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E-raamat: Computational Methods for Reproductive and Developmental Toxicology

Edited by (National Institutes of Health, Bethesda, Maryland, USA, and Risk Sciences International, Ottawa, Ontario, Canada)
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Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology.

The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development.

The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods.

The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.
Series Introduction vii
Preface ix
Editor xi
Contributors xiii
SECTION I Introduction
Chapter 1 Introduction
3(2)
Donald R. Mattison
Chapter 2 Visions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial Chemicals
5(18)
Karen A. Augustine-Rauch
Chapter 3 REACH and Environmental Chemicals
23(16)
Olivier Taboureau
Karine Audouze
Søren Brunak
SECTION II Reproduction and Development: Biological Processes and Endpoints
Chapter 4 Female Reproductive Physiology
39(32)
Mariangela Maluf
Paulo Marcelo Perin
Chapter 5 Maternal Recognition of Pregnancy
71(28)
Paulo Marcelo Perin
Mariangela Maluf
Chapter 6 Early Embryo Development and Bipotential Gonad Formation
99(30)
Paulo Marcelo Perin
Mariangela Maluf
Chapter 7 Assessing the Reproductive Health of Men with Occupational Exposures
129(34)
Steven M. Schrader
Susan Reutman
Katherine L. Marlow
SECTION III Reproduction and Development: Biological and Computational Methods
Chapter 8 Animal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental Toxicity
163(26)
Aldert H. Piersma
Chapter 9 U.S. National Library of Medicine Resources for Computational Toxicology
189(10)
Pertti J. Hakkinen
Chapter 10 Modeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential Equations
199(26)
Leona A. Harris
James F. Selgrade
Chapter 11 Molecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast Milk
225(30)
Snezana Agatonovic-Kustrin
David W. Morton
Chapter 12 Approaches for Pediatric Developmental Drug-Induced Liver Injury
255(34)
William F. Salminen
Xi Yang
Chapter 13 Adverse Outcome Pathways for Developmental Toxicity
289(26)
Damiano Portinari
Philip N. Judson
Index 315
Edited by

Donald R. Mattison, National Institutes of Health, Bethesda, Maryland, USA, and Risk Sciences International, Ottawa, Ontario, Canada