Although endometriosis and adenomyosis are often assessed under the same umbrella, the epidemiology, clinical manifestations and management strategies of endometriosis and adenomyosis occur differently during the life cycle of a woman. Endometriosis can be diagnosed at many points across the lifespan, including adolescence and the climacterium, as well as pregnancy. Being associated with potential adverse health effects, different clinical presentations requiring different therapeutic approaches render it imperative to tailor management strategies for each period of the lifespan: in utero and early life, puberty and adolescence, reproductive years, pregnancy, late reproductive age, and the menopause.
This book provides comprehensive insight into the general aspects, diagnosis and treatment modalities of endometriosis and adenomyosis in all stages of a woman’s life - a unique element of its approach. Thematic sections discuss the basics of diagnosis and management of both endometriosis and adenomyosis from birth through menopause, including aspects of fertility preservation, sexual dysfunction, psychological considerations and prevention. The current pharmaceutical approaches and efficacy are presented, including progestins, oral contraceptives, aromatase inhibitors and GnRH agonists and antagonists. The final section provides current practice guidelines for the management of both conditions as well as an investigation into future research and clinical strategies.
Taking a truly global perspective, Endometriosis and Adenomyosis will be a valuable resource for reproductive endocrinologists, infertility specialists and obstetricians and gynecologists worldwide.
Part I. Endometriosis: An Overview.- Endometriosis in Human History.-
Global Epidemiologic Data on Endometriosis.- Presumptive Causes of
Endometriosis across the Lifespan.- Pathogenesis of Endometriosis: Retrograde
Menstruation and Metaplasia, Inflammation, Autoimmunity, Genetics.-
Classification and Clinical Staging of Endometriosis.- Diagnostic Modalities:
Imaging and Markers.- Multidisciplinary Aspects of Chronic Pain without
Endometriosis.- Part II. Endometriosis across the Lifespan.- Endometriosis In
Utero and Early Life.- Endometriosis in Adolescence.- Endometriosis in the
Reproductive Years: Fertility and Pain.- Endometriosis in Peri- and
Postmenopausal Years.- Pregnancy and Obstetric Outcomes.- Part III.
Miscellaneous Clinical Presentations and Management of Endometriosis.-
Recurrent Endometriosis.- A Rare Entity of Extra Pelvic Endometriosis: Scar,
Diaphragmatic, Pulmonary Involvement.- Fertility Preservation for
Endometriosis.- Malignancy Risks Associatedwith Endometriosis.- Psychological
Considerations in Endometriosis.- Sexual Dysfunction and Endometriosis.-
Nutritional Interventions, Complementary and Alternative Medicine for
Endometriosis.- Prevention of Endometriosis: Is It Possible?- How to
Establish a Center of Excellence for Endometriosis.- Cost Estimates
Associated with Diagnosis and Treatment of Endometriosis.- Part IV.
Adenomyosis: An Overview.- What Is Adenomyosis?- Adenomyosis in Medicine.-
Insights into Adenomyosis Development.- Classification and Staging of
Adenomyosis.- Non-invasive Diagnosis of Adenomyosis: Ultrasonography and
MRI.- Part V: Adenomyosis across the Lifespan.- Adenomyosis in Adolescence.-
Adenomyosis in the Reproductive Years: Abnormal Uterine Bleeding, Pain,
Fertility.- Pregnancy and Obstetric Outcomes in Adenomyosis.- Does
Adenomyosis Increase Cancer Risk?- Part VI. Clinical Pharmaceutical Features
of Drugs Used in Endometriosis and Adenomyosis Treatment.- Hormonal Therapy:
OralContraceptives, Progestins, Danazol, Aromatase Inhibitors.- GnRH Agonists
and Antagonists.- Part VII. Guidelines and Future Prospects for Endometriosis
and Adenomyosis.- Recent Guidelines on Endometriosis and Adenomyosis.- The
Future of Endometriosis and Adenomyosis Research.
Engin Oral, MD, Endometriosis and Adenomyosis Society, Professor, Department of Obstetrics and Gynecology, Bezmialem University , Istanbul, Turkey
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