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E-raamat: Estrogen Action, Selective Estrogen Receptor Modulators And Women's Health: Progress And Promise

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Edited by (Georgetown Univ, Usa)
  • Formaat: 544 pages
  • Ilmumisaeg: 27-May-2013
  • Kirjastus: Imperial College Press
  • Keel: eng
  • ISBN-13: 9781848169593
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Estrogen Action, Selective Estrogen Receptor Modulators And Women's Health: Progress And PromiseSuurem pilt
  • Formaat: 544 pages
  • Ilmumisaeg: 27-May-2013
  • Kirjastus: Imperial College Press
  • Keel: eng
  • ISBN-13: 9781848169593
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This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs — tamoxifen and raloxifene — are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.
About the Author and Editor xi
Contributors xiii
Acknowledgements xxi
Forewords xxiii
Nancy Brinker
Bert W. O'Malley
Introduction: The Foundation of a Career xxix
V. Craig Jordan
Chapter 1 A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention 1(30)
V. Craig Jordan
Chapter 2 Diethylstilbestrol: A Tragedy in Reproductive Endocrinology But a Pioneering Cancer Treatment 31(24)
Joan Lewis-Wambi
V. Craig Jordan
Chapter 3 Oral Contraceptives and Women's Health 55(26)
V Daniel Castracane
V. Craig Jordan
Chapter 4 Hormone Replacement Therapy and Women's Health 81(30)
Jennifer Eng-Wong
Ifeyinwa Obiorah
V. Craig Jordan
Chapter 5 Induction of Ovulation by Nonsteroidal Antiestrogens 111(22)
Ifeyinwa Obiorah
V. Craig Jordan
Chapter 6 Clues About Estrogen and Antiestrogen Action from X-Ray Crystallography 133(20)
Geoffrey L. Greene
V. Craig Jordan
Chapter 7 Coregulators and Their Role in Selective Estrogen Receptor Modulator Action 153(22)
Christopher D. Chien
Anton Wellstein
Anna Riegel
Chapter 8 Role of Estrogen in Familial Breast Cancer 175(26)
Eliot Rosen
Claudine Isaacs
Chapter 9 Advances with Aromatase Inhibitors 201(28)
Saranya Chumsri
Ting Bao
Gauri Sabnis
Angela Brodie
Chapter 10 Adjuvant Antihormone Therapy 229(26)
Anthony Howell
V. Craig Jordan
Chapter 11 Pharmacogenomics of Tamoxifen 255(40)
Hiltrud B. Brauch
V. Craig Jordan
Chapter 12 Antihormone Drug Resistance 295(30)
Robert Clarke
V. Craig Jordan
Chapter 13 Novel Selective Estrogen Receptor Modulators 325(36)
Surojeet Sengupta
V. Craig Jordan
Chapter 14 Endocrine Prevention of Breast Cancer 361(30)
Trevor J. Powles
Russell E. McDaniel
V. Craig Jordan
Chapter 15 Selective Androgen Receptor Modulators as Improved Androgen Therapy for Women 391(40)
Christopher C. Coss
James T. Dalton
Chapter 16 An Emerging Principle: Selective Nuclear Receptor Modulators 431(26)
Ping Fan
V. Craig Jordan
Appendices 457(46)
Appendix
1. Scientific Survival Suggestions
459(6)
V. Craig Jordan
Appendix
2. Decades of Discovery: The SERM Story-The St. Gallen Prize
465(20)
V. Craig Jordan
Appendix
3. An Account of Students Obtaining a Ph.D. Degree (or an M.D. for Physicians in the British System) While in the Tamoxifen Team Over the Last 30 Years
485(18)
V. Craig Jordan
Index 503
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