Editors Hiraku, Kawanishi, and Ohshima present this volume on the role of inflammation in cancer and associated biological mechanisms. The first section gives a general overview of the links between infection, inflammation, and cancer, as well as stem cell theory and the epithelial-mesenchymal transition. Biochemistry and molecular biology of nitrative DNA damage, lipid peroxidation, DNA adducts, Toll-like receptors, inflammasomes, cytidine deaminase, and microRNAs are covered in the context of inflammation and cancer, and cancer resulting from specific causes including human papillomavirus (HPV), hepatitis, Epstein-Barr virus (EBV), Barrett’s esophagus, asbestos, nanomaterials, and radiation are discussed. Finally, a number of prevention approaches are presented, including anti-inflammatory drugs, nutraceuticals, phytochemicals, and dietary regulation. Annotation ©2014 Ringgold, Inc., Portland, OR (protoview.com)
A new perspective on the link between inflammation and cancer
Inflammation is the human body’s normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory response is triggered repeatedly and sustained for long periods of time? Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects discusses the mechanisms by which chronic inflammation can lead to cancer, the various causative agents, and possible prevention methods.
A compilation of the latest information coming out of the various fields of cancer research, this book provides a detailed look at inflammation-related carcinogenesis from the perspective of researchers at the forefront of the field. It takes an interdisciplinary approach to the topic, and provides comprehensive information about the major factors at work in inflammation, cancer, and the intersection of the two conditions. Topics include:
- A general overview of inflammation-related cancer
- The biochemistry of inflammation and its effects on DNA
- Molecular biology and the role of microRNA in carcinogenesis
- Specific causative agents including oncogenic viruses, asbestos, and nanomaterial
- Anti-inflammatories, nutraceuticals, and other preventative measures
A deeper understanding of the mechanisms behind inflammation-related carcinogenesis can lead to better patient outcomes by improving diagnostics and prevention, as well as altering the approach to treatment. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects provides the knowledge base researchers need to push the field forward.
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