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E-raamat: Handbook of Neurophotonics

Edited by (European Laboratory for Non Linear Spectroscopy (LENS), Italy), Edited by
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The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light.

Including 30 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain.

Key Features:





Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels. Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice. Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging. Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.
Preface ix
Editors xi
Contributors xiii
PART I Function and Structural Neurophotonic Imaging
Chapter 1 Miniaturized Optical Neuroimaging Systems
3(18)
Hang Yu
Janaka Senarathna
Betty M. Tyler
Nitish V. Thakor
Arvind P. Pathak
Chapter 2 Functional Imaging with Light-Sheet Microscopy
21(34)
Raghav K. Chhetri
Philipp J. Keller
Chapter 3 Two-Photon Microscopy in the Mammalian Brain
55(26)
Hod Dana
Shy Shoham
Chapter 4 Light Field Microscopy for In Vivo Ca2+ Imaging
81(32)
Tobias Nobauer
Alipasha Vaziri
Chapter 5 Genetically Encoded Activity Indicators
113(16)
Chenchen Song
Thomas Knopfel
Chapter 6 Functional Optoacoustic Imaging
129(18)
Daniel Razansky
Chapter 7 Imaging Deep in the Brain with Wavefront Engineering
147(26)
Roarke Horstmeyer
Maximillian Hoffmann
Haowen Ruan
Benjamin Judkewitz
Changhuei Yang
Chapter 8 Nanoscopic Imaging to Understand Synaptic Function
173(18)
Daniel Choquet
Anne-Sophie Hafner
Chapter 9 Chemical Clearing of Brains
191(30)
Klaus Becker
Christian Hahn
Nina Jahrling
Marko Pende
Inna Sabdyusheva-Litschauer
Saiedeh Saghafi
Martina Wanis
Hans-Ulrich Dodt
Chapter 10 Advanced Light-Sheet Microscopy to Explore Brain Structure on an Organ-Wide Scale
221(14)
Ludovico Silvestri
Francesco S. Pavone
PART II Neurophotonic Control and Perturbation
Chapter 11 Optogenetic Modulation of Neural Circuits
235(36)
Mathias Mahn
Oded Klavir
Ofer Yizhar
Chapter 12 Molecular Photoswitches for Synthetic Optogenetics
271(22)
Shai Berlin
Ehud Y. Isacoff
Chapter 13 Applications of Nanoparticles for Optical Modulation of Neuronal Behavior
293(24)
Chiara Paviolo
Shaun Gietman
Daniela Due
Simon E. Moulton
Paul R. Stoddart
Chapter 14 Optical Stimulation of Neural Circuits in Freely Moving Animals
317(16)
Leore R. Heim
Eran Stark
Chapter 15 Holographic Optical Neural Interfaces (HONIs)
333(20)
Shani Rosen
Shir Paluch
Shy Shoham
Chapter 16 Multi-Photon Nanosurgery
353(16)
Anna Letizia Allecra Mascaro
Francesco Saverio Pavone
PART III Clinical and Human Neurophotonics
Chapter 17 High Resolution Diffuse Optical Tomography of the Human Brain
369(30)
Muriah D. Wheelock
Adam T. Eccebrecht
Chapter 18 Human Brain Imaging by Optical Coherence Tomography
399(40)
Caroline Macnain
Jean C. Aucustinack
David Boas
Bruce Fischl
Taner Akkin
Ender Konukoglu
Hui Wang
Chapter 19 Acousto-Optic Cerebral Monitoring
439(20)
Michal Balberc
Revital Pery-Shechter
Chapter 20 Neurophotonic Vision Restoration
459(14)
Adi Schejter Bar-Noam
Shy Shoham
Chapter 21 Optical Cochlear Implants
473(30)
C.-P. Richter
Y. Xu
X. Tan
N. Xia
N. Suematsu
Chapter 22 Label-Free Fluorescence Interrogation of Brain Tumors
503(24)
Brad A. Hartl
Shamira Sridharan
Laura Marcu
Chapter 23 Higher Harmonic Generation Imaging for Neuropathology
527(18)
Nikolay Kuzmin
Sander Idema
Eleonora Aronica
Philip C. de Witt Hamer
Pieter Wesseung
Marie Louise Groot
Index 545
Francesco S. Pavone is full professor at the University of Florence in the Department of Physics and at the European Laboratory for Non-Linear Spectroscopy (LENS), and group leader at the Biophotonics Laboratories. He obtained a PhD in optics in 1993 and spent two years as postdoctoral fellow at the Ecole Normale Superieure with the group of Claude Cohen Tannoudjy (Nobel Prize, 1997). His research group is involved in developing new microscopy techniques for high-resolution and high-sensitivity imaging, and laser manipulation purposes. These techniques have been applied in singlemolecule biophysics, single-cell imaging, and optical manipulation. He is also engaged in tissue imaging research, for which nonlinear optical techniques have been applied to skin and neural tissue imaging. He is the author of more than 100 peer-reviewed journal articles, has delivered more than 60 invited talks. He coordinates various European projects and has organized international congresses. He is director of the international PhD program at LENS. He is on the editorial board of the journal Neurophotonics and is a principal investigator for the Human Brain Project, an EU Flagship initiative.

Shy Shoham is an Associate Professor at the Department of Biomedical Engineering in the Technion - Israel Institute of Technology. He was born in Rehovot, Israel, and holds a B.Sc. degree in Physics from Tel Aviv University and a Ph.D. in Bioengineering from the University of Utah. After completing his Ph.D., he was a Lewis-Thomas postdoctoral fellow at the department of Molecular Biology, Princeton University. In 2005 he joined the Technion's faculty of Biomedical Engineering, where he established the Neural Interface Engineering laboratory. His lab focuses on the development of implant-less retinal prostheses aimed at restoring vision loss from outer-retinal degenerative diseases, and on developing advanced technologies for acoustic neuromodulation, microscopic neuro-imaging and for bioengineering brain-like tissues. He is a recipient of a starting grant from the European Research Council, and of the Daniel Shiran and Juludan awards for engineering advances in bio-medicine, and is a member of the editorial boards of Journal of Neural Engineering, and of Translational Vision Science & Technology.