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E-raamat: Handbook of Epigenetics: The New Molecular and Medical Genetics

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Edited by (Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USA)
  • Formaat: PDF+DRM
  • Ilmumisaeg: 08-Sep-2022
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780323919500
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  • Formaat: PDF+DRM
  • Ilmumisaeg: 08-Sep-2022
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780323919500
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Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses.

In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources.

  • Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics
  • Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine
  • Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout
  • Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction
  • Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation

1. Epigenetics Overview

SECTION I: Molecular Mechanisms of Epigenetics
2. Mechanisms of DNA Methylation and Demethylation during Mammalian Development
3. Mechanisms of Histone Modification
4. The Epigenetics of Non-coding RNA
5. Prions and Prion-like Phenomena in Epigenetic Inheritance
6. Higher-order Chromatin Organization in Diseases
7. Polycomb-group Proteins and Epigenetic Control of Gene Activity

SECTION II: Methods in Epigenetics
8. Methods for Assessing DNA Cytosine Modifications Genome-wide
9. Analyses of Genome-wide Histone Modifications in the Mammalian Genome
10. Techniques for Genome-wide Expression of Non-coding RNA
11. Computational Epigenetics

SECTION III: Model Organisms of Epigenetics 12. Epigenetics of Lower Organisms
13. Drosophila Epigenetics
14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies
15. Plant Epigenomics

SECTION IV: Factors Influencing Epigenetic Changes
16. Dynamic Changes in Epigenetic Modifications During Mammalian Transitions
17. Epigenetic Biomarkers
18. Transposable elements shaping the epigenome
19. Metabolic Regulation of DNA Methylation in Mammalian Cells
20. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications
21. Epigenetics, Stem Cells and Cellular Differentiation
22. Regeneration Epigenetics
23. Epigenetics of X-chromosome Inactivation
24. Epigenetics of Memory Processes
25. Transgenerational Epigenetics
26. DNA Methylation Clocks in Age-related Disease

SECTION V: Evolutionary Epigenetics
27. Evolution of Epigenetic Mechanisms in Plants
28. Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation
29. Adaptive Evolution and Epigenetics

SECTION VI: Epigenetic Epidemiology
30. Epigenetics of Livestock Breeding
31. Nutritional Epigenetics and Metabolic Syndrome
32. Epigenetics of Drug Addiction
33. Environmental Influence of Epigenetics
34. The Gut Microbiota Influence on Human Epigenetics, Health and Disease
35. Population Pharmacoepigenomics

SECTION VII: Epigenetics and Human Disease
36. Cancer Epigenetics
37. The Role of Epigenetics in Autoimmune Disorders
38. Epigenetics of Brain Disorders
39. The Epigenetics of Metabolic Diseases
40. Imprinting Disorders in Humans

SECTION VIII: Epigenetic Therapy
41. DNA Demethylating Agents in Clinical Medicine
42. Clinical Applications of Histone Deacetylase Inhibitors
43. Combination Epigenetic Therapy

SECTION XI: The Future of Epigenetics
44. New Directions for Epigenetic Research: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research

Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewins GENES classic textbook and Lead Editor for Elseviers Translational Epigenetics Series. Dr. Tollefsbol has been named a Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.
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