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E-raamat: Biomedical Engineering: Bridging Medicine and Technology

(Yale University, Connecticut)
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The second edition of this popular introductory undergraduate textbook uses examples, applications, and profiles of biomedical engineers to show students the relevance of the theory and how it can be used to solve real problems in human medicine. The essential molecular biology, cellular biology, and human physiology background is included for students to understand the context in which biomedical engineers work. Updates throughout highlight important advances made over recent years, including iPS cells, microRNA, nanomedicine, imaging technology, biosensors, and drug delivery systems, giving students a modern description of the various subfields of biomedical engineering. Over two hundred quantitative and qualitative exercises, many new to this edition, help consolidate learning, whilst a solutions manual, password-protected for instructors, is available online. Finally, students can enjoy an expanded set of leader profiles in biomedical engineering within the book, showcasing the broad range of career paths open to students who make biomedical engineering their calling.

Arvustused

'This book sets a gold standard for textbooks in biomedical engineering. It is beautifully and clearly written, and explains all aspects, old and very new, of biomedical engineering in ways that are both exciting to the reader as well as easy to understand.' Robert Langer, Massachusetts Institute of Technology 'This textbook is a wonderful summary of the field of biomedical engineering - a must-have for any faculty member teaching an introductory BME course. As usual, Professor Saltzman has provided rich context and broad examples; he does an excellent job of weaving in valuable scenarios that are realistic, yet interesting - a great tool for engaging students. There are many creative and useful features to the text: the figures and illustrations provide much value to understanding the material, the problem sets offer both conceptual and quantitative review of the material, and the 'Key Concepts and Definitions' and 'Useful Links' sections at the end of each chapter are very practical for a student new to the field of BME. Of particular note, the 'Profiles in BME' vignettes for each chapter add a personal touch and serve to connect students to role models who are real people (with real stories) making an impact on the world.' Christine E. Schmidt, University of Florida 'This is an excellent book that covers the fundamentals of a broad array of specific fields within biomedical engineering. This textbook will certainly be adopted by many introductory biomedical engineering courses due to its meaningful organization, clear writing, illuminative figures, and variety of problems for students to work through. Its breadth and scope will stimulate all readers. Once again, Mark Saltzman has accomplished a major achievement by providing such a comprehensive text for students and educators alike.' Melissa Krebs, Colorado School of Mines 'This is a truly exceptional textbook. It is completely up-to-date and comprehensive, yet it is so readable that you can dip in at any page and find something that grabs you. It is designed for undergraduate students, and is a tremendous resource for course development - but equally, it is one of those essential bookshelf books, the one you will turn to when you need 'to brush up on your biology', or 'get your head straight on the engineering stuff'. A must for anyone interested in the very far-reaching field of biomedical engineering.' Quentin Pankhurst, University College London

Muu info

The second edition of this introductory textbook conveys the impact of biomedical engineering through examples, applications, and a problem-solving approach.
Preface xv
Acknowledgments xix
Abbreviations and Acronyms xxi
1 Introduction: What Is Biomedical Engineering?
1(36)
1.1 Prelude
1(3)
1.2 Engineering in modem medicine
4(4)
1.3 What is biomedical engineering?
8(15)
1.4 Biomedical engineering in the future
23(3)
1.5 How to use this book
26(11)
Profiles In BME: THE Author, W. Mark Saltzman
28(9)
Part
1. Molecular And Cellular Principles
2 Biomolecular Principles
37(57)
2.1 Prelude
37(2)
2.2 Bonding between atoms and molecules
39(4)
2.3 Water: The medium of life
43(2)
2.4 Biochemical energetics
45(5)
2.5 Importance of pH
50(8)
2.6 Macromolecules: Polymers of biological importance
58(14)
2.7 Lipids
72(22)
Profiles In BME: Tiffanee Green Mackey
80(14)
3 Biomolecular Principles: Nucleic Acids
94(66)
3.1 Prelude
94(5)
3.2 Overview: Genetics and inheritance
99(7)
3.3 Molecular basis of genetics
106(10)
3.4 The central dogma: Transcription and translation
116(7)
3.5 Control of gene expression
123(5)
3.6 Recombinant DNA technology
128(32)
Profiles In BME: Laura Liptai
143(17)
4 Biomolecular Principles: Proteins
160(30)
4.1 Prelude
160(2)
4.2 Protein structure
162(9)
4.3 Modification and processing of polypeptides
171(4)
4.4 Enzymes
175(15)
Profiles In BME: Brenda K. Mann
182(8)
5 Cellular Principles
190(41)
5.1 Prelude
190(2)
5.2 Cell structure and function
192(4)
5.3 ECM
196(2)
5.4 Molecules in the cell membrane
198(8)
5.5 Cell proliferation
206(4)
5.6 Cell differentiation and stem cells
210(3)
5.7 Cell death
213(1)
5.8 Cell culture technology
214(17)
Profiles In BME: E.E. "Jack" Richards II
219(12)
Part
2. Physiological Principles
6 Communication Systems in the Body
231(49)
6.1 Prelude
231(6)
6.2 Signaling fundamentals
237(5)
6.3 The nervous system
242(9)
6.4 The endocrine system
251(5)
6.5 The adaptive immune system
256(9)
6.6 Connections to biomedical engineering
265(15)
Profiles In BME: Douglas Lauffenburger
268(12)
7 Engineering Balances: Respiration and Digestion
280(61)
7.1 Prelude
280(1)
7.2 Introduction to mass balances
281(14)
7.3 Respiratory physiology
295(18)
7.4 Digestion and metabolism
313(28)
Profiles In BME: Dan Luo
331(10)
8 Circulation
341(36)
8.1 Prelude
341(1)
8.2 The circulating fluid
342(3)
8.3 The blood vessels
345(16)
8.4 The heart
361(16)
Profiles In BME: Curtis G. Neason
368(9)
9 Removal of Molecules from the Body
377(36)
9.1 Prelude
377(2)
9.2 Examples of elimination of molecules from the body
379(4)
9.3 Biotransformation and biliary excretion
383(2)
9.4 Elimination of molecules by the kidneys
385(28)
Part
3. Biomedical Engineering
10 Biomechanics
413(35)
10.1 Prelude
413(2)
10.2 Mechanical properties of materials
415(9)
10.3 Mechanical properties of tissues and organs
424(9)
10.4 Cellular mechanics
433(15)
Profiles In BME: Walt Baxter
438(10)
11 Bioinstrumentation
448(49)
11.1 Prelude
448(3)
11.2 Overview of measurement systems
451(2)
11.3 Types of sensors
453(10)
11.4 Instruments in medical practice
463(15)
11.5 Instruments in the research laboratory
478(4)
11.6 Biosensors
482(2)
11.7 Biomicroelectromechanical systems and lab-on-a-chip devices
484(13)
Profiles In BME: Bill Hawkins
488(9)
12 Bioimaging
497(47)
12.1 Prelude
497(4)
12.2 X-rays and CT
501(7)
12.3 Ultrasound imaging
508(5)
12.4 Nuclear medicine
513(7)
12.5 Optical bioimaging
520(4)
12.6 MRI
524(3)
12.7 Image processing and analysis
527(17)
Profiles In BME: Rebecca Richards-Kortum
535(9)
13 Biomolecular Engineering I: Biotechnology
544(44)
13.1 Prelude
544(2)
13.2 Drug delivery
546(13)
13.3 Tissue engineering
559(8)
13.4 Nanobiotechnology
567(7)
13.5 Other areas of biomolecular engineering
574(14)
Profiles In BME: Robert Langer
577(11)
14 Biomolecular Engineering II: Engineering of Immunity
588(38)
14.1 Prelude
588(2)
14.2 Antigens, Abs, and mAbs
590(2)
14.3 What are Abs?
592(5)
14.4 How can specific Abs be manufactured?
597(3)
14.5 Clinical uses of Abs
600(3)
14.6 Vaccines
603(23)
Profiles In BME: Eliah R. Shamir
618(8)
15 Biomaterials and Artificial Organs
626(40)
15.1 Prelude
626(1)
15.2 Biomaterials
627(7)
15.3 Hemodialysis
634(9)
15.4 Membrane oxygenators
643(2)
15.5 Artificial heart
645(5)
15.6 Biohybrid artificial organs
650(16)
Profiles In BME: Elias Quijano
659(7)
16 Biomedical Engineering and Cancer
666(39)
16.1 Prelude
666(1)
16.2 Introduction to cancer
667(2)
16.3 Surgery
669(2)
16.4 Radiation therapy
671(9)
16.5 Chemotherapy
680(6)
16.6 Hormonal and biological therapies
686(5)
16.7 Systems biology, biomedical engineering, and cancer
691(14)
Profiles In BME: Katie Serrano
699(6)
Appendix A Physiological Parameters 705(10)
Appendix B Chemical Parameters 715(6)
Appendix C Units and Conversion Factors 721(2)
Index 723
W. Mark Saltzman is the Goizueta Professor of Chemical and Biomedical Engineering at Yale University, and was the founding Chair of the Yale Department of Biomedical Engineering. He has taught numerous courses on topics in biomedical engineering over the last three decades, and has been widely recognised for his excellence in research and teaching. He is a Fellow of the American Institute for Medical and Biological Engineering and a Fellow of the Biomedical Engineering Society. He is also the recipient of the 2014 Mines Medal and has been elected to the Institute of Medicine.