Today, cytology of body cavity fluids is an integral part of Cancer staging. A positive diagnosis indicates a high-stage (III or IV) Cancer in a majority of instances. General Pathologists and Cytotechnologists rely on routine cytomorphologic criteria to help Oncologists in their staging of Cancer patients. The diagnostic clarity, however, is challenged by many false negatives and occasional false positive results. The former is usually followed by an unnecessary surgical procedure in the case of an under-staged Cancer and the latter may prevent treatment of a potentially curable disease due to a falsely up-staged Cancer.
Effusion Cytology is a practical manual in diagnosis and interpretation of body cavity fluid (BCF) specimens. This highly illustrated volume will provide handy information for the Residents, Fellows and General Pathologists with limited basic knowledge in the area of cytopathology. The book provides a step-by-step guide to evaluation of BCF specimens with the specific goal of identification of malignancies. Use of ancillary techniques such as immunocytochemistry is discussed where appropriate. Special attention is given to the formulation of final cytologic reports of the diagnosis of difficult cases.
Features of Effusion Cytology include:
Focus on Cancer diagnosis: The book seeks to answer the simple question - Does this fluid represent malignancy? Practicality: Offers practical approaches to resolving the numerous daily technical and diagnostic problems encountered in a cytology laboratory dealing with body cavity fluid specimens Use of limited panel of tumour markers by immunocytochemistry (ICC): Describes a simple innovative technique for applying ICC to cytologic smears A practical guide to formulate final cytologic reports: The reader will be guided as to how to convey any diagnostic difficulty or issue to the attending Physician
| Preface |
|
ix | |
|
1 Body-Cavity Fluid Cytology |
|
|
1 | (14) |
|
|
|
1 | (2) |
|
Source and Cellular Content |
|
|
3 | (11) |
|
|
|
14 | (1) |
|
2 General Diagnostic Criteria: Benign Versus Malignant |
|
|
15 | (22) |
|
|
|
16 | (12) |
|
|
|
28 | (6) |
|
|
|
34 | (3) |
|
3 Types of Malignancy Based on Conventional Cytology and Immunocytochemistry |
|
|
37 | (44) |
|
|
|
38 | (8) |
|
|
|
46 | (3) |
|
|
|
49 | (7) |
|
|
|
56 | (8) |
|
|
|
64 | (2) |
|
|
|
66 | (2) |
|
|
|
68 | (6) |
|
Undifferentiated Large-Cell Malignant Neoplasms |
|
|
74 | (4) |
|
|
|
78 | (3) |
|
4 Major Differential Diagnoses |
|
|
81 | (26) |
|
|
|
82 | (10) |
|
|
|
92 | (6) |
|
|
|
98 | (5) |
|
|
|
103 | (4) |
|
5 Detection of the Primary Site of Carcinomas |
|
|
107 | (22) |
|
Cytologic Type, Source of Sample, and Patient's Gender |
|
|
108 | (7) |
|
Major Primary Sites of Carcinomas |
|
|
115 | (12) |
|
|
|
127 | (2) |
|
6 Cerebrospinal Fluid Cytology |
|
|
129 | (14) |
|
|
|
129 | (1) |
|
Specimen Handling and Preparation |
|
|
130 | (1) |
|
|
|
131 | (11) |
|
|
|
142 | (1) |
|
|
|
143 | (10) |
|
Routine Cytopreparatory Techniques |
|
|
144 | (3) |
|
Immunocytochemistry Technique |
|
|
147 | (5) |
|
|
|
152 | (1) |
|
8 Flow Cytometry, Immunoassays, and Molecular Techniques |
|
|
153 | (14) |
|
|
|
153 | (9) |
|
Immunoassay and Molecular Techniques |
|
|
162 | (2) |
|
|
|
164 | (3) |
| Index |
|
167 | |
Professor of Pathology, Director of Cytology Laboratories, Jackson Memorial Health System, Sylvester Comprehensive Cancer Center, Director of the Cytopathology Fellowship Program, Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida
||Professor of Pathology, Department of Pathology, Miller School of Medicine, University of Miami, Director of Laboratory Services, Sylvester Comprehensive Cancer Center, University of Miami Hospitals, Miami, Florida
|Professor of Pathology, Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florid
Lisainfo e-raamatute kohta