Despite the phenomenal clinical success of antibody-based biopharmaceuticals in recent years, discovery and development of these novel biomedicines remains a costly, time consuming, and risky endeavor with low probability of success. To bring better biomedicines to patients faster, we have come up with a strategic vision of Biopharmaceutical Informatics which calls for syncretic use of computation and experiment at all stages of biologic drug discovery and pre-clinical development cycles to improve probability of successful clinical outcomes. Biopharmaceutical Informatics also encourages industry and academic scientists supporting various aspects of biotherapeutic drug discovery and development cycles to learn from our collective experiences of successes and, more importantly, failures. The insights gained from such learnings shall help us improve rate of successful translation of drug discoveries into drug products available to clinicians and patients; reduce costs and increase the speed of biologic drug discovery and development. Hopefully, the efficiencies gained from implementing such insights shall make novel biomedicines more affordable for the patients.
This unique volume describes ways to invent and commercialize biomedicines more efficiently:
- Calls for digital transformation of biopharmaceutical industry by appropriately collecting, curating and making available discovery and pre-clinical development project data using FAIR principles.
- Describes applications of artificial intelligence and machine learning (AIML) in Discovery of antibodies in silico (DAbI) starting with antigen design, constructing inherently developable antibody libraries, finding hits, identifying lead candidates and optimizing them.
- Details applications of AIML, physics-based computational design methods, and other bioinformatics tools in fields such as developability assessments, formulation and excipient design, analytical and bioprocess development, and pharmacology.
- Presents pharmacokinetics/pharmacodynamics (PK/PD) and Quantitative Systems Pharmacology (QSP) models for biopharmaceuticals.
- Describes uses of AIML in bispecific and multi-specific formats.
- Dr Sandeep Kumar has also edited a collection of articles dedicated to this topic which can be found in the Taylor and Francis journal mAbs.
This book describes ways to invent and commercialize biomedicines in a more time and cost-efficient manner. Failure to translate a discovery into a marketed drug denies us an opportunity to improve the lives of patients who do not have access to effective therapies. Here, the authors provide a greater understanding of biopharmaceutical informatics.
Foreword
Preface
About the editors
List of contributors
1. Biopharmaceutical Informatics: An Introduction
2. Digital transformation in the biopharmaceutical industry: rebuilding the
way we discover complex therapeutics
3. Computational protein design strategies for optimization of antigen
generation to drive antibody discovery
4. Bioinformatic Analyses of Antibody Repertoires and Their Roles in Modern
Antibody Drug Discovery
5. Applications of Artificial Intelligence and Machine Learning Towards
Antibody Discovery and Development
6. From Deep Generative Models to Structure-Based Simulations: Computational
Approaches for Antibody Design
7. Computational biophysical analyses of antibody structure-function
relationships with emphasis on therapeutic antibody-based biologics
8. Use of molecular simulations to understand structural dynamics of
antibodies
9. Considerations of developability during the early stages of antibody drug
discovery and design
10. In Silico Approaches to Deliver Better Antibodies by Design The Past,
the Present and the Future
11. Use of systems biology approaches towards target discovery, validation,
and drug development
12. Recent advances in PK/PD and Quantitative Systems Pharmacology (QSP)
models for biopharmaceuticals
13. The Artificial Intelligence Revolution: Transforming the Design and
Optimization of Multispecific Antibodies
Index.
Dr. Sandeep Kumar is currently a Distinguished Fellow (Executive Director) at the department of Computational Science in Moderna Therapeutics, Cambridge, MA where he leads Molecular Design and Modeling team. Sandeep Kumar holds a Ph.D. in Computational Biophysics and has over 25 years of experience researching protein structure Function relationships. Sandeep Kumar has so far contributed towards more than 100 research articles, reviews, book chapters, and has previously edited a book entitled Developability of Biotherapeutics: Computational Approaches. Sandeep has been contributing towards discovery and development of numerous monoclonal antibodies, antibody drug conjugates, bispecific and multi-specific modalities, as well as vaccines. Based on the insights gained from these experiences, Sandeep has been advocating for Biopharmaceutical Informatics, a strategic vision dedicated to synergistic use of computation and experimentation towards a cost effective and more efficient discovery and development of Biotherapeutics. More recently, he is promoting the concept of DAbI (Discovery of Antibodies in silico) where he sees an opportunity for generative AI to not only accelerate biopharmaceutical drug design but also to expand the antigen space druggable by antibody-based biotherapeutics.
Dr. Andrew Nixon is currently Vice President, Biotherapeutics Molecule Discovery at Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA. Andy earned his Ph.D. in Physical Biochemistry from the University of London for studies completed at the MRCs National Institute for Medical Research. Andy has over 20 years of experience in biologic drug discovery and has contributed to over 100 antibody discovery programs resulting in numerous clinical candidates and approved biologics including TAKHZYRO, a fully human antibody inhibitor of plasma kallikrein.
Lisainfo e-raamatute kohta