A critical factor in cell-to-cell interactions is the presence in the cell membrane of highly specific ion channels controlled by specific receptors that are bound to, and activated by, a gamut of external hormones and neurotransmitters. Through both this action on ion channels, and action on other membrane components (such as G-proteins), extracellular signals alter intracellular events, usually through the mediation of second messengers, and so provide the basis for the transduction mechanism connecting extracellular signals with intracellular effectors. This volume deals with the various ways that such membrane function is controlled.
Preface. Dedication. Contributors. Acknowledgements. Signal Transduction
. Signalling through phospholipid breakdown (J.H. Exton). Receptor-mediated
activation of phospholipase A2 (J. Axelrod). Protein phosphorylation in the
nervous system (R.L. Huganir). Alpha-adrenergic inhibition of N-type calcium
channels and neurotransmitter release in sympathetic neurones (D. Lipscombe,
S. Kongsamut and R.W. Tsien). Release of vasoactive intestinal peptide (VIP)
in mouse neocortex: Ca 2+ -channel subtypes and involvement of arachidonic
acid metabolites (J-L. Marin and P.J. Magistretti). The effects of calcium
channel agonists and antagonists on the binding of [ 3 H] nitrendipine to
synaptic membrane and postsynaptic density factions isolated from canine
cerebral cortex. Evidence for a separate-site model for agonists and
antagonists (P. Siekevitz and M. Ledoux). Adaptive changes in signal
transduction systems: Molecular mechanisms of opiate addiction in rate locus
coeruleus (E.J. Nestler). Does catecholamine-induced sequestration of
beat-adrenergic receptors involve endocytosis via the clathrin-coated PIT
pathway (J.P. Perkins). The molecular components of the olfactory signal
transduction cascade (R.R. Reed, H.A. Bakalyar, P.G. Feinstein and D.T.
Jones). The control of photoreceptor sensitivity (T.D. Lamb and V. Torre).
Receptor Structure and Function. What the structure of the acetylocholine
receptor tells us about the function of the ligand gated ion channel family
(R.M. Stroud). Characteristics of acetylcholine receptor-channels stably
expressed in fibroblasts (T. Claudio). The structure of the NMDA
receptor-channel complex (P. Ascher and J. Johnson). Are receptor-associated
nuclear proteins associated with the earliest effects of steroid hormones?
(E-E. Baulieu, N. Binart, F. Cadepond, M-G. Catelli, B. Chambraud, J.
Garnier, J-M. Gasc, G. Groyer-Schweizer, M-E. Rafestin-Oblin, C. Radanyi, G.
Reduilh, J-M. Renoir and M. Sabbah). Ion Channels. Characteristics of
beta-adrenergic-activitated Na-proton transport in red blood cells (R.
Motais, U. Scheuring, F. Borgese and F. Garcia-Romeu). Energy profiles for
ion permeation in pentameric protein channels: From viruses to receptor
channels (G. Eisenman, A. Villarroel, M. Montal and O. Alvarez). The LAC
permease of Escherichia coli: A prototype transport protein (P.D. Roepe and
H.R. Kaback). Studies on the two inorganic anion transport systems in the red
blood cell of the mouse (H. Passow, J. Wendel, E.-M. Gartner, B. Legrum, D.
Bartel and S. Lepke). Differential expression and developmental regulation of
NA, K-ATPASE isoforms in rat fetal telencephalon organotypic cell cultures
(I. Corthesy-Theulaz, B. Rossier and P. Honegger). Longterm Control
Mechanisms. Neuronal plasticity: Lectin-induced changes in the membrane
properties of cultured Aplysia neurons (I.B. Levitan, G.M. Carrow, D. Dagan,
S.S. Lin and M.P. Wilson). Long-term potentiation in the hippocampus (R.C.
Malenka, J.A. Kauer, D.J. Perkel and R.A.
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