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E-raamat: Chemotherapy-Induced Neuropathic Pain

Edited by (Temple University School of Medicine, Philadelphia, Pennsylvania, USA), Edited by , Edited by (Temple University School of Pharmacy, Philadelphia, Pennsylvania, USA), Edited by , Edited by (University of Arizona, Tucson, Arizona, USA University of Arizona, Tucson, Arizona, USA)
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 24-Jul-2012
  • Kirjastus: CRC Press Inc
  • Keel: eng
  • ISBN-13: 9781040198315
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  • Formaat: EPUB+DRM
  • Ilmumisaeg: 24-Jul-2012
  • Kirjastus: CRC Press Inc
  • Keel: eng
  • ISBN-13: 9781040198315
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"Written for Pain Management Practitioners, Oncologists, Oncology Nurses, Nurse Practitioners, Social Workers, Pharmacologists, and Primary Care Practitioners, as well as students in these fields, this reference provides insight into chemotherapy-inducedneuropathic pain cancer survivors suffer. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment. Bridging the gap between theory and practice, this reference covers both basic science and clinical research, providing a unique insight into drug discovery efforts"--Provided by publisher.



There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early years.

Written for pain management specialists, oncologists, pharmacologists, students, and primary care practitioners, Chemotherapy-Induced Neuropathic Pain provides insight into the important area of chemotherapy-induced neuropathic pain. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment.

The contributors comprise an impressive list of clinical and basic science experts in the fields of pain mechanisms and pain management. Included are clinical directors of pain clinics and clinical research facilities, directors of large academic pain research laboratories, analgesic drug developers, and presidents of the International Association for the Study of Pain (IASP), Association of Chronic Pain Patients (ACPP), and the British Pain Society (BPS). Through them, the book provides the reader with an exceptional opportunity to acquire a fundamental understanding of the basic concepts related to this topic.

Preface vii
About the Editors ix
Contributors xi
Chapter 1 Chemotherapy-Induced Neuropathic Pain: Clinical Features
1(10)
Michael Husband
Ricchard Langford
Chapter 2 Assessment and Grading of Cancer Chemotherapy-Induced Neuropathic Pain
11(8)
Judith A. Paice
Chapter 3 Chemotherapy-Induced Peripheral Neuropathy: Review of Clinical Studies
19(76)
Joseph V. Pergolizzi, Jr.
Jo Ann LeQuang
Chapter 4 Orofacial Neuropathy and Pain in Cancer Patients
95(18)
Yehuda Zadik
Noam Yarom
Sharon Elad
Chapter 5 Cancer Chemotherapy-Induced Neuropathic Pain: The Underlying Peripheral Neuropathy
113(24)
Robert B. Raffa
Joseph V. Pergolizzi, Jr.
Chapter 6 Bedside to Bench: Research on Chemotherapy-Induced Neuropathic Pain
137(10)
Haijun Zhang
Juan P. Cata
Patrick M. Dougherty
Chapter 7 In Vivo Models and Assessment of Pharmacotherapeutics for Chemotherapy-Induced Neuropathic Pain
147(16)
Sara Jane Ward
Chapter 8 Drug Treatment for Chemotherapy-Induced Neuropathic Pain: Amitriptyline as an Example
163(6)
Eija Kalso
Chapter 9 Experimental Design and Analysis of Drug Combinations Applicable to Chemotherapy-Induced Neuropathic Pain
169(12)
Ronald J. Tallarida
Chapter 10 Central Neuromodulation for Chemotherapy-Induced Neuropathic Pain
181(14)
Helena Knotkova
Dru J. Nichols
Ricardo A. Cruciani
Chapter 11 Nerve Decompression for Chemotherapy-Induced Neuropathic Pain
195(10)
Michael I. Rose
Bibliography 205(6)
Index 211
Robert B. Raffa, Ph.D. is Professor and Chair within the Department of Pharmaceutical Sciences at Temple University School of Pharmacy, in Philadelphia, Pennsylvania.





Ronald J. Tallarida, Ph.D. is Professor of Pharmacology at Temple University School of Medicine in Philadelphia, Pennsylvania.





Frank Porreca, Ph.D. is Professor of Pharmacology and Anesthesiology at Temple University in Philadelphia, Pennsylvania.





Joseph V. Pergolizzi, Jr., M.D. is Adjunct Assistant Professor at Johns Hopkins University School of Medicine in Baltimore, Maryland.