The handbook provides readers with a useful and accessible reference that summarizes and highlights critical findings in eating disorders to provide foundational knowledge of biological and brain function in eating disorders, how this relates to symptom expression and maintenance, and how this can inform future research and treatment development efforts needed to improve efficacy.
Eating disorders are associated with dangerous and costly medical morbidity, high rates of comorbid psychopathology, significant psychosocial impairment, substantial economic burden, and the highest mortality rate of any psychiatric disorder. These serious disorders have a long history in psychological research, yet advances in neurobiology are relatively new.
The Handbook of the Neurobiology of Eating Disorders provides readers with a useful and accessible reference that summarizes and highlights critical findings in eating disorders to provide foundational knowledge of biological and brain function in eating disorders, how this relates to symptom expression and maintenance, and how this can inform future research and treatment development efforts needed to improve efficacy. The book aims not only to assemble scientific information from a range of areas of neurobiology of eating disorders but also to promote discourse and encourage integration of perspectives. By highlighting the controversies in the field, the book clarifies the distinctions between what is known from the data and what is not yet known, to drive further discovery toward the common goal of improving understanding and treatment of eating disorders.
List of Figures List of Tables Acknowledgments List of Contributors
Christina E. Wierenga;Joanna E. Steinglass: Introduction Part I Overviews
1: B. Timothy Walsh;Hans W. Hoek: Overview of the Classification and
Epidemiology of Eating Disorders 2: William M. Howe;Alexandra G.
DiFeliceantonio: Neurobiology of Ingestive Behavior 3: Diana L.
Williams;Pamela K. Keel: Neuroendocrine Function and the Gut-Brain Axis in
Eating Disorders 4: Jet Termorshuizen;Stefana Aicoboaie;Mohamed
Abdulkadir;Zeynep Yilmaz: Genetics of Eating Disorders 5: Pradyumna
Sepúlveda;Ines Aitsahalia;Stella Dong;Kiyohito Iigaya: Computational
Psychiatry and Eating Disorders Part II Basic Neuroscience Domains in Eating
Disorders ("Bottom Up") 6: Susan Murray;Millie Kirchberg;Walter H. Kaye:
Appetite Regulation and Motivation to Eat 7: Adanya Johnson;Kira Venables;Ann
F. Haynos: Reward Processing and Reinforcement Learning in Eating Disorders
8: Emily M. Choquette;Sahib S. Khalsa: Interoception in Eating Disorders 9:
Carrie McAdams;Amy Harrison: Social Cognition and Processing in Eating
Disorders 10: Valentina Cardi;Natalia Lawrence: Inhibitory Control in
Binge-Type Eating Disorders 11: Andrea Phillipou;Stephanie Miles: Cognitive
Flexibility in Eating Disorders 12: Blair R. K. Shevlin;Maia A.
Chester;Jessica L. Qiu;Siyi Lou;Laura A. Berner: Self-Regulation in Eating
Disorders 13: C. Alix Timko;Annabel Susanin: Visuospatial and
Neuropsychological Functions in Eating Disorders Part III Manifest Symptoms
of Eating Disorders ("Top Down") 14: Karin Foerde: Restrictive Eating
Through the Lens of Choice 15: Kelsey E. Hagan: Binge Eating 16: Katherine
Schaumberg;Lauren Pictor;Max Frank;Sasha Gorrell: Physical Activity and
Exercise 17: Jamie D. Feusner;Valentina Cazzato: Body Image Part IV Emerging
Neurobiologically Informed Treatments 18: Joanna E. Steinglass;Deborah R.
Glasofer: Habit-Centered Treatment for Anorexia Nervosa 19: Christina E.
Wierenga;Stephanie Knatz Peck;Laura Hill: Temperament-Informed Treatment for
Anorexia Nervosa 20: Nancy Zucker: Interoceptive Exposure: Developing
Capacities to Discriminate and Adaptively Respond to Visceral Signals 21:
Philippe De Vloo;Elske Vrieze;Nir Lipsman;D. Blake Woodside;Andres Lozano:
Neurosurgery and Neuromodulation for Eating Disorders Part V Emerging Topics
22: Stephanie C. Dulawa: Advances in the Activity-Based Anorexia Paradigm:
An Animal Model for Aspects of Anorexia Nervosa 23: Jennifer J. Thomas;Laura
M. Holsen;Elizabeth A. Lawson: Neurobiological Model of Avoidant/Restrictive
Food Intake Disorder 24: Jochen Seitz;Stefanie Trinh: The
Microbiome-Gut-Brain Axis in Anorexia Nervosa 25: Guido K. W. Frank: Target
Engagement and Pharmacotherapy in Eating Disorders 26: Natalie
Gukasyan;Samantha Hilbert;Angela S. Guarda: The Potential of Psychedelics in
the Treatment of Eating Disorders Afterword Index
Christina E. Wierenga, PhD, is a Professor in the Department of Psychiatry at the University of California San Diego and a Fellow of Division 40 (Neuropsychology) of the American Psychological Association. Her programmatic research investigates cognitive, behavioral, and brain mechanisms underlying symptom expression in anorexia nervosa and bulimia nervosa to guide development of neurobiologically informed treatments, utilizing neuropsychological, neuroimaging, and computational neuroscience approaches. As the Director of Research and a clinical psychologist in the UCSD Health Eating Disorders Center for Treatment and Research, she has been working with adolescents and adults with eating disorders for more than a decade. She also teaches and supervises graduate students and postdoctoral fellows.
Joanna E. Steinglass, MD is a Professor of Psychiatry at Columbia University Irving Medical Center and the New York State Psychiatric Institute. She is the Director of Research for the Eating
Disorders Research Clinic and a Training Director for the research fellowship. Her interdisciplinary research investigates anorexia nervosa through study of the behavioral and neural mechanisms of illness, using tools from cognitive and computational neuroscience. She applies these insights to the development of behavioral, neuromodulatory, and pharmacological interventions.
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