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E-raamat: Evolutionary Biology: Cell-Cell Communication, and Complex Disease

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  • Formaat: PDF+DRM
  • Ilmumisaeg: 15-Mar-2012
  • Kirjastus: Wiley-Blackwell
  • Keel: eng
  • ISBN-13: 9781118130421
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Evolutionary Biology: Cell-Cell Communication, and Complex DiseaseSuurem pilt
  • Formaat: PDF+DRM
  • Ilmumisaeg: 15-Mar-2012
  • Kirjastus: Wiley-Blackwell
  • Keel: eng
  • ISBN-13: 9781118130421
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An integrative view of the evolution of genetics and the natural world Even in this advanced age of genomics, the evolutionary process of unicellular and multicellular organisms is continually in debate. Evolutionary Biology, CellCell Communication, and Complex Disease challenges current wisdom by using physiology to present an integrative view of the nature, origins, and evolution of fundamental biological systems.

Providing a deeper understanding of the way genes relate to the traits of living organisms, this book offers useful information applying evolutionary biology, functional genomics, and cell communication studies to complex disease. Examining the 4.5 billion-year evolution process from environment adaptations to cell-cell communication to communication of genetic information for reproduction, Evolutionary Biology hones in on the "why and how" of evolution by uniquely focusing on the cell as the smallest unit of biologic structure and function.

Based on empirically derived data rather than association studies, Evolutionary Biology covers:





A model for forming testable hypotheses in complex disease studies



The integrating role played by the evolution of metabolism, especially lipid metabolism



The evolutionary continuum from development to homeostasis



Regeneration and aging mediated by signaling molecules





Ambitious and game-changing Evolutionary Biology suggests that biology began as a mechanism for reducing energy within the cell, defying the Second Law of Thermodynamics. An ideal text for those interested in forward thinking scientific study, the insights presented in Evolutionary Biology help practitioners effectively comprehend the evolutionary process.

Arvustused

"the book offers the biology-savvy reader with interesting insights into the contribution of cell-cell interactions to the development and evolution of phenotypes.  Given the technical nature of the subject, this book will have particular appeal among researchers and students of cellular and molecular biology and among evolutionary biologists interested in the pathways linking genes to phenotypes.  In keeping with the complexity of the topic, there is much to digest here, and readers knowledgeable in these fields will find interesting food for thought.  (Quarterly Reviews in Biology, 1  July 2013)

 

Preface xi
About the Authors xiii
1 The Cellular Origin of Vertebrates
1(16)
The Origins of Unicellular Life on Earth
1(3)
Prokaryotes versus Eukaryotes
4(1)
Coevolution of traits
5(2)
Cholesterol Facilitates Lipid Rafts for Cell-Cell Communication
7(2)
The Endomembrane System
9(1)
The Cellular Mechanism of Evolution
10(1)
Why Evolve?
11(1)
Cell-Cell Communication and Aging
12(5)
2 Reducing Lung Physiology to Its Molecular Phenotypes
17(8)
Hormonal Acceleration of Lung Development
17(2)
Neutral Lipid Trafficking and Lung Evolution
19(4)
Other Examples of Cellular Cooperativity
23(1)
Summary
24(1)
3 A Cell-Molecular Strategy for Solving The Evolutionary Puzzle
25(10)
Rationale for Cell-Molecular Evolution
25(3)
Mechanism of Mammalian Lung Development
28(4)
Avian Lung Structure-Function Relationship: The Exception that Proves the Rule
32(1)
Does Ontogeny Recapitulate Phylogeny? The Role of PTHrP in Lung Development
32(1)
Interrelationship between PTHrP, Development, Physiology, and Repair: Is Repair a Recapitulation of Ontogeny and Phylogeny?
33(2)
4 The Evolution of Cell-Cell Communication
35(18)
Cell-Cell Communication as the Mechanistic Basis for Evolutionary Biology
36(1)
The Darwinian Biologic Spacetime Continuum and Einstein's Vision of the Universe
37(1)
Reverse Engineering of Physiologic Traits as a Portal for Viewing Evolution
38(3)
Cell-Cell Communication as the Basis for the Evolution of Metazoans
41(1)
Understanding Lung Evolution from the Middle Out
42(1)
The Cell-Cell Communication Model of Lung Evolution Traces Contemporary Phenotypes Back to Ancestral Phenotypes
43(1)
Predictive Value of the Lung Cell-Cell Communication Model for Understanding the Evolution of Physiologic Systems
44(2)
Sexual Dimorphism of Lung Development: A Case Study in Cell-Cell Communication and Evolutionary Plasticity
46(2)
Androgen Affects the Expression of Growth Factors Involved in Lung Development
48(1)
Evidence for an Association between Steroid-Resistant/Responsive Phenotypes and Human Lymphocyte Antigen (HLA) Haplotypes
49(4)
5 How to Integrate Cell-Molecular Development, Homeostasis, Ecology, and Evolutionary Biology: The Missing Links
53(22)
Neutral Theory versus Intelligent Design
54(1)
Internal Selection Theory
54(3)
The Counterintuitive Nature of Physiology and Solution to the Dead Sea Scrolls Puzzle
57(1)
The Continuum from Microevolution to Macroevolution
58(11)
cis Regulation and Adaptive Evolution
69(1)
Evolution of cis Regulatory Mechanisms
70(5)
6 From Cell-Cell Communication to The Evolution of Integrated Physiology
75(20)
Cell-Cell Signaling and Alveolar Development: A Reductionist Approach to the Evolution of Physiologic Traits
77(2)
An Integrated, Empiric, Middle-Out Approach to Physiology
79(3)
A Molecular Evolutionary Link between the Lung and the Kidney?
82(1)
The Berner Hypothesis and Emergence of the Adipocyte: The Evolutionary Origins of the Lipofibroblast
83(2)
Lung Biology as a Cipher for Evolution
85(1)
Do Stretch Effects on PTHrP Expression Reflect Its Role in Adapting to Gravity?
85(3)
Wolff's Law Works for Both Bone and Lung
88(1)
Functional Relationship between the External and Internal Environments
89(2)
An Evolutionary Vertical Integration of the Phylogeny and Ontogeny of the Thyroid
91(4)
7 Exploiting Cell-Cell Communication Across Spacetime to Deconstruct Evolution
95(20)
Somewhere between the Gene and the Phenotype Lies the Process of Evolution
98(2)
A Functional Genomic Approach to Evolution as an Example of Terminal Addition
100(2)
Seeking Deep Homologies in Lung Evolution
102(3)
Systems Biology Based on Cell-Cell Communication
105(3)
Vertical Integration of Leptin Signaling, Human Evolution, and the Trojan Horse Effect
108(1)
Leptin and Human Evolution: Food for Thought
109(6)
8 The Periodic Table of Biology
115(10)
The Prospect of a Periodic Table of Biology
115(1)
Cellular Cooperation Is Key
116(2)
Elemental Biology
118(1)
PTHrP as an Archetype
118(1)
Evolution as the Solution
119(2)
Ramping Up a Mathematical Model of Evolution
121(3)
The Anthropic Principle Results from the Evolution of Cell-Cell Interactions
124(1)
9 Value Added by Thinking in Terms of The Cell-Cell Communication Model for Evolution
125(14)
This is Not a Just-So Story
126(2)
Beyond Genomics
128(1)
From Fat Cells to Integrated Physiology
128(1)
Molecular Homologies Distinguish between the Evolutionary Forest and Trees
129(1)
The Oxygen-Cholesterol-Surfactant-Membrane Connection
130(1)
Cholesterol Metabolism as the Data Operating System for Vertebrate Biology?
131(1)
Translation of Genomics into the Periodic Table for Biology
132(2)
Deep Homologies
134(1)
Selection Pressure for Cell-Cell Communication: The Key to Understanding Evolution
135(4)
10 Cell-Cell Communication as The Basis for Practicing Clinical Medicine
139(12)
Cell-Cell Communication Maintenance and Breakdown Represent Heath and Disease, Respectively
140(1)
Cell-Cell Communications as a Framework for Human Evolution
140(1)
Canalization, Decanalization, and the Holistic Approach to the Practice of Medicine
141(1)
Exploiting Lung Evolution to Prevent and Treat Chronic Lung Disease
141(1)
Lung Evolution Explains the Magic of Continuous Positive Airway Pressure
142(1)
The Paradox of Infecting the Lung in Order to Treat Lung Disease Caused by Infection
143(1)
Exploiting Lung Evolution to Prevent and Treat Smoking-Related Lung Damage
144(1)
The Trojan Horse Effect of Canalization
145(1)
Impetus for Evolutionary Science as an Integral Part of the Clinical Curriculum
146(1)
Application of Evolutionary Science to Bioethics
147(1)
Evolutionary Science, a Biologic Periodic Table, and a Unified Theory of Biology
148(1)
Summary
149(2)
Name Index 151(2)
Subject Index 153
John Torday, PhD, is Professor of Pediatrics and Ob/Gyn at Harbor-UCLA Medical Center where he is also Director of The Henry L. Guenther Laboratory for Cell/Molecular Research and Director of Laboratory for Evolutionary Preventive Medicine.  He is the author of over 130 peer-reviewed articles, Dr. Torday specializes in pre and neo-natal lung development, particularly regarding cell-cell communication within this pathway. V.K. Rehan, MD, is Professor of Pediatrics and Director of the Neonatal Intensive Care Unit at Harbor-UCLA Medical Center.  The recipient of numerous teaching honors, Dr. Rehan is involved both in treating patients and continuing research on neo and peri-natal respiratory issues and lung development.
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