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E-raamat: Dopamine: Endocrine and Oncogenic Functions

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  • Ilmumisaeg: 12-Apr-2020
  • Kirjastus: CRC Press
  • Keel: eng
  • ISBN-13: 9780429688485
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Dopamine: Endocrine and Oncogenic FunctionsSuurem pilt
  • Formaat: PDF+DRM
  • Ilmumisaeg: 12-Apr-2020
  • Kirjastus: CRC Press
  • Keel: eng
  • ISBN-13: 9780429688485
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Dopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule.

Key Features:











Explores the many different faces of dopamine as autocrine, paracrine and endocrine molecule





Documents the adverse effects of antipsychotics on dopamine functions





Reviews the many ways dopamine affects the cardiovascular, renal and reproductive systems





Provides updates on receptor oligomerization and signaling





Examines the role of dopamine in tumorigenesis

Related Titles

Jones, S. ed. Dopamine - Glutamate Interactions in the Basal Ganglia (ISBN 978-0-3673-8197-4)

Luo, L. Principles of Neurobiology (ISBN 978-0-8153-4494-0)

Sidhu, A. et al., eds. Dopamine Receptors and Transporters (ISBN 978-0-8247-0854-2)

Arvustused

"With a highly thoughtful organization and progression, this robust book is a thorough investigation into what researchers would find useful for further study. This book is recommended to those pursuing original research, as it lays out the numerous pathways that have already been characterized to date. To broaden the audience to more clinicians, it could better highlight clinical correlates and related pharmacological interventions. Clinical students and providers may have trouble digesting the basic-science-heavy nature of this book and likely would prefer alternative sources specifically relevant to their field of practice." - Victor S Wang, MD (Thomas Jefferson University)

Preface xi
Author xiii
Chapter 1 Homeostasis of Dopamine
1(1)
1.1 Introduction
1(1)
1.2 Biosynthetic Enzymes
2(5)
1.2.1 Tyrosine hydroxylase
3(2)
1.2.2 Dopa decarboxylase
5(1)
1.2.3 Dopamine beta-hydroxylase and phenylethanolamine-N-methyltransferase
6(1)
1.3 Metabolic Enzymes
7(5)
1.3.1 Monoamine oxidases (MAOs)
8(1)
1.3.2 Catechol-O-methyltransferase
9(1)
1.3.3 Glucuronosyltransferases and sulfotransferases
10(2)
1.4 Membrane And Vesicular Transporters
12(7)
1.4.1 Transporters of monoamine neurotransmitters
12(2)
1.4.2 The dopamine transporter
14(1)
1.4.3 Pharmacology of DAT
15(1)
1.4.4 DAT-deficient mice
16(1)
1.4.5 Vesicular monoamine transporters
16(2)
1.4.6 Organic cation transporters and plasma membrane monoamine transporters
18(1)
1.5 Storage, Release, And Reuptake
19(5)
1.5.1 Functional coupling between DA synthesis and storage
19(1)
1.5.2 Characteristics of synaptic vs. secretory vesicles
20(2)
1.5.3 Mechanism of exocytosis
22(2)
References
24(3)
Chapter 2 Dopamine Receptors, Signaling Pathways, and Drugs
27(28)
2.1 Introduction
27(1)
2.2 Dopamine Receptors: Structure-Function Relationship
28(14)
2.2.1 Overview of G protein-coupled receptors (GPCR)
28(1)
2.2.2 Structural and functional classification of the GPCRs
29(1)
2.2.3 Coupling of the GPCRs to G proteins
30(3)
2.2.4 General characteristics and regulation of the DARs
33(3)
2.2.5 Specific properties and brain distribution of D1-like receptors
36(2)
2.2.6 Specific properties and brain distribution of D2-like receptors
38(2)
2.2.7 DAR oligomerization, desensitization, and constitutive activity
40(2)
2.3 Canonical Versus Noncanonical Signaling By Dar Subtypes
42(4)
2.3.1 The consequences of DAR coupling to G proteins
42(1)
2.3.2 The adenylate cyclase/cAMP/PKA signaling pathway
43(1)
2.3.3 Cross-talk of multiple signaling pathways
44(1)
2.3.4 Role of the cGMP pathway
45(1)
2.4 Dar Agonists And Antagonists
46(4)
2.4.1 Overview of DAR-selective ligands
46(1)
2.4.2 D2R-altering drugs
47(1)
2.4.3 Atypical antipsychotics
48(1)
2.4.4 Drug selectivity
48(1)
2.4.5 Peripheral dopaminergic altering drugs
49(1)
2.5 Dopamine Receptor Knockout Mice
50(1)
2.5.1 Phenotypes of individual DAR-KO mice
50(1)
2.5.2 D2R deletion and pituitary functions
51(1)
2.6 Synopsis
51(1)
References
52(3)
Chapter 3 Distribution and Characteristics of Brain Dopamine
55(26)
3.1 Introduction
55(1)
3.2 Noradrenergic And Adrenergic Neurons
56(4)
3.2.1 Historical perspectives
56(2)
3.2.2 Distribution and major functions of the brain noradrenergic neurons
58(1)
3.2.3 Distribution and major functions of the brain adrenergic neurons
59(1)
3.3 Dopaminergic Neurons
60(5)
3.3.1 Classification of the brain dopaminergic neurons
60(1)
3.3.2 Mesocortical, mesolimbic, and nigrostriatal dopaminergic pathways
61(2)
3.3.3 Retinal, olfactory, and pineal dopaminergic neurons
63(2)
3.4 The Hypothalamus: Structure And Functions
65(6)
3.4.1 Anatomy of the hypothalamus
65(1)
3.4.2 The hypothalamic nuclei: Locations and major neuroendocrine functions
66(4)
3.4.3 Catecholaminergic innervation of the hypothalamus
70(1)
3.5 The Hypothalamo-Pituitary Complex: Neural And Vascular Connections
71(7)
3.5.1 Functional anatomy of the hypothalamo-pituitary complex
71(1)
3.5.2 Embryonic development and gross anatomy of the pituitary gland
72(1)
3.5.3 The hypothalamo-pituitary complex: Neural connections and DA concentrations
73(2)
3.5.4 The hypothalamo-pituitary complex: Vascular connections and DA levels in portal blood
75(3)
3.6 Synopsis
78(1)
References
78(3)
Chapter 4 Endocrine Functions of Brain Dopamine
81(38)
4.1 Introduction
81(1)
4.2 Orcadian Rhythms
82(8)
4.2.1 Circadian rhythms and their impact on health and disease
82(2)
4.2.2 The neurocircuitry that controls circadian rhythms and the role of dopamine
84(1)
4.2.3 Dopamine and retinal rhythmicity
84(1)
4.2.4 Dopamine and the suprachiasmatic nucleus
85(1)
4.2.5 Effects of DA on the pineal: Regulation of melatonin synthesis and release
86(2)
4.2.6 Effects of dopamine on the circadian rhythms of circulating hormones
88(2)
4.3 The Neuroendocrine Stress Response
90(8)
4.3.1 Time-related, multi-facetted activation of the stress response
90(2)
4.3.2 Central dopamine and the stress response: Interactions with the HPA axis
92(2)
4.3.3 Circulating dopamine and the stress response
94(1)
4.3.4 Dopamine and the stress response: Interactions with sexually dimorphic hormones
95(3)
4.4 Food Intake And Metabolic Homeostasis
98(9)
4.4.1 Control of body weight and the consequences of dysregulation of food intake
98(1)
4.4.2 The hypothalamus: A major relay station that controls feeding behavior
98(3)
4.4.3 Leptin, a major suppressor of appetite
101(1)
4.4.4 Pancreatic hormones: Insulin and amylin
102(2)
4.4.5 Gastrointestinal hormones involved in the regulation of food intake
104(1)
4.4.6 Involvement of dopamine in the control of feeding behavior
105(2)
4.5 Neuroendocrine Regulation Of Reproduction And Sexual/Maternal Behavior
107(8)
4.5.1 Synthesis of GnRH, origin and migration of GnRH neurons, and genetic dysfunctions
108(1)
4.5.2 Kisspeptins, GnRH pulsatility, and the role of dopamine
108(2)
4.5.3 Reproductive functions of PRL and reciprocal interactions with dopamine
110(2)
4.5.4 Hyperprolactinemia and the suppression of GnRH release
112(1)
4.5.5 Regulation of sexual and maternal behavior
112(3)
4.6 SYNOPSIS
115(1)
References
115(4)
Chapter 5 Regulation of the Pituitary Gland by Dopamine
119(40)
5.1 Introduction
119(1)
5.2 Neural Lobe Hormones: Vasopressin And Oxytocin
119(8)
5.2.1 Ontogeny and composition of the posterior pituitary (neurointermediate lobe)
119(2)
5.2.2 Synthesis, transport, and processing of the neurohypophysial hormones
121(2)
5.2.3 Vasopressin: Receptors, functions, and regulation
123(1)
5.2.4 Oxytocin: Receptors, physiology, and regulation
124(2)
5.2.5 Effects of dopamine on the neurohypophysial hormones
126(1)
5.3 Intermediate Lobe Hormones: β-Endorphin And α-MSH
127(2)
5.3.1 Structure, innervation and regulation of the intermediate lobe
127(1)
5.3.2 Synthesis and processing of POMC and its derivatives
128(1)
5.3.3 Regulation of intermediate lobe hormones by dopamine
128(1)
5.4 Composition And Ontogeny Of The Anterior Pituitary
129(4)
5.4.1 Anterior pituitary structure, cell types, and dopamine receptors
129(2)
5.4.2 Ontogeny of anterior pituitary cell lineage
131(2)
5.5 Somatolactogenic Hormones: PRL And GH
133(8)
5.5.1 Structure and properties of somatotrophs and lactotrophs
134(1)
5.5.2 PRL: Structure, synthesis, regulation, and functions
134(4)
5.5.3 GH: Structure, synthesis, and regulation
138(3)
5.6 Reproductive Hormones: Lhandfsh
141(6)
5.6.1 The gonadotrophs: Structure, properties, and secretory products
142(1)
5.6.2 GnRH and the GnRH receptor
143(1)
5.6.3 FSH: Structure, synthesis, regulation and functions
144(1)
5.6.4 LH: Structure, synthesis, regulation, and functions
145(1)
5.6.5 Regulation of the hypothalamo-pituitaty-gonadal axis by dopamine
146(1)
5.7 Stress And Metabolic Hormones: ACTH And TSH
147(7)
5.7.1 Corticotrophs and ACTH
148(1)
5.7.2 Major disorders associated with dysfunctions oftheHPAaxis
149(2)
5.7.3 Involvement of dopamine in the regulation oftheHPAaxis
151(1)
5.7.4 Thyrotrophs and TSH
151(2)
5.7.5 Disorders of the hypothalamo-pituitary-thyroid axis
153(1)
5.7.6 Involvement of dopamine in the regulation of the HPT axis
154(1)
5.8 Asynopsis
154(1)
References
154(5)
Chapter 6 Attributes of Peripheral Dopamine and Dopamine Receptors
159(24)
6.1 Introduction
159(1)
6.2 Sources Of Circulating Dopamine
159(4)
6.2.1 Biosynthesis, storage, release, and metabolism of peripheral catecholamines
159(1)
6.2.2 The origin of circulating dopamine
160(2)
6.2.3 Special characteristics of peripheral dopamine
162(1)
6.3 Unique Characteristics Of Dopamine Sulfate
163(3)
6.3.1 Sulfoconjugation of peripheral dopamine
163(1)
6.3.2 Functions of DA-S and the role of arylsulfatase A
164(2)
6.4 Dopamine Receptors In The Cardiovascular, Pulmonary, And Renal Systems
166(3)
6.4.1 The cardiovascular and renal systems
166(1)
6.4.2 The respiratory system
167(2)
6.5 Dopamine Receptors In The Digestive System And In Organs That Regulate Metabolism
169(3)
6.5.1 The digestive system
169(2)
6.5.2 Metabolic regulation
171(1)
6.6 Dopamine Receptors In Hematopoietic And Immune Systems
172(2)
6.6.1 Dopamine receptors in lymphoid organs
172(1)
6.6.2 Dopamine receptors in peripheral blood lymphocytes
173(1)
6.7 Dopamine Receptors In Skin And Bones
174(2)
6.7.1 Skin structure
174(1)
6.7.2 Dopamine receptors in different skin components
174(1)
6.7.3 Bone structure
175(1)
6.7.4 Dopamine receptors in bone cells
175(1)
6.8 Dopamine Receptors In Male And Female Reproductive Systems
176(2)
6.8.1 Overall features of the reproductive system
176(1)
6.8.2 The male lower reproductive system
176(1)
6.8.3 The female reproductive system
177(1)
6.9 Synopsis
178(1)
References
179(4)
Chapter 7 Renal, Cardiovascular, and Pulmonary Functions of Dopamine
183(30)
7.1 Introduction
183(1)
7.2 Renal Fluid Hemodynamics And Hypertension
183(9)
7.2.1 Kidney development and gross anatomy
183(2)
7.2.2 The nephron: Structure-function relationship
185(1)
7.2.3 Urine formation and composition
186(1)
7.2.4 Endocrine regulation of blood pressure by the kidney
187(2)
7.2.5 Dopamine: Roles in essential hypertension and renal hemodynamics
189(3)
7.3 Renal Natriuresis, Oxidative Stress, And Diabetic Nephropathy
192(5)
7.3.1 Central role of the kidney in keeping electrolyte balance and osmolarity
192(1)
7.3.2 Endocrine regulation of natriuresis by the kidney
193(1)
7.3.3 Involvement of dopamine with natriuresis
194(1)
7.3.4 Renal dopamine and oxidative stress
195(1)
7.3.5 Dopamine and diabetic nephropathy
195(2)
7.4 Cardiac Functions
197(2)
7.4.1 Homeostasis of dopamine in the myocardium
197(1)
7.4.2 Actions of DA on the heart under pathophysiological conditions
198(1)
7.5 Blood Pressure Regulation In Various Vascular Beds
199(3)
7.5.1 Effects of DA on various circulation systems
199(2)
7.5.2 Dopamine and angiogenesis
201(1)
7.6 Respiration And Oxygen-Sensing
202(3)
7.6.1 Dopamine homeostasis in the upper respiratory tract
203(1)
7.6.2 Dopamine involvement in upper airway pathophysiology
204(1)
7.6.3 Dopamine and carotid body functions
204(1)
7.7 Pulmonary Ventilation And Pathophysiology
205(3)
7.7.1 De novo dopamine synthesis in the lung
206(1)
7.7.2 Actions of dopamine in the lung
206(2)
7.8 SYNOPSIS
208(1)
References
209(4)
Chapter 8 Digestive and Metabolic Actions of Dopamine
213(28)
8.1 Introduction
213(1)
8.2 Gastrointestinal System: Motility
214(5)
8.2.1 Pharynx and esophagus
214(2)
8.2.2 Stomach and duodenum
216(2)
8.2.3 Small and large intestine
218(1)
8.3 Gastrointestinal System: Digestive Functions
219(7)
8.3.1 Salivary glands
220(1)
8.3.2 The stomach
221(1)
8.3.3 Accessory digestive organs: Exocrine pancreas and gall bladder
222(1)
8.3.4 Small and large intestines
223(1)
8.3.5 Enteric dopaminergic system and the gut microbiome
224(2)
8.4 Organs That Regulate Metabolism: Pancreas, Adipose Tissue, And Liver
226(7)
8.4.1 Endocrine pancreas and glucose metabolism
227(1)
8.4.2 Adipose tissue
228(3)
8.4.3 The liver
231(2)
8.5 Diabetes, Obesity, And Adverse Effects Of Antipsychotic Drugs
233(2)
8.5.1 Dopamine, diabetes, and obesity
233(1)
8.5.2 Adverse effects of antipsychotic medication on body weight and metabolic syndrome
234(1)
8.6 Synopsis
235(1)
References
236(5)
Chapter 9 Dopamine in the Immune and Hematopoietic Systems
241(30)
9.1 Introduction
241(1)
9.2 Cells Derived From The Lymphoid Lineage
241(5)
9.2.1 T cells, B cells, and NK cells
243(1)
9.2.2 The dopaminergic system in lymphocytes and NK cells
244(2)
9.3 Cells Derived From The Myeloid Lineage
246(4)
9.3.1 The dopaminergic system in erythrocytes and platelets
246(2)
9.3.2 The dopaminergic system in various leucocyte subtypes
248(2)
9.4 Autoimmune Diseases And Neuropsychiatry Disorders
250(8)
9.4.1 Dopamine and autoimmune diseases
251(3)
9.4.2 Dopamine, immune system, and neurological disorders
254(3)
9.4.3 Dopamine, immune system, and psychiatric disorders
257(1)
9.5 Endothelial Cells, Angiogenesis, And Coagulation
258(6)
9.5.1 Endothelial cells and dopamine
258(1)
9.5.2 Angiogenesis and dopamine
259(3)
9.5.3 Blood clotting and the coagulation cascade
262(2)
9.6 Inflammation And Allergic Reactions
264(2)
9.6.1 Inflammation and dopamine
264(2)
9.7 SYNOPSIS
266(1)
References
267(4)
Chapter 10 Regulation of Reproduction by Dopamine
271(46)
10.1 Introduction
271(1)
10.2 Sex Determination And Sexual Differentiation Of The Brain
271(8)
10.2.1 Genetic and hormonal components of sexual determination and differentiation
271(3)
10.2.2 Temporal and spatial developmental stages of sexual differentiation in the brain
274(1)
10.2.3 Interference of the sexual differentiation program by endocrine disruptors
275(2)
10.2.4 Association of dopamine with sexual differentiation in the brain
277(1)
10.2.5 Gender identity and sexual preference
278(1)
10.3 Hypothalamo-Pituitary Regulation Of Reproduction In Both Sexes
279(4)
10.3.1 Common features of the central control of reproduction
279(1)
10.3.2 Involvement of dopamine in hypothalamic control of reproduction and sex behavior
280(1)
10.3.3 Involvement of dopamine in the control of reproduction by the pituitary
281(1)
10.3.4 Dopamine indirectly regulates reproductive functions through the control of prolactin
281(2)
10.4 Male Reproduction: Testes And The Genital Tract
283(5)
10.4.1 The male gonads: Spermatogenesis
284(1)
10.4.2 The male gonads: Steroidogenesis and protein hormone production
285(1)
10.4.3 Involvement of dopamine with testicular functions
286(1)
10.4.4 The male genital tract
287(1)
10.5 Female Reproduction: Ovaries And Genital Tract
288(10)
10.5.1 Unique characteristics of female reproduction
288(1)
10.5.2 The female gonads: Oogenesis, folliculogenesis, and ovulation
289(4)
10.5.3 The female gonads: Steroidogenesis
293(1)
10.5.4 Involvement of dopamine with ovarian functions
293(1)
10.5.5 The female genital tract
294(4)
10.6 Fertilization, Pregnancy, And Fetal Development
298(8)
10.6.1 Overview of conception, pregnancy, and embryonic development
298(1)
10.6.2 Fertilization
299(2)
10.6.3 Blastocyst transport and implantation
301(1)
10.6.4 Endocrine functions of the placenta
302(1)
10.6.5 L-Dopa and dopamine levels in different compartments of pregnancy
303(2)
10.6.6 Development of the fetal reproductive organs
305(1)
10.7 Parturition And Lactation
306(2)
10.7.1 The process of parturition
306(1)
10.7.2 Hormonal regulation of lactation
307(1)
10.8 Neonatal Development, Puberty, And Aging
308(3)
10.8.1 The reproductive axis during the neonatal and prepubertal periods
308(1)
10.8.2 Hormonal control of puberty and disorders of puberty
309(1)
10.8.3 Aging of the reproductive system
310(1)
10.9 Synopsis
311(1)
References
311(6)
Chapter 11 Actions of Dopamine on the Skin and the Skeleton
317(8)
11.1 Introduction
317(1)
11.2 Skin Structure And Wound Healing
318(7)
11.2.1 Overview of skin structure
318(2)
11.2.2 The complexity of wound healing
320(1)
11.2.3 Role of dopamine in wound healing
321(2)
11.2.4 Polydopamine nanopolymers used for drug delivery in wound healing
323(2)
1 1.3 Pigmentation And Melanogenesis
325(20)
11.3.1 Overview of skin pigmentation and melanogenesis
325(3)
11.3.2 Selected disorders of pigmentation
328(1)
11.3.3 Role of dopamine in skin pigmentation and its disorders
329(1)
11.4 Sweating
330(2)
11.4.1 Overview of sweating, apocrine, and eccrine glands
330(1)
11.4.2 Dopamine and sweating
330(2)
11.5 Hair Growth
332(2)
11.5.1 Overview of hair growth and its hormonal regulation
332(1)
11.5.2 Role of dopamine in hair growth
333(1)
11.6 The Skeleton And Bone Remodeling
334(3)
11.6.1 Overview of the skeleton and bone remodeling
334(2)
11.6.2 Involvement of dopamine in bone homeostasis
336(1)
11.7 Joints, Bones, And Muscles
337(5)
11.7.1 Overview of joints and muscles
337(1)
11.7.2 Involvement of dopamine in muscle disorders
338(2)
11.7.3 Involvement of dopamine in bone and synovial joint disorders
340(2)
11.8 Synopsis
342(1)
References
342(3)
Chapter 12 Dopamine and Tumorigenesis in Reproductive Tissues
345(28)
12.1 Introduction
345(1)
12.2 Pituitary Tumors
346(6)
12.2.1 Prevalence, classification, and molecular characterization of pituitary tumors
346(1)
12.2.2 Prolactinomas and dopamine: Pathogenesis and treatments
347(4)
12.2.3 Dopamine and other pituitary adenomas subtypes
351(1)
12.3 Breast Cancer
352(10)
12.3.1 Prevalence, classification, and molecular characterization of breast cancer
352(2)
12.3.2 Chemotherapy and immunotherapy in breast cancer
354(1)
12.3.3 Hormone and targeted therapies in breast cancer
355(3)
12.3.4 DARPP: A dopamine-regulated phosphatase involved in tumorigenesis
358(1)
12.3.5 D1R expression and actions in breast cancer
359(3)
12.4 Ovarian Cancer
362(3)
12.4.1 Characteristics of ovarian cancer
362(1)
12.4.2 Involvement of dopamine in ovarian cancer
363(2)
12.5 Endometrial And Cervical Cancer
365(1)
12.6 Prostate And Testicular Cancer
366(2)
12.6.1 Characteristics of prostate cancer
366(1)
12.6.2 Role of dopamine in prostate cancer
366(1)
12.6.3 Testicular cancer
367(1)
12.7 Synopsis
368(1)
References
368(5)
Chapter 13 Involvement of Dopamine with Various Cancers
373(30)
13.1 Introduction
373(1)
13.2 Hematological Malignancies
373(5)
13.2.1 Prevalence and classification of hematological malignancies
373(1)
13.2.2 Attributes and classification of leukemias
374(1)
13.2.3 Involvement of dopamine in leukemias
375(1)
13.2.4 Association of dopamine with lymphomas
376(2)
13.3 Gastrointestinal-Related Cancers
378(6)
13.3.1 Dopamine and overall incidence of GI malignancies
378(1)
13.3.2 Gastric cancer
379(1)
13.3.3 Colorectal cancer
380(2)
13.3.4 Liver cancer
382(1)
13.3.5 Pancreatic cancer
383(1)
13.4 Lung, Kidney, And Bladder Cancers
384(2)
13.4.1 Lung cancer and dopamine
384(2)
13.4.2 Kidney and bladder cancer
386(1)
13.5 Cancers Of The Skin
386(3)
13.5.1 Prevalence and attributes of skin cancer
386(1)
13.5.2 Dopamine and melanoma
387(2)
13.6 Head And Neck Cancer
389(2)
13.6.1 Prevalence and attributes of head and neck cancer
389(1)
13.6.2 Dopamine and DARPP-32 in head and neck and esophageal cancers
389(1)
13.6.3 Role of the cGMP/PDE/PKG pathway in head and neck cancer
390(1)
13.7 Neurological And Neuroendocrine Tumors
391(6)
13.7.1 Dopamine in brain tumors: Glioblastoma and meningioma
392(1)
13.7.2 Dopamine and neuroblastoma
393(1)
13.7.3 Prevalence and attributes of neuroendocrine tumors
394(1)
13.7.4 Dopamine in neuroendocrine tumors
395(2)
13.8 Synopsis
397(1)
References
397(6)
Glossary 403(10)
Index 413
Dr Nira Ben-Jonathan is Professor of Cancer Biology and Internal Medicine at the University of Cincinnati Medical School. She has published over 175 scholarly papers and reviews, edited a book - Catecholamines as Hormone Regulators - and contributed 14 chapters to medical textbooks and encyclopedias. She trained as a neuro-endocrinologist and endocrine physiologist and has focused her studies on prolactin, dopamine, endocrine disruptors, and other hormones as they affect brain, pituitary, and peripheral tissues, using cells, animal models and human tissues. More recently her focus has shifted to the role of hormones and signaling pathways in breast cancer and head and neck cancer. She has also been studying adipose tissue and human obesity. Dr Ben-Jonathan has served on many journal editorial boards and committees of scientific societies, reviewed manuscripts for dozens of journals. In 1992, she was elected chairman of the Gordon Research Conference on Prolactin. She has also been elected as a Fellow of the AAAS, and the Fellow of the Royal Society of Medicine. The University of Cincinnati awarded her the Rieveschl Award for Outstanding Scientific Research. She was selected to the Edward Merker Lectureship in Translational Endocrinology by the Mount Sinai School of Medicine, New York.
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