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E-raamat: Cell Volume Regulation

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This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few. Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.
Preface vii Introduction to Cell Volume Regulatory Mechanisms 1(7) Waldegger S. Matskevitch J. Busch G.L. Lang F. Cell Volume-Regulated Cation Channels 8(13) Wehner F. Cell Volume-Sensitive Chloride Channels 21(13) Okada Y. Mechanisms of Osmolyte Release 34(16) Kinne R.K.H. Sensors and Signal Transduction in the Activation of Cell Volume Regulatory Ion Transport Systems 50(29) Hoffmann E.K. Pedersen St.F. Activation of Protein Kinases upon Volume Changes: Role in Cellular Homeostasis 79(15) Shrode L.D. Krump E. Grinstein S. Intracellular Signaling in Response to Osmotic Stress 94(16) Kultz D. Burg M.B. Approaches to Identifying Cell Volume-Regulated Genes 110(11) Chevaile A. Santos B. Randall J. Stears R. Gullans St. R. The Cytoskeleton in Cell Volume Regulation 121(14) Moustakas A. Theodoropoulos P.A. Gravanis A. Haussinger D. Stournaras C. Cell Volume Regulatory Ion Transport in Cell Migration 135(23) Ritter M. Cell Volume in Cell Proliferation and Apoptotic Cell Death 158(11) Lang F. Lepple-Wienhues A. Szabo I. Siemen D. Gulbins E. Cellular Osmoregulation in Kidney Medulla 169(16) Beck F.-X. Guder W.G. Schmolke M. Osmoregulation of Liver Cell Function: Signalling, Osmolytes and Cell Heterogeneity 185(20) Haussinger D. Volume Regulation and `Cross-Talk in Sodium-Absorbing Epithelial Cells 205(15) Schultz St. G. Dubinsky W.P. Lapointe J-Y. Pathophysiology of Abnormal Cell Volume in Human Red Cells 220(20) Ellory J.C. Gibson J.S. Stewart G.W. Swelling-Activated Release of Excitatory Amino Acids in the Brain: Relevance for Pathophysiology 240(18) Kimelberg H.K. Mongin A.A. Author Index 258(1) Subject Index 259
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