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E-raamat: Handbook of Vascular Motion

(Adjunct Professor, Stanford University, California, USA)
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 15-Jun-2019
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128157145
  • Formaat - EPUB+DRM
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  • Formaat: EPUB+DRM
  • Ilmumisaeg: 15-Jun-2019
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128157145

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Handbook of Vascular Motion provides a comprehensive review of the strategies and methods to quantify vascular motion and deformations relevant for cardiovascular device design and mechanical durability evaluation. It also explains the current state of knowledge of vascular beds that are particularly important for the medical device industry. Finally, it explores the application of vascular motion to computational simulations, benchtop testing and fatigue analysis, as well as further implications on clinical outcomes, product development and business.

  • Describes methods to quantify vascular motion and deformations including choosing what data to collect, relevant medical imaging, image processing, geometric modeling, and deformation quantification techniques
  • Includes deformations for vascular beds of particular importance in medical devices including the coronary arteries and heart, arteries of the head and neck, thoracic aorta and arch branches, abdominal aorta and visceral branches, lower extremity arteries, inferior vena cava, and lower extremity veins
  • Explains how to convert raw deformations into boundary conditions suitable for durability evaluation, provides examples of using this information for computational simulations, benchtop testing, and fatigue analysis, and illustrates examples of how vascular motion affect clinical outcomes, product development, and business

Arvustused

"Its exciting when a new field opens up -- and thats where we are with vascular motion. Dr. Cheng has provided a clear and highly readable overview of the medical and engineering science surrounding the motion of vessels and the consequences for treatments and technologies. As a bonus, the book is sprinkled with some intriguing hints of new things to come as clinicians, investigators, and inventors pursue this rapidly evolving area." --Paul G. Yock Interventional Cardiologist, Martha Meier Weiland Professor of Medicine, Professor of Bioengineering and Mechanical Engineering (by courtesy), & Director of Byers Center for Biodesign, Stanford University, Stanford, CA

"This first of its kind textbook deals with topics that will gain increasing importance as endovascular grafts are increasingly used to treat vascular lesions. These endografts have to dwell and function in a hostile vascular environment governed by some of the forces described in this unique text. Overcoming these forces is a key challenge for the future. This book will help meet that challenge." --Frank J. Veith Vascular Surgeon, Professor of Surgery, New York University, New York, NY and Director of VEITHsymposium

"Handbook of Vascular Motion is destined to be a must-read for all those interested in the human vascular system. From anatomists to physiologists, vascular clinicians to sports medicine practitioners, biomedical engineers to medical device entrepreneurs, all will find that this special volume provides enlightening evidence of how data-driven insights have dramatically enhanced our understanding of vascular motion and its impact on normal function, development of vascular disease, and design of durable vascular implants. Indeed, Professor Cheng's superb text tackles a previously unaddressed need in an increasingly relevant field of study by focusing on how motion in a wide range of vascular beds impacts the design and performance of medical devices. It is the first comprehensive source to provide a well-organized presentation of the important considerations, including previously unpublished scientific and computational data that underpin the influential effects of vascular motion in humans." --Michael D. Dake Interventional Radiologist, Senior Vice President of University of Arizona Health Sciences & Professor of Medical Imaging, Surgery, and Medicine, University of Arizona, Tuscon, AZ

"I very much enjoyed reading this book which provides a wealth of information on the complex and dynamic movement of blood vessels and how this motion can affect the effectiveness and durability of intravascular devices used to treat cardiovascular disease. We have witnessed remarkable advances in the sophistication and effectiveness of implanted medical devices used to treat cardiovascular disease, which is the number one cause of death and disability in the world. However, our understanding of the biomechanical forces acting on these devices as a result of the complex, dynamic movement of blood vessels in everyday life is limited. This is the first book to bring together the large body of scientific information on the movement of blood vessels to show how this motion can impact the durability and function of implanted devices. This book is a must read and reference source for physicians, scientists, biomedical engineers, medical device developers, safety engineers, and regulators who have an interest in improving the treatment of cardiovascular disease." --Christopher K. Zarins Vascular Surgeon, Emeritus Professor of Surgery, Stanford University, Stanford, CA & Co-Founder and Senior VP of Medical Affairs, HeartFlow, Inc., Redwood City, CA

List of Contributors xi
Foreword xiii
Endorsements xv
Part I Tools For Quantifying Vascular Motion
1 Introduction
Christopher P. Cheng
Do Blood Vessels Move?
3(2)
Absence of Evidence is Not Evidence of Absence
5(1)
Importance of Vascular Motion
6(1)
2 Deciding What Vascular Motions You Need
Christopher P. Cheng
Function and Accommodation
7(2)
Indication and Patient Population
9(1)
Cardiac Pulsatility
10(2)
Respiration and Valsalva
12(2)
Musculoskeletal Influences
14(2)
Body Position and Gravity
16(2)
Don't Reinvent the Wheel
18(1)
Animal Studies
19(1)
Cadaver Studies
20(1)
Clinical Studies
21(1)
Outside Partners
22(1)
Conclusion
22(1)
Reference
22(1)
3 Medical Imaging Modalities and Protocols
Christopher P. Cheng
Medical Imaging Modalities
23(8)
Imaging Based on Target
31(3)
Imaging Based on Type of Motion
34(2)
Imaging Based on Timescale and Periodicity
36(4)
Medical Imaging Protocols
40(3)
Conclusion
43(1)
References
43(3)
4 Geometric Modeling of Vasculature
Christopher P. Cheng
Imaging Processing Software
46(1)
Image Format and Viewing
47(1)
Image Segmentation and Editing
48(5)
Centerline Extraction
53(4)
Optimization of Geometric Modeling
57(3)
Identifying Branch Vessel Ostia
60(2)
Model Coregistration
62(2)
Vessel Surface Modeling
64(2)
Conclusion
66(1)
References
66(1)
5 Quantifying Vascular Deformations
Christopher P. Cheng
Defining and Utilizing Fiducial Markers
67(2)
Cross-Sectional Deformation
69(3)
Axial Length Deformation
72(1)
Bending Deformation
73(4)
Branch Angle Deformation
77(1)
Axial Twist Deformation
77(4)
Surface Curvature Deformation
81(2)
Conclusion
83(1)
References
83(4)
Part II How The Blood Vessels Move
6 Coronary Arteries and Heart
G. Choi
J. Chen
J. Carroll
Christopher P. Cheng
Coronary Anatomy
87(1)
Coronary Artery Cross-Sectional Deformations
88(4)
Coronary Artery Axial, Bending, Twisting, and Bifurcation Angle Deformations
92(11)
Cardiac Anatomy
103(1)
Direct Measurement of Myocardial Motion and Deformation
104(5)
Myocardial Deformation Estimated From Coronary Artery Motion
109(1)
Aortic Valve Motion and Deformation
110(4)
Conclusion
114(1)
References
114(3)
7 Arteries of the Head and Neck
D. Frakes
Christopher P. Cheng
Carotid Artery Anatomy
117(2)
Carotid Artery Motion from Cardiac Pulsatility
119(6)
Carotid Artery Motion from Musculoskeletal Movement with and without Medical Devices
125(4)
Vertebrobasilar Artery Anatomy
129(2)
Vertebrobasilar Artery Motion from Natural Musculoskeletal Movement
131(2)
Vertebrobasilar Artery Motion from Manipulation
133(1)
Vertebrobasilar Artery Motion Due to Medical Devices
134(1)
Conclusion
135(1)
References
135(4)
8 Thoracic Aorta and Supra-Aortic Arch Branches
B. Ullery
G. Suh
Christopher P. Cheng
Anatomy of Thoracic Aorta
139(2)
Geometric Analysis Methods
141(2)
Pathologies of the Thoracic Aorta
143(2)
Thoracic Aortic Deformations
145(11)
Pathologies of the Aortic Arch and Supra-Aortic Arch Branches
156(2)
Supra-Aortic Arch Branch Vessel Deformations
158(2)
Conclusion
160(1)
References
160(5)
9 Abdominal Aorta and Renovisceral Arteries
G. Suh
B. Ullery
Christopher P. Cheng
Anatomy of Abdominal Aorta
165(1)
Geometric Analysis Methods
166(2)
Pathologies of the Abdominal Aorta
168(3)
Abdominal Aortic Deformations
171(6)
Pathologies of the Renovisceral Arteries
177(2)
Renovisceral Artery Deformations
179(8)
Conclusion
187(1)
References
187(4)
10 Lower Extremity Arteries
Christopher P. Cheng
Iliac Artery
191(9)
Femoropopliteal Artery
200(18)
Tibial Arteries
218(3)
Conclusion
221(1)
References
222(4)
11 Veins of the Upper Body
A. Carr
Christopher P. Cheng
Upper Body Venous Anatomy
226(2)
Changes in Venous Anatomy with Posture
228(2)
Respiration and Its Effects on Venous Caliber
230(3)
PathologiCal Conditions and Venous Devices
233(3)
Central Line Movements with Respiration and Postural Change
236(2)
Deep Versus Superficial Fixation and the Effects of Body Habitus
238(1)
Complications of Device Placement
239(2)
Upper Limb Deep Venous Thrombosis
241(1)
Challenges of Vascular Access for Renal Replacement Therapies
242(2)
Conclusion
244(1)
References
244(3)
12 Inferior Vena Cava and Lower Extremity Veins
Christopher P. Cheng
Veins versus Arteries
247(3)
Inferior Vena Cava and Renal Veins
250(8)
Iliofemoral Veins
258(7)
Femoropopliteal Veins
265(5)
Conclusion
270(1)
References
270(5)
Part III Utilizing Vascular Motion Data And Implications
13 Developing Boundary Conditions for Device Design and Durability Evaluation
Christopher P. Cheng
Choosing Deformation Metrics
275(2)
Sample Statistics
277(2)
Defining the Duty Cycle
279(7)
Number and Frequency of Cycles
286(1)
Goldilocks Zone
287(1)
Conclusion
288(1)
References
288(3)
14 Device Design and Computational Simulation
C. Bonsignore
Since the Dawn of Stent Engineering
291(1)
Rapid Change
292(1)
The Product Development Process
292(1)
The Discovery Cycle
293(1)
Inspiration
294(1)
Goals and Constraints
295(1)
Engineering
296(4)
Fabrication
300(1)
Design Control and Engineering Specifications
300(3)
Simulation
303(1)
Finite Element Analysis
304(3)
Feasibility Screening
307(3)
Prototype and Test
310(1)
Conclusion
311(1)
References
312(2)
15 Evaluation of Mechanical Fatigue and Durability
A.R. Pelton
Principles of Fatigue and Durability Assessment
314(1)
Cardiovascular Implant Analysis and Testing Methods
315(2)
Case Study 1: Balloon-Expandable Stent
317(4)
Case Study 2: Nitinol Self-Expanding Stent
321(8)
Case Study 3: Structural Heart Implant Device
329(3)
Conclusion
332(1)
References
333(5)
16 Clinical Implications of Vascular Motion
K. Ouriel
Clinical Consequences of Coronary Stent Fracture
338(1)
Clinical Consequences of Lower Extremity Artery Stent Fracture
339(1)
Clinical Consequences of Early Aortic Endograft Failures
340(3)
New Endografts: Are We Reliving Past Problems?
343(1)
Postimplantation Surveillance for Device Failure
344(3)
Conclusion
347(1)
References
347(5)
17 Product Development and Business Implications
C. Myers
B. Wolf
M. Nilson
A. Byrne
S. Rush
J. Elkins
A. Ragheb
B. Roeder
R. Swift
J. Metcalf
T. Duerig
Christopher P. Cheng
The Endurant Evo Experience
352(5)
The TAG Experience
357(3)
Coordination of R&D and Sales Rollout
360(2)
Surprises with Early Endovascular Aortic Repair
362(3)
The Zilver PTX Experience
365(4)
Improving Stent Performance
369(2)
Conclusion
371(1)
References
372(1)
18 Conclusion and Future Directions
Christopher P. Cheng
Vasculature Mobility Is Important
373(1)
Fractures Do Not Equal Failures
374(2)
Vascular Deformations Beyond Mechanical Durability Testing
376(2)
Improving Mechanical Durability in a Pinch
378(2)
Conclusion
380(1)
References
380(1)
Acknowledgments 381(2)
About the Author 383(2)
Index 385
Dr. Christopher Cheng has over 20 years of experience in academic research and the medical device industry. His academic research has focused on hemodynamics and vascular structure mechanics, with an emphasis on disease research and medical device interactions with the body. He has authored over 80 journal, conference, and book chapter publications. In his industry experience, Dr. Cheng has worked at small and large medical device companies, with experience spanning design, manufacturing, preclinical testing, clinical trials, and marketing. Currently, Dr. Cheng is CEO of Koli, Inc., an early-stage medical device company developing a catheter-based solution for gallstone disease. Dr. Cheng is also an Adjunct Professor in the Division of Vascular Surgery at Stanford, where he runs the Vascular Intervention Biomechanics & Engineering (VIBE) lab. Dr. Cheng earned his undergraduate degree in Biomedical Engineering and Electrical & Computer Engineering at Duke University. He then earned Masters and Ph.D. degrees in Biomechanics at Stanford University.