Bone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive overview of recent knowledge and advances of bone cell biomechanics and the related bone diseases, highlighting the cellular basis for bone responding to mechanical stimuli. The book not only provides a general overview of bone cell biology, but also provides the most recent advances of bone cell biomechanics, mechanobiology, the relationship between bone cell biomechanics and bone diseases, as well as the underlying mechanism. This will be useful for better understanding the role of mechanobiology in both bone health and bone diseases, as well as for investigating novel strategies for diagonisis and therapy of bone diseases.
The cells covered in the book include osteocyte, BM-MSC, osteoblast, osteoclast, and chondrocyte. The bone diseases covered are osteoporosis, scoliosis, and osteoarthritis.
This comprehensive reference is written for researchers, scientists, clinicians, and students.
- Presents a comprehensive introduction of current knowledge and recent advances of bone cell biomechanics
- Introduces new technologies for bone cell research
- Discusses the bone cell mechanotransduction, mechanism and bone diseases
1. Introduction
2. Methods and models for the study of bone cell mechanobiology
3. Osteocyte Mechanobiology
4. Bone marrow mesenchymal stem cell (BM-MSC) Mechanobiology
5. Osteoblast Mechanobiology
6. Osteoclast Mechanobiology
7. Crosstalk among bone cells mechanotransduction
8. Bone cell biomechanics and the whole bone mechanic property
9. Chondrocyte mechanobiology
10. Bone cell and chondrocyte mechanobiology in bone diseases
11. New technologies for bone cell study
Dr. Qian received her bachelors degree in public health, a Masters in pathology, and her PhD in cell biology. Her areas of focus are biomechanics, mechanobiology, bone metabolism diseases, space biology, space biotechnology, and nuclear acid drugs research; and she has published more than 200 publications and invented more than 30 patents. Dr. Qian is the Associate Editor of Frontiers in Physiology, an Editorial Board Member of Endocrine, Metabolic & Immune Disorders - Drug Targets, Guest Editor of Seminars in Cell and Developmental Biology, and Guest Editor of Frontiers in Cell and Developmental Biology. She was awarded New Century Outstanding Talents of the Ministry of Education”, The 9th Shaanxi Youth Science and Technology Award”, The 2nd Xi'an Young Science and Technology Talent Award”, and Elsevier 2021 Most Cited Chinese Researchers”.
Dr. Hu received her bachelors degree in biology, a Masters in biomedical engineering, and her PhD in man-machine and environmental engineering. She focuses on bone biology, biomechanics, mechanobiology, bone diseases, space biology, and cell and molecular biology research and has published more than 50 publications and invented 10 patents. Dr. Hu is the Review Editor of Frontiers in Physiology, Editorial Board Member of BMC Musculoskeletal Disorders, Guest Editor of Seminars in Cell and Developmental Biology, Guest Editor of Frontiers in Cell and Developmental Biology, and Official Peer Reviewer of World Journal of Stem Cells. She was awarded The Outstanding Paper Award for Young Scientists” by the Committee on Space Research.
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