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E-raamat: Glaucoma: An Open-Window to Neurodegeneration and Neuroprotection

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Edited by (Professsor of Pharmacology, University of Calabria, Arcavata di Rende, Italy), Edited by (Professor of Ophthalmology, Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Italy), Edited by (Oxford University, UK), Edited by
  • Formaat: PDF+DRM
  • Sari: Progress in Brain Research
  • Ilmumisaeg: 05-Nov-2008
  • Kirjastus: Elsevier Science Ltd
  • Keel: eng
  • ISBN-13: 9780080932804
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Glaucoma: An Open-Window to Neurodegeneration and NeuroprotectionSuurem pilt
  • Formaat: PDF+DRM
  • Sari: Progress in Brain Research
  • Ilmumisaeg: 05-Nov-2008
  • Kirjastus: Elsevier Science Ltd
  • Keel: eng
  • ISBN-13: 9780080932804
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Glaucoma is one of the main causes of blindness throughout the world. It is characterized by death of the retinal ganglion cells, which is associated with loss of the axons making up the optic nerve. Recent studies have demonstrated support for the classification of glaucoma as a degenerative disease of the central nervous system (CNS). The search for treatment modalities that are effective for all patients with glaucoma has resulted in numerous studies aimed at identifying neuroprotection strategies for the treatment of this disease, like those used for other degenerative diseases of the CNS.

The present book will provide an in-depth examination of the most recent findings regarding glaucoma, including risk factors, diagnosis, clinical monitoring, treatment, and above all, the need for treatment based on the concept of neuroprotection. A large part of the book is devoted to research related to this new approach to the treatment of glaucoma. Aspects that will be analyzed include experimental models of glaucoma, clinical protocols for the study of neuroprotective therapies, mechanisms underlying glaucomatous damage to neurons of the retina and other “stations? in the visual pathways of the CNS, and finally proposals for new strategies for preventing neuronal injury in glaucoma patients.

* Describes the most recent developments on neuroprotection of the optic nerve, including experimental models now used and clinical protocols
* Discusses new strategies for the prevention of neuronal injury in glaucoma patients
* Focuses on evidence-based risk factors, innovative diagnostic aspects and advanced medical/surgical treatment of glaucoma

Glaucoma is one of the main causes of blindness throughout the world. It is characterized by death of the retinal ganglion cells, which is associated with loss of the axons making up the optic nerve. Recent studies have demonstrated support for the classification of glaucoma as a degenerative disease of the central nervous system (CNS), leading researchers to look at identifying neuroprotection strategies for the treatment of this disease, like those used for other degenerative diseases of the CNS.

This book will provide an in-depth examination of the most recent findings regarding glaucoma, including risk factors, diagnosis, clinical monitoring, treatment, and above all, the need for treatment based on the concept of neuroprotection. A large part of the book is devoted to research related to this new approach to the treatment of glaucoma.

* Describes the most recent developments on neuroprotection of the optic nerve, including experimental models now used and clinical protocols
* Discusses new strategies for the prevention of neuronal injury in glaucoma patients
* Focuses on evidence-based risk factors, innovative diagnostic aspects and advanced medical/surgical treatment of glaucoma

Muu info

An in-depth examination on risk factors, diagnosis, clinical monitoring and treatment of glaucoma.
List of contributors
v
Preface xi
I. Epidemiology and Clinical Assessment of the Disease
Epidemiology of primary glaucoma: prevalence, incidence, and blinding effects
3(12)
C. Cedrone
R. Mancino
A. Cerulli
M. Cesareo
C. Nucci
Predictive models to estimate the risk of glaucoma development and progression
15(10)
F.A. Medeiros
R.N. Weinreb
Intraocular pressure and central corneal thickness
25(6)
G. Manni
F. Oddone
V. Parisi
A. Tosto
M. Centofanti
Angle-closure: risk factors, diagnosis and treatment
31(16)
N. Amerasinghe
T. Aung
Early diagnosis in glaucoma
47(12)
D.F. Garway-Heath
Monitoring glaucoma progression
59(18)
P. Brusini
II. Anatomical and Functional Monitoring
Standard automated perimetry and algorithms for monitoring glaucoma progression
77(24)
G.L. Scuderi
M. Cesareo
A. Perdicchi
S.M. Recupero
Short-wavelength automated perimetry and frequency-doubling technology perimetry in glaucoma
101(24)
P. Fogagnolo
L. Rossetti
S. Ranno
A. Ferreras
N. Orzalesi
Scanning laser polarimetry and confocal scanning laser ophthalmoscopy: technical notes on their use in glaucoma
125(14)
F. Ferreri
P. Aragona
G. Ferreri
The role of OCT in glaucoma management
139(10)
M.M. Pagliara
D. Lepore
E. Balestrazzi
Functional laser Doppler flowmetry of the optic nerve: physiological aspects and clinical applications
149(16)
C.E. Riva
B. Falsini
Advances in neuroimaging of the visual pathways and their use in glaucoma
165(16)
F.G. Garaci
V. Cozzolino
C. Nucci
F. Gaudiello
A. Ludovici
T. Lupattelli
R. Floris
G. Simonetti
III. Current Therapy
Primary open angle glaucoma: an overview on medical therapy
181(14)
M. Vetrugno
F. Cantatore
G. Ruggeri
P. Ferreri
A. Montepara
A. Quinto
C. Sborgia
The treatment of normal-tension glaucoma
195(16)
P.V. Desai
J. Caprioli
The management of exfoliative glaucoma
211(14)
R. Ritch
Laser therapies for glaucoma: new frontiers
225(12)
G.L. Scuderi
N. Pasquale
Modulation of wound healing during and after glaucoma surgery
237(18)
S. Georgoulas
A. Dahlmann-Noor
S. Brocchini
P.T. Khaw
Surgical alternative to trabeculectomy
255(8)
R.G. Carassa
Modern aqueous shunt implantation: future challenges
263(16)
K. Barton
D.K. Heuer
IV. Experimental Approaches to Model Disease
Model systems for experimental studies: retinal ganglion cells in culture
279(6)
E. Goodyear
L.A. Levin
Rat models for glaucoma research
285(18)
J.C. Morrison
E. Johnson
W.O. Cepurna
Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection
303(20)
G.R. Howell
R.T. Libby
S.W.M. John
Clinical trials in neuroprotection
323(16)
S.M. Whitcup
V. Neuroprotection: New Vistas in Pathophysiology
Pathogenesis of ganglion ``cell death'' in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria
339(14)
N.N. Osborne
Astrocytes in glaucomatous optic neuropathy
353(22)
M.R. Hernandez
H. Miao
T. Lukas
Glaucoma as a neuropathy amenable to neuroprotection and immune manipulation
375(10)
M. Schwartz
A. London
Oxidative stress and glaucoma: injury in the anterior segment of the eye
385(24)
S.C. Sacca
A. Izzotti
TNF-α signaling in glaucomatous neurodegeneration
409(14)
G. Tezel
Involvement of the Bcl2 gene family in the signaling and control of retinal ganglion cell death
423(14)
R.W. Nickells
S.J. Semaan
C.L. Schlamp
Assessment of neuroprotection in the retina with DARC
437(14)
L. Guo
M.F. Cordeiro
Potential roles of (endo)cannabinoids in the treatment of glaucoma: from intraocular pressure control to neuroprotection
451(14)
C. Nucci
M. Bari
A. Spano
M.T. Corasaniti
G. Bagetta
M. Maccarrone
L.A. Morrone
Glaucoma of the brain: a disease model for the study of transsynaptic neural degeneration
465(14)
Y. Yucel
N. Gupta
Changes of central visual receptive fields in experimental glaucoma
479(16)
S.C. Sharma
VI. Neuroprotection: Evidence for Future Strategies
Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma
495(16)
M. Seki
S.A. Lipton
Stem cells for neuroprotection in glaucoma
511(10)
N.D. Bull
T.V. Johnson
K.R. Martin
The relationship between neurotrophic factors and CaMKII in the death and survival of retinal ganglion cells
521(20)
N.G.F. Cooper
A. Laabich
W. Fan
X. Wang
Evidence of the neuroprotective role of citicoline in glaucoma patients
541(14)
V. Parisi
G. Coppola
M. Centofanti
F. Oddone
A.M. Angrisani
L. Ziccardi
B. Ricci
L. Quaranta
G. Manni
Neuroprotection: VEGF, IL-6, and clusterin: the dark side of the moon
555(20)
S. Pucci
P. Mazzarelli
F. Missiroli
F. Regine
F. Ricci
Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection
575(8)
R. Russo
F. Cavaliere
L. Rombola
M. Gliozzi
A. Cerulli
C. Nucci
E. Fazzi
G. Bagetta
M.T. Corasaniti
L.A. Morrone
17β-Estradiol prevents retinal ganglion cell loss induced by acute rise of intraocular pressure in rat
583(8)
R. Russo
F. Cavaliere
C. Watanabe
C. Nucci
G. Bagetta
M.T. Corasaniti
S. Sakurada
L.A. Morrone
Subject Index 591
Carlo Nucci is Professor of Ophthalmology in the Ophthalmology Unit, Department of Experimental Medicine at the University of Rome Tor Vergata, Italy. Giacinto Bagetta is Professsor of Pharmacology and works in the Department of Pharmacy, Health Science and Nutrition at University of Calabria, Arcavata di Rende, Italy.
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