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E-raamat: Computational Modeling in Bioengineering and Bioinformatics

(Faculty of Engineering, Center for Bioengineering, University of Kragujevac; BioIRC, Bioengineering Research and Development Center, Kragujevac, Serbia)
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 09-Oct-2019
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128195840
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Computational Modeling in Bioengineering and BioinformaticsSuurem pilt
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 09-Oct-2019
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128195840
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Computational Modeling in Bioengineering and Bioinformatics promotes complementary disciplines that hold great promise for the advancement of research and development in complex medical and biological systems, and in the environment, public health, drug design, and so on. It provides a common platform by bridging these two very important and complementary disciplines into an interactive and attractive forum. Chapters cover biomechanics and bioimaging, biomedical decision support system, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, biomedical image processing, analysis and visualization, high performance computing and sports bioengineering.

The book's chapters are the result of many international projects in the area of bioengineering and bioinformatics done at the Research and Development Center for Bioengineering BioIRC and by the Faculty of Engineering at the University of Kragujevac, Serbia.

  • Presents recent advances at the crossroads of biomedical engineering and bioinformatics, one of the hottest areas in biomedical and clinical research
  • Discusses a wide range of leading-edge research topics, including biomechanics and bioimaging, biomedical decision support systems, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, amongst others
  • Includes coverage of biomechanical, bioengineering and computational methods of treatment and diagnosis
Contributors xi
About the author xiii
Preface xv
1 Computational modeling of atherosclerosis
1(40)
Nenad Filipovic
1 Theoretical background
1(3)
2 Methods
4(6)
3 Results
10(27)
4 Conclusions
37(1)
Acknowledgments
38(1)
References
38(1)
Further reading
39(2)
2 Machine learning approach for breast cancer prognosis prediction
41(28)
Bojana R. Andjelkovic Cirkovic
1 Introduction
41(3)
2 Machine learning applications for prediction of breast cancer prognosis
44(2)
3 Methodological framework for machine learning techniques
46(9)
4 To what extent can we trust a prediction model?
55(2)
5 Findings
57(6)
6 Conclusions and future trends
63(2)
References
65(4)
3 Topological and parametric optimization of stent design based on numerical methods
69(36)
Dalibor D. Nikolic
Nenad Filipovic
1 Introduction
69(1)
2 Endovascular prosthesis: Stent
70(1)
3 History of endovascular prosthesis: STENT
71(5)
4 Classification of stents
76(2)
5 Stent modeling
78(8)
6 Stent geometry optimization
86(4)
7 Nonparametric optimization of the model
90(2)
8 Parametric optimization
92(3)
9 Creation of a 3D model of the whole stent
95(4)
10 Conclusion
99(1)
References
99(6)
4 Lung on a chip and epithelial lung cells modeling
105(32)
Milica Nikolic
Nenad Filipovic
1 Introduction
105(6)
2 Model of the bioreactor for organ-on-a-chip usage
111(11)
3 Model of the A549 lung epithelial cell line
122(6)
4 Discussion and conclusions
128(5)
Acknowledgments
133(1)
References
133(4)
5 Aortic dissection: Numerical modeling and virtual surgery
137(42)
Igor B. Saveljic
Nenad Filipovic
1 Introduction
138(1)
2 Aortic dissection
139(4)
3 Diagnostic techniques
143(5)
4 Treatment of acute aortic dissection
148(4)
5 Solution of nonalinear problems with the final elements method
152(1)
6 Basic equations of fluid flow
153(2)
7 Basic equations of solid motion
155(3)
8 Solid fluid interaction
158(1)
9 3D modeling of aortic dissection
159(1)
10 3D reconstruction using Materialize Mimics 10.01
160(1)
11 Geometric 3D modeling using Geomagic Studio 10.0
161(1)
12 Virtual surgery
161(2)
13 Results of numerical analysis
163(1)
14 Results of the simulation of preoperative models
164(4)
15 Results of simulation of postoperative models
168(4)
16 Results of simulation of the wall shear stress on the false lumen of preoperative models
172(2)
17 Conclusion
174(1)
References
175(4)
6 The biomechanics of lower human extremities
179(32)
Aleksandra Z. Vulovic
Nenad Filipovic
1 Introduction
180(2)
2 Anatomy of lower extremities
182(4)
3 Finite element method application in biomechanics
186(3)
4 3D model development
189(2)
5 Material properties
191(8)
6 Boundary conditions
199(2)
7 Finite element analysis of the knee joint with ruptured anterior cruciate ligament
201(5)
8 Conclusion
206(1)
Acknowledgment
207(1)
References
207(4)
7 Different theoretical approaches in the study of antioxidative mechanisms
211(46)
Zoran S. Markovic
Dejan A. Milenkovic
1 Prevention of oxidative stress
211(1)
2 Characteristics of good antioxidants in general
212(3)
3 The proposed reaction mechanisms
215(4)
4 Radical adduct formation
219(4)
5 Mechanistic approach
223(3)
6 Thermodynamical parameters for quercetin, gallic acid, and DHBA
226(2)
7 Antiradical mechanisms in the presence of different free radicals
228(2)
8 Mechanistic approach to analysis of the antioxidant action
230(13)
9 Kinetics of HAT and PCET mechanism
243(2)
10 Radical adduct formation (RAF) mechanism
245(5)
11 Conclusion
250(1)
References
251(5)
Further reading
256(1)
8 Computational modeling of dry-powder inhalers for pulmonary drug delivery
257(32)
Tijana I. Sustersic
Nenad Filipovic
1 Theoretical background
257(11)
2 Literature review: Particle engineering strategies for pulmonary drug delivery
268(3)
3 Simulations performed on dry-powder inhaler Aerolizer
271(11)
4 Conclusions and recommendations
282(2)
Acknowledgments
284(1)
References
284(5)
9 Computer modeling of cochlear mechanics
289(32)
Velibor Isailovic
Nenad Filipovic
1 Introduction
289(4)
2 Concepts of modeling
293(2)
3 Solid model
295(1)
4 Fluid model
296(1)
5 Loose coupling algorithm
297(1)
6 Strong coupling algorithm
298(2)
7 Finite element modeling
300(3)
8 Finite element models
303(9)
9 Model of cochlea including feedforward and feedbackward forces
312(5)
10 Conclusion
317(1)
Acknowledgment
318(1)
References
318(1)
Further reading
319(2)
10 Numerical modeling of cell separation in microfluidic chips
321(32)
Tijana Bukic
Nenad Filipovic
1 Introduction
321(4)
2 Numerical model
325(16)
3 Numerical simulations
341(7)
4 Conclusion
348(1)
Acknowledgments
349(1)
References
350(3)
11 Computational analysis of abdominal aortic aneurysm before and after endovascular aneurysm repair
353(34)
Smiljana Dorovic
Nenad Filipovic
1 Introduction
353(2)
2 Risk factors and surgical treatments for AAA
355(2)
3 Computational methods applied for AAA
357(1)
4 Geometrical model of AAA
358(9)
5 Numerical model of AAA
367(3)
6 Finite element procedure and fluid-structure interaction
370(4)
7 Results
374(6)
8 Discussion
380(2)
9 Conclusion
382(1)
Acknowledgment
382(1)
References
382(5)
12 Sport biomechanics: Experimental and computer simulation of knee joint during jumping and walking
387(32)
Radivoje Radakovic
Nenad Filipovic
1 Introduction
387(4)
2 Methods
391(14)
3 Results
405(9)
4 Discussion and Conclusion
414(1)
References
415(2)
Further reading
417(2)
Index 419
Nenad D. Filipovic is Rector of University of Kragujevac, Serbia, full Professor at Faculty of Engineering and Head of Center for Bioengineering at University of Kragujevac, Serbia. He was Research Associate at Harvard School of Public Health in Boston, US. His research interests are in the area of biomedical engineering, cardiovascular disease, fluid-structure interaction, biomechanics, bioinformatics, biomedical image processing, medical informatics, multi-scale modeling, data mining, software engineering, parallel computing, computational chemistry and bioprocess modeling. He is author and co-author 16 textbooks and 11 monographies, over 300 publications in peer review journals and over 10 software for modeling with finite element method and discrete methods from biofluid mechanics and multiphysics. He also leads a number of national and international projects in EU and US in area of bioengineering and software development. He is Director of Center for Bioengineering at University of Kragujevac and leads joint research projects with Harvard University and University of Texas in area of bio-nano-medicine computer simulation. He also leads a number of national and international projects in area of bioengineering and bioinformatics. He is a Managing Editor for Journal of Serbian Society for Computational Mechanics and member of European Society of Biomechanics (ESB), European Society for Artificial Organs (ESAO) and IEEE member.
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