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E-raamat: Diagnosis and Treatment of Spinal Cord Injury

Edited by , Edited by (Professor, Department of Clinical Biochemistry, Kings College Hospital, London, UK; Emeritus Profes), Edited by (Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Heath Affairs, Riyadh, Saudi Arabia)
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  • Ilmumisaeg: 10-May-2022
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128224991
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  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128224991
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Diagnosis and Treatment of Spinal Cord Injury will enhance readers’ understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries.

  • Covers both the diagnosis and treatment of spinal cord injury
  • Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
  • Features chapters on epidemiology and pain
  • Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury
  • Discusses pain reduction, drug delivery, and rehabilitation
Contributors xxi
Preface xxvii
Section A Setting the scene: Introductory chapters
1 Traumatic spinal cord injury and outcomes in low-resource settings
Avital Yohann
Laura N. Purcell
Anthony Charles
Introduction
3(1)
Epidemiology
3(1)
Sex and age
4(1)
Etiology
4(2)
Falls
4(1)
Road traffic injuries
5(1)
Violence and other causes
6(1)
Spinal cord level and severity
6(1)
Diagnosis
6(2)
Prehospital and acute management
8(1)
Treatment strategies
8(1)
Post-acute medical care and rehabilitation
9(2)
Applications to other areas of neuroscience
11(1)
Key facts of global traumatic spinal cord injury epidemiology and etiology
11(1)
Summary points
11(1)
References
12(3)
2 Biomechanics and patterns of spine injuries associated with spinal cord injury
Salomon Florez-Jimenez
Etienne Bourassa-Moreau
Jean-Marc Mac-Thiong
Gilles Maurais
Introduction
15(1)
Pathogenesis of TSCI: The critical role of spine biomechanics
15(1)
Patterns of spine injuries associated with spinal cord injuries
16(6)
Traumatic spinal cord injury in a stable spine
16(2)
Traumatic spinal cord injury in an unstable spine
18(4)
Applications to other areas of neuroscience
22(1)
Mini-dictionary of terms
22(1)
Key facts
23(1)
Summary points
23(1)
References
23(4)
3 Body, action, and space representations in people affected by spinal cord injuries
Michele Scandola
Introduction
27(1)
The neuroplasticity following SCI and the networks involved in the body, space, and action representations
27(1)
The body representations
28(2)
The action representation
30(2)
The space representation
32(1)
The effects of rehabilitation on the body, action, and space representations
32(2)
Conclusions
34(1)
Applications to other areas of neuroscience
34(2)
Mini-dictionary of terms
36(1)
Key facts of neuroplasticity following spinal cord injury
36(1)
Summary points
36(1)
References
37(4)
4 Methods for treating pain and painful syndromes in spinal cord injury: Medications, therapies, interventions, and neuromodulation
James J. Bresnahan
James C. Pendleton
Benjamin R. Scoblionko
Patricia Orme
Philip J. Koehler
Introduction
41(1)
Application to other areas of neuroscience
42(1)
Main narrative text
43(4)
Physical therapy and exercise
43(1)
Medications
43(2)
"Typical" nociceptive pain interventions
45(1)
Neuromodulation
46(1)
Spinal cord stimulation in SCI
47(1)
Other forms of neuromodulation
47(1)
Mini-dictionary of terms
47(1)
Key facts of pain after SCI
48(1)
Summary points
48(1)
References
48(7)
Section B Clinical features of spinal injury
5 Factors contributing to pressure injuries in traumatic spinal cord injury
Gabrielle Gour-Provengal
Jehane H. Dagher
Introduction
55(1)
Pathophysiology of pressure injuries
56(1)
Pressure and shear
56(1)
Tissue tolerance
57(1)
Prevalence, impact, and cost of pressure injuries in patients with SCI
57(1)
Most common locations and severity
57(1)
Impact
57(1)
Cost
58(1)
Structural and physiological changes following SCI
58(2)
Skin
58(1)
Muscle and bone
59(1)
Macro- and micro-vasculature
59(1)
Inflammation and immune function
59(1)
Temperature
59(1)
Sensory impairments
59(1)
Risk assessment tools
60(1)
Risk factors associated with pressure injuries in patients with traumatic spinal cord injury
60(3)
Non-modifiable factors
60(2)
Modifiable factors
62(1)
Conclusion
63(1)
Applications to other areas of neuroscience
63(1)
Mini-dictionary of terms
63(1)
Key facts of pressure injuries
63(1)
Summary points
64(1)
References
64(5)
6 Venous thromboembolism in spinal cord injury--Prophylaxis, diagnosis and treatment
Rodrigo Lanna de Almeida
Introduction
69(1)
Epidemiology
69(2)
Screening
71(1)
Prophylaxis
71(1)
Acute phase
71(1)
Sub-acute and chronic phase
71(1)
Non-pharmacological methods
72(1)
Diagnosis
72(2)
D-dimer
72(1)
Lower limb ultrasonography
73(1)
Lower limb venography
73(1)
CT pulmonary angiography
73(1)
Treatment
74(5)
Initial management
74(1)
Anti-coagulation after initial management
75(2)
Special situations
77(1)
Outpatient management
77(1)
Duration of anti-coagulation
77(2)
Conclusion
79(1)
Applications to other areas of neuroscience
79(1)
Mini-dictionary of terms
79(1)
Key facts of venous thromboembolism in spinal cord injury
79(1)
Summary points
79(1)
References
80(3)
7 Osteoporosis-related fractures: What they are and how they occur following spinal cord injury
Ana Paula Silva Champs
Gustavo Correa Netto de Melo
Gabriela Afonso Galante Maia
Fabiana Goncalves Oliveira
Antonio Lopes da Cunha Junior
Maria Marta Sarquis Soares
Introduction
83(1)
Physiopathology
84(1)
Fractures
84(1)
Risk factors
85(1)
Diagnosis
85(1)
Laboratory
85(1)
Dual-energy X-ray absorptiometry
85(1)
Quantitative computed tomography
85(1)
Treatment
85(5)
Pharmacologic therapy
87(1)
Rehabilitation/non-pharmacological therapy
87(3)
Combined treatments
90(1)
Conclusion
90(1)
Applications to other areas of neuroscience
91(1)
Mini-dictionary of terms
91(1)
Key facts of osteoporosis after spinal cord injury
91(1)
Key facts of fragility fractures after spinal cord injury
91(1)
Key facts of diagnosis of osteoporosis after spinal cord injury
91(1)
Key facts of treatment for osteoporosis-related fractures after spinal cord injury
92(1)
Summary points
92(1)
References
92(3)
8 Understanding the effects of prolonged cervical spinal cord compression on the brain. Current knowledge and future challenges
Angela Bernabeu-Sanz
Eduardo Fernandez-Jover
Introduction
95(4)
Cervical spine compression causes brain atrophy
99(1)
Cervical spine compression causes neural plasticity to preserve function
99(1)
Cervical spine compression changes the functional connectivity of the brain
100(1)
Cervical spine compression also damages the brain WM
101(1)
Conclusion and future perspectives
102(1)
Applications to other areas of neuroscience
102(1)
Mini-dictionary of terms
102(1)
Key facts of spinal cord compression
103(1)
Key facts of advanced MRI techniques
103(1)
Summary points of cervical spine compression
103(1)
References
104(3)
9 Spasticity in spinal cord injury
Ramiro Palazon-Garda
Introduction
107(1)
Pathophysiology of spasticity
107(1)
Manifestations of spasticity in spinal injuries
108(1)
Assessment of spasticity and its consequences
108(2)
Tone measurement
108(1)
Assessment of dynamic phenomena
108(1)
Functional assessment
109(1)
Subjective evaluation
110(1)
Other types of assessment
110(1)
Treatment of spasticity
110(1)
Treatment indications
110(1)
Modalities of treatment in spinal injury
110(2)
Outcome measures after treatment
112(1)
Management protocol for spasticity in spinal cord injury
112(1)
Applications to other areas of neuroscience
113(1)
Mini-dictionary of terms
113(1)
Key facts of "diagnosis of spasticity in spinal cord injury"
113(1)
Key facts of "treatment of spasticity in spinal cord injury"
114(1)
Summary points
114(1)
References
114(3)
10 Fall circumstances, consequences, assessments, and interventions to manage fall risk among individuals living with spinal cord injury
L.A. Rice
L. Abou
R. Yarnot
E. Wong K. Chhatwani
L. Hawari
Introduction
117(1)
Fall frequency
117(2)
Recurrent falls
118(1)
Fall circumstances
119(1)
Biological risk factors
119(1)
Behavioral risk factors
119(1)
Environmental risk factors
120(1)
Social and economic
120(1)
Consequences of falls
120(2)
Physical consequences of falls
120(1)
Psychosocial consequences of falls
121(1)
Societal consequences of falls
122(1)
Assessment of fall risk
122(2)
Assessment among ambulatory people with SCI
122(1)
Assessment among nonambulatory people with SCI
123(1)
Assessing fear of falling
124(1)
Intervention program to manage fall risk
124(1)
Application to other areas of neuroscience
124(2)
Mini-dictionary of terms
126(1)
Key facts of fall frequency and fall circumstances
126(1)
Key facts of consequences of falls
126(1)
Summary points
126(1)
References
127(4)
11 Infections and spinal cord injury: Covid-19 and beyond
Raquel Madronero-Mariscal
Angel Arevalo-Marti'n
Francisco Gutierrez-Henares
Miguel Rodriguez-Cola
Melchor Alvarez de Mon
Elisa Lopez-Dolado
Introduction
131(1)
Immunosuppression due to spinal cord injury
132(2)
Pathophysiology of spinal cord injury-induced immunodepression
132(2)
Leading infection diseases in spinal cord-injured patients
134(6)
Urinary tract infections (UTI)
135(4)
Pulmonary infections (PI)
139(1)
COVID-19 disease: A new infectious normality in spinal cord-injured patients?
140(3)
Applications to other areas of neuroscience
141(1)
Mini-dictionary of terms
142(1)
Key facts of "infections and spinal cord injury: Covid-19 and beyond"
143(1)
Key facts of "immunosuppression due to spinal cord injury"
143(1)
Key facts of "Leading infection diseases in spinal cord-injured patients"
143(1)
Key facts of "Covid-19 disease"
143(1)
Summary points
143(1)
References
144(3)
12 Sleep problems in spinal cord injury
David J. Berlowitz
Marnie Graco
Introduction
147(1)
Sleep-disordered breathing
148(1)
Prevalence of sleep-disordered breathing after tetraplegia
149(1)
Sleep-disordered breathing is an acute and direct consequence of cervical SCI
149(1)
Sleep-disordered breathing after tetraplegia has clinically important impacts
149(2)
Why do people with tetraplegia have sleep-disordered breathing, predominantly obstructive sleep apnea?
151(1)
Clinical management of sleep-disordered breathing in people with SCI
152(1)
How does SCI alter the circadian rhythm?
153(1)
Periodic leg movements of sleep in SCI
154(1)
Applications to other areas of neuroscience
154(1)
Mini-dictionary of terms
154(1)
Key facts of sleep
155(1)
Summary points
155(1)
References
155(2)
Further reading
157(5)
Section C Diagnosis and evaluation
13 Biomarkers in spinal cord injury: A highlight on prognostic insights
Leonardo Fonseca Rodrigues
Tania Cristina Leite de Sampaio e Spohr
Introduction
162(1)
Pathophysiology of SCI
162(1)
Biomarkers of SCI
163(2)
SCI in the acute stage
163(1)
SCI in the sub-acute stage
164(1)
SCI in the chronic stage
165(1)
MicroRNAs as biomarkers
165(2)
Exosomes
167(1)
Conclusions
168(1)
Applications to other areas of neuroscience
168(1)
Mini-dictionary of terms
168(1)
Key facts of biomarkers spinal cord injury
169(1)
Summary points
169(1)
Acknowledgments
169(1)
References
169(4)
14 Quality of life tools for spinal cord-injured people
Sebastian Salvador-De La Barrera
Ibone Gimenez-Jimenez
Manuel Astray-Lopaz
Antonio Rodnguez-Sotillo
M. Elena Ferreiro-Velasco
Introduction
173(1)
Definitions: Quality of life and health-related quality of life
174(1)
Implementation in the study of quality of life in people with spinal cord injury
175(7)
Databases
175(7)
Integrative quality of life assessment instruments
182(2)
Health-related quality of life assessment instruments for conditions resulting from spinal cord injury
184(1)
Conclusions
185(1)
Applications to other areas of neuroscience
186(1)
Dictionary of terms
186(1)
Key facts of measuring quality of life in sci people
186(1)
Summary
187(1)
References
187(4)
15 S100b in spinal cord injury
Andreas Zigouris
Georgios Kafritsas
George A. Alexiou
Spyridon Voulgaris
Introduction
191(1)
S100b characteristics
191(1)
S100b and CNS pathology
192(1)
Biomarkers in SCI
193(1)
SlOObandSCI
194(2)
Limitations and perspectives
196(1)
Applications to other areas of neuroscience
196(1)
Mini-dictionary of terms
197(1)
Key facts of calcium-binding proteins
197(1)
Summary points
197(1)
References
197(2)
16 Assessment of postural control after spinal cord injury or disease: A narrative review
Kristin E. Musselman
Janelle Linger
Jean-Francois Lemay
Introduction
199(1)
Chapter Objectives
200(1)
Comprehensive assessment of postural control
200(4)
Current state of postural control assessment in clinical settings
204(1)
Instrumented assessments of postural control
204(1)
Individualized and comprehensive assessment of postural control after SCI/D
205(2)
Wheelchair users: Assessment of postural control
207(2)
Stage 0
207(2)
Stages 0.5 and 1A
209(1)
Stages 1B, 1C, and 2A
209(1)
Part-time ambulators: Assessment of postural control
209(1)
Full-time ambulators: Assessment of postural control
209(1)
Summary
210(1)
Applications to other areas of neuroscience
210(1)
Mini-dictionary of terms
210(1)
Key facts of postural control
211(1)
Summary points
211(1)
References
211(6)
Section D Treatments: Experimental and clinical
17 Surgical management of acute spinal cord injury in emergency setting
Federico Fusini
Angela Coniglio
Alessandro Rava
Salvatore Risitano
Alessandro Masse
Massimo Girardo
Introduction
217(1)
Natural history of patients with acute cervical SCI
218(1)
Natural history of patients with thoracic or thoracolumbar SCI
218(1)
Surgical procedures
219(1)
How to define early versus late surgery post SCI?
220(1)
Which is the most efficacious threshold?
220(2)
Ultra-early threshold (8-12 h post SCI)
221(1)
Early threshold (24 h post SCI)
221(1)
Late, threshold (48-72 h post SCI)
222(1)
What threshold is feasible?
222(1)
Does ESD offers the same benefit for all acute SCI?
222(1)
Complete versus incomplete SCI
222(1)
Effects of ESD on different neurological level of injury
223(1)
Effect of SD in patients with cervical SCI
223(1)
Effect of SD in patients with thoracic and thoracolumbar SCI
223(1)
Effect of SD on miscellaneous SCI
223(1)
The special case of Central Cord Syndrome
224(1)
Conclusions
225(1)
Applications to other areas of neuroscience
225(1)
Mini-dictionary of terms
225(1)
Key facts of surgical treatment of spinal cord injury
226(1)
Summary points
226(1)
References
226(3)
18 Spinal cord epidural stimulation for autonomic nervous system control: A focus on improving bladder, bowel, and cardiovascular function
April N. Herrity
Sevda C. Asian
Susan J. Harkema
Charles H. Hubscher
Introduction
229(9)
Bladder dysfunction after SCI
230(1)
Bowel dysfunction after SCI
231(1)
Cardiovascular dysfunction and interactions with other autonomic systems after SCI
231(2)
Introduction of spinal cord stimulation
233(1)
Neuromodulation to improve bladder function
233(5)
Neuromodulation to improve bowel function
238(1)
Neuromodulation to improve cardiovascular function
238(1)
Future directions with scES and applications to other areas of neuroscience
238(1)
Mini-dictionary of terms
239(1)
Key facts of autonomic dysfunction after SCI
239(1)
Key facts of scES after SCI
240(1)
Summary points
240(1)
References
240(5)
19 Treating spinal cord injury with implanted spinal cord stimulators
Hengze You
Yong-Ping Zheng
Monzurul Alam
Introduction
245(2)
Spinal cord injury
245(1)
Treatments for SCI
246(1)
Spinal cord stimulation
247(1)
Principles of SCS
247(1)
Functional rehabilitation with SCS
248(1)
Spinal cord stimulators
248(5)
Current spinal cord stimulators
248(4)
Surgical implantation of neurostimulators
252(1)
Significance of SCS
253(1)
Current limitations of the neurostimulators
253(1)
Advanced neurostimulators
254(1)
Prospects of the stimulation for spinal cord injury rehabilitation
254(1)
Applications to other areas of neuroscience
254(1)
Mini-dictionary of terms
255(1)
Key facts of spinal cord injury
255(1)
Summary points
255(1)
References
256(3)
20 Bowel dysfunction in spinal cord injury
Maria Elena Ferreiro-Velasco
Antonio Montoto-Marques
M. Eugenia Diaz-Recarey
Renato Vilas-Boas
Sebastian Salvador-De La Barrera
Antonio Rodnguez-Sotillo
Introduction
259(1)
Characteristics of neurogenic bowel in spinal cord injury
259(1)
Clinical manifestations
260(1)
Diagnosis
261(2)
Assessment scales
261(2)
Conservative treatment of the neurogenic bowel
263(4)
General recommendations
263(1)
Diet
263(1)
Physical exercise
263(1)
Abdominal massage
263(1)
Mechanical techniques to ease bowel movements
263(1)
Pharmacological treatment
263(2)
Other drugs
265(1)
Bowel program
266(1)
Anorectal biofeedback
267(1)
Transanal irrigation
267(1)
Surgical treatment of the neurogenic bowel
267(2)
Electrical stimulation
267(1)
Antegrade continence enema
267(1)
Colostomy and ileostomy
267(2)
Conclusions
269(1)
Applications to other areas of neuroscience
269(1)
Dictionary of terms
270(1)
Key facts of neurogenic bowel dysfunction
270(1)
Summary points
270(1)
References
270(3)
21 Management of neurogenic lower urinary tract dysfunction due to spinal cord injury
Noritoshi Sekido
Introduction
273(2)
Physiology of storage and emptying
275(1)
Pathophysiology of NLUTD due to SCI
275(1)
Classification of NLUTD due to SCI
275(1)
Association between neurological level of SCI and NLUTD
275(1)
Elderly SCI
275(1)
Overview of management of patients with NLUTD due to SCI
276(1)
Clinical outcomes of management of NLUTD
276(1)
Pathway of NLUTD management
276(1)
Basic and optional assessments
276(1)
Urinary management
277(3)
Urinary management during acute phase
277(1)
Urinary management during chronic phase
278(2)
Pharmacological treatment
280(1)
To facilitate urine storage
280(1)
To facilitate bladder emptying
280(1)
Assessment of clinical outcomes (periodic follow-up)
280(1)
Proposal for follow-up protocol
280(1)
Proposal for repeated urodynamic study
281(1)
Proposal for surveillance for bladder cancer
281(1)
Surgical treatment
281(2)
Transurethral intra-detrusor injection of type A botulinum toxin (BoNT-A)
281(1)
Other surgical treatments
281(2)
Applications to other areas of neuroscience
283(1)
Mini-dictionary of terms
283(1)
Key facts of catheters for clean intermittent catheterization
283(1)
Summary points
284(1)
References
285(2)
22 Bed support surfaces for preventing pressure injuries after spinal cord injury
Annie Levasseur
Jean-Marc Mac-Thiong
Andreane Richard-Denis
Introduction
287(1)
Pressure injuries (PI): Definition, epidemiology and impacts
287(1)
Pathogenesis of pressure injuries following spinal cord injury
288(1)
Support surfaces: An approach for prevention and treatment of pressure injuries
288(7)
Biomechanical properties of support surfaces during loading
288(2)
Main configurations and classification of support surfaces
290(1)
Reactive support surfaces
290(2)
Active support surfaces
292(1)
Air fluidized
293(1)
Emerging technologies
293(1)
Positioning, surface material and bed making
293(1)
Global evidence on the effectiveness of support surfaces
294(1)
Decision-making for selecting proper support surfaces
294(1)
Conclusion
295(1)
Applications to other areas of neuroscience
295(1)
Mini-dictionary of terms
296(1)
Key facts of pressure injuries after spinal cord injury
296(1)
Summary points
296(1)
References
296(3)
23 Nerve and tendon transfers in tetraplegia: A new narrative
Federico Fusini
Paolo Titolo
Stefano Artiaco
Bruno Battiston
Salvatore Risitano
Alessandro Masse
Introduction
299(1)
Classifications
300(1)
Indications and timing
301(3)
Group 0
304(1)
Group 1
305(1)
Group 2
305(1)
Group 3
306(1)
Group 4
307(1)
Group 5
308(1)
Group 6
308(1)
Group 7
308(1)
Group 8
308(1)
Group 9
309(1)
Conclusions
309(1)
Applications to other areas of neuroscience
309(1)
Mini-dictionary of terms
309(1)
Key facts of nerve and tendon transfers in tetraplegia: A new narrative
310(1)
Key facts of nerve and tendon transfer
310(1)
Summary points
310(1)
References
310(3)
24 GEMINI-supported spinal cord transplantation for the treatment of chronic spinal paralysis: Overview and initial clinical translation
X.P. Ren
P. Henderson
C.Y. Kim
S. Canavero
Introduction
313(1)
The GEMINI spinal cord fusion protocol: Overview
313(1)
GEMINI: Fusogens
314(1)
GEMINI: Electrical stimulation
314(1)
Clinical translation
315(2)
Gemini hydrogelation
315(1)
Resection-apposition (Freeman-GEMINI approach)
316(1)
Spinal cord transplantation (Shirres-GEMINI approach)
316(1)
Current human trial
317(5)
Conclusion
322(1)
Applications to other areas of neuroscience
322(1)
Mini-dictionary of terms
322(1)
Key facts of the GEMINI spinal cord fusion protocol for spinal cord injury
322(1)
Summary points
323(1)
References
323(2)
25 Chondroitinase ABC I as a novel candidate for reducing damage in spinal cord injury
Akram Shirdel
Khosrow Khalifeh
Molecular perspectives
325(3)
Glycosaminoglycans and proteoglycans
325(1)
Distribution and functions of GAGs and proteoglycans
326(1)
CSPGs in the nervous system
327(1)
Implication of CSPGs in pathogen conditions
328(1)
Glycosaminoglycan degrading enzymes: A brief description
328(1)
Structural features of chondroitinase ABC I
328(1)
Chondroitinase ABC I and spinal cord injury
329(1)
Chondroitinase ABC I for enzyme therapy: Challenges and perspectives
330(1)
Protein engineering strategies toward functional drug delivery
330(1)
Combinatorial therapy with chondroitinase ABC I
330(1)
Applications to other areas of neuroscience
331(1)
Mini-dictionary of terms
331(1)
Key facts of chondroitinase ABC I
332(1)
Key facts of the therapeutic potential of chondroitinase ABC I
332(1)
Summary points
332(1)
References
332(5)
26 Phenol neurolysis for spasticity management in people with spinal cord injury
Radha Korupolu
Lavina Jethani
Introduction
337(1)
Phenol or alcohol neurolysis history
338(1)
Mechanism of action
339(1)
Phenol neurolysis technique and dose
339(2)
Upper extremity targets
340(1)
Lower extremity targets
340(1)
Adverse effects
341(1)
Case study
342(1)
Conclusion/summary
343(1)
Applications to other areas of neuroscience
343(1)
Mini-dictionary of terms
343(1)
Key facts of phenol
344(1)
Summary points
344(1)
References
344(3)
27 Anti-repulsive guidance molecule: An antibody treatment in spinal cord injury
Takahide Itokazu
Toshihide Yamashita
Introduction
347(1)
Characteristics of RGMa
348(2)
Ligand-receptor interactions and downstream signaling of RGMa
348(2)
RGMa in spinal cord injury (SCI)
350(2)
RGMa expression after SCI
350(1)
RGMa inhibition promotes recovery after SCI in rodents
350(2)
RGMa inhibition promotes recovery after SCI in primates
352(1)
Clinical studies
352(1)
RGMa in other CNS disorders
353(1)
Conclusions
354(1)
Applications to other areas of neuroscience
354(1)
Mini-dictionary of terms
355(1)
Key facts of axonal sprouting
355(1)
Summary points
355(1)
References
355(5)
28 Mitochondrial biogenesis for the treatment of spinal cord injury
Epiphani C. Simmons
Natalie E. Scholpa
Joshua D. Crossman
Rick G. Schnellmann
Introduction
360(1)
Mitochondrial dysfunction
360(1)
Mitochondrial biogenesis
361(1)
Regulation of MB
361(1)
Cell type-specific mitochondrial dysfunction and MB
362(4)
Neurons
362(1)
Astrocytes
363(2)
Endothelial cells
365(1)
Mitochondrial biogenesis mediates consequences of SCI
366(1)
Mitochondrial homeostasis and functional recovery
366(1)
Body composition
366(1)
Axonal growth
367(1)
Inflammation
367(1)
Limitations of MB
367(2)
Applications to other areas of neuroscience
368(1)
Mini-dictionary
369(1)
Key facts
369(1)
Summary points
369(1)
References
370(3)
29 Exploring the exogenous and endogenous effects of melatonin on spinal cord injury
Dewan Md. Sumsuzzman
Kanghui Park
Yonggeun Hong
Introduction
373(1)
Effects of exogenous melatonin on secondary injury after spinal cord injury
374(4)
Effects of exogenous melatonin on oxidative stress
375(1)
Effects of exogenous melatonin on inflammation
376(1)
Effects of exogenous melatonin on autophagy
376(2)
Combination treatment strategy for spinal cord injury
378(1)
Melatonin combined with exercise
378(1)
Role of endogenous melatonin in spinal cord injury
378(2)
Clinical application of melatonin in spinal cord injury
380(1)
Conclusion
380(1)
Applications to other areas of neuroscience
381(1)
Mini-dictionary of terms
382(1)
Key facts
382(1)
Key facts of melatonin and exercise combination strategy for spinal cord injury
382(1)
Key facts of endogenous melatonin levels after spinal cord injury
382(1)
Summary points
382(1)
References
382(3)
30 High-intensity interval training in individuals with spinal cord injury
Byron Lai
Jereme Wilroy
Gordon Fisher
Introduction
385(1)
Section 1 Background and overview
385(1)
Incidence and prevalence
385(1)
Healthcare and economic burden
386(1)
Section 2 Cardiometabolic comorbidities associated with SCI
386(1)
Associated risk factors
386(1)
Health disparities, barriers, and SCI
387(1)
Section 3 SCI exercise benefits, guidelines, and participation
387(2)
Exercise benefits
387(1)
Exercise guidelines
388(1)
Exercise participation
389(1)
Section 4 Health benefits of high-intensity interval training
389(2)
High-intensity interval training in able-bodied individuals
389(1)
High-intensity interval training in individuals with spinal cord injury
390(1)
Telehealth strategies to promote exercise adherence to high-intensity interval training
390(1)
Applications to other areas of neuroscience
391(1)
Mini-dictionary of terms
391(1)
Key facts of SCI and exercise
392(1)
Summary points
392(1)
References
392(5)
31 Stem cells and chronic spinal cord injury: Overview
Leonardino A. Digma
Pavan S. Upadhyayula
Joel R. Martin
Joseph D. Ciacci
Introduction
397(1)
Pathophysiology of SCI
397(1)
Stem cells: A brief overview
398(1)
Embryonic stem cells--An overview of pre-clinical findings
398(2)
Animal-derived ESCs
398(1)
Human-derived ESCs
399(1)
ESC limitations
399(1)
Toward autologous transplantation: Mesenchymal stem cells
400(1)
Bone marrow-derived MSCs
400(1)
Adipose tissue-derived MSCs
400(1)
Umbilical cord-derived MSCs
400(1)
Cellular reprogramming: Induced pluripotent stem cells
401(1)
Translation to the bedside
401(3)
Development of a more accurate model
401(1)
Human studies and clinical trials
402(2)
The role of immunity
404(1)
Applications to other areas of neuroscience
405(1)
Conclusion
406(1)
Mini-dictionary of terms
406(1)
Key facts for stem cells
406(1)
Key facts for spinal cord injury
406(1)
Summary points
406(1)
Acknowledgements
407(1)
Funding
407(1)
Disclosure statement
407(1)
References
407(4)
32 Viral vector gene therapy approaches for regeneration and repair in spinal cord injury
Simon J. O'Carroll
Connor A. Clemett
Introduction
411(1)
Viral vector approaches
411(3)
Adenovirus
413(1)
Poliovirus
414(1)
Herpes simplex virus
414(1)
Lentivirus
414(1)
Adeno-associated virus
414(1)
Routes of administration
414(3)
Intramuscular and intraneural delivery
416(1)
Intravenous delivery
416(1)
Intrathecal delivery
416(1)
Intraparenchymal delivery
416(1)
Viral vector approaches for therapeutic delivery
417(1)
Neurotrophins
417(1)
CSPG
417(1)
Other approaches
418(1)
Applications to other areas of neuroscience
419(1)
Mini-dictionary of terms
419(1)
Key facts of viral vectors and spinal cord injury
419(1)
Summary points
420(1)
References
420(5)
33 Curcumin usage for inflammation and spinal cord injury
Subum Lee
Kyoung-Tae Kim
Introduction
425(1)
Structure, pharmacology, and biological targets
426(1)
Anti-inflammatory effects
427(2)
Anti-oxidant effects
429(1)
Stem cell and progenitor cell proliferation
430(1)
Facilitation of neurologic function recovery
430(1)
Conclusion and future direction
430(2)
Applications to other areas of neuroscience
432(1)
Mini-dictionary of terms
432(1)
Key facts of curcumin
433(1)
Summary points
433(1)
References
433(5)
34 Use of (-)-epigallocatechin-3-gallate on spinal cord injury
Ali Reza Khalatbary
Introduction
438(1)
In vivo studies
439(2)
In vitro studies
441(1)
Applications to other areas of neuroscience
442(5)
Conclusion
447(1)
Mini-dictionary of terms
447(1)
Key facts of EGCG
448(1)
Summary points
448(1)
References
448(5)
35 Vitamin D and spinal cord injury
Kelly Pritchett
Brianna Rice
Sophia Berg
Introduction
453(1)
Vitamin D recommendations: Intake, sources, and status
453(3)
Function and physiology
456(1)
Bone health
456(1)
Muscle function
457(1)
Extraskeletal functions
457(1)
Vitamin D status of active individuals with SCI
457(1)
Vitamin D and athletic performance in athletes with SCI
458(1)
Conclusion
458(1)
Application to other areas of neuroscience (200-750 words)
458(1)
Mini-dictionary of terms
459(1)
Key facts of vitamin D and spinal cord injury
459(1)
Summary points
459(1)
References
459(2)
36 Corticospinal tract regeneration after spinal cord injury: Implications for treatment and recovery
Yuanyuan Li
Paul Lu
Introduction
461(1)
CST development
462(2)
CST outgrowth
462(1)
CST location and termination pattern in spinal cord
462(1)
Precise control of skilled motor functions by defined CST populations
463(1)
Identification of cellular node for CST control of motor function in mice
464(1)
Spinal cord injury induced spontaneous sprouting of CST
464(1)
Classical work
464(1)
Dorsal injury: Ventral CST sprouting
464(1)
Dorsal column injury: Dorsolateral CST spouting
464(1)
Unilateral hemisection: CST cross into denervated side in monkeys
465(1)
Rewiring hindlimb CST
465(1)
Promotion of CST regenerative sprouting
465(2)
Promotion of CST regenerative sprouting by NT-3
465(1)
Promotion of CST regenerative sprouting by overcome of myelin inhibitors
466(1)
Promotion of CST regenerative sprouting by overcome of CSPC
466(1)
Promotion of CST regenerative sprouting by genetic manipulation of certain genes
467(1)
Robust CST regeneration into caudalized NPC graft after SCI
467(2)
Transplantation of non-neural cells or fetal neural tissue
467(1)
Transplantation of caudalized neural progenitor cells
467(2)
Mechanisms of CST regeneration
469(1)
Reconnect injured spinal cord through neuronal relays
469(1)
Future prospective
470(1)
Applications to other areas of neuroscience
471(1)
Mini-dictionary of terms
471(1)
Key facts of corticospinal tract regeneration after spinal cord injury
471(1)
Summary points
472(1)
References
472(3)
37 Trophic factors in patients with spinal cord injury
J. Luis Quintanar
Maria del Carmen Diaz-Galindo
Denisse Calderon-Vallejo
Francisco Jaramillo-Gonzalez
Introduction
475(1)
Role of neurotrophic factors in human neural plasticity after SCI
476(2)
Nerve growth factor (NGF)
477(1)
Brain-derived neurotrophic factor (BDNF)
477(1)
Neurotrophin NT3 and NT4/5
477(1)
Glial-derived neurotrophic factor (GDNF)
477(1)
Fibroblast growth factors (FGFs)
477(1)
Different environments enhance trophic factors delivery
478(2)
Exercise
478(1)
Electrical stimulation
479(1)
Cell transplantation
479(1)
Therapeutic potential of trophic factors
480(2)
Molecules with properties of trophic factor in clinical trials
481(1)
Applications to other areas of neuroscience
482(2)
Mini-dictionary of terms
484(1)
Key facts of spinal cord injury
484(1)
Key facts therapeutic approaches
484(1)
Summary points
484(1)
References
485(6)
Section E Rehabilitation in spinal injury
38 Spinal cord injury: Multiple family group (MFG) education and support
Dennis G. Dyck
Crystal Lederhos Smith
Bruce E. Becker
Introduction
491(1)
Epidemiology of spinal cord injury
491(1)
Life impact and medical support
491(1)
Spinal cord injury after-effects
492(1)
Impacts of SCI on family caregivers
493(1)
Impact of multiple family groups (MFG) on psychiatric outcomes
493(1)
Adapting multiple family group treatment for brain and spinal cord injury
494(1)
Comparison of MFG to educational control (EC)
495(3)
Implementation and dissemination opportunities and barriers
498(1)
Application to other areas of neuroscience
498(1)
Conclusion
499(1)
Summary points
499(1)
References
499(2)
39 Spinal cord injury rehabilitation: Linking service delivery and community integration
Linda Barclay
Gillean Hilton
Introduction
501(1)
Prioritizing community integration
501(1)
Interplay between health condition, person factors, and environmental factors
502(1)
Models and approaches to community integration
502(2)
Community integration embedded within inpatient rehabilitation
502(1)
Transitional rehabilitation program
503(1)
Extended community integration service
504(1)
Telehealth follow-up
504(1)
Assistive technology, transport, housing
504(2)
Assistive technology
504(1)
Transport
504(1)
Housing
505(1)
Leisure and social participation
506(1)
Participating in leisure assists adjustment following SCI
506(1)
Health benefits of physical leisure participation
506(1)
The role of peer mentors in community integration
506(1)
Peer mentors assist in transition from hospital to home
506(1)
Active rehabilitation
506(1)
Return to work
506(1)
Benefits of employment
507(1)
Vocational rehabilitation
507(1)
Self-management, education and health literacy
507(1)
Importance of education in maintaining physical and mental health
507(1)
Role of peer educators in facilitating self-management
508(1)
Summary
508(1)
Applications to other areas of neuroscience
508(1)
Mini-dictionary of terms
508(1)
Key facts of spinal cord injury community integration
509(1)
Summary points
509(1)
References
509(4)
40 Rehabilitation in spinal cord injury: Exercise and testing for cardiorespiratory endurance and musculoskeletal fitness
Kerri A. Morgan
Kelly L. Taylor
Susan Tucker
Introduction
513(1)
Exercise and persons with a spinal cord injury
513(2)
Exercise and spinal cord injury considerations
514(1)
Exercise recommendations for persons with spinal cord injury
514(1)
Barriers to exercise
514(1)
Importance of exercise testing
514(1)
Exercise testing for persons with a spinal cord injury
515(1)
General considerations for exercise testing for people with spinal cord injury
515(1)
Cardiorespiratory endurance testing
515(3)
V02peak testing in people with spinal cord injury
515(1)
Equipment options for V02peak fitness testing in people with spinal cord injury
516(1)
Submaximal field tests
517(1)
Musculoskeletal fitness testing
518(3)
Considerations for strength testing in persons with spinal cord injury
519(1)
Strength testing equipment
520(1)
Testing procedures
521(1)
Application to other areas in neuroscience
521(1)
Mini-dictionary of terms
521(1)
Key facts of rehabilitation in spinal cord injury: Exercise and testing for cardiorespiratory endurance and musculoskeletal fitness
522(1)
Key facts of spinal cord injury and exercise
522(1)
Key facts of exercise testing for persons with spinal cord injury
522(1)
Summary points
522(1)
References
522(3)
41 Community-based activity-based therapy for spinal cord injuries rehabilitation
Natalia Padula
Camila Quel de Oliveira
Introduction
525(1)
Recovery after spinal cord injuries
526(1)
Conventional rehabilitation after spinal cord injuries
527(1)
Activity-based therapies
527(7)
Definition
527(1)
Goals
528(1)
Multimodal activity-based therapy
528(1)
Locomotor and gait training
529(1)
Neuromuscular electrical stimulation (NMES) and functional electrical stimulation (FES)
530(1)
Developmental postures: Weight-bearing activities
531(1)
Vibration
531(1)
Strength and aerobic training
531(1)
Active and active-assisted exercises
532(1)
Dosage
533(1)
Assessment and outcome measures
533(1)
Practical aspects of ABT in the community
534(1)
Applications to other areas of neuroscience
534(1)
Mini dictionary of terms
534(1)
Key facts of activity-based therapy in the community
535(1)
Summary points
535(1)
References
535(4)
42 Mobile health apps and self-management for spinal cord injury rehabilitation
Gurkaran Singh
Megan K. MacGillivray
Ethan Simpson
Bonita J. Sawatzky
W. Ben Mortenson
Introduction
539(1)
Chronic disease management
539(1)
Traditional SCI self-management interventions
540(1)
Ehealth technology and mHealth apps
541(1)
Mhealth app needs among individuals with SCI
542(1)
Development and pilot implementation of mHealth apps for SCI self-management
542(2)
Clinical interventions on mHealth apps for SCI self-management
544(1)
Applications to other areas of neuroscience
545(1)
Mini-dictionary of terms
545(1)
Key facts of spinal cord injury
546(1)
Key facts of eHealth
546(1)
Summary points
546(1)
References
546(3)
43 Biomaterials, spinal cord injury, and rehabilitation: A new narrative
Elisa Lacroce
Giuseppe Perale
Filippo Rossi
Introduction
549(1)
Hydrogels and scaffolds
550(2)
Synthetic-based hydrogels
550(1)
Hydrogel functionalization with cell-adhesive peptides
551(1)
Porosity orientation
551(1)
Natural-based hydrogels
551(1)
Extracellular matrix-based hydrogels
552(1)
Nanomaterials
552(5)
Nanotechnology and nanomedicine
552(1)
Properties of nanomaterials
552(1)
Nanoparticles
553(2)
Functionalization of nanoparticles
555(1)
The effects of encapsulated neurotrophin
555(1)
Nanogels
555(1)
Functionalization of nanogels
556(1)
Nanochannels, nanotubes, nanowires, and conduits
557(1)
Case study: Agarose-carbomer-based hydrogels
557(1)
Applications to other areas of neuroscience
558(2)
Mini-dictionary of terms
560(1)
Key facts of "Biomaterials, spinal cord injury, and rehabilitation: A new narrative"
560(1)
Summary points
560(1)
References
560(3)
44 Support in spinal cord injury: A focus on robotics
Angel Gil-Agudo
Guillermo Asin-Prieto Eng
Introduction
563(1)
Upper limb robots
564(2)
MIT MANUS
565(1)
ReoGo
565(1)
Armeo
565(1)
Other devices
566(1)
Stationary lower limb robots
566(2)
End effector devices
567(1)
Stationary exoskeletons
567(1)
Ambulatory exoskeletons
568(2)
Applications to other areas of neuroscience
570(1)
Mini-dictionary of terms
570(1)
Key facts of functional recovery
571(1)
Summary points
571(1)
References
571(6)
Section F Resources
45 Recommended resources and sites for the neuroscience of spinal cord injury
Rajkumar Rajendram
Vinood B. Patel
Victor R. Preedy
Introduction
577(1)
Resources
578(2)
Application to other areas of neuroscience
580(5)
Mini-dictionary of terms
585(1)
Key facts of spinal cord injury
585(1)
Summary points
586(1)
Acknowledgements (in alphabetical order)
586(1)
References
586(1)
Index 587
Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guys, Kings and St. Thomas Medical School, Kings College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.



Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.

Dr Rajendrams focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of Kings College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at Kings College Hospital and Emeritus Professor of Nutritional Biochemistry at Kings College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at Kings College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books. Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.