assays (ELISAs) |
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125 | (1) |
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126 | (1) |
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Inhibition of hemagglutination |
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126 | (1) |
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127 | (2) |
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129 | (2) |
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Chapter 8 Strategies to Protect Against and Combat Viral Infection |
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131 | (16) |
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Vaccination - Induction of Immunity to Prevent Virus Infection |
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132 | (6) |
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132 | (1) |
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Smallpox and the history of vaccination |
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132 | (1) |
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How a vaccine is produced |
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133 | (4) |
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134 | (1) |
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135 | (1) |
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Recombinant virus vaccines |
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136 | (1) |
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Capsid and subunit vaccines |
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136 | (1) |
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137 | (1) |
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137 | (1) |
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Problems with vaccine production and use |
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137 | (1) |
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Eukaryotic Cell-Based Defenses Against Virus Replication |
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138 | (1) |
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Cellular defenses against viral infection |
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138 | (1) |
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138 | (1) |
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Cellular factors that restrict retrovirus replication |
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139 | (1) |
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139 | (5) |
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Targeting antiviral drugs to specific features of the virus replication cycle |
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140 | (3) |
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Acyclovir and the herpesviruses |
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141 | (1) |
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Blocking influenza virus entry and virus maturation |
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141 | (1) |
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Chemotherapeutic approaches for HIV |
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142 | (1) |
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Multiple-drug therapies to reduce or eliminate mutation to drug resistance |
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143 | (1) |
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143 | (1) |
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Bacterial Antiviral Systems - Restriction Endonucleases |
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144 | (1) |
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145 | (1) |
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145 | (2) |
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147 | (4) |
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Additional Reading for Part II |
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151 | (2) |
| Part III Working With Virus |
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153 | (92) |
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Chapter 9 Visualization and Enumeration of Virus Particles |
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155 | (8) |
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Using the Electron Microscope to Study and Count Viruses |
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155 | (4) |
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Counting (enumeration) of virions with the electron microscope |
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157 | (2) |
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Atomic Force Microscopy - A Rapid and Sensitive Method for Visualization of Viruses and Infected Cells, Potentially in Real Time |
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159 | (1) |
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Indirect Methods for "Counting" Virus Particles |
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160 | (1) |
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161 | (2) |
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Chapter 10 Replicating and Measuring Biological Activity of Viruses |
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163 | (18) |
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164 | (4) |
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Maintenance of bacterial cells |
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164 | (1) |
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164 | (1) |
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Culture of animal and human cells |
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165 | (3) |
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Maintenance of cells in culture |
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165 | (1) |
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165 | (2) |
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Loss of contact inhibition of growth and immortalization of primary cells |
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167 | (1) |
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The Outcome of Virus Infection in Cells |
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168 | (4) |
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168 | (2) |
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Fate of the cell following virus infection |
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170 | (2) |
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Cell-mediated maintenance of the intra- and intercellular environment |
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170 | (1) |
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Virus-mediated cytopathology - changes in the physical appearance of cells |
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171 | (1) |
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Virus-mediated cytopathology - changes in the biochemical properties of cells |
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171 | (1) |
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Measurement of the Biological Activity of Viruses |
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172 | (7) |
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Quantitative measure of infectious centers |
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172 | (2) |
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172 | (1) |
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Generation of transformed cell foci |
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173 | (1) |
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Use of virus titers to quantitatively control infection conditions |
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174 | (3) |
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Examples of plaque assays |
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175 | (1) |
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Statistical analysis of infection |
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176 | (1) |
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Dilution endpoint methods |
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177 | (4) |
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The relation between dilution endpoint and infectious units of virus |
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177 | (2) |
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179 | (2) |
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Chapter 11 Physical and Chemical Manipulation of the Structural Components of Viruses |
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181 | (16) |
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Viral Structural Proteins |
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181 | (6) |
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Isolation of structural proteins of the virus |
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182 | (1) |
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Size fractionation of viral structural proteins |
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183 | (4) |
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Determining the stoichiometry of capsid proteins |
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185 | (1) |
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The poliovirus capsid - a virion with equimolar capsid proteins |
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186 | (1) |
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Analysis of viral capsids that do not contain equimolar numbers of proteins |
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187 | (1) |
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Characterizing Viral Genomes |
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187 | (9) |
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Sequence analysis of viral genomes |
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188 | (2) |
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190 | (2) |
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High-throughput equencing (HTS) |
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192 | (1) |
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The polymerase chain reaction - detection and characterization of extremely small quantities of viral genomes or transcripts |
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192 | (5) |
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Real-time per for precise quantitative measures of viral DNA |
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193 | (2) |
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195 | (1) |
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PCR as an epidemiological tool |
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195 | (1) |
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196 | (1) |
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Chapter 12 Characterization of Viral Products Expressed in the Infected Cell |
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197 | (20) |
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Characterization of Viral Proteins in the Infected Cell |
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197 | (12) |
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Pulse labeling of viral proteins at different times following infection |
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198 | (2) |
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Use of immune reagents for study of viral proteins |
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200 | (9) |
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200 | (3) |
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Detection of viral proteins using immunofluorescence |
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203 | (2) |
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Related methods for detecting antibodies bound to antigens |
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205 | (4) |
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Detecting and Characterizing Viral Nucleic Acids in Infected Cells |
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209 | (5) |
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Detecting the synthesis of viral genomes |
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209 | (1) |
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Characterization of viral mRNA expressed during infection |
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210 | (9) |
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212 | (2) |
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Further characterization of specific viral mRNA molecules |
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214 | (1) |
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Use of Microarray Technology for Getting a Complete Picture of the Events Occurring in the Infected Cell |
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214 | (2) |
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216 | (1) |
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Chapter 13 Viruses Use Cellular Processes to Express their Genetic Information |
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217 | (24) |
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Prokaryotic DNA Replication Is an Accurate Enzymatic Model for the Process Generally |
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219 | (2) |
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The replication of eukaryotic DNA |
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220 | (1) |
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The replication of viral DNA |
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221 | (1) |
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The effect of virus infection on host DNA replication |
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221 | (1) |
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221 | (2) |
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Prokaryotic Transcription |
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223 | (2) |
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Prokaryotic RNA polymerise |
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223 | (1) |
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The prokaryotic promoter and initiation of transcription |
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224 | (1) |
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Control of prokaryotic initiation of transcription |
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224 | (1) |
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Termination of prokaryotic transcription |
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225 | (1) |
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225 | (10) |
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The promoter and initiation of transcription |
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225 | (2) |
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Control of initiation of eukaryotic transcription |
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227 | (2) |
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Processing of precursor mRNA |
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229 | (4) |
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Location of splices in eukaryotic transcripts |
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233 | (1) |
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Posttranscriptional regulation of eukaryotic mRNA function |
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233 | (1) |
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Virus-induced changes in transcription and posttranscriptional processing |
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234 | (1) |
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The Mechanism of Protein Synthesis |
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235 | (4) |
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235 | (2) |
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237 | (1) |
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Virus-induced changes in translation |
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238 | (1) |
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239 | (2) |
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241 | (2) |
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Additional Reading for Part III |
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243 | (2) |
| Part IV Replication Patterns Of Specific Viruses |
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245 | (192) |
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Chapter 14 Replication of Positive-Sense RNA Viruses |
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247 | (30) |
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RNA Viruses - General Considerations |
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248 | (2) |
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A general picture of RNA-directed RNA replication |
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248 | (2) |
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Replication of Positive-Sense RNA Viruses Whose Genomes Are Translated as the First Step in Gene Expression |
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250 | (1) |
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Positive-Sense RNA Viruses Encoding a Single Large Open Reading Frame |
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251 | (9) |
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251 | (7) |
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The poliovirus genetic map and expression of poliovirus proteins |
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251 | (3) |
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The poliovirus replication cycle |
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254 | (2) |
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Picornavirus cytopathology and disease |
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256 | (2) |
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258 | (2) |
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Positive-Sense RNA Viruses Encoding More Than One Translational Reading Frame |
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260 | (10) |
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Two viral mRNAs are produced in different amounts during togavirus infections |
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260 | (5) |
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260 | (1) |
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The virus replication cycle |
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261 | (2) |
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Generation of structural proteins |
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263 | (1) |
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Togavirus cytopathology and disease |
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263 | (2) |
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A somewhat more complex scenario of multiple translational reading frames and subgenomic mRNA expression: coronavirus replication |
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265 | (5) |
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266 | (2) |
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Cytopathology and disease caused by coronaviruses |
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268 | (2) |
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Replication of Plant Viruses with RNA Genomes |
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270 | (2) |
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Viruses with one genome segment |
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271 | (1) |
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Viruses with two genome segments |
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271 | (1) |
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Viruses with three genome segments |
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272 | (1) |
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Replication of Bacteriophages with RNA Genomes |
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272 | (4) |
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Regulated translation of bacteriophage mRNA |
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272 | (4) |
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276 | (1) |
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Chapter 15 Replication Strategies of RNA Viruses Requiring RNA-directed mRNA Transcription as the First Step in Viral Gene Expression |
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277 | (30) |
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Replication of Negative-Sense RNA Viruses with a Monopartite Genome |
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279 | (8) |
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The replication of vesicular stomatitis virus - a model for mononegavirales |
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279 | (1) |
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The vesicular stomatitis virus virion and genome |
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279 | (5) |
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Generation, capping, and polyadenylation of mRNA |
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280 | (2) |
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The generation of new negative-sense virion RNA |
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282 | (1) |
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The mechanism of host shutoff by vesicular stomatitis virus |
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283 | (1) |
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The cytopathology and diseases caused by rhabdoviruses |
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284 | (1) |
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284 | (2) |
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The pathogenesis of paramyxoviruses |
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284 | (2) |
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Filoviruses and their pathogenesis |
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286 | (1) |
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287 | (1) |
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Other mononegavirales families |
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287 | (1) |
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Negative-Sense RNA Viruses with a Multipartite Genome |
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287 | (6) |
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Involvement of the nucleus in flu virus replication |
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289 | (1) |
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Generation of new flu nucleocapsids and maturation of the virus |
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289 | (2) |
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291 | (2) |
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Other Negative-Sense RNA Viruses with Multipartite Genomes |
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293 | (4) |
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293 | (3) |
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Virus structure and replication |
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293 | (2) |
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295 | (1) |
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296 | (1) |
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296 | (1) |
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296 | (1) |
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Viruses with Double-Stranded RNA Genomes |
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297 | (3) |
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297 | (1) |
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The orthoreovirus replication cycle |
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297 | (2) |
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299 | (1) |
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300 | (4) |
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300 | (1) |
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301 | (3) |
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304 | (3) |
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Chapter 16 Replication Strategies of Small and Medium-sized DNA Viruses |
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307 | (28) |
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DNA Viruses Express Genetic Information and Replicate Their Genomes in Similar, yet Distinct, Ways |
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308 | (1) |
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309 | (14) |
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Replication of SV40 virus - the model polyomavirus |
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309 | (9) |
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The SV40 genome and genetic map |
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313 | (1) |
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Productive infection by SV40 |
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314 | (2) |
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Abortive infection of cells nonpermissive for SV40 replication |
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316 | (2) |
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The replication of papillomaviruses |
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318 | (5) |
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320 | (1) |
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Virus replication and cytopathology |
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320 | (3) |
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The Replication of Adenoviruses |
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323 | (4) |
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Physical properties of adenovirus |
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323 | (1) |
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323 | (1) |
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323 | (1) |
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The adenovirus replication cycle |
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323 | (4) |
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323 | (2) |
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Adenovirus DNA replication |
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325 | (1) |
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325 | (1) |
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VA transcription and cytopathology |
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325 | (2) |
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Transformation of nonpermissive cells by adenovirus |
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327 | (1) |
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Replication of Some Single-Stranded DNA Viruses |
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327 | (5) |
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Replication of parvoviruses |
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327 | (2) |
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Dependovirus DNA integrates in a specific site in the host cell genome |
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328 | (1) |
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Parvoviruses have potentially exploitable therapeutic applications |
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329 | (1) |
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DNA viruses infecting vascular plants |
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329 | (1) |
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329 | (1) |
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The single-stranded DNA bacteriophage ΦX174 packages its genes very compactly |
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330 | (2) |
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332 | (3) |
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Chapter 17 Replication of Some Nuclear-replicating Eukaryotic DNA Viruses with Large Genomes |
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335 | (28) |
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Herpesvirus Replication and Latency |
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336 | (2) |
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The herpesviruses as a group |
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336 | (2) |
|
Genetic complexity of herpesviruses |
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337 | (1) |
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Common features of herpesvirus replication in the host |
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337 | (1) |
|
The replication of the prototypical alphaherpesvirus - HSV |
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338 | (21) |
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338 | (1) |
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338 | (11) |
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342 | (7) |
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349 | (6) |
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HSV transcription during latency and reactivation |
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352 | (1) |
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How do the LAT and other specific HSV genes function to accommodate reactivation? |
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353 | (2) |
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EBV latent infection of lymphocytes: a different set of problems and answers |
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355 | (2) |
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Pathology of herpesvirus infections |
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357 | (2) |
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Herpesviruses as infectious co-carcinogens |
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358 | (1) |
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Baculovirus: An Insect Virus with Important Practical Uses in Molecular Biology |
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359 | (2) |
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359 | (1) |
|
Viral gene expression and genome replication |
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359 | (1) |
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360 | (1) |
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Importance of baculoviruses in biotechnology |
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360 | (1) |
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361 | (2) |
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Chapter 18 Replication of Cytoplasmic DNA Viruses and "Large" Bacteriophages |
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363 | (22) |
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Poxviruses - DNA Viruses that Replicate in the Cytoplasm of Eukaryotic Cells |
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364 | (6) |
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The pox virion is complex and contains virus-coded transcription enzymes |
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364 | (1) |
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The poxvirus replication cycle |
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365 | (3) |
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367 | (1) |
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367 | (1) |
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Intermediate and late stages of replication |
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368 | (1) |
|
Pathogenesis and history of poxvirus infections |
|
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368 | (1) |
|
Is smallpox virus a potential biological terror weapon? |
|
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369 | (1) |
|
Replication of "Large" DNA-Containing Bacteriophages |
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370 | (10) |
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Components of large DNA-containing phage virions |
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370 | (1) |
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370 | (2) |
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370 | (1) |
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Phage-controlled transcription |
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370 | (2) |
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The Practical Value of T7 |
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372 | (1) |
|
T4 bacteriophage: the basic model for all DNA viruses |
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372 | (3) |
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372 | (2) |
|
Regulated gene expression during T4 replication |
|
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374 | (1) |
|
Capsid maturation and release |
|
|
374 | (1) |
|
Replication of phage X: a "Simple" model for latency and reactivation |
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375 | (11) |
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377 | (1) |
|
Phage X gene expression immediately after infection |
|
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377 | (1) |
|
Biochemistry of the decision between lyric and lysogenic infection in E. coil |
|
|
378 | (2) |
|
A Group of Algal Viruses Shares Features of its Genome Structure with Poxviruses and Bacteriophages |
|
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380 | (1) |
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381 | (4) |
|
Chapter 19 Retroviruses: Converting RNA to DNA |
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385 | (18) |
|
Retrovirus Families and Their Strategies of Replication |
|
|
386 | (10) |
|
The molecular biology of retroviruses |
|
|
387 | (3) |
|
Retrovirus structural proteins |
|
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387 | (1) |
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388 | (2) |
|
Genetic maps of representative retroviruses |
|
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390 | (1) |
|
Replication of retroviruses: an outline of the replication process |
|
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390 | (5) |
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|
|
390 | (3) |
|
Capsid assembly and maturation |
|
|
393 | (1) |
|
Action of reverse transcriptase and RNase H in synthesis of cDNA |
|
|
393 | (2) |
|
Retrovirus gene expression, assembly, and maturation |
|
|
395 | (1) |
|
Transcription and translation of viral mRNA |
|
|
395 | (1) |
|
Capsid assembly and morphogenesis |
|
|
396 | (1) |
|
Mechanisms of Retrovirus Transformation |
|
|
396 | (3) |
|
Transformation through the action of a viral oncogene - a subverted cellular growth control gene |
|
|
396 | (1) |
|
Oncornavirus alteration of normal cellular transcriptional control of growth regulation |
|
|
397 | (1) |
|
Oncornavirus transformation by growth stimulation of neighboring cells |
|
|
397 | (2) |
|
Cellular Genetic Elements Related to Retroviruses |
|
|
399 | (2) |
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|
|
400 | (1) |
|
The relationship between transposable elements and viruses |
|
|
400 | (1) |
|
|
|
401 | (2) |
|
Chapter 20 Human Immunodeficiency Virus Type 1 (HIV-1) and Related Lentiviruses |
|
|
403 | (12) |
|
HIV-1 and Related Lentiviruses |
|
|
403 | (1) |
|
The Origin of HIV-1 and AIDS |
|
|
403 | (1) |
|
HIV-1 and Lentiviral Replication |
|
|
404 | (8) |
|
Destruction of the Immune System by HIV-1 |
|
|
412 | (2) |
|
|
|
414 | (1) |
|
Chapter 21 Hepadnaviruses: Variations on the Retrovirus Theme |
|
|
415 | (10) |
|
The Virion and the Viral Genome |
|
|
416 | (1) |
|
The Viral Replication Cycle |
|
|
417 | (1) |
|
The Pathogenesis of Hepatitis B Virus |
|
|
417 | (1) |
|
Prevention and Treatment of Hepatitis B Virus Infection |
|
|
418 | (1) |
|
|
|
419 | (1) |
|
A Plant "Hepadnavirus": Cauliflower Mosaic Virus |
|
|
420 | (1) |
|
|
|
421 | (1) |
|
Viral gene expression and genome replication |
|
|
421 | (1) |
|
The Evolutionary Origin of Hepadnaviruses |
|
|
421 | (2) |
|
|
|
423 | (2) |
|
|
|
425 | (8) |
|
Additional Reading for Part IV |
|
|
433 | (4) |
| Part V Molecular Genetics Of Viruses |
|
437 | (66) |
|
Chapter 22 The Molecular Genetics of Viruses |
|
|
439 | (28) |
|
Mutations in Genes and Resulting Changes to Proteins |
|
|
441 | (1) |
|
|
|
442 | (2) |
|
|
|
442 | (2) |
|
|
|
444 | (1) |
|
|
|
444 | (1) |
|
HSV thymidine kinase - a portable selectable marker |
|
|
444 | (1) |
|
|
|
445 | (1) |
|
A Tool Kit for Molecular Virologists |
|
|
445 | (1) |
|
|
|
445 | (1) |
|
Locating Sites of Restriction Endonuclease Cleavage on the Viral Genome - Restriction Mapping |
|
|
446 | (2) |
|
|
|
448 | (10) |
|
Cloning of fragments of viral genomes using bacterial plasmids |
|
|
449 | (4) |
|
Cloning single-stranded DNA with bacteriophage M13 |
|
|
453 | (1) |
|
|
|
454 | (2) |
|
|
|
455 | (1) |
|
|
|
455 | (1) |
|
Adenovirus and adeno-associated virus provide vectors that can deliver genes to specific tissue |
|
|
455 | (1) |
|
RNA virus expression systems |
|
|
456 | (1) |
|
|
|
456 | (1) |
|
|
|
456 | (1) |
|
Defective virus particles |
|
|
457 | (1) |
|
Directed Mutagenesis of Viral Genes |
|
|
458 | (2) |
|
Site-directed mutagenesis |
|
|
458 | (2) |
|
Generation of Recombinant Viruses |
|
|
460 | (5) |
|
|
|
461 | (1) |
|
Bacterial artificial chromosomes |
|
|
461 | (3) |
|
|
|
464 | (1) |
|
|
|
465 | (2) |
|
Chapter 23 Molecular Pathogenesis |
|
|
467 | (10) |
|
An Introduction to the Study of Viral Pathogenesis |
|
|
467 | (1) |
|
|
|
468 | (2) |
|
Choosing a model: natural host versus surrogate models |
|
|
468 | (1) |
|
Development of new models: transgenic animals |
|
|
468 | (1) |
|
Chimeric models: the SCID-hu mouse |
|
|
468 | (1) |
|
Considerations regarding the humane use of animals |
|
|
469 | (1) |
|
Methods for the Study of Pathogenesis |
|
|
470 | (4) |
|
|
|
470 | (2) |
|
Analysis of viral spread within the host |
|
|
472 | (1) |
|
Resolving the infection to the level of single cells |
|
|
473 | (1) |
|
Characterization of the Host Response |
|
|
474 | (2) |
|
|
|
475 | (1) |
|
Use of transgenic mice to dissect critical components of the host immune response that modulate the viral infection |
|
|
475 | (1) |
|
|
|
476 | (1) |
|
Chapter 24 Viral Bioinformatics |
|
|
477 | (12) |
|
|
|
477 | (1) |
|
Bioinformatics and virology |
|
|
478 | (1) |
|
|
|
478 | (2) |
|
|
|
479 | (1) |
|
|
|
479 | (1) |
|
|
|
479 | (1) |
|
|
|
480 | (1) |
|
|
|
480 | (3) |
|
Similarity-searching tools |
|
|
480 | (2) |
|
Protein functional analysis |
|
|
482 | (1) |
|
|
|
482 | (1) |
|
|
|
482 | (1) |
|
|
|
482 | (1) |
|
Systems Biology and Viruses |
|
|
483 | (4) |
|
|
|
487 | (1) |
|
|
|
488 | (1) |
|
Chapter 25 Viruses and the Future - Problems and Promises |
|
|
489 | (10) |
|
Clouds on the Horizon - Emerging Disease |
|
|
490 | (4) |
|
Sources and causes of emergent virus disease |
|
|
492 | (1) |
|
The threat of bioterrorism |
|
|
493 | (1) |
|
What are the Prospects of Using Medical Technology to Eliminate Specific Viral and Other Infectious Diseases? |
|
|
494 | (1) |
|
Silver Linings - Viruses as Therapeutic Agents |
|
|
495 | (2) |
|
Viruses for gene delivery |
|
|
495 | (1) |
|
Using viruses to destroy other viruses |
|
|
496 | (1) |
|
Viruses and nanotechnology |
|
|
496 | (1) |
|
The place of viruses in the biosphere |
|
|
497 | (1) |
|
|
|
497 | (1) |
|
|
|
497 | (2) |
|
|
|
499 | (2) |
|
Additional Reading for Part V |
|
|
501 | (2) |
| Appendix Resource Center |
|
503 | (6) |
|
Books of Historical and Basic Value |
|
|
503 | (1) |
|
|
|
504 | (1) |
|
Molecular Biology and Biochemistry Texts |
|
|
505 | (1) |
|
|
|
505 | (1) |
|
Sources for Experimental Protocols |
|
|
506 | (1) |
|
|
|
506 | (3) |
|
|
|
506 | (1) |
|
Important Websites for Organizations and Facilities of Interest |
|
|
507 | (2) |
| Technical Glossary |
|
509 | (24) |
| Index |
|
533 | |
Lisainfo e-raamatute kohta