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E-raamat: Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance

  • Formaat: 152 pages
  • Ilmumisaeg: 13-Jul-2021
  • Kirjastus: National Academies Press
  • Keel: eng
  • ISBN-13: 9780309304085
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  • Formaat: 152 pages
  • Ilmumisaeg: 13-Jul-2021
  • Kirjastus: National Academies Press
  • Keel: eng
  • ISBN-13: 9780309304085
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Each year, tens of millions of individuals in the U.S. suffer from neurological and psychiatric disorders including neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease, and psychiatric disorders such as autism spectrum disorder, depression and schizophrenia. Treatments for these diseases are often completely lacking or only partially effective, due in large part to the difficulty of conducting brain research and the complexity of the brain itself.



Researchers in recent years have developed new models to better represent and study the human brain. The three models considered in this report, all of which generate and use pluripotent stem cells from healthy individuals and patients, are human neural organoids, human neural transplants, and human-animal neural chimeras. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance reviews the status of research, considers its benefits and risks, discusses associated ethical issues, and considers governance mechanisms for this type of research.

Table of Contents



Front Matter Summary 1 Introduction 2 The Science of Human Neural Organoids, Transplants, and Chimeras 3 Ethical Concerns 4 Oversight and Governance 5 Public Engagement 6 Findings of the Committee References Appendix A: Biographies of Committee and Staff Members Appendix B: Committee Meeting Agendas
Summary 1(10)
1 Introduction
11(8)
Overview of Brain Research
12(2)
Study Charge
14(2)
Organization of the Report
16(3)
2 The Science of Hum An Neural Organoids, Transplants, and Chimeras
19(26)
Human Neural Organoids
26(5)
Human Neural Transplants
31(1)
Human Neural Chimeras
32(2)
Capacities of Human Neural Organoids, Transplants, and Chimeras
34(7)
Measuring Characteristics of Human Neural Organoids, Transplants, and Chimeras
41(4)
3 Ethical Concerns
45(20)
Issues Common to All Three Models
46(6)
Issues Specific to Human Neural Organoids, Transplants, and Chimeras
52(11)
Ethical Issues Specific to Human Neural Organoids
63(1)
Summary
64(1)
4 Oversight and Governance
65(26)
Use of Human Stem Cells
66(3)
Informed Consent
69(3)
Use and Care of Animals in Research
72(2)
Use of Nonhuman Primates in Research
74(1)
U.S. Policy and Guidance Specific to Neural Transplants and Chimeras
75(7)
Graded Oversight: A Three-Tiered Approach
82(1)
International Policy Specific to Neural Organoids, Transplants, and Chimeras
82(4)
Future Oversight
86(5)
5 Public Engagement
91(6)
Public Engagement Internationally and in the United States
91(2)
Potential Contribution of Social Science Research
93(1)
Nomenclature
94(3)
6 Findings of the Committee
97(8)
Value of This Research
97(8)
References 105(14)
Appendixes
A Biographies of Committee and Staff Members 119(10)
B Committee Meeting Agendas 129