Accessible and user-friendly, Cell Biology, 4th Edition, provides a strong foundation for students entering health care career paths as well as higher level research areas. Clear, readable text and high-quality, detailed illustrations help readers quickly grasp challenging content-all focusing on cellular processes without delving into molecular processes. Drs. Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz, and author/illustrator Dr. Graham Johnson have thoroughly updated this popular text to ensure its relevance for students in biology, biotechnology, medicine, and pathophysiology, covering key principles of cellular function and explaining how molecular defects lead to cellular dysfunction and cause human disease.
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Balances depth of detail with clear, readable explanations, providing a concise but comprehensive overview of this complex topic.????
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An intuitive chapter flow leads with genome organization, gene expression, and RNA processing as a foundation for understanding cellular interactions and cell physiology.?
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Brings cellular biology to life for students in clinically focused programs, as breakthroughs in areas like gene editing, epigenetics, and the understanding of the microbiome continue to grow in clinical application.?
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Features unique illustrations with realistic proportions and relationships, including many new instructive illustrations- from structure of volume-regulated LRRC8 Cl -1 channel and generation of circular RNAs from introns . to deadenylation cycles and assembly of SARS CoV-2).?
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Covers new topics such as optogenetics and super resolution fluorescence microscopy; predicting 3D protein structure; gene expression profiling by single-cell RNA sequencing; protein misfolding and human disease; mechanism of CFTR and new drugs to treat cystic fibrosis; new insights on carriers and channels and their clinical implications; mitochondrial genomes from sperm; and biogenesis of lipid droplets and lipid transfer between organelles.?
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Uses real examples to illustrate key cell biology concepts, includes beneficial cell physiology coverage, and relates cell biology to pathophysiology and medicine.?
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.?
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SECTION I Introduction to Cell Biology |
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1 Cells as the Basis of Life on Earth |
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3 | (12) |
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2 Evolution of Life on Earth |
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15 | (18) |
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SECTION II Chemical and Physical Background |
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3 Molecules: Structures and Dynamics |
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33 | (22) |
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55 | (10) |
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5 Macromolecular Assembly |
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65 | (14) |
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79 | (32) |
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SECTION III Chromatin, Chromosomes, and the Cell Nucleus |
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7 Chromosome Organization |
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111 | (20) |
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8 DNA Packaging in Chromatin and Chromosomes |
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131 | (20) |
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9 Nuclear Structure and Dynamics |
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151 | (22) |
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SECTION IV Central Dogma: From Gene to Protein |
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173 | (26) |
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11 Eukaryotic RNA Processing |
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199 | (20) |
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12 Protein Synthesis and Folding |
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219 | (18) |
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SECTION V Membrane Structure and Function |
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13 Membrane Structure and Dynamics |
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237 | (14) |
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251 | (12) |
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263 | (8) |
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271 | (24) |
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295 | (18) |
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SECTION VI Cellular Organelles and Membrane Trafficking |
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18 Posttranslational Targeting of Proteins |
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313 | (14) |
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19 Mitochondria, Chloroplasts, Peroxisomes |
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327 | (14) |
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341 | (24) |
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21 Mechanisms of Vesicular Transport |
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365 | (12) |
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22 Secretory Membrane System and Golgi Apparatus |
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377 | (16) |
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23 Endocytosis and the Endosomal Membrane System |
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393 | (18) |
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24 Processing and Degradation of Cellular Components |
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411 | (18) |
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SECTION VII Signaling Mechanisms |
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25 Plasma Membrane Receptors |
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429 | (16) |
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26 Protein Hardware for Signaling |
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445 | (18) |
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463 | (20) |
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28 Integration of Signals |
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483 | (28) |
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SECTION VIII Cellular Adhesion and the Extracellular Matrix |
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29 Cells of the Extracellular Matrix and Immune Systems of Animals |
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511 | (16) |
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30 Extracellular Matrix Molecules |
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527 | (20) |
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547 | (18) |
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32 Intercellular Junctions |
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565 | (12) |
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577 | (20) |
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SECTION IX Cytoskeleton and Cellular Motility |
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34 Actin and Actin-Binding Proteins |
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597 | (18) |
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35 Microtubules and Centrosomes |
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615 | (20) |
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36 Intermediate Filaments |
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635 | (10) |
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645 | (16) |
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38 Intracellular Motility |
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661 | (12) |
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673 | (20) |
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693 | (26) |
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41 Introduction to the Cell Cycle |
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719 | (16) |
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42 G2 Phase and Regulation of Cell Proliferation |
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735 | (16) |
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43 S Phase and DNA Replication |
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751 | (18) |
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44 G2 Phase: Responses to DNA Damage and Control of Entry Into Mitosis |
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769 | (12) |
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781 | (20) |
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801 | (12) |
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813 | (20) |
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833 | (22) |
| Cell Snapshots |
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855 | (22) |
| Glossary |
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877 | (30) |
| Index |
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907 | |
Thomas Dean Pollard is a prominent educator, cell biologist and biophysicist whose research focuses on understanding cell motility through the study of actin filaments and myosin motors. He is Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Cell Biology and Molecular Biophysics & Biochemistry at Yale University. He was Dean of Yale's Graduate School of Arts and Sciences from 2010 to 2014, and President of the Salk Institute for Biological Studies from 1996 to 2001. Pollard is very active in promoting scientific education and research primarily through two major societies, both of which he is a past President: the American Society for Cell Biology and the Biophysical Society William Charles Earnshaw is Professor of Chromosome Dynamics at the University of Edinburgh where he has been a Wellcome Trust Principal Research Fellow since 1996. Earnshaw is an elected Fellow of the Royal Society since 2013 for his studies of mitotic chromosome structure and segregation. Before Edinburgh, he was Professor of Cell Biology and Anatomy at Johns Hopkins School of Medicine. Jennifer Lippincott-Swartz is Group Leader at the Howard Hughes Medical Institute Janelia Research Campus. Her lab uses live cell imaging approaches to analyze the spatio-temporal behaviour and dynamic interactions of molecules in cells with a special focus on neurobiology. Before Janelia, Lippincott-Swartz was a primary investigator and chief of the Section on Organelle Biology in the Cell Biology and Metabolism Branch. Her work there included a collaboration with physicists Eric Betzig and Harald Hess (now group leaders at Janelia), who proposed a new function for the photoactivatable protein. The scientists used the protein to generate photoactivatable fluorophores, or dyes, which enabled them to illuminate different sets of molecules sequentially, creating a microscope image far more detailed than previously possible. The method, called super-resolution microscopy, garnered Betzig the 2014 Nobel Prize in Chemistry. Graham Johnson is a computational biologist and Certified Medical Illustrator (CMI) with approx. 20 years of professional experience. He is Director of the Animated Cell at the Allen Institute. Before the Allen Institute, Johnson's lab in the California Institute for Quantitative Biosciences at the University of California, San Francisco worked to generate, simulate and visualize molecular models of cells. His lab's Mesoscope project and his team at Allen Institute continue this mission by uniting biologists, programmers and artists to interoperate the computational tools of science and art.