Caused by an epidemic increase in obesity and diabetes and metabolic syndromes, diabetic nephropathy has become a leading cause of end-stage renal disease in many developed countries. The publication at hand provides a concise overview of the current state of clinical and basic research in the field. It starts with a summary of the epidemiology and genetics of diabetic nephropathy in different ethnic groups, followed by a review of its clinical manifestation, the link with the metabolic syndrome and obesity, and the pathology of diabetic nephropathy. Building on this basis, the latest findings on pathogenetic, epigenetic and inflammatory mechanisms are presented. The publication also looks at advances in the areas of tubulopathy and the kallikrein-kinin system as well as at the latest animal models and the role of lipoproteins and proteomics. This is followed by a discussion of promising therapeutic approaches such as experimental anti-fibrotic strategies, stem cell therapy and pancreatic transplantation; expert reviews on the emerging entity of new onset diabetes after transplantation and the preventive strategies for diabetic nephropathy conclude the material presented. Written by a panel of leading international experts, this book is highly recommended for nephrologists, diabetologists, internist, transplant physicians, scientists, geneticists, epidemiologists and stem cell biologists working in the field of diabetic nephropathy.
Preface: Lai, K.N.; Tang, S.C.W.; Clinicopathological Features of
Diabetic Nephropathy; Epidemiology of Diabetic Nephropathy: Reutens, A.T.;
Atkins, R.C.; Genetics of Diabetic Nephropathy in Diverse Ethnic Groups:
Brorsson, C.; Pociot, F.; Clinical Manifestation and Natural History of
Diabetic Nephropathy: Ritz, E. et al.; Obesity, Metabolic Syndrome and
Diabetic Nephropathy: Maric, C.; Hall, J.E.; Pathology of Human Diabetic
Nephropathy: Najafian, B. et al.; Pathogenetic Mechanisms of Diabetic
Nephropathy; Pathogenesis and Progression of Proteinuria: Thomas, M.C.;
Epigenetic Mechanisms: Villeneuve, L.M.; Natarajan, R.; Advanced Glycation
End-Products: Thomas, M.C.; Transforming Growth Factor-[ beta] and Smads: Lan,
H.Y.; Chung, A.C.K.; Angiogenic Factors: Khoury, C.C.; Ziyadeh, F.N.;
Endothelial Nitric Oxide Synthase: Nakagawa, T.; Johnson, R.J.; Reactive
Oxygen Species and Oxidative Stress: Noh, H.; Ha, H.; Inflammatory Pathways:
Navarro-Gonzalez, J.F.; Mora-Fernandez, C.; Diabetic Tubulopathy: An Emerging
Entity: Tang, S.C.W. et al.; The Renin-Angiotensin System: Lai, K.N. et al.;
The Kallikrein-Kinin System: Tang, S.C.W. et al.; Translating Experimental
Diabetic Nephropathy Studies from Mice to Men: Breyer, M.D.; Role of
Triglyceride-Rich Lipoproteins in Renal Injury: Ng, K.F. et al.; The Study of
Diabetic Nephropathy in the Proteomic Era: Thongboonkerd, V.; Therapeutic
Approach of Diabetic Nephropathy; Treatment and Landmark Clinical Trials for
Renoprotection: Ting, R.Z.W. et al.; Intensive Glycemic Control and Renal
Outcome: Jun, M. et al.; Nuclear Hormone Receptors as Therapeutic Targets:
Levi, M. et al.; Antifibrotic Treatment and Other New Strategies for
Improving Renal Outcomes: Mathew, A. et al.; Kidney Regeneration: Any
Prospects? Romagnani, P.; Effects of Pancreas Transplantation on the
Prevention and Reversal of Diabetic Nephropathy: Fioretto, P.; Mauer, M.;
Prevention of Diabetic Nephropathy; New-Onset Diabetes and Nephropathy after
Renal Transplantation: Guitard, J. et al.; Into the Future: Prevention of
Diabetes: Bogaert, Y.E.; Schrier, R.W.
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