Preface |
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xi | |
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1 Introduction to Generalized Linear Models |
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1 | (8) |
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1 | (2) |
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3 | (1) |
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1.3 The Generalized Linear Model |
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4 | (5) |
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2 Linear Regression Models |
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9 | (68) |
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2.1 The Linear Regression Model and Its Application |
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9 | (1) |
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2.2 Multiple Regression Models |
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10 | (24) |
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2.2.1 Parameter Estimation with Ordinary Least Squares |
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10 | (5) |
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2.2.2 Properties of the Least Squares Estimator and Estimation of σ2 |
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15 | (4) |
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2.2.3 Hypothesis Testing in Multiple Regression |
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19 | (10) |
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2.2.4 Confidence Intervals in Multiple Regression |
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29 | (3) |
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2.2.5 Prediction of New Response Observations |
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32 | (2) |
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2.2.6 Linear Regression Computer Output |
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34 | (1) |
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2.3 Parameter Estimation Using Maximum Likelihood |
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34 | (5) |
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2.3.1 Parameter Estimation Under the Normal-Theory Assumptions |
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34 | (4) |
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2.3.2 Properties of the Maximum Likelihood Estimators |
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38 | (1) |
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2.4 Model Adequacy Checking |
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39 | (13) |
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39 | (4) |
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2.4.2 Transformation of the Response Variable Using the Box-Cox Method |
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43 | (2) |
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45 | (5) |
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2.4.4 Influence Diagnostics |
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50 | (2) |
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2.5 Using R to Perform Linear Regression Analysis |
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52 | (2) |
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2.6 Parameter Estimation by Weighted Least Squares |
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54 | (4) |
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2.6.1 The Constant Variance Assumption |
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54 | (1) |
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2.6.2 Generalized and Weighted Least Squares |
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55 | (3) |
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2.6.3 Generalized Least Squares and Maximum Likelihood |
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58 | (1) |
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2.7 Designs for Regression Models |
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58 | (7) |
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65 | (12) |
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3 Nonlinear Regression Models |
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77 | (42) |
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3.1 Linear and Nonlinear Regression Models |
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77 | (4) |
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3.1.1 Linear Regression Models |
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77 | (1) |
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3.1.2 Nonlinear Regression Models |
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78 | (1) |
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3.1.3 Origins of Nonlinear Models |
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79 | (2) |
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3.2 Transforming to a Linear Model |
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81 | (3) |
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3.3 Parameter Estimation in a Nonlinear System |
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84 | (18) |
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3.3.1 Nonlinear Least Squares |
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84 | (2) |
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3.3.2 The Geometry of Linear and Nonlinear Least Squares |
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86 | (1) |
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3.3.3 Maximum Likelihood Estimation |
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86 | (3) |
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3.3.4 Linearization and the Gauss-Newton Method |
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89 | (10) |
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3.3.5 Using R to Perform Nonlinear Regression Analysis |
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99 | (1) |
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3.3.6 Other Parameter Estimation Methods |
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100 | (1) |
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101 | (1) |
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3.4 Statistical Inference in Nonlinear Regression |
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102 | (4) |
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3.5 Weighted Nonlinear Regression |
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106 | (1) |
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3.6 Examples of Nonlinear Regression Models |
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107 | (1) |
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3.7 Designs for Nonlinear Regression Models |
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108 | (3) |
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111 | (8) |
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4 Logistic and Poisson Regression Models |
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119 | (83) |
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4.1 Regression Models Where the Variance Is a Function of the Mean |
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119 | (1) |
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4.2 Logistic Regression Models |
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120 | (56) |
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4.2.1 Models with a Binary Response Variable |
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120 | (3) |
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4.2.2 Estimating the Parameters in a Logistic Regression Model |
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123 | (5) |
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4.2.3 Interpertation of the Parameters in a Logistic Regression Model |
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128 | (4) |
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4.2.4 Statistical Inference on Model Parameters |
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132 | (11) |
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4.2.5 Lack-of-Fit Tests in Logistic Regression |
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143 | (12) |
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4.2.6 Diagnostic Checking in Logistic Regression |
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155 | (7) |
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4.2.7 Classification and the Receiver Operating Characteristic Curve |
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162 | (2) |
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4.2.8 A Biological Example of Logistic Regression |
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164 | (4) |
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4.2.9 Other Models for Binary Response Data |
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168 | (1) |
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4.2.10 More than Two Categorical Outcomes |
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169 | (7) |
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176 | (8) |
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4.4 Overdispersion in Logistic and Poisson Regression |
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184 | (5) |
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189 | (13) |
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5 The Generalized Linear Model |
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202 | (70) |
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5.1 The Exponential Family of Distributions |
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202 | (3) |
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5.2 Formal Structure for the Class of Generalized Linear Models |
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205 | (2) |
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5.3 Likelihood Equations for Generalized Linear models |
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207 | (4) |
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211 | (2) |
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5.5 Other Important Distributions for Generalized Linear Models |
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213 | (3) |
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214 | (1) |
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5.5.2 Canonical Link Function for the Gamma Distribution |
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215 | (1) |
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5.5.3 Log Link for the Gamma Distribution |
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215 | (1) |
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5.6 A Class of Link Functions---The Power Function |
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216 | (1) |
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5.7 Inference and Residual Analysis for Generalized Linear Models |
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217 | (3) |
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5.8 Examples with the Gamma Distribution |
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220 | (9) |
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5.9 Using R to Perform GLM Analysis |
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229 | (4) |
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5.9.1 Logistic Regression, Each Response is a Success or Failure |
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231 | (1) |
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5.9.2 Logistic Regression, Response is the Number of Successes Out of n Trials |
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232 | (1) |
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232 | (1) |
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5.9.4 Using the Gamma Distribution with a Log Link |
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233 | (1) |
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5.10 GLM and Data Transformation |
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233 | (7) |
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5.11 Modeling Both a Process Mean and Process Variance Using GLM |
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240 | (10) |
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5.11.1 The Replicated Case |
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240 | (4) |
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5.11.2 The Unreplicated Case |
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244 | (6) |
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5.12 Quality of Asymptotic Results and Related Issues |
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250 | (17) |
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5.12.1 Development of an Alternative Wald Confidence Interval |
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250 | (9) |
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5.12.2 Estimation of Exponential Family Scale Parameter |
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259 | (1) |
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5.12.3 Impact of Link Misspecification on Confidence Interval Coverage and Precision |
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260 | (1) |
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5.12.4 Illustration of Binomial Distribution with a True Identity Link but with Logit Link Assumed |
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260 | (2) |
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5.12.5 Poisson Distribution with a True Identity Link but with Log Link Assumed |
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262 | (1) |
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5.12.6 Gamma Distribution with a True Inverse Link but with Log Link Assumed |
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263 | (1) |
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5.12.7 Summary of Link Misspecification on Confidence Interval Coverage and Precision |
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264 | (1) |
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5.12.8 Impact of Model Misspecification on Confidence Interval Coverage and Precision |
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264 | (3) |
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267 | (5) |
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6 Generalized Estimating Equations |
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272 | (47) |
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6.1 Data Layout for Longitudinal Studies |
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272 | (2) |
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6.2 Impact of the Correlation Matrix R |
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274 | (1) |
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6.3 Iterative Procedure in the Normal Case, Identity Link |
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275 | (2) |
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6.4 Generalized Estimating Equations for More Generalized Linear Models |
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277 | (6) |
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278 | (5) |
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6.4.2 Iterative Computation of Elements in R |
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283 | (1) |
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283 | (25) |
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308 | (3) |
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311 | (8) |
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7 Random Effects in Generalized Linear Models |
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319 | (89) |
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7.1 Linear Mixed Effects Models |
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320 | (34) |
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7.1.1 Linear Regression Models |
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320 | (2) |
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7.1.2 General Linear Mixed Effects Models |
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322 | (4) |
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7.1.3 Covariance Matrix, V |
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326 | (6) |
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7.1.4 Parameter Estimation in the General Linear Mixed Model |
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332 | (2) |
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7.1.5 Statistical Inference on Regression Coefficients and Variance Components |
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334 | (3) |
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7.1.6 Conditional and Marginal Means |
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337 | (1) |
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7.1.7 Estimation of the Random Coefficients |
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338 | (2) |
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340 | (6) |
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346 | (8) |
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7.2 Generalized Linear Mixed Models |
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354 | (34) |
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7.2.1 The Generalized Linear Mixed Model |
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357 | (3) |
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7.2.2 Parameter Estimation in the GLMM |
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360 | (6) |
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7.2.3 Statistical Inference on Regression Coefficients and Variance Components |
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366 | (2) |
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7.2.4 Subject-Specific Versus Population-Averaged Prediction Models |
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368 | (1) |
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369 | (13) |
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382 | (6) |
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7.3 Generalized Linear Mixed Models Using Bayesian Methods |
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388 | (9) |
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388 | (2) |
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390 | (5) |
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7.3.3 Inference on Response Distribution Characteristics |
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395 | (2) |
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397 | (11) |
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8 Designed Experiments and the Generalized Linear Model |
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408 | (56) |
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408 | (1) |
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8.2 Experimental Designs for Generalized Linear Models |
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409 | (28) |
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8.2.1 Review of Two-Level Factorial and Fractional Factorial Designs |
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409 | (2) |
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8.2.2 Finding Optimal Designs in GLMs |
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411 | (10) |
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8.2.3 The Use of Standard Designs in Generalized Linear Models |
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421 | (3) |
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8.2.4 Orthogonal Designs in GLM: The Variance-Stabilizing Link |
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424 | (3) |
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427 | (9) |
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8.2.6 Further Comments Concerning the Nature of the Design |
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436 | (1) |
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8.3 GLM Analysis of Screening Experiments |
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437 | (21) |
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458 | (6) |
Appendix A.1 Background on Basic Test Statistics |
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464 | (3) |
Appendix A.2 Background from the Theory of Linear Models |
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467 | (5) |
Appendix A.3 The Gauss-Markov Theorem, Var(ε) = σ2I |
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472 | (2) |
Appendix A.4 The Relationship Between Maximum Likelihood Estimation of the Logistic Regression Model and Weighted Least Squares |
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474 | (4) |
Appendix A.5 Computational Details for GLMs for a Canonical Link |
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478 | (3) |
Appendix A.6 Computational Details for GLMs for a Noncanonical Link |
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481 | (3) |
References |
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484 | (9) |
Index |
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493 | |