De novo Peptide Design: Principles and Applications presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focuses on the design of peptides, particularly how peptides may be tailored to specific functions. It includes computational and experimental protocols to assist in the design of peptides. Sections cover the basics of protein and peptide structure, modeling and simulation, solid phase peptide synthesis, peptide-based antibiotics, drug delivery, peptide nanomaterials, aromatic interactions directing nano-assembly, protein/peptide aggregation, therapeutic interventions against protein/peptide aggregation diseases, peptide based hydrogels, computational tools and algorithms for peptide design, and experimental protocols in peptide chemistry.
In addition, the book covers key aspects in peptide design, providing a solution for researchers working within the 'peptidic universe' to create new therapeutic agents.
- Gives comprehensive coverage, including peptide design, modeling, synthesis and applications
- Presents emerging topics in the design of peptide-based therapeutics
- Details the latest developments in the fields of therapeutic peptides and bio-nanotechnology
- Considers peptide design and the tailoring of peptides to specific functions
- Offers computational tools and algorithms for peptide design and experimental protocols for peptide chemistry
1. Molecular interactions for protein folding
2. Modeling and simulation of peptides
3. Solid phase peptide synthesis
4. Peptide-based antibiotics
5. Cell-penetrating peptides
6. Peptide-based nanomaterials: applications and challenges
7. Peptide nanocatalystes
8. Bioinspired functional molecular constructs
9. Patents in peptide science
Dr. Vibin Ramakrishnan is a Professor of Biosciences and Bioengineering at IIT Guwahati. Dr. Vibin earned his Masters in Applied Chemistry from Cochin University of Science and Technology and Ph.D. from School of Biosciences and Bioengineering, IIT Bombay. He worked as a Postdoctoral Research Associate at Rennsselaer Polytechnic Institute, New York and a Faculty scientist at IBAB Bangalore, before joining Department of Biosciences & Bioengineering at IITG. He has more than 50 research papers in reputed international journals and 10 patents, including an international patent to his credit. He is the principal scientific advisor of two biotech companies. Vibin is the editorial board member of two reputed journals, the Journal of Controlled Release of Elsevier and Scientific Reports of Nature publishing group. The Department of Biotechnology, Govt. of India has awarded Vibin the Innovative Young Biotechnologist Award (IYBA) in the year 2007-08 to recognize his contributions and innovative approach in biotechnology research. Dr. Kirti Patel is Assistant Professor of Chemistry at N. B. Mehta Science College, affiliated to University of Mumbai. Dr. Patel earned his Masters in Organic Chemistry from University of Pune and Ph.D. from Department of Chemistry, IIT Bombay. He worked as an Assistant Professor at Bytco College, Nashik before joining N. B. Mehta Science College, Mumbai University. His research work is mostly concentrated in developing peptide-based biomaterials, and he has already published 10 research papers in this area. Dr. Ruchika Goyal is a Postdoctoral Fellow at University of Strathclyde, Glasgow. She completed her B. Tech (Biotechnology) from G. B. Pant University of Agriculture and Technology, Pantnagar and M. Tech (Biotechnology) from Graphic Era University, Dehradun before joining her doctoral research at IIT Guwahati. In her entire career, she have been associated with many prestigious institutes like NIPER Guwahati, RGCB Trivandrum, BBCI Guwahati, AIIMS New Delhi, JNU New Delhi, etc. She has half a dozen publications and a patent in drug delivery vehicles. She was also selected for the award of prestigious D. S. Kothari Postdoctoral Fellowship 2021 and Marie Curie Postdoctoral Fellowship 2021.
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