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E-raamat: Gene Therapy for Cartilage and Bone Tissue Engineering

  • Formaat: PDF+DRM
  • Sari: SpringerBriefs in Bioengineering
  • Ilmumisaeg: 26-Jan-2014
  • Kirjastus: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Keel: eng
  • ISBN-13: 9783642539237
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Gene Therapy for Cartilage and Bone Tissue EngineeringSuurem pilt
  • Formaat: PDF+DRM
  • Sari: SpringerBriefs in Bioengineering
  • Ilmumisaeg: 26-Jan-2014
  • Kirjastus: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Keel: eng
  • ISBN-13: 9783642539237
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"Gene Therapy for Cartilage and Bone Tissue Engineering" outlines the tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic principles of gene therapy, vectors and gene delivery, specifically for cartilage and bone engineering. It is intended for tissue engineers, cell therapists, regenerative medicine scientists and engineers, gene therapist and virologists. Dr. Yu-Chen Hu is a Distinguished Professor at the Department of Chemical Engineering, National Tsing Hua University and has received the Outstanding Research Award (National Science Council), Asia Research Award (Society of Chemical Engineers, Japan) and Professor Tsai-Teh Lai Award (Taiwan Institute of Chemical Engineers). He is also a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a member of the Tissue Engineering International & Regenerative Medicine Society (TERMIS)-Asia Pacific Council.
1 Bone and Cartilage Tissue Engineering
1(16)
1.1 Bone
1(4)
1.1.1 Bone Components and Bone Formation
1(1)
1.1.2 Medical Need for Bone Repair and Current Treatments
2(1)
1.1.3 Bone Cell Types and Bone Healing
3(2)
1.2 Articular Cartilage
5(2)
1.2.1 Cartilage Types
5(1)
1.2.2 Cells and Components in Articular Cartilages
5(1)
1.2.3 Medical Need for Articular Cartilage Repair and Current Treatments
6(1)
1.2.4 Cartilage Formation/Hypertrophy and Repair Process
6(1)
1.3 Tissue Engineering
7(10)
1.3.1 Cells
8(1)
1.3.2 Scaffolds
8(1)
1.3.3 Biological Factors
9(2)
References
11(6)
2 Viral Gene Therapy Vectors
17(16)
2.1 Gene Therapy
17(1)
2.2 Vectors for Gene Delivery
18(15)
2.2.1 Nonviral vs. Viral Vectors
18(1)
2.2.2 Retrovirus/Lentivirus
19(2)
2.2.3 Adenovirus
21(1)
2.2.4 AAV
22(2)
2.2.5 Baculovirus
24(1)
References
25(8)
3 Gene Therapy for Bone Tissue Engineering
33(22)
3.1 In Vivo Gene Delivery-Based Bone Engineering
33(4)
3.1.1 Direct Injection
33(2)
3.1.2 Gene Activated Matrix (GAM)
35(2)
3.2 Ex Vivo Gene Delivery-Based Bone Formation
37(18)
3.2.1 Systemic Delivery
37(1)
3.2.2 Local Delivery
38(9)
References
47(8)
4 Gene Therapy for Cartilage Tissue Engineering
55(28)
4.1 Gene Products for Promoting Chondrogenesis
55(1)
4.2 In Vivo Gene Delivery-Based Cartilage Engineering
56(3)
4.2.1 Strategies to Suppress Cartilage Degeneration
57(1)
4.2.2 Strategies to Promote Cartilage Formation
58(1)
4.2.3 Problems in Direct Gene Transfer
58(1)
4.3 Ex Vivo Gene Therapy
59(24)
4.3.1 Gene Transfer to Chondrocytes
59(6)
4.3.2 Gene Transfer to Chondroprogenitor Cells
65(3)
4.3.3 Gene Transfer to Mesenchymal Stem Cells (MSCs)
68(2)
4.3.4 Gene Transfer to ASCs
70(3)
4.3.5 Gene Transfer via Gene Activated Matrix (GAM)
73(1)
4.3.6 Comparison of Cell Sources
74(1)
References
75(8)
5 Conclusions and Perspectives
83(4)
5.1 Concluding Remarks on Gene Therapy in Bone Tissue Engineering
83(2)
5.1.1 Immune Responses Against Viral Vectors/Transgenes
83(1)
5.1.2 Roles of Host Immunity on Bone Healing
84(1)
5.1.3 Genotoxicity
85(1)
5.2 Concluding Remarks on Gene Therapy in Cartilage Tissue Engineering
85(2)
5.3 Future Perspectives
87(1)
References 87
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