Electrical Disease of the Heart, 2nd Edition, volume 1, provides a valuable insight to the latest developments in the field of cardiac electrophysiology and clinical electrocardiology. Each chapter includes up-to-date results of studies aimed at providing an understanding of the electrical function of the heart in health and disease, established and evidence-based knowledge of clinical outcomes, areas of controversy, and future trends. This book is highly relevant to a broad audience, ranging from medical and graduate students, to clinicians and scientists.
In its 2nd Edition, this book offers valuable insight into current developments in cardiac electrophysiology and clinical electrocardiology. Covers established and evidence-based knowledge of clinical outcomes, areas of controversy and future research trends.
Basic Cardiac Electrophysiology- Promises Kept and Promises to Keep.-
Basic Physiology of Ion Channel Function.- Developmental Aspects of the
Electrophysiology of the Heart: Function Follows Form.- Anatomic and
Histopathologic Characteristics of the Conductive Tissues of the Heart.-
Neural Regulation of the Heart in Health and Disease.- Mechanisms of Cardiac
Arrhythmia.- Mechanisms of Action of Antiarrhythmic Drugs in Ventricular
Arrhythmias.- Mechanisms of Action of Antiarrhythmic Drugs in Atrial
Fibrillation.- Mechano-Electrical Interactions and their Role in Electrical
Function of the Heart.- Pathological Roles of the Cardiac Sodium Channel Late
Current (late INa).- Sodium Ion Channelopathies.- L-Type Calcium Channel
Disease.- Nerve Sprouting, Defibrillation and Calcium Waves.- K+
Channelopathies (IKs, IKr, and Ito).- Cardiac ATP-Sensitive Potassium
Channels and Associated Channelopathies.- Cardiac KATP Channels in Health and
Diseases.- Ca2+ Release Channels (Ryanodine Receptors) and Arrhythmogenesis.-
Caveolae and Arrhythmogenesis.- Senescence and Arrhythmogenesis.- Comparisons
of Substrates Responsible for Atrial versus Ventricular Fibrillation.- Single
Nucleotide Polymorphisms in Health and Cardiac Disease.- Electrophysiological
Remodeling in Heart Failure.- Ventricular Electrical Remodeling in
Compensated Cardiac Hypertrophy.- Physiological and Other Biological
Pacemakers.- Cardiac Memory: From Electrical Curiosity to Clinical Diagnostic
and Research Tool.- Heritable Arrhythmogenic Channelopathies, Primary
Electrical Diseases, and Sudden Cardiac Death.- Celebrating the Challenge of
Cardiac Arrhythmias.- Congenital Long QT Syndrome.- Brugada Syndrome
Clinical and Genetic Aspects.- Brugada Syndrome: Cellular Mechanisms and
Approaches to Therapy.- Early Repolarization Syndrome: Epidemiology,
Genetics, and Risk Stratification.- Catecholaminergic Polymorphic
VentricularTachycardia.- Andersen-Tawil and Timothy Syndromes.- Short QT
Syndrome.- Progressive Cardiac Conduction Disease.- Genetics of Atrial
Fibrillation.- Idiopathic Ventricular Fibrillation.
Ihor Gussak, MD, PhD, Charles Antzelevitch, PhD, FACC, FAHA, FHRS, Arthur A.M. Wilde, MD, PhD, Brian D. Powell, MD, Michael J. Ackerman, MD, PhD and Win-Kuang Shen, MD