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E-raamat: Chesley's Hypertensive Disorders in Pregnancy

Edited by (Professor of Physiology, Department of Physiology ), Edited by , Edited by , Edited by (Professor of Obstetrics and Gynecology and Assistant Dean for Student and Academic Affairs, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA), Edited by
  • Formaat: PDF+DRM
  • Ilmumisaeg: 07-Dec-2021
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128184189
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  • Formaat: PDF+DRM
  • Ilmumisaeg: 07-Dec-2021
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128184189
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Leon Chesley’s Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley’s Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.

  • Summarizes the most relevant basic and clinical studies on hypertensive disorders of pregnancy, helping researchers and students stay up-to-date
  • Discusses the roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia
  • Widely acclaimed as an essential scholastic resource and enthusiastically endorsed by clinicians and scientists
List of Contributors
vii
About the Editors xi
Prefaces xiii
Chapter 1 The Spectrum of Hypertensive Disorders in Pregnancy: Dr. Leon Chesley's Legacy
1(20)
Kirk P. Conrad
Robert N. Taylor
Sandra T. Davidge
Anne Cathrine Staff
James M. Roberts
Marshall D. Lindheimer
Chapter 2 Epidemiology of Hypertensive Disorders in Pregnancy
21(24)
Jennifer J. Stuart
Kathryn J. Gray
Janet W. Rich-Edwards
James M. Roberts
Chapter 3 Genetic Factors in the Etiology of Preeclampsia/Edampsia
45(26)
Kenneth Ward
Hannele Laivuori
Robert N. Taylor
Chapter 4 Preconceptional and Periconceptional Pathways to Preeclampsia
71(24)
Kirk P. Conrad
Ira M. Bernstein
Alison D. Demand
Chapter 5 Placentation and Placental Function in Normal and Preeclamptic Pregnancies
95(22)
Graham J. Burton
Tereza Cindrova-Davies
Hong Wa Yung
Robert N. Taylor
Chapter 6 Unbiased Approaches for Addressing the Complexities of the Placenta's Role in the Preeclampsia Syndrome
117(14)
Alejandra E. Ontiveros
Susan J. Fisher
James M. Roberts
Chapter 7 The Immunology of Preeclampsia
131(24)
Christopher W.G. Redman
Sarah A. Robertson
Robert N. Taylor
Chapter 8 Trophoblast Extracellular Vesicles in Preeclampsia
155(10)
Manu Vatish
Christopher W.G. Redman
Sandra T. Davidge
Chapter 9 Angiogenesis and Preeclampsia
165(22)
S. Ananth Karumanchi
Sarosh Rana
Robert N. Taylor
Chapter 10 Vascular Endothelial Cell Dysfunction in Preeclampsia
187(32)
Styliani Goulopoulou
Christianne de Groot
Robert N. Taylor
Sandra T. Davidge
Chapter 11 Cardiovascular Alterations in Normal and Preeclamptic Pregnancy
219(26)
Sanjeev G. Shroff
Alisse Hauspurg
Judith U. Hibbard
Kirk P. Conrad
Chapter 12 Cardiometabolic Antecedents of Preeclampsia
245(20)
Arun Jeyabalan
Carl A. Hubel
Sandra T. Davidge
Chapter 13 Cerebrovascular Pathophysiology in Preeclampsia and Eclampsia
265(24)
Eliza C. Miller
Sarah Schalekamp-Timmermans
Marilyn J. Cipolla
Anne Cathrine Staff
Chapter 14 The Kidney in Normal Pregnancy and Preeclampsia
289(46)
Kate Wiles
Isaac E. Stillman
Kirk P. Conrad
Chapter 15 Salt, Aldosterone, and the Renin---Angiotensin System in Pregnancy
335(20)
Ralf Dechend
Babbette Lamarca
Sandra T. Davidge
Chapter 16 Platelets, Coagulation, and the Liver
355(20)
Kate Navaratnam
Louise Kenny
Robert N. Taylor
Chapter 17 Clinical Management and Antihypertensive Treatment of Hypertensive Disorders of Pregnancy
375(30)
Christianne de Groot
Jason C. Umans
Arun Jeyabalan
Anne Cathrine Staff
Chapter 18 Prediction and Prevention of Preeclampsia
405(14)
Anne Cathrine Staff
Jason G. Umans
Arun Jeyabalan
Chapter 19 Long-Term Effects of Preeclampsia on Mothers and Offspring
419(16)
Anne Cathrine Staff
Ernesto Figueiro-Filho
Sandra T. Davidge
Chapter 20 Animal Models Used for Investigating Pathophysiology of Preeclampsia and Identifying Therapeutic Targets
435(14)
Eric M. George
Bhavisha A. Bakrania
Joey P. Granger
Kirk P. Conrad
Chapter 21 Harmonization of Data and Biobanks for Preeclampsia Research
449(10)
Anne Cathrine Staff
Christopher W.G. Redman
James M. Roberts
Index 459
Robert N. Taylor, MD, PhD is Professor of Obstetrics and Gynecology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY. Previously, he was Professor of Obstetrics and Gynecology at The University of Utah, Wake Forest School of Medicine, Emory University, and Director of the Center for Reproductive Sciences at the University of California, San Francisco. Taylor received his undergraduate education at Stanford University and the combined MD-PhD at Baylor College of Medicine. He is a board-certified obstetrician-gynecologist and reproductive endocrinologist whose major research foci have included the role of placental angiogenesis and endothelial cell activation in preeclampsia, and the molecular actions of estrogen and progesterone on endometrial differentiation and neuroangiogenesis as they relate to endometriosis. Dr. Taylor served on executive committees of the American Board of Obstetrics and Gynecology, NIH Reproductive Scientist Development Program, the World Endometriosis Society and the California Institute for Regenerative Medicine. Dr. Conrad has had a longstanding research interest in the hormonal, cellular and molecular mechanisms underlying maternal renal and systemic vasodilation, and increased arterial compliance during normal pregnancy with emphasis on the ovarian hormone, relaxin. More recently, he has been PD/PI of a NIH Program Project Grant designed to explore maternal pregnancy physiology and outcome in women conceiving through in vitro fertilization with focus on the contribution of the corpus luteum. Finally, Dr. Conrad has been exploring a role for dysregulated (pre)decidualization in the genesis of preeclampsia, and in the larger context of endometrium spectrum disorders”. Dr. Conrad has combined preclinical and clinical research throughout his career to translate findings in animal models, tissues and cells to humans or vice versa. The main disease focus of his pregnancy research has been preeclampsiaa hypertensive syndrome peculiar to human pregnancy. Dr. Davidge is a Distinguished University Professor in the Faculty of Medicine & Dentistry at the University of Alberta and Executive Director of the Women and Childrens Health Research Institute, Edmonton, Alberta, Canada. Davidge received her PhD from the University of Vermont and completed her postdoctoral fellowship training at the Magee Womens Research Institute in Pittsburgh, PA, USA. Davidges research program is focused on understanding mechanisms for vascular dysfunction in pregnancy complications, particularly preeclampsia, and subsequent impact on later-life cardiovascular health. Her fundamental studies are currently focused on developing early intervention strategies for improving pregnancy outcomes to enhance life-long maternal and offspring cardiovascular health. Davidge is a Fellow in the Canadian Academy of Health Science and a past president of Society for Reproductive Investigation (2017-2018). Anne Cathrine (Annetine) Staff, MD, PhD, is a full-time Professor of Obstetrics and Gynaceology at the Faculty of Medicine, University of Oslo, Norway. She is also Head of Research at the Division of Obstetrics and Gynaecology at Oslo University Hospital, Norway. She obtained her Medical Degree in 1987 at The University of Oslo, where she also did her PhD in 2000 on Preeclampsia and uteroplacental tissues: lipids, oxidative stress, and trophoblast invasion”. She is a board certified specialist in Gynecology and Obstetrics since 1996, and have worked clinically in the field since 1989. Dr. Staff is head of a research group in Oslo, where one main research area is within molecular understanding of pregnancy complications associated with placental dysfunction, including preeclampsia, and its relation to future maternal cardiovascular health.

Dr. Staff was previously the EPG (European Placenta Group) Spokesperson 2011-17 and the Vice-President of the ISSHP (International Society for the Study of Hypertension in Pregnancy) 2012-16, and is currently an ISSHP Executive Committee member and part of the Global Pregnancy Collaboration team. Dr. Roberts research is interdisciplinary and involves fundamental, clinical, behavioral and epidemiological studies. He has been involved in several seminal studies of preeclampsia including the recognition of preeclampsia as involving endothelial dysfunction and being more than hypertension in pregnancy. He currently is involved in global health research as part of the Global Pregnancy Collaboration, a consortium of 40 centers world-wide that facilitates collaborative research. He is a co-investigator on studies in Brazil and South Africa. He chaired the ACOG Hypertension Task Force and was co-chair of the NHLBI NIH workshop on research on pregnancy hypertension.