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E-raamat: Bioinformatics in MicroRNA Research

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This thorough volume provides an in-depth introduction to and discussion of microRNAs (miRs) and their targets, miR functions, and computational techniques applied in miR research, thus serving the need for a comprehensive book focusing on miR target genes, miR regulation mechanisms, miR functions performed in various human diseases, and miR databases/knowledgebases. Without prior knowledge of the area of study, computational biologists, computer scientists, bioinformaticians, bench biologists, as well as clinical investigators will find it easy to follow the techniques in this collection. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that ensures successful results. 

Accessible and practical, Bioinformatics in MicroRNA Research functions as an ideal guide for researchers of all backgrounds to explore this vital area of study.
Preface v
Contributors ix
1 MicroRNAs, Long Noncoding RNAs, and Their Functions in Human Disease
1(26)
Min Xue
Ying Zhuo
Bin Shan
2 MicroRNA Expression: Protein Participants in MicroRNA Regulation
27(12)
Valeria M. King
Glen M. Borchert
3 Viral MicroRNAs, Host MicroRNAs Regulating Viruses, and Bacterial MicroRNA-Like RNAs
39(18)
Sara-Elizabeth Cardin
Glen M. Borchert
4 MicroRNAs: Biomarkers, Diagnostics, and Therapeutics
57(12)
Weill Huang
5 Relational Databases and Biomedical Big Data
69(14)
N.H. Nisansa D. de Silva
6 Semantic Technologies and Bio-Ontologies
83(10)
Fernando Gutierrez
7 Genome-Wide Analysis of MicroRNA-Regulated Transcripts
93(16)
David Chevalier
Glen M. Borchert
8 Computational Prediction of MicroRNA Target Genes, Target Prediction Databases, and Web Resources
109(14)
Justin T. Roberts
Glen M. Borchert
9 Exploring MicroRNA: Target Regulatory Interactions by Computing Technologies
123(10)
Yue Hu
Wenjun Lan
Daniel Miller
10 The Limitations of Existing Approaches in Improving MicroRNA Target Prediction Accuracy
133(26)
Rasiah Loganantharaj
Thomas A. Randall
11 Genomic Regulation of MicroRNA Expression in Disease Development
159(10)
Feng Liu
12 Next-Generation Sequencing for MicroRNA Expression Profile
169(10)
Tue Hu
Wenjun Lan
Daniel Miller
13 Handling High-Dimension (High-Feature) MicroRNA Data
179(8)
Tue Hu
Wenjun Lan
Daniel Miller
14 Effective Removal of Noisy Data Via Batch Effect Processing
187(10)
Ryan G. Benton
15 Logical Reasoning (Inferencing) on MicroRNA Data
197(14)
Jingsong Wang
16 Machine Learning Techniques in Exploring MicroRNA Gene Discovery, Targets, and Functions
211(14)
Sumi Singh
Ryan G. Benton
Anurag Singh
Anshuman Singh
17 Involvement of MicroRNAs in Diabetes and Its Complications
225(16)
Bin Wu
Daniel Miller
18 MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role
241(20)
Lihua Zhang
Daniel Miller
Qiuping Yang
Bin Wu
19 Expression of MicroRNAs in Thyroid Carcinoma
261(20)
Gaohong Zhu
Lijun Xie
Daniel Miller
Index 281