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E-raamat: Electrospun Materials for Tissue Engineering and Biomedical Applications: Research, Design and Commercialization

Edited by (CEO, KEMYK, CEST GmbH (Centre of electrochemical surface technology), Austria), Edited by (UNAM-Institute of Materials Science and Nanotechnology, Bilkent University, Ankara, Turkey)
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 31-May-2017
  • Kirjastus: Woodhead Publishing Ltd
  • Keel: eng
  • ISBN-13: 9780081022221
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  • Formaat: EPUB+DRM
  • Ilmumisaeg: 31-May-2017
  • Kirjastus: Woodhead Publishing Ltd
  • Keel: eng
  • ISBN-13: 9780081022221

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Electrospinning, an electro-hydrodynamic process, is a versatile and promising platform technology for the production of nanofibrous materials for tissue engineering and biomedical applications. Electrospun Materials for Tissue Engineering and Biomedical Applications, examines the rapid development of electrospun materials for use in tissue engineering and biomedical applications. With a strong focus on fundamental materials science and engineering, this book also looks at successful technology transfers to the biomedical industry, highlighting biomedical products already on the market as well as the requirements to successfully commercialize electrospun materials for potential use in tissue engineering and biomedical areas. This book is a valuable resource for materials and biomedical scientists and engineers wishing to broaden their knowledge on the tissue engineering and biomedical applications of electrospun fibrous materials.Provides all-encompassing coverage of fundamental science, technology and industrial case studiesPresents guidance on industrial scalability of electrospun biomaterialsWritten by a multidisciplinary team or researchers from academia and industry, offering a balanced viewpoint on the subject

Muu info

Comprehensive look at the fundamental materials, technologies and biomedical applications of electrospun materials
List of contributors
xi
Preface xv
Part One Introduction to Electrospinning for Biomedical and Tissue Engineering Applications
1(114)
1 Electrospinning: A versatile processing technology for producing nanofibrous materials for biomedical and tissue-engineering applications
3(40)
A. Senthamizhan
B. Balusamy
T. Uyar
1.1 Introduction
3(1)
1.2 Biomedical application of electrospun nanofibers
4(30)
1.3 Commercialization prospectus
34(2)
1.4 Conclusion
36(7)
Acknowledgments
38(1)
References
38(5)
2 General requirements of electrospun materials for tissue engineering: Setups and strategy for successful electrospinning in laboratory and industry
43(14)
E. Kijenska
W. Swieszkowski
2.1 Electrospinnable materials for TE applications
45(2)
2.2 Electrospinning technologies and set-ups
47(6)
2.3 Basics of industrial upscaling of electrospinning
53(1)
2.4 Conclusions
53(4)
References
54(3)
3 Biomedical applications of electrospinning, innovations, and products
57(16)
J.M. Lagaron
A. Solouk
S. Castro
Y. Echegoyen
3.1 Innovative technologies with potential for scaling
57(1)
3.2 Brief history of electrospinning
57(1)
3.3 Nozzle-based multijet electrospinning
58(2)
3.4 Electroblowing
60(1)
3.5 Fiber generators in needleless electrospinning
60(4)
3.6 Bubble-electrospinning
64(2)
3.7 Electrospinning-based scaled up developments and commercial products
66(3)
3.8 Future prospects and outlook
69(4)
References
69(4)
4 Structuring of electrospun nanofiber mats by 3D printing methods
73(14)
N. Shah Hosseini
N. Khenoussi
4.1 Introduction
73(1)
4.2 Obtaining oriented nanofibers
74(9)
4.3 Conclusion and future perspectives
83(4)
References
83(4)
5 Melt electrospinning in tissue engineering
87(14)
S.M. Willerth
5.1 Introduction to the process of melt electrospinning
87(2)
5.2 Comparison with solution electrospinning
89(2)
5.3 Applications in tissue engineering
91(4)
5.4 Future directions for the field of melt electrospinning and potential commercial applications
95(6)
References
96(4)
Resource List
100(1)
6 In vivo safety evaluations of electrospun nanofibers for biomedical applications
101(14)
B. Balusamy
A. Senthamizhan
T. Uyar
6.1 Introduction
101(1)
6.2 Safety evaluations of nanofibers
102(10)
6.3 Conclusions and outlook
112(3)
Acknowledgments
112(1)
References
113(2)
Part Two Specific Biomedical and Tissue Engineering Application Areas of Electrospinning
115(304)
7 Electrospun systems for drug delivery
117(30)
B.A. Minden-Birkenmaier
G.S. Selders
A.E. Fetz
C.J. Gehrmann
G.L. Bowlin
7.1 Introduction
117(2)
7.2 Postelectrospinning modification
119(6)
7.3 Polymer/drug blend electrospinning
125(6)
7.4 Coaxial electrospinning
131(1)
7.5 Electrospinning drug-loaded micro/nanoparticles
132(2)
7.6 Commercialization prospects
134(4)
7.7 Outlook, problems to be overcome
138(2)
7.8 Conclusion
140(7)
References
141(6)
8 Electrospun nanofibrous materials for wound healing applications
147(32)
B. Balusamy
A. Senthamizhan
T. Uyar
8.1 Introduction
147(3)
8.2 Electrospun nanofibrous scaffolds in wound healing
150(23)
8.3 Current challenges and future directions
173(6)
Acknowledgments
174(1)
References
174(5)
9 Electrospun biomaterials for dermal regeneration
179(54)
E.A. Growney Kalaf
K.R. Hixon
P.U. Kadakia
A.J. Dunn
S.A. Sell
9.1 Overview
179(13)
9.2 Electrospun scaffolds for dermal wound healing
192(26)
9.3 Conclusions and outlook
218(15)
References
220(13)
10 Electrospun materials for bone and tendon/ligament tissue engineering
233(28)
N. Bolgen
10.1 Introduction
233(1)
10.2 Bone structure and bone tissue engineering
234(1)
10.3 Electrospun scaffolds for bone regeneration
235(13)
10.4 Tendon/ligament structure and tendon/ligament tissue engineering
248(1)
10.5 Electrospun scaffolds for tendon/ligament regeneration
248(4)
10.6 Conclusions
252(9)
Acknowledgment
254(1)
References
254(7)
11 Electrospun scaffolds for vascular tissue engineering
261(28)
O. Karaman
M. Sen
E.A. Demirci
11.1 Introduction
261(1)
11.2 Structure of blood vessels
262(4)
11.3 Biomaterials used for nanofiber fabrication in vascularization
266(2)
11.4 Fabrication parameters for electrospun scaffolds
268(2)
11.5 Biological and mechanical properties of electrospun scaffolds for vascular tissue engineering
270(6)
11.6 In vivo applications of tubular electrospun scaffolds in vascular tissue engineering
276(3)
11.7 Conclusions and future perspectives
279(10)
Acknowledgments
280(1)
References
280(9)
12 Electrospun scaffolds for cardiac tissue engineering
289(10)
A.H. Hekmati
M. Norouzi
12.1 Introduction
289(1)
12.2 Cardiac patch
290(2)
12.3 Bio-functionalized cardiac patch
292(2)
12.4 Heart valve scaffolds
294(1)
12.5 Conclusion
295(4)
References
295(4)
13 Electrospun scaffolds for neural tissue engineering
299(22)
P. Chen
A.E. Rodda
H.C. Partington
J.S. Forsythe
13.1 Introduction
299(2)
13.2 3D in vitro platforms to study neuronal physiology
301(4)
13.3 Surface functionalization and drug release
305(4)
13.4 Electrospun fibers for brain repair
309(2)
13.5 Electroactive fibers for nerve stimulation
311(2)
13.6 Commercialization aspects
313(1)
13.7 Future challenges
314(7)
References
315(6)
14 Coaxial electrospun nanofibers for nanomedicine
321(16)
K. Vodsed' Alkova
L. Vyslouzilova
L. Berezkinova
14.1 Introduction
321(1)
14.2 Coaxial electrospinning
322(10)
14.3 Conclusion
332(5)
References
333(4)
15 Electrospun-based systems in cancer therapy
337(20)
M. Norouzi
B. Nazari
D.W. Miller
15.1 Introduction
337(1)
15.2 Chemotherapy
338(6)
15.3 Magnetic hyperthermia therapy
344(2)
15.4 Photothermal-chemotherapy
346(1)
15.5 Gene therapy
347(2)
15.6 Circulating tumor cell capturing
349(2)
15.7 Conclusions and future perspectives
351(6)
References
351(6)
16 Electrospun nanofibers for regenerative dentistry
357(28)
D. Pankajakshan
M.T.P. Albuquerque
M.C. Bottino
16.1 Introduction
357(1)
16.2 Periodontal disease and treatment modalities
358(1)
16.3 Periodontal-specific tissue engineering
358(1)
16.4 Electrospun bioactive membranes for periodontal regeneration
359(11)
16.5 Caries and pulpal disease
370(4)
16.6 Conclusions and future perspectives
374(11)
Acknowledgments
376(1)
References
376(9)
17 Electrospinning: A versatile technology to design biosensors and sensors for diagnostics
385(34)
A. Macagnano
F. De Cesare
17.1 Introduction
385(3)
17.2 ES-nanosensors for blood analysis
388(10)
17.3 ES-nanosensors for breath analysis
398(8)
17.4 Electronic nose devices for breath analysis
406(4)
17.5 Summary and outlooks
410(9)
References
413(6)
Index 419
Prof. Tamer Uyar obtained his Ph.D. degree from North Carolina State University, Fiber & Polymer Science program in 2005. Currently, he is an Associate Professor at Institute of Materials Science & Nanotechnology (UNAM) at Bilkent University, Ankara, Turkey. Prof. Uyar is very active in the field of Electrospinning of nanofiber by publishing over 100 peer-reviewed journal papers in this field with the interest of potential applications in Environmental/Filtration, Healthcare, Catalysis, Sensors, Food and Active Food Packaging, Energy, NanoTextiles and NanoAgriculture. Prof. Uyar is Founding Editor of the journal Electrospinning (by De Gruyter Open) and currently he is also serving in Editorial Board Member for Scientific Reports (by Springer Nature), Editorial Board of Journal of Nanomaterials (by Hindawi) and Editorial Advisory Board of e-Polymers (by De Gruyter). Prof. Uyar is the Vice-Chair of COST Action MP1206 for Electrospinning of nanofibers. As a young scientist, Prof. Uyar is the recipient of several prestigious International awards/fellowships including 2016 International Cyclodextrin József Szejtli Award and 2012 Fiber Society Distinguished Achievement Award and 2010 Marie Curie International Reintegration Grant (IRG) Fellowship. He also received numerous National awards given only under 40 years of age including 2014 TÜBTAK Incentive Award, 2012 Turkish Academy of Sciences Outstanding Young Scientists Award (GEBP), 2010 METU Parlar Foundation Research Incentive Award and 2009 Outstanding Young Scientist Award by FABED. Dr. Erich Kny, an expert in materials science and technology with a focus on metals and composite materials and surface technologies, is currently the CEO of KEMYK, an independent company specializing in the commercialization of new technologies. He has published over 100 publications, 3 book contributions and several patents and has edited the conference symposium proceedings at the EMRS 2009 on Polymer Nanocomposites. Dr. Kny obtained his PhD from the University of Vienna and has many years of academic & research experience, having been head of the Engineering Department at the Austrian Research Centre for 17 years as well as a university teaching assistant in the Department of Physical Chemistry of the University of Vienna, Austria. This is complemented by his long industrial experience as deputy head of R&TD at the company Plansee in Austria. He has founded in 2007 the scientific COST network on Polymer Nanocomposites (MP701) and in 2012 the scientific COST network on electrospun nanofibres (MP1206). In both of these scientific networks he holds the position of an action chair.