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E-raamat: Glaucoma: A Neurodegenerative Disease of the Retina and Beyond Part B

Edited by (Professor of Ophthalmology, Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Italy), Edited by (Professsor of Pharmacology, University of Calabria, Arcavata di Rende, Italy)
  • Formaat: PDF+DRM
  • Sari: Progress in Brain Research
  • Ilmumisaeg: 26-Sep-2020
  • Kirjastus: Elsevier - Health Sciences Division
  • Keel: eng
  • ISBN-13: 9780323853422
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Glaucoma: A Neurodegenerative Disease of the Retina and Beyond Part BSuurem pilt
  • Formaat: PDF+DRM
  • Sari: Progress in Brain Research
  • Ilmumisaeg: 26-Sep-2020
  • Kirjastus: Elsevier - Health Sciences Division
  • Keel: eng
  • ISBN-13: 9780323853422
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Glaucoma: A Neurodegenerative Disease of the Retina and Beyond Part B, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics covered in this new release include Glaucoma neurodegeneration and myopia, Links between obstructive sleep apnea and glaucoma neurodegeneration, Artificial intelligence and deep learning in glaucoma: Current state and future prospects, Brain networks reorganization and functional disability in glaucoma, Advanced vascular examinations of the retina and optic nerve head in glaucoma, and much more.
  • Covers all key aspects of current research on glaucoma
  • Provides extensively referenced chapters, giving readers a comprehensive list of resources on topics covered
  • Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists
Contributors v
Preface xiii
Chapter 1 Glaucoma neurodegeneration and myopia
1(18)
Jost B. Jonas
Songhomitra Panda-Jonas
Ya Xing Wang
1 Introduction
2(1)
2 Optic nerve head
2(2)
3 Peripapillary ring
4(1)
4 Peripapillary scleral flange
5(1)
5 Peripapillary border tissues
5(1)
6 Peripapillary arterial circle of Zinn-Haller
6(1)
7 Parapapillary alpha, beta, gamma and delta zones
7(1)
8 Clinical diagnosis of glaucoma in high myopia
8(1)
9 Differential diagnosis of optic nerve damage in high myopia
9(1)
10 Myopic macular changes with respect to glaucoma
9(1)
11 Mechanisms potentially involved in the process of axial elongation leading to the myopic changes in the optic nerve head
10(3)
12 Conclusion
13(1)
Funding
13(1)
Financial interest
13(1)
References
13(6)
Chapter 2 Links between obstructive sleep apnea and glaucoma neurodegeneration
19(18)
Massimo Cesareo
Clarissa Giannini
Alessio Martucci
Matteo Di Marino
Giulio Pocobelli
Francesco Aiello
Raffaele Mancino
Carlo Nucci
1 Introduction
20(1)
2 Definition
20(1)
3 Diagnosis
20(1)
4 Risk factors, clinical presentation and therapeutic options
21(1)
5 Association between obstructive sleep apnea syndrome and glaucoma in adults
22(1)
6 Prevalence of glaucoma in patients with OS AS
22(1)
7 Pathogenesis
23(4)
7.1 Hypoxia and hypercapnia
24(1)
7.2 Vascular changes
24(1)
7.3 Mechanical factors
25(2)
8 Anatomical and functional findings
27(3)
9 Conclusions
30(1)
References
31(6)
Chapter 3 Artificial intelligence and deep learning in glaucoma: Current state and future prospects
37(28)
Michael J.A. Girard
Leopold Schmetterer
1 Introduction
38(1)
2 AI to better assess optic nerve head structure
39(4)
3 AI for glaucoma diagnosis
43(3)
4 AI for glaucoma prognosis
46(1)
5 AI for cost-effective screening
47(3)
6 AI and genetics in glaucoma
50(1)
7 Discussion
50(3)
Acknowledgments
53(1)
Support
53(1)
References
53(12)
Chapter 4 Brain networks reorganization and functional disability in glaucoma
65(12)
Alessio Martucci
Massimo Cesareo
Nicola Toschi
Francesco Garaci
Giacinto Bagetta
Carlo Nucci
1 Introduction
66(1)
2 Brain involvement in glaucoma: Histological and neuroimaging evidence
67(1)
3 Cerebral neurofunctional alterations and disabilities in glaucoma
68(4)
4 Conclusions
72(1)
Disclosure statement
72(1)
References
72(5)
Chapter 5 Advanced vascular examinations of the retina and optic nerve head in glaucoma
77(8)
Joao Barbosa Breda
Jan Van Eijgen
Ingeborg Stalmans
References
81(4)
Chapter 6 Evaluation of putative differences in vessel density and flow area in normal tension and high-pressure glaucoma using OCT-angiography
85(14)
Alessio Martucci
Clarissa Giannini
Matteo Di Marino
Roberto Pietro Sorge
Francesco Aiello
Damiana Scuteri
Raffaele Mancino
Carlo Nucci
Massimo Cesareo
1 Introduction
86(1)
2 Materials and methods
87(1)
3 Statistical analysis
88(3)
4 Results
91(2)
5 Discussion
93(2)
Acknowledgments
95(1)
Conflicts of interest
96(1)
Funding
96(1)
References
96(3)
Chapter 7 Towards stem cell-based neuronal regeneration for glaucoma
99(20)
Zi-Qj Hua
Hui Liu
Ningli Wang
Zi-Bing Jin
1 Introduction
99(1)
2 RGC degeneration in glaucoma
100(1)
3 RGC regeneration
100(8)
3.1 ESC-derived RGCs
101(1)
3.2 iPSC-derived RGCs
102(5)
3.3 Muller glia in RGC regeneration
107(1)
3.4 MSCs in RGC regeneration
107(1)
4 Purification and transplantation of stem cell-derived RGCs
108(1)
5 Other source cells
109(1)
6 Perspectives
110(1)
References
111(8)
Chapter 8 Naturally occurring neuroprotectants in glaucoma
119(22)
Radhika Pooja Patel
Ehtesham Shamsher
Daniel Hill
Maria Francesca Cordeiro
1 Introduction
119(3)
2 Resveratrol
122(4)
2.1 Role in neuroprotection
122(2)
2.2 Clinical trials
124(1)
2.3 Drug delivery systems for resveratrol
125(1)
3 Curcumin
126(3)
3.1 Role in neuroprotection
127(1)
3.2 Drug delivery systems for curcumin
128(1)
3.3 Clinical trials
129(1)
4 Ubiquinone
129(3)
4.1 Role in neuroprotection
130(2)
5 Early diagnostic tools in glaucoma
132(1)
6 Conclusion
133(1)
References
134(7)
Chapter 9 Impact of nutraceuticals on glaucoma: A systematic review
141(14)
Damiana Scuteri
Laura Rombola
Chizuko Watanabe
Shinobu Sakurada
Maria Tiziana Corasaniti
Giacinto Bagetta
Paolo Tonin
Rossella Russo
Carlo Nucci
Luigi Antonio Morrone
1 Introduction
142(1)
2 Methods
143(2)
2.1 Inclusion criteria
143(1)
2.2 Exclusion criteria
143(2)
3 Results
145(2)
4 Discussion
147(5)
Acknowledgments
152(1)
Conflicts of interest
152(1)
Author contributions
152(1)
References
152(3)
Chapter 10 Evidence on the neuroprotective properties of brimonidine in glaucoma
155
Damiana Scuteri
Giacinto Bagetta
Carlo Nucci
Francesco Aiello
Massimo Cesareo
Paolo Tonin
Maria Tiziana Corasaniti
1 Introduction
156(1)
2 Methods
157(1)
2.1 Inclusion criteria
157(1)
2.2 Exclusion criteria
157(1)
3 Results
158(5)
3.1 Results of the search and included studies
158(2)
3.2 Risk of bias assessment and meta-analysis
160(3)
4 Discussion
163(1)
Acknowledgments
164(1)
Author contributions
164(1)
Conflicts of interest
164(1)
References
164
Giacinto Bagetta is Professsor of Pharmacology and works in the Department of Pharmacy, Health Science and Nutrition at University of Calabria, Arcavata di Rende, Italy. Carlo Nucci is Professor of Ophthalmology in the Ophthalmology Unit, Department of Experimental Medicine at the University of Rome Tor Vergata, Italy.
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