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E-raamat: Harper's Textbook of Pediatric Dermatology

Edited by (University College London Institute of Child Health, London, UK), Edited by (University of Pennsylvania, Philadelphia, PA, USA), Associate editor , Associate editor , Consultant editor (University College London, UK), Associate editor , Consultant editor (Erasmus Medical Center, Rotterdam, Netherlands-), Associate editor , Associate editor , Edited by (University of Hamburg, Germany)
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  • Ilmumisaeg: 04-Dec-2019
  • Kirjastus: Wiley-Blackwell
  • Keel: eng
  • ISBN-13: 9781119142805
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  • Ilmumisaeg: 04-Dec-2019
  • Kirjastus: Wiley-Blackwell
  • Keel: eng
  • ISBN-13: 9781119142805
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A consummate classic with a fresh approach to pediatric dermatology

Children s skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment.
This fourth edition of the Harper classic provides state-of-the-art information on all aspects of skin disease in children. It covers the diagnosis and treatment of all conditions - both common and rare - with a consistently evidence-based approach. Existing content has been refreshed and fully updated to reflect emerging thinking and to incorporate the latest in research and clinical data - especially at the genetic level.

This new fourth edition includes:

  • Greater focus on the genetics behind skin disease, including new genes/genodermatoses, progress in genetic analysis, and stem cell transplants
  • Increased coverage of lasers and other technologies used to treat skin disease
  • More summary tables, learning points, tables of differential diagnosis, and clinical algorithms for diagnosis and management
  • Additional online features, including patient information links and multiple choice questions

Harper's Textbook of Pediatric Dermatology delivers crucial clinical insights and up-to-date research information that spans the breadth of the field. As the most comprehensive reference book on this subject available, this revised fourth edition will support and guide the daily practice of both dermatologists and pediatricians across the world.

Volume 1
List of Contributors
xi
Preface to the Fourth Edition
xxiv
Dedication to Arnold P. Oranje
xxv
Acknowledgements
xxvi
List of Abbreviations
xxvii
Section 1 Development, Structure and Physiology of the Skin
1 Embryogenesis of the Skin
1(35)
Lara Wine Lee
Karen A. Holbrook
2 Molecular Genetics in Paediatric Dermatology
36(10)
Anna C. Thomas
Veronica A. Kinsler
3 Cutaneous Microbiome
46(10)
Carrie C. Coughlin
William H. McCoy IV
4 Physiology of Neonatal Skin
56(7)
Peter H. Hoeger
Section 2 Skin Disorders of the Neonate and Young Infant
5 Neonatal Skin Care
63(9)
Peter H. Hoeger
6 Transient Skin Disorders in the Neonate and Young Infant
72(12)
Margarita Larralde
Maria Eugenia Abad
7 Congenital and Acquired Infections in the Neonate
84(9)
Scott H. James
Nico G. Hartwig
David W. Kimberlin
Peter H. Hoeger
8 Transplacentally Acquired Dermatoses
93(8)
Paula Carolina Luna
9 Developmental Anomalies
101(20)
Marion Wobser
Henning Hamm
10 Differential Diagnosis of Neonatal Erythroderma
121(13)
Hagen Ott
Peter H. Hoeger
11 Vesiculopustular, Bullous and Erosive Diseases of the Neonate
134(20)
Caroline Mahon
Anna E. Martinez
12 Iatrogenic Disorders of the Newborn
154(13)
Elia F. Maalouf
Wilson Lopez
Section 3 Atopic Dermatitis and Related Disorders
13 Epidemiology of Atopic Dermatitis
167(17)
Carsten Flohr
Jonathan I. Silverberg
Joy Wan
Sinead M. Langan
14 Genetics and Aetiology of Atopic Dermatitis
184(9)
Elke Rodriguez
Stephan Weidinger
15 Clinical Features and Diagnostic Criteria of Atopic Dermatitis
193(19)
Sinead M. Langan
Hywel C. Williams
16 Severity Scoring and Quality of Life Assessment in Atopic Dermatitis
212(16)
Christian Apfelbacher
Cecilia A.C. Prinsen
Daniel Heinl
Hywel C. Williams
17 Atopic Dermatitis and Related Disorders: Special Types of Presentation
228(17)
Nawaf Almutairi
18 Atopic Dermatitis: Complications
245(8)
Kevin B. Yarbrough
Eric L. Simpson
19 Management of Atopic Dermatitis
253(12)
Lea Solman
Mary Glover
Section 4 Other Types of Dermatitis
20 Napkin Dermatitis
265(14)
Arnold P. Oranje
Ernesto Bonifazi
Paul J. Honig
Albert C. Yan
21 Adolescent Seborrhoeic Dermatitis
279(8)
Roselyn Kellen
Nanette Silverberg
22 Irritant Contact Dermatitis
287(13)
David Luk
23 Allergic Contact Dermatitis
300(16)
Sharon E. Jacob
Hannah Hill
Alina Goldenberg
24 Hypereosinophilic Disorders
316(19)
Eirini E. Merika
Nerys Roberts
25 Juvenile Plantar Dermatosis
335(3)
John C. Browning
Margaret Brown
26 Perioral Dermatitis
338(5)
Marius Rademaker
Section 5 Psoriasis
27 Psoriasis: Epidemiology
343(7)
Matthias Augustin
Marc Alexander Radtke
28 Psoriasis: Aetiology and Pathogenesis
350(4)
Jonathan Barker
29 Psoriasis: Clinical Features and Comorbidities
354(8)
Derek H. Chu
Kelly M. Cordoro
30 Psoriasis: Classification, Scores and Diagnosis
362(6)
Nirav Patel
Megha Tollefson
31 Psoriasis: Management
368(9)
Marieke M.B. Seyger
Section 6 Other Papulosquamous Disorders
32 Pityriasis Rubra Pilaris
377(13)
Liat Samuelov
Eli Sprecher
33 Lichen Planus
390(13)
Vibhu Mendiratta
Sarita Sanke
34 Lichen Nitidus
403(5)
Jasem M. Alshaiji
35 Lichen Striatus
408(8)
Franck Boralevi
Alain Tareb
36 Pityriasis Rosea
416(7)
Antonio A.T. Chuh
Vijay Zawar
Section 7 Bacterial Skin Infections
37 Pyodermas and Bacterial Toxin-mediated Syndromes
423(11)
James R. Treat
Christian R. Millett
Warren R. Heymann
Steven M. Manders
38 Cutaneous Manifestations of Gram-negative Infections
434(22)
Saul N. Faust
Diane Gbesemete
Robert S. Heyderman
39 Pitted Keratolysis, Erythrasma and Erysipeloid
456(7)
Zhe Xu
Yuanyuan Xiao
Ying Xiu
Lin Ma
40 Lyme Borreliosis
463(12)
Susan O'Connell
41 Bartonella Infections
475(10)
Sonia Kamath
Minnelly Luu
42 Mycobacterial Skin Infections
485(18)
G. Sethuraman
Tanvi Dev
V. Ramesh
43 Rickettsial Disease
503(12)
Arun C. Inamadar
Aparna Palit
44 Endemic Treponematoses: Yaws, Pinta and Endemic Syphilis
515(8)
Herman Jan H. Engelkens
45 Tropical Ulcer
523(4)
Vibhu Mendiratta
Soumya Agarwal
Section 8 Fungal Skin Infections
46 Superficial Fungal Infections
527(33)
Peter Mayser
Yvonne Grdser
47 Deep Fungal Infections
560(19)
Maria Teresa Garcia-Romero
Section 9 Viral Skin Infections and Opportunistic Infections
48 Molluscum Contagiosum
579(9)
Joachim J. Bugert
Ali Alikhan
Tor Shwayder
49 Human Papillomavirus Infection
588(10)
Yun Tong
Stephen K. Tyring
Zsuzsanna Z. Szalai
50 Herpes Simplex Virus Infections
598(14)
Manuraj Singh
Helen M. Goodyear
Judith Breuer
51 Varicella Zoster Virus Infections
612(12)
Manuraj Singh
Judith Breuer
52 Poxvirus Infections
624(25)
Susan Lewis-Jones
Jane C. Sterling
53 HIV and HTLV-1 Infection
649(11)
Neil S. Prose
Ncoza C. Dlova
Rosalia A. Ballona
Coleen K. Cunningham
54 Viral Exanthems
660(21)
Jusleen Ahluwalia
Pamela Gangar
Sheila Fallon Friedlander
55 Eruptive Hypomelanosis
681(3)
Vijay Zawar
Antonio A.T. Chuh
56 Cutaneous Infections in Immunocompromised Children
684(9)
Miriam Weinstein
Hagen Ott
Peter H. Hoeger
Section 10 Parasitic Skin Infestations and Sting Reactions
57 Leishmaniasis
693(9)
Bernardo Gontijo
Carolina Talhari
58 Helminthic Infections
702(9)
Hector Caceres-Rios
Felipe Velasquez
59 Scabies and Pseudoscabies
711(12)
Wingfield E. Rehmus
Julie S. Prendiville
60 Pediculosis and Cimicosis
723(10)
Sandipan Dhar
Sahana M. Srinivas
61 Noxious and Venomous Creatures
733(13)
Kam Lun Ellis Hon
Theresa Ngan Ho Leung
Ting Fan Leung
62 Aquatic Dermatoses
746(5)
Sarah Hill
Section 11 Urticaria, Erythemas and Drug Reactions
63 Urticaria
751(13)
Bettina Wedi
64 Annular Erythemas
764(7)
Kimberly A. Horii
65 Gianotti-Crosti Syndrome
771(6)
Carlo M. Gelmetti
66 Erythema Multiforme, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
777(8)
Benjamin S. Daniel
Lizbeth Ruth Wheeler
Dedee F. Murrell
67 Hypersensitivity Reactions to Drugs
785(18)
Mohannad Abu-Hilal
Neil Shear
Section 12 Acne and Acneiform Disorders
68 Acne
803(18)
Marissa J. Perman
Bodo C. Melnik
Anne W. Lucky
69 Childhood Rosacea
821(4)
Clio Dessinioti
Andreas Katsambas
70 Hidradenitis Suppurativa
825(6)
Peter Theut Riis
Gregor B.E. Jemec
Section 13 Nutritional Disorders
71 Skin Manifestations of Nutritional Disorders
831(10)
Carola Duran McKinster
Luz Orozco-Covarrubias
72 Skin Manifestations of Paediatric Metabolic Syndrome
841(18)
Gregor Holzer
Beatrix Volc-Platzer
Section 14 Blistering Disorders
73 Differential Diagnosis of Vesiculobullous Lesions
859(9)
Sharleen F. Hill
Dedee F. Murrell
74 Autoimmune Bullous Diseases
868(30)
Nina van Beek
Enno Schmidt
75 Childhood Dermatitis Herpetiformis
898(9)
Carmen Liy Wong
Irene Lara-Corrales
76 Epidermolysis Bullosa and Kindler Syndrome
907(36)
Jemima E. Mellerio
Anna E. Martinez
Christina Has
Section 15 Photodermatoses, Photoprotection and Environmental Skin Disorders
77 The Idiopathic Photodermatoses and Skin Testing
943(14)
Erhard Holzle
Robert Dawe
78 The Porphyrias
957(12)
Jorge Frank
79 Photoprotection
969(14)
Lachlan Warren
Genevieve Casey
80 Skin Reactions to Plants, Cold, Heat and Chemicals
983(12)
Tuyet A. Nguyen
Christopher Lovell
Andrew C. Krakowski
Section 16 Granulomatous Diseases
81 Sarcoidosis
995(11)
Lisa M. Arkin
Julie L. Cantatore-Francis
Julie V. Schaffer
82 Granuloma Annulare
1006(11)
Annalisa Patrizi
Iria Neri
83 Orofacial Granulomatosis
1017(6)
Lisa Weibel
Martin Theiler
Section 17 Neutrophilic Dermatoses
84 Sweet Syndrome
1023(4)
Peter von den Driesch
85 Pyoderma Gangrenosum
1027(8)
Karolina Gholam
Section 18 Lymphocytic Disorders
86 Pityriasis Lichenoides
1035(5)
Christine T. Lauren
Maria C. Garzon
87 Jessner Lymphocytic Infiltrate of the Skin
1040(4)
R.M. Ross Hearn
88 Primary Cutaneous Lymphoma
1044(19)
Rebecca Levy
Elena Pope
89 Childhood Leukaemias and Lymphomas
1063(8)
Keith Morley
Jennifer Huang
Section 19 Histiocytic Disorders
90 Langerhans Cell Histiocytosis
1071(7)
Sylvie Fraitag
Jean Donadieu
91 Juvenile Xanthogranuloma and Other Non-Langerhans Cell Histiocytoses
1078(19)
Gudrun Ratzinger
Bernhard W.H. Zelger
Section 20 Mastocytosis
92 Paediatric Mastocytosis
1097(14)
Laura Polivka
Christine Bodemer
Section 21 Disorders of Connective Tissue
93 Ehlers-Danlos Syndromes
1111(14)
Nigel P. Burrows
94 Pseudoxanthoma Elasticum and Cutis Laxa
1125(14)
Sean D. Reynolds
Lionel Bercovitch
95 Buschke-Ollendorff Syndrome, Marfan Syndrome and Osteogenesis Imperfecta
1139(12)
Marc Lacour
96 Anetodermas and Atrophodermas
1151(13)
Marc Lacour
97 Hyalinoses, Stiff Skin Syndrome and Restrictive Dermopathy
1164(8)
David G. Paige
98 Striae in Children and Adolescents
1172(3)
Marcelo Ruvertoni
99 Morphoea (Localized Scleroderma)
1175(8)
Despina Eleftheriou
Lindsay Shaw
100 Systemic Sclerosis in Childhood
1183(12)
Christopher P. Denton
Carol M. Black
Index
i1
Volume 2
Section 22 Disorders of Fat Tissue
101 Lipoma and Lipomatosis
1195(12)
Siriwan Wananukul
Susheera Chatproedprai
102 Panniculitis in Children
1207(14)
Christine Bodemer
103 Lipodystrophies
1221(8)
Robert K. Semple
Section 23 Mosaic Disorders, Naevi and Hamartomas
104 An Introduction to Mosaicism
1229(8)
Veronica A. Kinsler
105 Melanocytic Naevi
1237(23)
Veronica A. Kinsler
106 Epidermal Naevi
1260(16)
Leopold M. Groesser
Christian Hafner
107 Other Naevi and Hamartomas
1276(7)
Jonathan A. Dyer
108 Proteus Syndrome and Other Localized Overgrowth Disorders
1283(13)
Veronica A. Kinsler
109 Mosaic Disorders of Pigmentation
1296(17)
Veronica A. Kinsler
Section 24 Nonvascular Skin Tumours
110 Differential Diagnosis of Skin Nodules and Cysts
1313(12)
Susanne Abraham
Peter H. Hoeger
111 Adnexal Disorders
1325(13)
Andrew Wang
Robert Sidbury
112 Calcification and Ossification in the Skin
1338(12)
Amanda T. Moon
Albert C. Yan
Eulalia T. Baselga
113 Angiolymphoid Hyperplasia with Eosinophilia
1350(6)
Jasem M. Alshaiji
114 Fibromatoses
1356(14)
Jenna L. Streicher
Moise L. Levy
Albert C. Yan
115 Carcinomas of the Skin
1370(7)
Karen Agnew
116 Childhood Melanoma
1377(5)
Birgitta Schmidt
Elena B. Hawryluk
117 Other Malignant Skin Tumours
1382(17)
Andrea Bettina Cervini
Marcela Bocian
Maria Marta Bujan
Paola Stefano
Section 25 Vascular Tumours and Malformations
118 Vascular Malformations
1399(26)
Laurence M. Boon
Miikka Vikkula
119 Infantile Haemangiomas
1425(15)
Anna L. Bruckner
Ilona J. Frieden
Julie Powell
120 Other Vascular Tumours
1440(12)
Ann M. Kulungowski
Taizo A. Nakano
Anna L. Bruckner
121 Disorders of Lymphatics
1452(11)
Arin K. Greene
Jeremy A. Goss
Section 26 Disorders of Pigmentation
122 Inherited and Acquired Hyperpigmentation
1463(13)
Leslie Castelo-Soccio
Alexis Weymanh Perlmutter
123 Vitiligo
1476(10)
Julien Seneschal
Juliette Mazereeuw-Hautier
Alain Taieb
124 Albinism
1486(6)
Fanny Morice-Picard
Alain Taieb
125 Disorders of Hypopigmentation
1492(7)
M.W. Bekkenk
A. Wolkerstorfer
126 Dyschromatosis
1499(16)
Liat Samuelov
Eli Sprecher
Section 27 Disorders of Keratin and Keratinization
127 Review of Keratin Disorders
1515(9)
Maurice A.M. van Steensel
Peter M. Steijlen
128 Mendelian Disorders of Cornification (MEDOC): The Keratodermas
1524(25)
Edel A. O'Toole
129 Mendelian Disorders of Cornification (MEDOC): The Ichthyoses
1549(50)
Angela Hernandez
Robert Gruber
Vinzenz Oji
130 Keratosis Pilaris and Darier Disease
1599(9)
Flora B. de Waard-van der Spek
Arnold P. Oranje
131 The Erythrokeratodermas
1608(5)
Juliette Mazereeuw-Hautier
S. Leclerc-Mercier
E. Bourrat
132 Netherton Syndrome
1613(10)
Wei-Li Di
John Harper
133 Porokeratosis
1623(6)
Leslie Castelo-Soccio
Section 28 Focal or Generalized Hypoplasia and Premature Ageing
134 Ectodermal Dysplasias
1629(77)
Cathal O'Connor
Yuka Asai
Alan D. Irvine
135 Focal Dermal Hypoplasia
1706(12)
Bret L. Bostwick
Ignatia B. Van den Veyver
V Reid Sutton
136 Incontinentia Pigmenti
1718(7)
Elizabeth A. Jones
Dian Donnai
137 Premature Ageing Syndromes
1725(18)
Helga V Toriello
Caleb P. Bupp
Section 29 Genetic Diseases Predisposing to Malignancy
138 Xeroderma Pigmentosum and Related Diseases
1743(26)
Steffen Schubert
Steffen Emmert
139 Gorlin (Naevoid Basal Cell Carcinoma) Syndrome
1769(17)
Kai Ren Ong
Peter A. Farndon
140 Rothmund-Thomson Syndrome, Bloom Syndrome, Dyskeratosis Congenita, Fanconi Anaemia and Poikiloderma with Neutropenia
1786(16)
Lisa L. Wang
Moise L. Levy
141 Other Genetic Disorders Predisposing to Malignancy
1802(21)
Julie V. Schaffer
Section 30 Neurofibromatosis, RASopathies and Hamartoma-Overgrowth Syndromes
142 The Neurofibromatoses
1823(14)
Amy Theos
Kevin P. Boyd
Bruce R. Korf
143 Tuberous Sclerosis Complex
1837(20)
Francis J. DiMario Jr
144 Other RASopathies
1857(8)
Fanny Morice-Picard
Section 31 Vasculitic and Rheumatic Syndromes
145 Cutaneous Vasculitis
1865(26)
Joyce C. Chang
Pamela F. Weiss
146 Purpura Fulminans
1891(15)
Michael Levin
Brian Eley
Saul N. Faust
147 Kawasaki Disease
1906(12)
Wynnis L. Tom
Jane C. Burns
148 Polyarteritis Nodosa, Granulomatosis with Polyangiitis and Microscopic Polyangiitis
1918(15)
Paul A. Brogan
149 Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus and Juvenile Dermatomyositis
1933(19)
Elena Moraitis
Despina Eleftheriou
150 Behcet Disease and Relapsing Polychondritis
1952(9)
Sibel Ersoy-Evans
Awn Karaduman
Seza Ozen
151 Erythromelalgia
1961(4)
Nedaa Skeik
Section 32 Cutaneous Manifestations of Systemic Disease
152 Metabolic Disorders and the Skin
1965(23)
Fatma Al Jasmi
Hassan Galadari
Peter T. Clayton
Emma J. Footitt
153 Cystic Fibrosis
1988(5)
Roderic J. Phillips
154 Cutaneous Manifestations of Endocrine Disease
1993(17)
Devika Icecreamwala
Tor A. Shwayder
155 Autoinflammatory Diseases and Amyloidosis
2010(18)
Antonio Torrelo
Sergio Hernandez-Ostiz
Teri A. Kahn
156 Immunodeficiency Syndromes
2028(39)
Julie V. Schaffer
Melanie Makhija
Amy S. Paller
157 Graft-Versus-Host Disease
2067(12)
John Harper
Paul Veys
Section 33 The Oral Cavity
158 The Oral Mucosa and Tongue
2079(24)
Jane Luker
Crispian Scully
Section 34 Hair, Scalp and Nail Disorders
159 Hair Disorders
2103(36)
Elise A. Olsen
Matilde Iorizzo
160 Alopecia Arcata
2139(8)
Kerstin Foitzik-Lau
161 Nail Disorders
2147(12)
Antonella Tosti
Bianca Maria Piraccini
Section 35 Anogenital Disease in Children
162 Genital Disease in Children
2159(36)
Gayle O. Fischer
163 Sexually Transmitted Diseases in Children and Adolescents
2195(24)
Arnold P. Oranje
Robert A.C. Bilo
Nico G. Hartwig
Section 36 Cutaneous Signs of Child Maltreatment and Sexual Abuse
164 Maltreatment, Physical and Sexual Abuse
2219(22)
Bernhard Herrmann
Section 37 Psychological Aspects of Skin Disease in Children
165 Assessing and Scoring Life Quality
2241(14)
Andrew Y. Finlay
166 Coping with the Burden of Disease
2255(7)
Sarah L. Chamlin
167 Physiological Habits, Self-Mutilation and Factitious Disorders
2262(13)
Arnold P. Oranje
Jeroen Novak
Robert A.C. Bilo
Section 38 Principles of Treatment in Children
168 Topical Therapy
2275(7)
Johannes Wohlrab
169 Systemic Therapy in Paediatric Dermatology
2282(19)
Blanca Rosa Del Pozzo-Magana
Irene Lara-Corrales
170 New Genetic Approaches to Treating Diseases of the Skin
2301(9)
Stephen Hart
Amy Walker
171 Surgical Therapy
2310(9)
Julianne A. Mann
Jane S. Bellet
172 Laser Therapy
2319(11)
Samira Batul Syed
Maria Gnarra
Sean Lanigan
173 Sedation and Anaesthesia
2330(11)
Brenda M. Simpson
Yuin-Chew Chan
Lawrence F. Eichenfield
Section 39 Diagnostic Procedures in Dermatology
174 Approach to the Paediatric Patient
2341(16)
Diana Purvis
175 Dermoscopy of Melanocytic Lesions in the Paediatric Population
2357(21)
Maria L. Marino
Jennifer L. DeFazio
Ralph P. Braun
Ashfaq A. Marghoob
176 The Role of Histopathology and Molecular Techniques in Paediatric Dermatology
2378(15)
Lori Prok
Adnan Mir
Section 40 Nursing Care of Cutaneous Disorders in Children
177 Nursing Care of the Skin in Children
2393
Bisola Laguda
Hilary Kennedy
Jackie Denyer
Heulwen Wyatt
Jean Robinson
Karen Pett
Index i1
EDITORS

Peter Hoeger is Head of the Departments of Pediatrics and Pediatric Dermatology, Catholic Children's Hospital Wilhelmstift, and Professor of Pediatrics and Dermatology, University of Hamburg, Hamburg, Germany.

Veronica Kinsler is Consultant Paediatric Dermatologist and Academic Lead Clinician, Paediatric Dermatology Department, Great Ormond Street Hospital for Children, and Associate Professor, Genetics and Genomic Medicine, University College London Institute of Child Health, London, UK.

Albert Yan is Professor of Pediatrics and Dermatology and Chief of Pediatric Dermatology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

John Harper is Honorary Professor of Paediatric Dermatology, University College London, Institute of Child Health / Great Ormond Street Hospital, London, UK.

Arnold Oranje was formerly Consultant in General and Pediatric Dermatology and Professor of Pediatric Dermatology, Department of Pediatrics, Erasmus Medical Center, Rotterdam, Netherlands.

Christine Bodemer is Professor in Dermatology and Coordinator, Centre de reference sur les Maladies Génétiques à Expression Cutanée (MAGEC), Hôpital Necker-Enfants Malades, Paris, France.

Margarita Larralde is Tenured Professor of Dermatology at the University of Buenos Aires (UBA) and Director of the Carrera de Médicos Specialists in Pediatric Dermatology at Ramos Mejía Hospital Headquarters, Buenos Aires, Argentina.

David Luk is Consultant Pediatrician, Department of Pediatrics, United Christian Hospital, Kwun Tong, Hong Kong.

Vibhu Mendiratta is Professor of Dermatology, Lady Hardinge Medical College, Delhi, India.

Diana Purvis is Paediatric Dermatologist, Starship Children's Health, Auckland, New Zealand.