Bioresorbable Polymers and their Composites: Characterization and Fundamental Processing for Pharmaceutical and Medical Device Development provides a holistic view of these unique materials and their usage in a range of biomedical applications. The book is evenly divided between fundamentals, processing methods and modeling approaches, and includes detailed coverage of a variety of applications, such as drug delivery, medical devices and wound healing. Key aspects including biocompatibility, biodegradability and toxicology are also thoroughly covered, enabling the reader to be fully informed when fabricating and utilizing their selected bioresorbable polymer.
This book is an interdisciplinary and important reference for researchers in the fields of materials science, biomedical engineering, pharmaceutical science and regenerative medicine, as well as R&D groups in the development of medical devices.
- Introduces the reader to various processing and modeling techniques for bioresorbable polymers, including electrospinning, molecular and finite element modeling
- Covers a range of key bioresorbable composites, such as PCL, PLA/PLLA and PHA/PHB/PHBV
- Explores a wide selection of biomedical applications of bioresorbable polymers, from tissue engineering and stents, to biosensors and medical devices/implants
Part I Fundamentals, Processing, and Modelling
1. Introduction to bioresorbable polymers: types and composites processing
2. Bioresorbable polymers and their composites for biomedical applications
3. Processing techniques for bioresorbable-based composites for medical device applications
4. PCL-based composites and their utilizations in medical sectors
5. Processing of PLA/PLLA based composites for medical device applications
6. PHA/PHB/PHBV based composites: Development and biomedical applications
7. Synthesis and Applications of Bioresorbable polymers for tissue engineering scaffolds
8. Processing of Bioresorbable based hydrogels for drug release applications
9. Molecular modelling of polymers for efficient drug carrier applications
10. Bioresorbable polymers: Thermal degradation and molecular dynamics-based simulations11. Finite element modelling of bioresorbable polymers
12. Bioresorbable polymers degradation: A multi scale modelling approach
13. Erosion behavior of bioresorbable polymers and their composites
14. Electrospinning in bioresorbable based medical devices15. Modelling of drug release from Bioresorbable Polymer Matrix system
Part II Biomedical Applications
16. Bioresorbable polymers: A prospective utilization as an implant
17. Biocompatibility and toxicology of bioresorbable polymers for medical devices
18. Advantages and disadvantages of bioabsorbable polymers in medical devices
19. Bioresorbable polymer-based composites for wound healing
20. Bioresorbable polymers/HNT blends composite wound dressings
21. Bioresorbable polymers in implantable electrical circuits
22. Bioresorbable polymers for stent applications
23. Bioresorbable polymers for controlled drug delivery
24. Bioresorbable polymer blends for cardiovascular implants
25. Bioresorbable polymer-based sensors for medical applications
26. Bioresorbable derived nanofibers for bone tissue engineering
Deepak Verma is currently working as an Assistant Professor, in the Department of Mechanical Engineering, at Graphic Era Hill University, Dehradun, India. He received his M.Tech from the College of Technology, GBPUA&T Pantnagar, India. He has more than 7 years of experience in teaching, research, and working within industry. His research interests include: Hybrid Reinforced/Filled Polymer Composites, Advance Materials: Graphene and Nanoclay, Wood fiber Reinforced/Filled Polymer Composites, Modification and Treatment of Natural Fibres and Solid Wood Composites, and Polymer blends. He has published 2 books, 16 book chapters, and more than 10 International journal papers in reputed journals. Dr. Manunya Okhawilai is a researcher at Metallurgy and Materials Science Research Institute, Chulalongkorn University. Her interest lies in polymer blends and polymer composite. Her main research areas are ballistic armour made from pure polymer composite, bipolar plate for polymer electrolyte membrane fuel cell and solid-state polymer electrolyte for energy storage.
She has published over 20 publications including conference papers. Moreover, she has published book chapters in Advanced and Emerging Polybenzoxazine Science and Technology” published by Elsevier. Prof Kheng-Lim Goh is the director of research at the Newcastle University of Singapore, and associate professor in mechanics of materials. He leads the Advanced Composite Research Group where the research is focused on the mechanics of composite materials, covering development (lightweight composite materials), damage studies and repair, sustainability (UN SDG, Net Zero), mechanical systems and structures underpinning composite materials, with applications from aerospace, to automotive, construction and biomedical industry. He has published 100+ research articles in several international journals, conference proceedings and book chapters. As a Global Engagement Fellow presently he is working with his colleagues at University of Pittsburg, USA, on materials and sustainability. Seeram Ramakrishna is the Director of the Center for Nanofibres and Nanotechnology at the National University of Singapore (NUS), which is ranked among the top 20 universities in the world. He is regarded as the modern father of electrospinning. He is an elected Fellow of UK Royal Academy of Engineering (FREng); Singapore Academy of Engineering; Indian National Academy of Engineering; and ASEAN Academy of Engineering & Technology. He is an elected Fellow of the International Union of Societies of Biomaterials Science and Engineering (FBSE); Institution of Engineers Singapore; ISTE, India; Institution of Mechanical Engineers and Institute of Materials, Minerals & Mining, UK; and American Association of the Advancement of Science; ASM International; American Society for Mechanical Engineers; American Institute for Medical & Biological Engineering, USA. He is an editor of Elsevier journal Current Opinion in Biomedical Engineering. Prof. Pooria holds a bachelor's degree in Materials Science and Engineering with a focus on Ceramics, a masters degree in Metallurgy and Materials Selection, and a Ph.D. in Polymer Composites. With over 17 years of research, academic, and industrial experience, he has worked on numerous industrial, government-funded, and research projects in various countries, including Australia, Malaysia, Italy, the UK, Denmark, Singapore, and Iran. His areas of expertise included polymers, fibers, coatings, minerals, nanomaterials, biomedical applications, fuel cells, building materials, and composites. Throughout his career, he has held positions as an Associate Professor at Monash University Malaysia, a postdoctoral researcher at the University of Adelaide, and a Technical Sales Specialist at Anton Paar Australia. Additionally, he has been recognized as one of the Worlds Top 2% Scientists” since 2020 for his research impact in the fields of Materials,” Polymers,” and Chemistry,” according to data released by Stanford University and Elsevier.
Dr Sharmas current assignments are focused on lead technology acquisition for advanced materials innovative. He has lead major research projects in liaison with key industries and high value ventures, which aims to create social impact and value capture. He is proficiently contributing to filing patents (US, Singapore), industrial know-hows, technology showcases and publishing peer reviewed research papers in the area of advanced composites materials, energy saving/heat regulating coatings and tribological materials. His current research interests are composites materials processing & analyses, Nano-structured fiber-polymer interphases, Carbon/glass/polymer/natural fibers reinforced nano-composites, Nano-ceramics/metal oxide based coatings for energy saving and UV shielding applications, Industrial coatings and paint additives, Aviation grease degradation and RUL, Solid lubricants, Tribological analysis of materials in harsh environments, advanced structural materials development for aerospace, marine offshore and biomedical arenas. Before joining A*STAR in 2013, Dr Sharma worked as a Guest Scientist at Leibniz Institute of Polymer Research (IPF) Dresden, Germany and Institute of Lightweight Structures and Polymer Technology (ILK) Technical University (TU) Dresden, Germany.