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E-raamat: Data Mining Techniques for the Life Sciences

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  • Formaat: EPUB+DRM
  • Sari: Methods in Molecular Biology 2449
  • Ilmumisaeg: 04-May-2022
  • Kirjastus: Springer-Verlag New York Inc.
  • Keel: eng
  • ISBN-13: 9781071620953
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  • Formaat: EPUB+DRM
  • Sari: Methods in Molecular Biology 2449
  • Ilmumisaeg: 04-May-2022
  • Kirjastus: Springer-Verlag New York Inc.
  • Keel: eng
  • ISBN-13: 9781071620953
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This third edition details new and updated methods and protocols on important databases and data mining tools. Chapters guides readers through archives of macromolecular sequences and three-dimensional structures, databases of protein-protein interactions, methods for prediction conformational disorder, mutant thermodynamic stability, aggregation, and drug response. Quality of structural data and their release, soft mechanics applications in biology, and protein flexibility are considered, too, together with pan-genome analyses, rational drug combination screening and Omics Deep Mining. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials, includes step-by-step, readily reproducible protocols.





 





Authoritative and cutting-edge, Data Mining Techniques for the Life Sciences, Third Edition aims to be a practical guide to researches to help furthertheir study in this field.
 EBI data resources.- IMEx databases: displaying molecular interactions
into a single, standards-compliant dataset.- Protein Three-dimensional
Structure Databases.- Predicting protein conformational disorder and
disordered binding sites.- Profiles of natural and designed protein-like
sequences effectively bridge protein sequence gaps: Implications in distant
homology detection.- Turning failures into applications: the problem of
protein G prediction.- Dissecting the genome for drug response
prediction.- Prediction of the effect of pH on the aggregation and
conditional folding of intrinsically disordered proteins with SolupHred and
DispHred.- Extracting the dynamic motion of proteins using Normal Mode
Analysis.- Pre- and Post- Publication Verification for Reproducible Data
Mining in Macromolecular Crystallography.- Soft Statistical Mechanics for
Biology.- Uses and abuses of the atomic displacement parameters in structural
biology.- Optimizing the Parametrization of Homologue Classification in the
Pan-Genome Computation for a Bacterial Species: Case Study Streptococcus
pyogenes.- Computational pipeline for rational drug combination screening in
patient-derived cells.- Deep Mining from Omics Data.