Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice.
Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies.
- Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications
- Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs
- Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways
- Each chapter updated to include summaries, definitions, and vibrant imagery and figures to reinforce understanding
- Features step-by-step methods and disease research case studies to put book concepts into practice
Section I: Introduction
1. Epigenetics of Human Disease: An Overview
Section II: Methodology
2. Methods and Strategies to Determine Epigenetic Variation in Human Disease
3. DNA MethylationBased Measures of Biological Aging
4. Bioinformatics of Epigenomic Data Generated From Next-Generation
Sequencing
Section III: Human Cancer
5. DNA Methylation Alterations in Human Cancer
6. Alterations of Histone Modifications in Cancer
7. MicroRNA in Cancer
8. Epigenetic Approaches to Cancer Therapy
Section IV: Neurological Disease
9. Epigenetics in Neurobehavioral Disease
10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders
11. The Epigenetics of Alzheimer's and Other Neurodegenerative Disorders
12. Epigenetic Modulation of Human Neurobiological Disorders
Section V: Autoimmune Disease
13. Epigenetic Basis of Autoimmune Disorders in Humans
14. Approaches to Autoimmune Diseases Using Epigenetic Therapy
Section VI: Metabolic Disorders
15. Epigenomics and Human Obesity
16. Epigenetic Approaches to Control Obesity
17. Early-Life Nutrition, Epigenetics and Prevention of Obesity
18. Epigenetics of Diabetes in Humans
19. The Potential of Epigenetic Compounds in Treating Diabetes
Section VII: Other Disorders/Diseases
20. Epigenetic-Processes Driven Disorders and Therapeutics
21. Epigenetics of Allergic Diseases Allergies, Eczema, Asthma, and Rhinitis
22. Therapy of Airway Disease: Epigenetic Potential
23. The Role of Epigenetics in Cardiovascular Disease
24. Epigenetic Treatment Approaches to Cardiovascular Disease
25. Epigenetics and Human Infectious Diseases
26. Therapy of Infectious Diseases Using Epigenetic Approaches
27. Translational Aspects of the Endometriosis Epigenome
28. Aberrant DNA Methylation Patterns in Gynecologic Cancers: Implications
for Prevention and Therapy
29. Epigenetics in Human Reproduction and Gynecologic Diseases
Section VIII: Development, Aging and Transgenerational Effects
30. Epigenetics of Transgenerational Inheritance of Disease
31. Epigenomic Mechanisms of Human Developmental Disorders
32. Therapeutic Approaches to Imprinting Diseases
33. Stem Cell Epigenetics and Human Disease
34. Noncoding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell
Renewal and Differentiation: Implications for Stem Cell Therapy
35. Aging and Disease: The Epigenetic Bridge
36. Epigenetic Programming of Human Disease and Aging
Section IX: Future Research
37. Epigenetic Prospects in Epidemiology and Public Health
Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewins GENES classic textbook and Lead Editor for Elseviers Translational Epigenetics Series. Dr. Tollefsbol has been named a Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.
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