Foreword |
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vii | |
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Foreword to the First Edition |
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ix | |
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Preface to the First Edition |
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xi | |
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Preface |
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xv | |
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Acknowledgements |
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xvii | |
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PART I PRINCIPLES OF GENOMIC MEDICINE |
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1 Genes, genetics, and human genomics |
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3 | (10) |
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2 The human genome---structure and organization |
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13 | (14) |
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27 | (12) |
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4 Epigenetics, epigenomics, and human disease |
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39 | (22) |
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5 Genes, genome, and developmental malformations |
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61 | (22) |
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6 Bioinformatics, systems biology, and systems medicine |
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83 | (14) |
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7 Pharmacogenomics---critical component of genomic medicine |
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97 | (17) |
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8 New drug development, drug response, and precision medicines |
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114 | (17) |
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9 Mitochondrial genetics and genomics in clinical medicine |
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131 | (17) |
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10 Genomics technology in clinical diagnostics |
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148 | (19) |
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11 Microbial genomics: targeted antimicrobial therapy and genome vaccines |
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167 | (13) |
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180 | (30) |
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13 Genomics in public and population health |
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210 | (8) |
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14 Genetic testing and genomic screening |
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218 | (17) |
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15 Biobanking for genomics-based translational medicine |
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235 | (7) |
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16 Genetics and genomics education: the path from helix to health |
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242 | (8) |
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17 Ethical, legal, and social issues in clinical genomics |
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250 | (9) |
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18 The regulation of human genomics research |
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259 | (10) |
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PART II GENOMICS IN CLINICAL PRACTICE |
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19 Genetic and genomic approaches to clinical medicine |
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269 | (25) |
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20 Genetic and genomic taxonomy of human disease |
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294 | (22) |
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21 Genomics of complex cardiovascular disease |
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316 | (21) |
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22 Genomics of type 2 diabetes mellitus and obesity |
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337 | (15) |
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23 Genetics and genomics of osteoporosis and related disorders |
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352 | (17) |
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24 Genetics and genomics of chronic kidney disease |
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369 | (24) |
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25 Genetics and genomics in clinical hematology, I: Hemostasis and thrombosis |
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393 | (11) |
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26 Genetics and genomics in clinical hematology, II: Inherited disorders of hemoglobin |
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404 | (8) |
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27 Genetic and genomics in clinical hematology, III: Acute leukemias |
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412 | (19) |
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28 Genetics and genomics of chronic inflammatory disorders, I: Inflammatory bowel disease |
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431 | (17) |
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29 Genetics and genomics of chronic inflammatory disorders, II: Rheumatoid arthritis and related arthropathies |
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448 | (14) |
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30 Genetics and genomics of chronic inflammatory disorders, III: Bronchial asthma |
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462 | (11) |
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31 Genetics and genomics of neuro-psychiatric diseases, I: Seizure disorders |
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473 | (14) |
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32 Genetics and genomics of neuro-psychiatric diseases, II: Multiple sclerosis |
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487 | (21) |
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33 Genetics and genomics of neuro-psychiatric diseases, III: The common dementias |
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508 | (13) |
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34 Genetics and genomics of neuro-psychiatric diseases, IV: Schizophrenia and bipolar disorder |
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521 | (9) |
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35 Genetics and genomics of neuro-psychiatric diseases, V: Learning and behavioral disorders |
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530 | (11) |
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36 Clinical cancer genomics |
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541 | (24) |
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37 Genomics and infectious diseases: susceptibility, resistance, response, and antimicrobial therapy |
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565 | (26) |
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38 Genomic perspectives of clinical immunology |
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591 | (12) |
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39 Genomic applications in clinical pediatrics |
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603 | (20) |
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40 Genetics and genomics in clinical ophthalmology, I: The spectrum of genetic eye disease |
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623 | (13) |
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41 Genetics and genomics in clinical ophthalmology, II: Glaucoma |
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636 | (16) |
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42 Genetics and genomics in clinical ophthalmology, III: Age-related macular degeneration |
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652 | (11) |
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43 Genomic applications in audiological medicine |
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663 | (20) |
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44 Genetics and genomics of skin diseases I: Atopic dermatitis and other skin complex diseases |
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683 | (13) |
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45 Genetics and genomics of skin diseases, II: Genomics of pigmentation and skin cancer |
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696 | (17) |
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46 The genetic and genomic practice of reproductive medicine |
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713 | (28) |
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47 Stem cell genomics: Developmental competence |
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741 | (25) |
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48 Genomic applications in critical care medicine |
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766 | (15) |
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49 Molecularly targeted therapy for Mendelian disorders |
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781 | (7) |
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50 Glossary for genetic and genomic medicine |
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788 | (13) |
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Index |
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801 | |