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E-raamat: Biomarkers of Human Aging

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  • Formaat: PDF+DRM
  • Sari: Healthy Ageing and Longevity 10
  • Ilmumisaeg: 13-Sep-2019
  • Kirjastus: Springer Nature Switzerland AG
  • Keel: eng
  • ISBN-13: 9783030249700
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Biomarkers of Human AgingSuurem pilt
  • Formaat: PDF+DRM
  • Sari: Healthy Ageing and Longevity 10
  • Ilmumisaeg: 13-Sep-2019
  • Kirjastus: Springer Nature Switzerland AG
  • Keel: eng
  • ISBN-13: 9783030249700
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This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging.





In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function).





The book goes on to describe DNA methylation, known as the epigenetic clock, as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education.





Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging.





Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.





 
Introduction.- Section-1 BIOMARKERS OF AGING AND HEALTH.- Practical
Detection of Biological Age: Why it is not a trivial task.-  Biological age
is a universal marker of aging, stress, and frailty.- Biomarkers of health
and healthy ageing from the outside-in.- Biomarkers of aging.- Review of
molecular and cellular biomarkers of aging.- Section-2 PROTEOMICS AND
GLYCOMICS BIOMARKERS OF AGING.-  IgG glycans as a biomarker of biological
age.- Oxidatively modified proteins and maintenance systems as biomarkers of
aging.- Is impaired proteodynamics a key to understand the biomarkers of
cellular aging.- Section-3 GENETICS AND EPIGENETICS AGING MARKERS.-  Genetic
markers of extreme human longevity.- Epigenetic biomarkers of aging.- DNA
methylation biomarkers to assess biological age.- Epigenetics of brain aging:
lessons from chemo brain and tumor brain.- Approaches and methods for variant
analysis in a cell.- Section 4 IMMUNOSENESCENCE ANDINFLAMMAGING MARKERS.- Is
there any reliable biomarker for immunosenescence and inflammaging?.- Immune
parameters associated with mortality in longitudinal studies of very old
people can be markedly dissimilar even in apparently similar populations.-
Gut microbiota and aging.- Section-5 SYSTEMS BIOLOGY OF AGING, BIOLOGICAL AGE
AND MORTALITY MARKERS.- Deep integrated biomarkers of aging.- Quantification
of the biological age of the brain using.- Arterial aging: the role of
hormonal and metabolic status and telomere biology.- Circulating Biomarkers
of Aging.- Molecular signature of aging driven by Wnt signaling pathway:
Lessons from nematodes.- The problem of integrating of biological and
clinical markers of aging.- Index.
Prof. Alexey Moskalev is a Corresponding member of Russian Academy of Sciences, Doctor of Biology, the Head of the Laboratory of Geroprptective and Radioprotective Technologies in the Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, the Head of the Department of Ecology of the Syktyvkar State University named after Pitirim Sorokin, the Head of the Laboratory of Genetics of Aging and Longevity in the Moscow Institute of Physics and Technology.
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