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E-raamat: Cerebrospinal Fluid in Clinical Neurology

  • Formaat: PDF+DRM
  • Sari: Medicine
  • Ilmumisaeg: 05-Feb-2015
  • Kirjastus: Springer International Publishing AG
  • Keel: eng
  • ISBN-13: 9783319012254
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  • Formaat: PDF+DRM
  • Sari: Medicine
  • Ilmumisaeg: 05-Feb-2015
  • Kirjastus: Springer International Publishing AG
  • Keel: eng
  • ISBN-13: 9783319012254

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The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cerebrospinal fluid analysis and its use in the diagnosis of common neurological diseases. The first part addresses preclinical aspects such as the history of CSF, as well as the anatomical, physiological, and biological background of this valuable fluid. In addition, CSF collection, its preanalytical and methodological implications, and the increasing number of disease-specific markers in CSF are discussed in detail. Lastly, CSF analyses are put into context with clinical syndromes, demonstrating their diagnostic value in neurological clinical practice. Cerebrospinal Fluid in Clinical Neurology helps readers understand the preanalytical and analytical aspects of CSF diagnostics and offers a valuable reference guide for interpreting CSF results during the clinical work-up for neurological patients.



This book helps readers understand preanalytical and analytical issues of cerebrospinal fluid (CSF) analysis diagnostics and will be a valuable reference for the interpretation of CSF results during the clinical work-up of neurological patients.
Part I Basic Aspects of the Cerebrospinal Fluid
1 The History of Cerebrospinal Fluid
3(14)
Florian Deisenhammer
2 Anatomy of CSF-Related Spaces and Barriers Between Blood, CSF, and Brain
17(8)
Hayrettin Tumani
3 Physiology and Constituents of CSF
25(10)
Hayrettin Tumani
4 Techniques, Contraindications, and Complications of CSF Collection Procedures
35(24)
Ellis Niemantsverdriet
Hanne Struyfs
Flora Duits
Charlotte E. Teunissen
Sebastiaan Engelborghs
5 Importance of Pre-analytical Stability for CSF Biomarker Testing
59(22)
Eline A.J. Willemse
Charlotte E. Teunissen
Part II Methods of CSF Analyses
6 Cell Count and Staining
81(20)
Herwig Strik
Ingelore Nagel
7 Glucose and Lactate
101(6)
Hayrettin Tumani
Harald Hegen
8 CSF Total Protein
107(4)
Hayrettin Tumani
Harald Hegen
9 CSF Albumin: Albumin CSF/Serum Ratio (Marker for Blood-CSF Barrier Function)
111(4)
Hayrettin Tumani
Harald Hegen
10 Immunoglobulins in Cerebrospinal Fluid
115(16)
Finn Sellebjerg
11 Detection of Infectious Agents
131(12)
Annette Spreer
12 Immunohistochemistry
143(16)
Romana Hoftberger
Simone Mader
Markus Reindl
13 Methods for Biomarker Analysis
159(16)
Diego Franciotta
Massimo Alessio
Livia Garzetti
Roberto Furlan
Part III CSF in Clinical Syndromes
14 Acute Infectious Diseases
175(36)
Erich Schmutzhard
Bettina Pfausler
15 Chronic Infectious Inflammatory Diseases of the Central Nervous System
211(36)
Pille Taba
Irja Lutsar
16 Autoimmune Encephalitis
247(30)
Agnes van Sonderen
Maarten J. Titulaer
17 Chronic Noninfectious Inflammatory CNS Diseases
277(16)
Irina Elovaara
Sanna Hagman
Aki Hietaharju
18 CSF Findings in Guillain-Barre Syndrome: Demyelinating and Axonal Acute Inflammatory Polyneuropathies
293(18)
Zsolt Illes
Morten Blaabjerg
19 Alterations of the Cerebrospinal Fluid in Chronic Inflammatory Diseases of the Peripheral Nervous System
311(18)
Zsolt Illes
Morten Blaabjerg
20 Alzheimer's Disease and Other Neurodegenerative Disorders
329(24)
Christoffer Rosen
Henrik Zetterberg
Kaj Blennow
21 Paraneoplastic Neurological Syndromes
353(34)
Jan Lewerenz
Frank Leypoldt
22 Laboratory Diagnosis of Subarachnoid Haemorrhage
387(8)
Markus Otto
Karin Nagy
Niklas Mattson
23 CSF-orrhoea
395(12)
Geoffrey Keir
Ligy Thomas
24 Guidelines on Cerebrospinal Fluid Analysis
407(22)
Harald Hegen
Charlotte E. Teunissen
Finn Sellebjerg
Hayrettin Tumani
Florian Deisenhammer
Index 429