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E-raamat: Genomics and Proteomics for Clinical Discovery and Development

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The book is intended to be a resource for students as well as scientists in education and for the general public to learn about proteomics and genomics. Chromosomes form the basis for our genetic heritage and are the code for protein synthesis. The Human Genome Map came out in 2002, and the Proteome Sequence Map is under currently being created by a global consortia initiative. Proteome and genome building blocks already form the basis of scientific research areas as well as large parts of the pharmaceutical and biomedical industry. The book initiative will provide the background to and our current understanding of these gene and protein areas, as well as describe how cutting-edge science is using these resources to develop new medicines and new diagnostics for patient care and treatment. The book will be useful for undergraduate students as well as university students and researchers who need a good understanding of genomics and proteomics within the clinical field. The book will also be targeted at a broad public as well as readers not specialized within this field.

Dr. Marko-Varga is the head of the Head of Div. Clinical Protein Science & Imaging at the Biomedical Center, Dept. of Measurement Technology and Industrial Electrical Engineering, Lund University, and Professor at the 1st Department of Surgery, Tokyo Medical University, Tokyo, Japan.

1 Introduction to Genomics and Proteomics for Clinical Discovery and Development
1(6)
Gyorgy Marko-Varga
2 Identification of Missing Proteins: Toward the Completion of Human Proteome
7(12)
Akos Vegvari
3 Chromosome Transcriptome Profiling in the Context of High-Throughput Proteomics Studies
19(22)
Elizabeth Guruceaga
Mariana B. Monteiro
Maria I. Mora
Lourdes Ortiz
Fernando J. Corrales
Victor Segura
4 Standards for Proteomics Data Dissemination and Experiments Reporting
41(28)
J. Alberto Medina-Aunon
Juan P. Albar
5 Mass Spectrometry-Based Protein Sequencing Platforms
69(32)
Toshihide Nishimura
Hiromasa Tojo
6 Post-translational Modifications in the Human Proteome
101(36)
Cheryl F. Lichti
Norelle C. Wildburger
Mark R. Emmett
Ekaterina Mostovenko
Alexander S. Shavkunov
Shinji K. Strain
Carol L. Nilsson
7 Biomarker Discovery Utilizing Biobanking Archives and the Diagnostic Market
137(10)
Melinda Rezeli
Karin Sjodin
David Erlinge
Gyorgy Marko-Varga
8 Protein Microarrays: Overview, Applications and Challenges
147(28)
Lucia Lourido
Paula Diez
Noelia Dasilva
Maria Gonzalez-Gonzalez
Cristina Ruiz-Romero
Francisco Blanco
Alberto Orfao
Joshua LaBaer
Manuel Fuentes
9 Clinical Bioinformatics: A New Emerging Science of Biomarker Development
175(18)
Xiaodan Wu
Xiaocong Fang
Zhitu Zhu
Xiangdong Wang
10 Rapid Advances in the Field of Epigenetics
193(32)
Takeshi Kawamura
11 Pharmacogenomics in Drug Development
225(18)
Lena Gustavsson
12 The Role of Proteomics in the Development of Personalized Medicine, Diagnostic Methods and Large Scale Biobanking
243(14)
Johan Malm
Gyorgy Marko-Varga
13 Imaging Techniques in Proteomics Research
257(16)
Devipriya Subramaniyam
Goutham Edula
Index 273