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xi | |
Preface |
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xv | |
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Part One Introduction to Electrospinning for Biomedical and Tissue Engineering Applications |
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1 | (114) |
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1 Electrospinning: A versatile processing technology for producing nanofibrous materials for biomedical and tissue-engineering applications |
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3 | (40) |
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3 | (1) |
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1.2 Biomedical application of electrospun nanofibers |
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4 | (30) |
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1.3 Commercialization prospectus |
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34 | (2) |
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36 | (7) |
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38 | (1) |
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38 | (5) |
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2 General requirements of electrospun materials for tissue engineering: Setups and strategy for successful electrospinning in laboratory and industry |
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43 | (14) |
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2.1 Electrospinnable materials for TE applications |
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45 | (2) |
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2.2 Electrospinning technologies and set-ups |
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47 | (6) |
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2.3 Basics of industrial upscaling of electrospinning |
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53 | (1) |
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53 | (4) |
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54 | (3) |
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3 Biomedical applications of electrospinning, innovations, and products |
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57 | (16) |
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3.1 Innovative technologies with potential for scaling |
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57 | (1) |
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3.2 Brief history of electrospinning |
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57 | (1) |
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3.3 Nozzle-based multijet electrospinning |
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58 | (2) |
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60 | (1) |
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3.5 Fiber generators in needleless electrospinning |
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60 | (4) |
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3.6 Bubble-electrospinning |
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64 | (2) |
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3.7 Electrospinning-based scaled up developments and commercial products |
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66 | (3) |
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3.8 Future prospects and outlook |
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69 | (4) |
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69 | (4) |
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4 Structuring of electrospun nanofiber mats by 3D printing methods |
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73 | (14) |
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73 | (1) |
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4.2 Obtaining oriented nanofibers |
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74 | (9) |
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4.3 Conclusion and future perspectives |
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83 | (4) |
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83 | (4) |
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5 Melt electrospinning in tissue engineering |
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87 | (14) |
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5.1 Introduction to the process of melt electrospinning |
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87 | (2) |
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5.2 Comparison with solution electrospinning |
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89 | (2) |
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5.3 Applications in tissue engineering |
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91 | (4) |
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5.4 Future directions for the field of melt electrospinning and potential commercial applications |
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95 | (6) |
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96 | (4) |
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100 | (1) |
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6 In vivo safety evaluations of electrospun nanofibers for biomedical applications |
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101 | (14) |
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101 | (1) |
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6.2 Safety evaluations of nanofibers |
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102 | (10) |
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6.3 Conclusions and outlook |
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112 | (3) |
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112 | (1) |
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113 | (2) |
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Part Two Specific Biomedical and Tissue Engineering Application Areas of Electrospinning |
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115 | (304) |
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7 Electrospun systems for drug delivery |
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117 | (30) |
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117 | (2) |
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7.2 Postelectrospinning modification |
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119 | (6) |
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7.3 Polymer/drug blend electrospinning |
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125 | (6) |
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7.4 Coaxial electrospinning |
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131 | (1) |
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7.5 Electrospinning drug-loaded micro/nanoparticles |
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132 | (2) |
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7.6 Commercialization prospects |
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134 | (4) |
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7.7 Outlook, problems to be overcome |
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138 | (2) |
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140 | (7) |
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141 | (6) |
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8 Electrospun nanofibrous materials for wound healing applications |
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147 | (32) |
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147 | (3) |
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8.2 Electrospun nanofibrous scaffolds in wound healing |
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150 | (23) |
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8.3 Current challenges and future directions |
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173 | (6) |
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174 | (1) |
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174 | (5) |
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9 Electrospun biomaterials for dermal regeneration |
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179 | (54) |
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179 | (13) |
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9.2 Electrospun scaffolds for dermal wound healing |
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192 | (26) |
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9.3 Conclusions and outlook |
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218 | (15) |
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220 | (13) |
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10 Electrospun materials for bone and tendon/ligament tissue engineering |
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233 | (28) |
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233 | (1) |
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10.2 Bone structure and bone tissue engineering |
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234 | (1) |
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10.3 Electrospun scaffolds for bone regeneration |
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235 | (13) |
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10.4 Tendon/ligament structure and tendon/ligament tissue engineering |
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248 | (1) |
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10.5 Electrospun scaffolds for tendon/ligament regeneration |
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248 | (4) |
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252 | (9) |
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254 | (1) |
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254 | (7) |
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11 Electrospun scaffolds for vascular tissue engineering |
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261 | (28) |
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261 | (1) |
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11.2 Structure of blood vessels |
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262 | (4) |
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11.3 Biomaterials used for nanofiber fabrication in vascularization |
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266 | (2) |
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11.4 Fabrication parameters for electrospun scaffolds |
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268 | (2) |
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11.5 Biological and mechanical properties of electrospun scaffolds for vascular tissue engineering |
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270 | (6) |
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11.6 In vivo applications of tubular electrospun scaffolds in vascular tissue engineering |
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276 | (3) |
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11.7 Conclusions and future perspectives |
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279 | (10) |
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280 | (1) |
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280 | (9) |
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12 Electrospun scaffolds for cardiac tissue engineering |
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289 | (10) |
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289 | (1) |
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290 | (2) |
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12.3 Bio-functionalized cardiac patch |
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292 | (2) |
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12.4 Heart valve scaffolds |
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294 | (1) |
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295 | (4) |
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295 | (4) |
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13 Electrospun scaffolds for neural tissue engineering |
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299 | (22) |
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299 | (2) |
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13.2 3D in vitro platforms to study neuronal physiology |
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301 | (4) |
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13.3 Surface functionalization and drug release |
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305 | (4) |
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13.4 Electrospun fibers for brain repair |
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309 | (2) |
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13.5 Electroactive fibers for nerve stimulation |
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311 | (2) |
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13.6 Commercialization aspects |
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313 | (1) |
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314 | (7) |
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315 | (6) |
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14 Coaxial electrospun nanofibers for nanomedicine |
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321 | (16) |
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321 | (1) |
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14.2 Coaxial electrospinning |
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322 | (10) |
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332 | (5) |
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333 | (4) |
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15 Electrospun-based systems in cancer therapy |
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337 | (20) |
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337 | (1) |
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338 | (6) |
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15.3 Magnetic hyperthermia therapy |
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344 | (2) |
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15.4 Photothermal-chemotherapy |
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346 | (1) |
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347 | (2) |
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15.6 Circulating tumor cell capturing |
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349 | (2) |
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15.7 Conclusions and future perspectives |
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351 | (6) |
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351 | (6) |
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16 Electrospun nanofibers for regenerative dentistry |
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357 | (28) |
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357 | (1) |
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16.2 Periodontal disease and treatment modalities |
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358 | (1) |
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16.3 Periodontal-specific tissue engineering |
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358 | (1) |
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16.4 Electrospun bioactive membranes for periodontal regeneration |
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359 | (11) |
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16.5 Caries and pulpal disease |
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370 | (4) |
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16.6 Conclusions and future perspectives |
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374 | (11) |
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376 | (1) |
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376 | (9) |
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17 Electrospinning: A versatile technology to design biosensors and sensors for diagnostics |
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385 | (34) |
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385 | (3) |
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17.2 ES-nanosensors for blood analysis |
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388 | (10) |
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17.3 ES-nanosensors for breath analysis |
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398 | (8) |
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17.4 Electronic nose devices for breath analysis |
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406 | (4) |
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17.5 Summary and outlooks |
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410 | (9) |
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413 | (6) |
Index |
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419 | |