| Contributors |
|
xiv | |
| Preface |
|
xxv | |
| Acknowledgments |
|
xxvi | |
|
1 Historical Principles and Perspectives |
|
|
1 | (15) |
|
|
|
2 Toxicologic Misfortunes and Catastrophes in History |
|
|
16 | (11) |
|
|
|
PART A THE GENERAL APPROACH TO THE PATIENT |
|
|
27 | (128) |
|
|
|
27 | (1) |
|
3 Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes |
|
|
28 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
32 | (1) |
|
4 Principles of Managing the Acutely Poisoned or Overdosed Patient |
|
|
33 | (15) |
|
|
|
|
|
|
|
|
|
|
|
|
|
SC1 Principles of Antidote Stocking |
|
|
42 | (6) |
|
|
|
|
|
|
|
5 Techniques Used to Prevent Gastrointestinal Absorption |
|
|
48 | (42) |
|
|
|
SC2 Decontamination Principles: Prevention of Dermal, Ophthalmic, and Inhalational Absorption |
|
|
71 | (5) |
|
|
|
|
|
76 | (7) |
|
|
|
|
|
A2 Whole-Bowel Irrigation and Other Intestinal Evacuants |
|
|
83 | (7) |
|
|
|
|
|
6 Principles and Techniques Applied to Enhance Elimination |
|
|
90 | (11) |
|
|
|
|
|
|
|
101 | (13) |
|
|
|
|
|
8 Principles of Diagnostic Imaging |
|
|
114 | (26) |
|
|
|
9 Pharmacokinetic and Toxicokinetic Principles |
|
|
140 | (15) |
|
|
|
PART B THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY |
|
|
155 | (317) |
|
Section I Biochemical and Molecular Concepts |
|
|
|
|
|
155 | (12) |
|
|
|
|
|
11 Biochemical and Metabolic Principles |
|
|
167 | (22) |
|
|
|
|
|
12 Fluid, Electrolyte, and Acid-Base Principles |
|
|
189 | (14) |
|
|
|
|
|
13 Neurotransmitters and Neuromodulators |
|
|
203 | (33) |
|
|
|
|
|
|
|
|
|
|
|
236 | (8) |
|
|
|
|
|
Section II Pathophysiologic Basis: Organ Systems |
|
|
|
|
|
242 | (2) |
|
15 Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles |
|
|
244 | (16) |
|
|
|
16 Cardiologic Principles II: Hemodynamics |
|
|
260 | (9) |
|
|
|
|
|
|
|
268 | (1) |
|
17 Dermatologic Principles |
|
|
269 | (18) |
|
|
|
|
|
|
|
SC3 Transdermal Toxicology |
|
|
284 | (3) |
|
|
|
18 Gastrointestinal Principles |
|
|
287 | (10) |
|
|
|
|
|
19 Genitourinary Principles |
|
|
297 | (13) |
|
|
|
20 Hematologic Principles |
|
|
310 | (17) |
|
|
|
|
|
327 | (13) |
|
|
|
|
|
|
|
339 | (1) |
|
|
|
340 | (9) |
|
|
|
|
|
349 | (7) |
|
|
|
|
|
356 | (7) |
|
|
|
25 Otolaryngologic Principles |
|
|
363 | (10) |
|
|
|
|
|
26 Psychiatric Principles |
|
|
373 | (16) |
|
|
|
|
|
|
|
|
|
|
|
384 | (5) |
|
|
|
|
|
|
|
|
|
|
|
389 | (10) |
|
|
|
|
|
28 Respiratory Principles |
|
|
399 | (12) |
|
|
|
|
|
29 Thermoregulatory Principles |
|
|
411 | (17) |
|
|
|
|
|
Section III Special Populations |
|
|
|
30 Reproductive and Perinatal Principles |
|
|
428 | (20) |
|
|
|
|
|
448 | (12) |
|
|
|
|
|
|
|
459 | (1) |
|
|
|
460 | (12) |
|
|
|
|
|
|
|
PART C THE CLINICAL BASIS OF MEDICAL TOXICOLOGY |
|
|
472 | (1) |
|
Section I A. Analgesics and Antiinflammatory Medications |
|
|
|
|
|
472 | (29) |
|
|
|
|
|
|
|
492 | (9) |
|
|
|
|
|
34 Colchicine, Podophyllin, and the Vinca Alkaloids |
|
|
501 | (10) |
|
|
|
|
|
35 Nonsteroidal Antiinflammatory Drugs |
|
|
511 | (8) |
|
|
|
|
|
519 | (36) |
|
|
|
|
|
|
|
538 | (7) |
|
|
|
|
|
SC5 Internal Concealment of Xenobiotics |
|
|
545 | (6) |
|
|
|
SC6 Prevention, Treatment, and Harm Reduction Approaches to Opioid Overdoses |
|
|
551 | (4) |
|
|
|
|
|
|
|
555 | (19) |
|
|
|
|
|
567 | (7) |
|
|
|
|
|
B Food, Diet, and Nutrition |
|
|
|
|
|
574 | (18) |
|
|
|
|
|
586 | (6) |
|
|
|
|
|
|
|
592 | (14) |
|
|
|
|
|
40 Dieting Xenobiotics and Regimens |
|
|
606 | (10) |
|
|
|
41 Athletic Performance Enhancers |
|
|
616 | (11) |
|
|
|
|
|
627 | (11) |
|
|
|
43 Plant- and Animal-Derived Dietary Supplements |
|
|
638 | (16) |
|
|
|
|
|
654 | (15) |
|
|
|
|
|
669 | (12) |
|
|
|
|
|
676 | (5) |
|
|
|
|
|
|
46 Pharmaceutical Additives |
|
|
681 | (13) |
|
|
|
|
|
47 Antidiabetics and Hypoglycemics/Antiglycemics |
|
|
694 | (25) |
|
|
|
|
|
707 | (6) |
|
|
|
|
|
|
|
713 | (6) |
|
|
|
|
|
|
|
719 | (19) |
|
|
|
|
|
732 | (4) |
|
|
|
|
|
736 | (2) |
|
49 Antihistamines and Decongestants |
|
|
738 | (21) |
|
|
|
A11 Physostigmine Salicylate |
|
|
755 | (4) |
|
|
|
|
|
759 | (8) |
|
|
|
51 Methotrexate 5-Fluorouracil, and Capecitabine |
|
|
767 | (38) |
|
|
|
A12 Folates: Leucovorin (Folinic Acid) and Folic Acid |
|
|
775 | (7) |
|
|
|
|
|
A13 Glucarpidase (Carboxypeptidase G1) |
|
|
782 | (7) |
|
|
|
|
|
789 | (4) |
|
|
|
SC7 Intrathecal Administration of Xenobiotics |
|
|
793 | (9) |
|
|
|
SC8 Extravasation of Xenobiotics |
|
|
802 | (3) |
|
|
|
52 Antimigraine Medications |
|
|
805 | (7) |
|
|
|
53 Thyroid and Antithyroid Medications |
|
|
812 | (9) |
|
|
|
|
|
|
54 Antibacterials, Antifungals, and Antivirals |
|
|
821 | (15) |
|
|
|
|
|
836 | (14) |
|
|
|
56 Antituberculous Medications |
|
|
850 | (15) |
|
|
|
|
|
|
|
862 | (3) |
|
|
|
E Cardiopulmonary Medications |
|
|
|
|
|
865 | (18) |
|
|
|
|
|
|
|
876 | (7) |
|
|
|
|
|
883 | (43) |
|
|
|
|
|
A17 Prothrombin Complex Concentrates and Direct Oral Anticoagulant Antidotes |
|
|
908 | (7) |
|
|
|
|
|
|
|
915 | (4) |
|
|
|
|
|
919 | (5) |
|
|
|
|
|
924 | (2) |
|
59 β-Adrenergic Antagonists |
|
|
926 | (19) |
|
|
|
|
|
941 | (4) |
|
|
|
|
|
60 Calcium Channel Blockers |
|
|
945 | (14) |
|
|
|
|
|
953 | (6) |
|
|
|
|
|
61 Miscellaneous Antihypertensives and Pharmacologically Related Agents |
|
|
959 | (10) |
|
Hallam Melville Gugelmann |
|
|
|
|
|
|
969 | (16) |
|
|
|
A22 Digoxin-Specific Antibody Fragments |
|
|
977 | (8) |
|
|
|
|
|
63 Methylxanthines and Selective B2-Adrenergic Agonists |
|
|
985 | (9) |
|
|
|
F Anesthetics and Related Medications |
|
|
|
|
|
994 | (17) |
|
|
|
|
|
1004 | (7) |
|
|
|
|
|
65 Inhalational Anesthetics |
|
|
1011 | (7) |
|
|
|
|
|
66 Neuromuscular Blockers |
|
|
1018 | (14) |
|
|
|
|
|
|
|
1029 | (3) |
|
|
|
|
|
G Psychotropic Medications |
|
|
|
|
|
1032 | (12) |
|
|
|
68 Cyclic Antidepressants |
|
|
1044 | (10) |
|
|
|
|
|
69 Serotonin Reuptake Inhibitors and Atypical Antidepressants |
|
|
1054 | (11) |
|
|
|
|
|
1065 | (10) |
|
|
|
71 Monoamine Oxidase Inhibitors |
|
|
1075 | (9) |
|
|
|
|
|
1084 | (15) |
|
|
|
|
|
|
|
1094 | (5) |
|
|
|
|
|
|
|
|
1099 | (12) |
|
|
|
|
|
|
|
1111 | (13) |
|
|
|
|
|
1124 | (19) |
|
|
|
|
|
|
|
1135 | (8) |
|
|
|
|
|
|
|
|
|
|
|
1143 | (22) |
|
|
|
A27 Thiamine Hydrochloride |
|
|
1157 | (8) |
|
|
|
|
|
1165 | (7) |
|
|
|
|
|
78 Disulfiram and Disulfiramlike Reactions |
|
|
1172 | (6) |
|
|
|
|
|
1178 | (10) |
|
|
|
|
|
80 γ-Hydroxybutyric Acid (γ-Hydroxybutyrate) |
|
|
1188 | (5) |
|
|
|
|
|
|
|
1193 | (10) |
|
|
|
|
|
1203 | (7) |
|
|
|
|
|
83 Phencyclidine and Ketamine |
|
|
1210 | (13) |
|
|
|
|
|
|
|
|
1222 | (1) |
|
|
|
1223 | (5) |
|
|
|
|
|
|
|
1228 | (9) |
|
|
|
|
|
1237 | (18) |
|
|
|
A28 Dimercaprol (British Anti-Lewisite or Bal) |
|
|
1251 | (4) |
|
|
|
|
|
1255 | (4) |
|
|
|
|
|
1259 | (5) |
|
|
|
|
|
|
|
1264 | (4) |
|
|
|
|
|
1268 | (5) |
|
|
|
|
|
1273 | (10) |
|
|
|
|
|
1283 | (9) |
|
|
|
|
|
1292 | (27) |
|
|
|
|
|
A29 Succimer (2,3 Dimercaptosuccin1C Acid) and Dmps (2,3-Dimercapto-1- Ropanesulfonic Acid) |
|
|
1309 | (6) |
|
|
|
A30 Edetate Calcium Disodium (CaNa2EDTA) |
|
|
1315 | (4) |
|
|
|
|
|
1319 | (5) |
|
|
|
|
|
|
|
1324 | (9) |
|
|
|
|
|
1333 | (6) |
|
|
|
|
|
1339 | (5) |
|
|
|
|
|
1344 | (6) |
|
|
|
|
|
|
|
1350 | (12) |
|
|
|
|
|
|
|
1357 | (5) |
|
|
|
|
|
1362 | (6) |
|
|
|
|
|
|
101 Antiseptics, Disinfectants, and Sterilants |
|
|
1368 | (12) |
|
|
|
|
|
102 Camphor and Moth Repellents |
|
|
1380 | (8) |
|
|
|
|
|
1388 | (9) |
|
|
|
|
|
104 Hydrofluoric Acid and Fluorides |
|
|
1397 | (12) |
|
|
|
|
|
1403 | (6) |
|
|
|
|
|
|
|
1409 | (12) |
|
|
|
|
|
|
|
1420 | (1) |
|
|
|
1421 | (33) |
|
|
|
|
|
1435 | (5) |
|
|
|
|
|
1440 | (4) |
|
|
|
|
|
1444 | (6) |
|
|
|
|
|
|
|
|
1450 | (4) |
|
|
|
1454 | (3) |
|
|
|
|
|
1457 | (9) |
|
|
|
|
|
|
|
1466 | (20) |
|
|
|
110 Insecticides: Organic Phosphorous Compounds and Carbamates |
|
|
1486 | (28) |
|
|
|
|
|
1503 | (5) |
|
|
|
|
|
1508 | (6) |
|
|
|
111 Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and Insect Repellents |
|
|
1514 | (14) |
|
|
|
|
|
1528 | (5) |
|
|
|
113 Sodium Monofluoroacetate and Fluoroacetamide |
|
|
1533 | (3) |
|
|
|
|
|
1536 | (4) |
|
|
|
L Naturaltoxins and Envenomations |
|
|
|
|
|
1540 | (27) |
|
|
|
|
|
|
|
1559 | (4) |
|
|
|
|
|
|
|
1563 | (4) |
|
|
|
|
|
|
|
1567 | (14) |
|
|
|
|
|
|
|
1581 | (16) |
|
|
|
|
|
1597 | (20) |
|
|
|
|
|
119 Native (US) Venomous Snakes and Lizards |
|
|
1617 | (23) |
|
|
|
|
|
A39 Antivenom for North American Venomous Snakes (Crotaline and Elapid) |
|
|
1627 | (6) |
|
|
|
|
|
SC10 Exotic Nonnative Snake Envenomations |
|
|
1633 | (6) |
|
|
|
|
|
|
|
|
|
M Occupational and Environmental Toxins |
|
|
|
|
|
1639 | (1) |
|
|
|
1640 | (11) |
|
|
|
|
|
|
|
1650 | (1) |
|
121 Simple Asphyxiants and Pulmonary Irritants |
|
|
1651 | (12) |
|
|
|
|
|
|
|
1663 | (21) |
|
|
|
|
|
1676 | (8) |
|
|
|
123 Cyanide and Hydrogen Sulfide |
|
|
1684 | (19) |
|
|
|
|
|
|
|
1694 | (4) |
|
|
|
A42 Nitrites (Amyl and Sodium) and Sodium Thiosulfate |
|
|
1698 | (5) |
|
|
|
124 Methemoglobin Inducers |
|
|
1703 | (14) |
|
|
|
|
|
1713 | (4) |
|
|
|
|
|
1717 | (24) |
|
|
|
|
|
|
|
|
1741 | (12) |
|
|
|
|
|
1753 | (9) |
|
|
|
|
|
1762 | (20) |
|
|
|
|
|
1775 | (4) |
|
|
|
A45 Pentetic Acid or Pentetate (Zinc or Calcium) Trisodium (DTPA) |
|
|
1779 | (3) |
|
|
|
|
|
|
SECTION I POISON CONTROL CENTERS, HEALTH SYSTEMS, AND EPIDEMIOLOGY |
|
|
|
129 Poison Prevention and Education |
|
|
1782 | (7) |
|
|
|
130 Poison Control Centers and Poison Epidemiology |
|
|
1789 | (8) |
|
|
|
|
|
131 Principles of Occupational Toxicology: Diagnosis and Control |
|
|
1797 | (9) |
|
|
|
132 Hazardous Materials Incident Response |
|
|
1806 | (8) |
|
|
|
|
|
133 Risk Assessment and Risk Communication |
|
|
1814 | (8) |
|
|
|
|
|
1820 | (2) |
|
134 Medication Safety and Adverse Drug Events |
|
|
1822 | (11) |
|
|
|
135 Drug Development, Adverse Drug Events, and Postmarketing Surveillance |
|
|
1833 | (11) |
|
|
|
136 International Perspectives on Medical Toxicology |
|
|
1844 | (8) |
|
|
|
137 Principles of Epidemiology and Research Design |
|
|
1852 | (8) |
|
|
|
Section II Legal Aspects of Toxicology |
|
|
|
138 Risk Management and Legal Principles |
|
|
1860 | (8) |
|
|
|
139 Medicolegal Interpretive Toxicology |
|
|
1868 | (16) |
|
|
|
SC11 Assessment of Ethanol-Induced Impairment |
|
|
1876 | (8) |
|
|
|
140 Postmortem Toxicology |
|
|
1884 | (11) |
|
|
|
|
|
SC12 Organ Procurement from Poisoned Patients |
|
|
1892 | (3) |
| Index |
|
1895 | |
Lisainfo e-raamatute kohta