Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.
- Represents a comprehensive means for those involved in the aortic research and the related developments in the industry
- Introduces the most recent imaging technologies to characterize factors, such as aortic geometry, mechanical properties of the aortic tissue, and the local cellular activity in the vessel wall
- Synthesizes advances in vascular biomechanics, medical imaging and computational finite element fluid and solid models to increase understanding of aorta function
PART 1 Anatomy, biology, physiopathology
1. Physiopathology
2. Genetics of aortic disease
3. Mechanobiology of aortic cells and extracellular matrix
4. Clinical treatment options PART 2 Imaging and tissue/rheology characterization
5. Novel experimental methods to characterize the mechanical properties of the aorta
6. Imaging aortic flows in 4D using MRI
7. Ultrasound imaging for aortic biomechanics
8. Functional imaging, focus on [ 18F]FDG positron emission tomography
9. Image processing: Deep learning for aorta model reconstruction PART 3 Tissue modeling and rupture
10. On simulation of the biophysical behavior of the aortic heart valve interstitial cell
11. Abdominal Aortic Aneurysm and thrombus modeling
12. Computational modeling of aneurysm growth in mechanobiology
13. Analysis of aortic rupture: A computational biomechanics perspective
14. Multiscale modeling of aortic mechanics: Tissue, network, and protein PART 4 Flow modeling and algorithm
15. Multiphysics flow modeling in the aorta
16. Novel Approaches for the numerical solution of fluid-structure interaction in the Aorta
17. Turbulence modeling of blood flow
18. Inverse problems in aortic flow modeling
19. Modeling of flow induced mechanosignaling
20. Reduced order modeling of cardiovascular hemodynamics PART 5 Applications
21. Transcatheter aortic valve implantation (TAVI)
22. Abdominal Aortic Aneurysm rupture prediction
23. (T)EVAR simulation
24. Fluid Structure Interaction (FSI) in aortic dissections
25. Pharmacological treatments, mouse models, and the aorta
T. Christian Gasser is a professor of biomechanics at the KTH Royal Institute of Technology in Stockholm, Sweden, and an adjunct professor at the University of Southern Denmark in Odense, Denmark. Professor Gasser is the principal founder of VASCOPS GmbH, Graz, Austria, and ARTEC Vascular Diagnosis AB, Stockholm, Sweden. His scientific interest relates to vascular biomechanical problems, with particular emphasis on numerical techniques to solve clinically relevant questions. Constitutive models developed by Professor Gasser have been implemented in many major finite element simulation packages, and translational research led to diagnostic software that is used at many clinical centers. Professor Gasser is among the highest-cited researchers in vascular biomechanics. He has taught numerous courses at undergraduate and graduate levels, served as a supervisor for many engineering and clinical PhD students, is a frequent member of examination and grading committees, and is a reviewer of several science councils as well as the most relevant scientific journals in the field. Stéphane Avril is a distinguished Full Professor at Institut Mines Telecom affiliated at Mines Saint-Etienne in France. Stéphane received his PhD in mechanical and civil engineering in 2002 at Mines Saint-Etienne (France). After positions at Arts et Métiers ParisTech (France) and Loughborough University (UK), Stéphane returned to his alma mater in 2008 and extended his experience of inverse problems to soft tissue biomechanics, especially regarding aortic aneurisms in close collaboration with vascular surgeons. Stéphane was a visiting Professor at Yale University between 2014 and 2019 and is currently a guest professor at TU Vienna and TU Graz in Austria. Stéphane has received many awards and distinctions including an ERC (European Research Council) consolidator grant for the Biolochanics project on: Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine. Most of Stéphanes research is aimed at improving the treatment of cardiovascular diseases by assisting physicians and surgeons with biomechanical numerical simulations. In 2017, Stéphane co-founded Predisurge, a spin-off company of IMT at Mines Saint-Etienne. PrediSurge offers innovative software solutions for patient-specific numerical simulation of surgical procedures with first applications in endovascular aneurysm repair (EVAR). John A. Elefteriades is the William W.L. Glenn Professor of Surgery at Yale University and the Emeritus Director of the Aortic Institute at Yale New Haven Hospital. He is a past president of the Connecticut Chapter of the American College of Cardiology and a member of the national Board of Governors of the College. Dr. Elefteriades is also the past president of the International College of Angiology. He serves on the editorial board of the American Journal of Cardiology, the Journal of Cardiac Surgery, Cardiology, and the Journal of Thoracic and Cardiovascular Surgery, and he is the editor-in-chief of the journal AORTA. He has been a member of the Thoracic Surgery Directors Association and has been named consistently in The Best Doctors in America. He is a frequently requested international lecturer, visiting professor, and guest surgeon. He has received the Walter Bleifeld Memorial Award for Distinguished Contribution in Clinical Research in Cardiology and the John B. Chang Research Achievement Award. In 2005, he was selected to lecture at the Leadership in Biomedicine Series at the Yale University School of Medicine. In 2006, he received the Socrates Award from the Thoracic Residents Association, the Thoracic Surgery Directors Association, and the Society of Thoracic Surgeons, recognizing exceptional achievement in teaching and mentoring residents. In 2017, Dr. Elefteriades was awarded an honorary PhD from the University of Liege (Belgium) in recognition of his work in the diagnosis and treatment of aortic diseases. In 2020, Dr. Elefteriades was recognized by Expertscape as the top aortic specialist in the world.
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