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E-raamat: Brain Research in Addiction

Volume editor (Head of the School of Physiology, University of the Witwatersrand, South Africa), Volume editor (University of Witwatersrand, South Africa)
  • Formaat: EPUB+DRM
  • Sari: Progress in Brain Research
  • Ilmumisaeg: 19-Oct-2017
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128135020
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Brain Research in AddictionSuurem pilt
  • Formaat: EPUB+DRM
  • Sari: Progress in Brain Research
  • Ilmumisaeg: 19-Oct-2017
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128135020
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Brain Research in Addiction, Volume 235, the latest volume in this groundbreaking series on addiction, presents the neurobiological, pathological, cognitive and evolutionary aspects of addiction, with new chapters covering the Neurobiology of drug intake escalation, the Role of the orexinergic system in reward, Mental time travel and addictive behaviors, An evolutionary perspective on addiction- Addiction is the price we pay for innovation and adaptability, and how Cocaine exposure affects object-place recognition memory in non-human primates.

Chapters in this serial are presented by leading researchers from North America, South America, Europe, Africa, Asia and Australia, who present addiction research from the bottom up, including how addiction evolved, basic research on animal models, and the psychiatric, psychological and cognitive characteristics of addictive behaviors in humans.

  • Presents chapters written by global leaders in research on brain research and its relation to addiction
  • Provides an interdisciplinary approach that will be of interest to many professionals
  • Includes sections on the evolution of addiction, the effects of substance use on primate cognition, and addictive behaviors in humans

Muu info

Presents a multidisciplinary collection of the latest research on addiction, including its origins and animal models
Contributors v
Preface xv
Chapter 1 The extended evolutionary synthesis and addiction: the price we pay for adaptability
1(18)
Tanya Calvey
1 Introduction
1(1)
2 The Dopamine Theory of Addiction
2(1)
3 Substance Use in Animals and Humans
3(2)
4 Psychiatric Comorbidity
5(2)
5 Dopamine and Impulsivity
7(1)
6 Human Flexibility, Adaptability, and Innovation
8(1)
7 Pleiotropy
9(1)
8 The EES and Addiction
9(2)
9 Discussion
11(1)
10 Conclusion
12(7)
Acknowledgement
12(1)
References
12(5)
Further Reading
17(2)
Chapter 2 Cross-talk between the epigenome and neural circuits in drug addiction
19(46)
Philipp Mews
Erin S. Calipari
1 Introduction
19(1)
2 Drug Addiction Is a Behavioral Learning Disorder
20(2)
2.1 Learning About Response Contingencies
20(2)
2.2 Learning About Drug-Associated Cues
22(1)
3 Drug-Induced Plasticity: How Is Drug-Associated Information Stored for Long Periods of Time in the Brain?
22(3)
4 The Neural Circuits Controlling Motivated Behaviors and Their Dysregulation in Drug Addiction
25(10)
4.1 The Shift From Acute Pharmacology to Remodeled Neural Circuits
25(2)
4.2 Changes in Dopaminergic Encoding of Information in Addiction
27(1)
4.3 Dopamine-Induced Changes in the Neural Circuit Remodeling of Downstream Inputs
28(7)
5 How Are Changes in Neural Morphology and Function Maintained?
35(2)
5.1 The Epigenome as the Molecular Hub of Information Encoding in Addiction
35(2)
6 Epigenetic Regulation Is the Key to a Central Property of Neural Networks: Plasticity
37(3)
7 The Interface Between Neuronal Activation and Epigenetic Remodeling
40(3)
7.1 Drug-Induced Transient Changes in Chromatin Structure
40(1)
7.2 Transient Changes as a Scaffold for Long-Term Epigenetic Changes
41(1)
7.3 Permanent epigenetic changes as mediators of gene priming
42(1)
8 Bidirectional Cross-Talk Between the Epigenome and Cellular Activity
43(1)
9 Focusing to the Future
44(21)
9.1 Goals of Treatment
44(2)
9.2 Complex Interplay Between Circuits and Transcription
46(1)
9.3 What to Target and How
47(1)
References
48(17)
Chapter 3 Addiction: A dysregulation of satiety and inflammatory processes
65(28)
Rivona Harricharan
Oualid Abboussi
William M.U. Daniels
1 Background
66(1)
2 Brief Summaries of Selected Theories of Addiction
66(3)
2.1 The Hedonic Theory
66(1)
2.2 Sensitization
67(1)
2.3 Counteradaptation
67(1)
2.4 Abnormal Behavioral Control and Decision Making
68(1)
2.5 Maladaptive Associative Learning
68(1)
2.6 Dopamine-Mediated Reward Prediction Errors
68(1)
3 Brain Circuitry and Areas Involved in Addiction
69(1)
4 Drug-Induced Alterations in Dopamine Neurotransmission
70(1)
5 Changes in Dopamine Signaling May Mediate Addictive Behavior
71(1)
6 Regulation of Satiety
72(1)
7 The Hypothalamus: The Intersect Between Addiction and Satiety
73(1)
8 Inflammation and Addiction
74(6)
8.1 The Immune System of the Brain
75(1)
8.2 Drugs Affecting Immune Cells
75(2)
8.3 Immune Cells Affecting Dopamine Transmission
77(1)
8.4 Drugs Affecting Cytokine Release
78(1)
8.5 Cytokines Mediating Drug-Associated Molecular Effects
79(1)
9 Conclusion
80(13)
References
81(12)
Chapter 4 Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior
93(20)
Ana-Clara Bobadilla
Jasper A. Heinsbroek
Cassandra D. Gipson
William C. Griffin
Christie D. Fowler
Paul J. Kenny
Peter W. Kalivas
1 Introduction: Ensembles in Addiction
94(1)
2 Constitutive Changes Induced by Drugs of Abuse
95(2)
3 Glutamate Spillover and Transient Synaptic Plasticity, Common to All Drugs of Abuse
97(3)
4 Could the t-SP Be Embedded in a Neuronal Network Specific to Drug Seeking?
100(5)
5 Concluding Remarks
105(8)
Acknowledgments
105(1)
References
106(7)
Chapter 5 Paraventricular thalamus: Gateway to feeding, appetitive motivation, and drug addiction
113(26)
E. Zayra Millan
ZhiYi Ong
Gavan P. McNally
1 Introduction
113(3)
2 Anatomical Organization of the PVT Within a Motivational Framework
116(4)
2.1 PVT Afferents
116(1)
2.2 PVT Efferents
117(2)
2.3 Collateral Projections
119(1)
3 PVT and Appetitive Motivation
120(4)
3.1 PVT and Food Intake
122(1)
3.2 PVT and Food Cues
123(1)
4 PVT in Drug Taking, Withdrawal, and Relapse
124(7)
4.1 Drug Taking
125(2)
4.2 Drug Withdrawal
127(1)
4.3 Relapse
128(3)
5 Conclusions
131(8)
Acknowledgments
132(1)
References
132(7)
Chapter 6 Functional roles of orexin/hypocretin receptors in reward circuit
139(16)
Abbas Haghparast
Zahra Fatahi
Reza Arezoomandan
Sara Karimi
Zahra Taslimi
Shahram Zarrabian
1 Introduction
140(1)
1.1 Orexin
140(1)
1.2 Orexin Receptors
140(1)
1.3 Orexin Receptors and Pharmacological Agents
140(1)
1.4 The Distribution of Orexin Receptors
140(1)
1.5 Orexinergic Neurons and Their Connectivity
141(1)
2 Reward and Reward Processing
141(4)
2.1 Reward Circuitry
142(2)
2.2 Reward and Neurotrophic Factors
144(1)
3 Reward Processing and Drug Abuse
145(3)
3.1 The VTA and Reward Processing
146(1)
3.2 The NAc and Reward Processing
147(1)
3.3 The HIP and Reward Processing
148(1)
4 Reward Promotion
148(1)
5 Conclusion
149(6)
References
149(6)
Chapter 7 Differential modulatory effects of cocaine on marmoset monkey recognition memory
155(22)
Jonathan L. Melamed
Fernando M. de Jesus
Jessica Aquino
Clarissa R.S. Vannuchi
Renata B.M. Duarte
Rafael S. Maior
Carlos Tomaz
Marilia Barros
1 Introduction
156(1)
2 Material and Methods
157(4)
2.1 Ethics Statement
157(1)
2.2 Subjects and Housing Conditions
158(1)
2.3 Apparatus and Experimental Setup
158(1)
2.4 Drug
158(1)
2.5 Procedure
159(1)
2.6 Behavioral Analyses
160(1)
2.7 Statistical Analyses
161(1)
3 Results
161(3)
3.1 Acute Postsample Cocaine on SOL Task Performance
161(1)
3.2 Prior Repeated Cocaine on SOL Task Performance
162(2)
4 Discussion
164(4)
4.1 Acute Postsample Cocaine on Spatial Recognition Memory
164(2)
4.2 Prior Repeated Exposure to Cocaine on Spatial Recognition Memory
166(2)
5 Conclusions
168(9)
Acknowledgments
169(1)
References
169(8)
Chapter 8 Using the research domain criteria (RDoC) to conceptualize impulsivity and compulsivity in relation to addiction
177(42)
Samantha J. Brooks
Christine Lochner
Steve Shoptaw
Dan J. Stein
1 Introduction
178(10)
1.1 Broad Definitions of Impulsivity/Compulsivity
184(1)
1.2 Impulsivity
184(2)
1.3 Compulsivity
186(1)
1.4 Interaction Between Impulsivity/Compulsivity
187(1)
2 NIH RDoC Units of Analysis and Research Domains and Their Relationship to the Interaction Between Impulsivity and Compulsivity
188(19)
2.1 NIH RDoC Units of Analysis
188(11)
2.2 NIH RDoC Research Domains
199(8)
3 Conclusions
207(12)
References
208(10)
Further Reading
218(1)
Chapter 9 Addictive behaviors: Why and how impaired mental time matters?
219(20)
Xavier Noel
Nematollah Jaafari
Antoine Bechara
1 Introduction
219(2)
2 Autonoetic Reliving of Past Events and Addictive Behaviors
221(1)
3 Future-Oriented Time Travel and Addictive Behaviors
222(1)
4 Discounting the Future and Episodic Future Imagination
223(3)
5 MTT and Theory of Mind
226(1)
6 Clinical Implications and Perspectives
227(12)
Acknowledgment
230(1)
References
230(9)
Chapter 10 Neuroscience-informed psychoeducation for addiction medicine: A neurocognitive perspective
239(26)
Hamed Ekhtiari
Tara Rezapour
Robin L. Aupperle
Martin P. Paulus
1 Introduction
240(2)
2 Neurocognitive Approach to PE: Content
242(3)
3 Neurocognitive Approach to PE: Structure
245(3)
3.1 Attention and Memory
245(1)
3.2 Self-Awareness
246(2)
4 Cartoon as a Structure for Psychoeducation: A Neurocognitive Perspective
248(4)
5 NIPE Example: Brain Awareness for Addiction Recovery Initiative
252(3)
6 Future Directions for NIPE
255(2)
7 Conclusion
257(8)
Acknowledgments
257(1)
References
258(5)
Further Reading
263(2)
Index 265
Dr. Tanya Calvey has a background in evolutionary neurobiology and lectures morphological anatomy in the Faculty of Health Sciences, University of the Witwatersrand. Tanyas current research is on the neuropsychopharmacology of ibogaine and substance use disorders in humans and animals. Her research team is multidisciplinary and her research is funded by the South African Medical Research Council, the South African National Research Foundation and the International Society for Neurochemistry. Tanya is also actively involved in developing neuroscience research in Africa. She is the Secretary of the Southern African Neuroscience Society and the co-founder of the Wits Cortex Club. Willie Daniels obtained his PhD degree from the University of Stellenbosch and completed postdoctoral studies at the University of Texas in San Antonio. He was also a recipient of a Commonwealth Research Fellowship and subsequently spent time at the Wellcome Trust Sanger Institute in Hinxton, Cambridgeshire, UK. Willie is currently the Head of the School of Physiology at the University of the Witwatersrand. Previously he held positions at the University of KwaZulu-Natal, Durban, South Africa (Dean and Head of School of Laboratory Medicine and Medical Sciences) and before that he headed the Division of Medical Physiology at the University of Stellenbosch. His main research thrust entails the use of animal models to study the pathophysiology of neurological and psychiatric diseases. He has published more than 85 papers in renowned journals on addiction, neurodegenerative disorders (Parkinsons disease, Alzheimers disease), epilepsy, stress and anxiety-related disorders and HIV-associated neurocognitive disorders. He has an H-index of 24 and an i10-index of 41 (Google Scholar). Willie has served on a number of professional societies including the Society of Neuroscientists of Africa (SONA) as Secretary-General, the Society for Neuroscience (SfN) as International Affairs Committee member, and the International Brain Research Organization (IBRO) as Council Member.
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