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E-raamat: Harrison's Principles of Internal Medicine 19th Edition and Harrison's Manual of Medicine 19th Edition (EBook)VAL PAK

  • Formaat: EPUB+DRM
  • Ilmumisaeg: 18-Nov-2017
  • Kirjastus: McGraw-Hill Education
  • Keel: eng
  • ISBN-13: 9781260129076
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  • Formaat: EPUB+DRM
  • Ilmumisaeg: 18-Nov-2017
  • Kirjastus: McGraw-Hill Education
  • Keel: eng
  • ISBN-13: 9781260129076
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SPECIAL OFFER! SAVE WHEN YOU PURCHASE HARRISON’S PRINCIPLES OF INTERNAL MEDICINE, 19e ALONG WITH THE COMPANION HARRISON’S MANUAL!

This dollar-saving Harrison’s bundle includes these two great resources: 

Harrison’s Principles of Internal Medicine, Nineteenth Edition

Through six decades, no resource has matched the authority, esteemed scholarship, and scientific rigor of  Harrison's Principles of Internal Medicine. Capturing the countless advances and developments across the full span of medicine, the 19th edition of Harrison’s provides a complete update of essential content related to disease pathogenesis, clinical trials, current diagnostic methods and imaging approaches, evidence-based practice guidelines, and established and newly approved treatment methods.

Here are just a few of the outstanding features of the Nineteenth Edition:
Presented in two volumes: Volume 1 is devoted to foundational principles, cardinal manifestations of disease and approach to differential diagnosis; Volume 2 covers disease pathogenesis and treatment
NEW chapters on important topics such as Men’s Health, The Impact of Global Warming on Infectious Diseases, Fatigue, and many more
Critical updates in management and therapeutics in Hepatitis, Coronary Artery Disease, Ebola Virus Disease, Multiple Sclerosis, Diabetes, Hypertension, Deep Vein Thrombosis and Pulmonary Embolism, Acute and Chronic Kidney Disease, Inflammatory Bowel Disease, Lipoprotein Disorders, HIV and AIDS, and more.
Increased number of the popular Harrison’s clinical algorithms; clinically relevant radiographic examples spanning hundreds of diseases; clinical-pathological images in full color; crystal clear, full color drawings and illustrations and helpful tables and summary lists that make clinical application of the content faster than ever
Access to outstanding multi-media resources including practical videos demonstrating essential bedside procedures, physical examination techniques, endoscopic findings, cardiovascular findings, and more

The package also includes…..

Harrison’s Manual of Medicine, Nineteenth Edition 
Harrison’s Manual of Medicine is a concise, bedside resource derived from content found in Harrison’s Principles of Internal Medicine, Nineteenth Edition.  Perfect for use at the point of care, the Manual presents clinical information covering key aspects of the diagnosis, clinical manifestations, and treatment of the major diseases that are likely to be encountered in medical practice. Presented in full color and incorporating an efficient blend of succinct text, bullet points, algorithms, and tables Harrison’s Manual of Medicine, Nineteenth Edition covers every area of clinical medicine, including:
•        Etiology and Epidemiology
•        Clinically Relevant Pathophysiology
•        Signs and Symptoms
•        Differential Diagnosis
•        Physical and Laboratory Findings
•        Therapeutics
•        Practice Guidelines
 

Harrison's Principles of Internal Medicine: Volume 1
Contributors
xix
Preface
xxxvii
Part 1: General Considerations in Clinical Medicine
1 The Practice of Medicine
1(6)
Anthony S. Fauci
Stephen L. Hauser
J. Larry Jameson
Dennis L. Kasper
Dan L. Longo
Joseph Loscalzo
2 Global Issues in Medicine
7(11)
Paul Farmer
Joseph Rhatigan
3 Decision-Making in Clinical Medicine
18(8)
Daniel B. Mark
John B. Wong
4 Screening and Prevention of Disease
26(5)
Katrina Armstrong
Gary J. Martin
5 Principles of Clinical Pharmacology
31(14)
Dan M. Roden
6e Women's Health
45(1)
Andrea Dunaif
7e Men's Health
45(1)
Shalender Bhasin
Shehzad Basaria
8 Medical Disorders During Pregnancy
45(6)
Robert L. Barbieri
John T. Repke
9 Medical Evaluation of the Surgical Patient
51(4)
Wei C. Lau
Kim A. Eagle
10 Palliative and End-of-Life Care
55(15)
Ezekiel J. Emanuel
11 Clinical Problems of Aging
70(15)
Luigi Ferrucci
Stephanie Studenski
12e The Safety and Quality of Health Care
85(1)
David W. Bates
13e Primary Care in Low-and Middle-Income Countries
85(1)
Tim Evans
Kumanan Rasanathan
14e Complementary, Alternative, and Integrative Health Practices
86(1)
Josephine P. Briggs
15e The Economics of Medical Care
86(1)
Joseph P. Newhouse
16e Racial and Ethnic Disparities in Health Care
86(1)
Joseph R. Betancourt
Alexander R. Green
17e Ethical Issues in Clinical Medicine
86(1)
Bernard Lo
Christine Grady
Part 2: Cardinal Manifestations and Presentation of Diseases
Section 1: Pain
18 Pain: Pathophysiology and Management
87(8)
James P. Rathmell
Howard L. Fields
19 Chest Discomfort
95(8)
David A. Morrow
20 Abdominal Pain
103(4)
Danny O. Jacobs
William Silen
21 Headache
107(4)
Peter J. Goadsby
Neil H. Raskin
22 Back and Neck Pain
111(12)
John W. Engstrom
Richard A. Deyo
Section 2: Alterations In Body Temperature
23 Fever
123(4)
Charles A. Dinarello
Reuven Porat
24 Fever and Rash
127(8)
Elaine T. Kaye
Kenneth M. Kaye
25e Atlas of Rashes Associated with Fever
135(1)
Kenneth M. Kaye
Elaine T. Kaye
26 Fever of Unknown Origin
135(7)
Chantal P. Bleeker-Rovers
Jos W.M. van der Meer
Section 3: Nervous System Dysfunction
27 Syncope
142(6)
Roy Freeman
28 Dizziness and Vertigo
148(3)
Mark F. Walker
Robert B. Daroff
29 Fatigue
151(3)
Jeffrey M. Gelfand
Vanja C. Douglas
30 Neurologic Causes of Weakness and Paralysis
154(4)
Michael J. Aminoff
31 Numbness, Tingling, and Sensory Loss
158(4)
Michael J. Aminoff
32 Gait and Balance Disorders
162(3)
Lewis Sudarsky
33e Video Library of Gait Disorders
165(1)
Gail Kang
Nicholas B. Galifianakis
Michael D. Geschwind
34 Confusion and Delirium
166(4)
S. Andrew Josephson
Bruce L. Miller
35 Dementia
170(6)
William W. Seeley
Bruce L. Miller
36 Aphasia, Memory Loss, and Other Focal Cerebral Disorders
176(8)
M.-Marsel Mesulam
37e Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders
184(1)
Maria Luisa Gorno-Tempini
Jennifer Ogar
Joel Kramer
Bruce L. Miller
Gil Rabinovici
Maria Carmela Tartaglia
38 Sleep Disorders
184(11)
Charles A. Czeisler
Thomas E. Scammell
Clifford B. Saper
Section 4: Disorders Of Eyes, Ears, Nose, And Throat
39 Disorders of the Eye
195(16)
Jonathan C. Horton
40e Use of the Hand-Held Ophthalmoscope
211(1)
Homayoun Tabandeh
Morton F. Goldberg
41e Video Library of Neuro-Ophthalmology
211(1)
Shirley H. Wray
42 Disorders of Smell and Taste
211(6)
Richard L. Doty
Steven M. Bromley
43 Disorders of Hearing
217(8)
Anil K. Lalwani
44 Sore Throat, Earache, and Upper Respiratory Symptoms
225(10)
Michael A. Rubin
Larry C. Ford
Ralph Gonzales
45 Oral Manifestations of Disease
235(7)
Samuel C. Durso
46e Atlas of Oral Manifestations of Disease
242(1)
Samuel C. Durso
Janet A. Yellowitz
Section 5: Alterations In Circulatory And Respiratory Functions
47e Dyspnea
243(1)
Richard M. Schwartzstein
48 Cough and Hemoptysis
243(4)
Patricia A. Kritek
Christopher H. Fanta
49 Hypoxia and Cyanosis
247(3)
Joseph Loscalzo
50 Edema
250(3)
Eugene Braunwald
Joseph Loscalzo
51e Approach to the Patient with a Heart Murmur
253(1)
Patrick T. O'Gara
Joseph Loscalzo
52 Palpitations
254(1)
Joseph Loscalzo
Section 6: Alterations In Gastrointestinal Function
53 Dysphagia
254(4)
Ikuo Hirano
Peter J. Kahrilas
54 Nausea, Vomiting, and Indigestion
258(6)
William L. Hasler
55 Diarrhea and Constipation
264(10)
Michael Camilleri
Joseph A. Murray
56 Involuntary Weight Loss
274(2)
Russell G. Robertson
J. Larry Jameson
57 Gastrointestinal Bleeding
276(3)
Loren Laine
58 Jaundice
279(6)
Savio John
Daniel S. Pratt
59 Abdominal Swelling and Ascites
285(3)
Kathleen E. Corey
Lawrence S. Friedman
Section 7: Alterations In Renal And Urinary Tract Function
60e Dysuria, Bladder Pain, and the Interstitial Cystitis/Bladder Pain Syndrome
288(1)
John W. Warren
61 Azotemia and Urinary Abnormalities
289(6)
Julie Lin
Bradley M. Denker
62e Atlas of Urinary Sediments and Renal Biopsies
295(1)
Agnes B. Fogo
Eric G. Neilson
63 Fluid and Electrolyte Disturbances
295(17)
David B. Mount
64e Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples
312(1)
David B. Mount
Thomas D. DuBose Jr
65 Hypercalcemia and Hypocalcemia
313(2)
Sundeep Khosla
66 Acidosis and Alkalosis
315(9)
Thomas D. DuBose Jr
Section 8: Alterations In Sexual Function And Reproduction
67 Sexual Dysfunction
324(7)
Kevin T. McVary
68 Hirsutism
331(4)
David A. Ehrmann
69 Menstrual Disorders and Pelvic Pain
335(4)
Janet E. Hall
Section 9: Alterations In The Skin
70 Approach to the Patient with a Skin Disorder
339(5)
Thomas J. Lawley
Kim B. Yancey
71 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
344(9)
Leslie P. Lawley
Calvin O. McCall
Thomas J. Lawley
72 Skin Manifestations of Internal Disease
353(17)
Jean L. Bolognia
Irwin M. Braverman
73 Immunologically Mediated Skin Diseases
370(7)
Kim B. Yancey
Thomas J. Lawley
74 Cutaneous Drug Reactions
377(8)
Kanade Shinkai
Robert S. Stern
Bruce U. Wintroub
75 Photosensitivity and Other Reactions to Light
385(6)
Alexander G. Marneros
David R. Bickers
76e Atlas of Skin Manifestations of Internal Disease
391(1)
Thomas J. Lawley
Calvin O. McCall
Robert A. Swerlick
Section 10: Hematologic Alterations
77 Anemia and Polycythemia
392(8)
John W. Adamson
Dan L. Longo
78 Bleeding and Thrombosis
400(7)
Barbara A. Konkle
79 Enlargement of Lymph Nodes and Spleen
407(6)
Patrick H. Henry
Dan L. Longo
80 Disorders of Granulocytes and Monocytes
413(11)
Steven M. Holland
John I. Gallin
81e Atlas of Hematology and Analysis of Peripheral Blood Smears
424(1)
Dan L. Longo
Part 3: Genes, the Environment, and Disease
82 Principles of Human Genetics
425(20)
J. Larry Jameson
Peter Kopp
83e Chromosome Disorders
445(1)
Nancy B. Spinner
Laura K. Conlin
84 The Practice of Genetics in Clinical Medicine
446(5)
Susan M. Domchek
J. Larry Jameson
Susan Miesfeldt
85e Mitochondrial DNA and Heritable Traits and Diseases
451(1)
Karl Skorecki
Doron Behar
86e The Human Microbiome
451(1)
Jeffrey I. Gordon
Rob Knight
87e Network Medicine: Systems Biology in Health and Disease
451(2)
Joseph Loscalzo
Part 4: Regenerative Medicine
88 Stem Cell Biology
453(2)
Minoru S.H. Ko
89e Hematopoietic Stem Cells
455(1)
David T. Scadden
Dan L. Longo
90e Applications of Stem Cell Biology in Clinical Medicine
455(1)
John A. Kessler
91e Gene Therapy in Clinical Medicine
456(1)
Katherine A. High
92e Tissue Engineering
456(1)
Anthony Atala
Part 5: Aging
93e World Demography of Aging
457(1)
Richard M. Suzman
John G. Haaga
94e The Biology of Aging
457(2)
Rafael de Cabo
David G. Le Couteur
Part 6: Nutrition and Weight Loss
95e Nutrient Requirements and Dietary Assessment
459(1)
Johanna Dwyer
96e Vitamin and Trace Mineral Deficiency and Excess
459(1)
Robert M. Russell
Paolo M. Suter
97 Malnutrition and Nutritional Assessment
459(6)
Douglas C. Heimburger
98e Enteral and Parenteral Nutrition Therapy
465(2)
Bruce R. Bistrian
L. John Hoffer
David F. Driscoll
Harrison's Principles of Internal Medicine: Volume 2
Part 7: Oncology and Hematology
Section 1: Neoplastic Disorders
99 Approach to the Patient with Cancer
467(8)
Dan L. Longo
100 Prevention and Early Detection of Cancer
475(8)
Jennifer M. Croswell
Otis W. Brawley
Barnett S. Kramer
101e Cancer Genetics
483(1)
Pat J. Morin
Jeffrey M. Trent
Francis S. Collins
Bert Vogelstein
102e Cancer Cell Biology
483(1)
Jeffrey W. Clark
Dan L. Longo
103e Principles of Cancer Treatment
483(1)
Edward A. Sausville
Dan L. Longo
104 Infections in Patients with Cancer
484(9)
Robert W. Finberg
105 Cancer of the Skin
493(9)
Walter J. Urba
Brendan D. Curti
106 Head and Neck Cancer
502(4)
Everett E. Vokes
107 Neoplasms of the Lung
506(17)
Leora Horn
Christine M. Lovly
David H. Johnson
108 Breast Cancer
523(9)
Marc E. Lippman
109 Upper Gastrointestinal Tract Cancers
532(5)
Robert J. Mayer
110 Lower Gastrointestinal Cancers
537(7)
Robert J. Mayer
111 Tumors of the Liver and Biliary Tree
544(10)
Brian I. Carr
112 Pancreatic Cancer
554(3)
Elizabeth Smyth
David Cunningham
113 Endocrine Tumors of the Gastrointestinal Tract and Pancreas
557(18)
Robert T. Jensen
114 Bladder and Renal Cell Carcinomas
575(4)
Howard I. Scher
Jonathan E. Rosenberg
Robert J. Motzer
115 Benign and Malignant Diseases of the Prostate
579(9)
Howard I. Scher
James A. Eastham
116 Testicular Cancer
588(4)
Robert J. Motzer
Darren R. Feldman
George J. Bosl
117 Gynecologic Malignancies
592(6)
Michael V. Seiden
118 Primary and Metastatic Tumors of the Nervous System
598(10)
Lisa M. DeAngelis
Patrick Y. Wen
119e Soft Tissue and Bone Sarcomas and Bone Metastases
608(1)
Shreyaskumar R. Patel
Robert S. Benjamin
120e Carcinoma of Unknown Primary
608(1)
Gauri R. Varadhachary
James L. Abbruzzese
121 Paraneoplastic Syndromes: Endocrinologic/Hematologic
608(6)
J. Larry Jameson
Dan L. Longo
122 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis
614(5)
Josep Dalmau
Myrna R. Rosenfeld
123e Thymoma
619(1)
Dan L. Longo
124e Neoplasia During Pregnancy
620(1)
Michael F. Greene
Dan L. Longo
125 Late Consequences of Cancer and Its Treatment
620(5)
Carl E. Freter
Dan L. Longo
Section 2: Hematopoietic Disorders
126 Iron Deficiency and Other Hypoproliferative Anemias
625(6)
John W. Adamson
127 Disorders of Hemoglobin
631(9)
Edward J. Benz Jr
128 Megaloblastic Anemias
640(9)
A. Victor Hoffbrand
129 Hemolytic Anemias and Anemia Due to Acute Blood Loss
649(13)
Lucio Luzzatto
130 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
662(10)
Neal S. Young
131 Polycythemia Vera and Other Myeloproliferative Neoplasms
672(6)
Jerry L. Spivak
132 Acute Myeloid Leukemia
678(9)
Guido Marcucci
Clara D. Bloomfield
133 Chronic Myeloid Leukemia
687(8)
Hagop Kantarjian
Jorge Cortes
134 Malignancies of Lymphoid Cells
695(15)
Dan L. Longo
135e Less Common Hematologic Malignancies
710(1)
Ayalew Tefferi
Dan L. Longo
136 Plasma Cell Disorders
710(9)
Nikhil C. Munshi
Dan L. Longo
Kenneth C. Anderson
137 Amyloidosis
719(5)
David C. Seldin
John L. Berk
138e Transfusion Biology and Therapy
724(1)
Jeffery S. Dzieczkowski
Kenneth C. Anderson
139e Hematopoietic Cell Transplantation
725(1)
Frederick R. Appelbaum
Section 3: Disorders Of Hemostasis
140 Disorders of Platelets and Vessel Wall
725(7)
Barbara A. Konkle
141 Coagulation Disorders
732(8)
Valder R. Arruda
Katherine A. High
142 Arterial and Venous Thrombosis
740(5)
Jane E. Freedman
Joseph Loscalzo
143 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
745(16)
Jeffrey I. Weitz
Part 8: Infectious Diseases
Section 1: Basic Considerations In Infectious Diseases
144 Approach to the Patient with an Infectious Disease
761(7)
Neeraj K. Surana
Dennis L. Kasper
145e Molecular Mechanisms of Microbial Pathogenesis
768(1)
Gerald B. Pier
146 Genomics and Infectious Disease
768(11)
Roby P. Bhattacharyya
Yonatan H. Grad
Deborah T. Hung
147 Approach to the Acutely Ill Infected Febrile Patient
779(6)
Tamar F. Barlam
Dennis L. Kasper
148 Immunization Principles and Vaccine Use
785(8)
Anne Schuchat
Lisa A. Jackson
149 Health Recommendations for International Travel
793(9)
Jay S. Keystone
Phyllis E. Kozarsky
150e Laboratory Diagnosis of Infectious Diseases
802(1)
Alexander J. McAdam
Andrew B. Onderdonk
151e Climate Change and Infectious Disease
803(1)
Aaron S. Bernstein
152e Infections in Veterans Returning from Foreign Wars
803(1)
Andrew W. Artenstein
Section 2: Clinical Syndromes: Community-Acquired Infections
153 Pneumonia
803(10)
Lionel A. Mandell
Richard G. Wunderink
154 Lung Abscess
813(3)
Rebecca M. Baron
Miriam Baron Barshak
155 Infective Endocarditis
816(11)
Adolf W. Karchmer
156 Infections of the Skin, Muscles, and Soft Tissues
827(6)
Dennis L. Stevens
157 Infectious Arthritis
833(5)
Lawrence C. Madoff
158 Osteomyelitis
838(8)
Werner Zimmerli
159 Intraabdominal Infections and Abscesses
846(6)
Miriam Baron Barshak
Dennis L. Kasper
160 Acute Infectious Diarrhea! Diseases and Bacterial Food Poisoning
852(5)
Regina C. LaRocque
Edward T. Ryan
Stephen B. Calderwood
161 Clostridium difficile Infection, Including Pseudomembranous Colitis
857(4)
Dale N. Gerding
Stuart Johnson
162 Urinary Tract Infections, Pyelonephritis, and Prostatitis
861(8)
Kalpana Gupta
Barbara W. Trautner
163 Sexually Transmitted Infections: Overview and Clinical Approach
869(14)
Jeanne M. Marrazzo
King K. Holmes
164 Meningitis, Encephalitis, Brain Abscess, and Empyema
883(23)
Karen L. Roos
Kenneth L. Tyler
165 Chronic and Recurrent Meningitis
906(5)
Walter J. Koroshetz
Avindra Nath
166e Infectious Complications of Burns
911(1)
Lawrence C. Madoff
Florencia Pereyra
167e Infectious Complications of Bites
911(1)
Lawrence C. Madoff
Florencia Pereyra
Section 3: Clinical Syndromes: Health Care-Associated Infections
168 Infections Acquired in Health Care Facilities
911(8)
Robert A. Weinstein
169 Infections in Transplant Recipients
919(11)
Robert W. Finberg
Joyce Fingeroth
Section 4: Approach To Therapy For Bacterial Diseases
170 Treatment and Prophylaxis of Bacterial Infections
930(16)
David C. Hooper
Erica S. Shenoy
Christy A. Varughese
Section 5: Diseases Caused By Gram-Positive Bacteria
171 Pneumococcal Infections
946(8)
David Goldblatt
Katherine L. O'Brien
172 Staphylococcal Infections
954(9)
Franklin D. Lowy
173 Streptococcal Infections
963(8)
Michael R. Wessels
174 Enterococcal Infections
971(6)
Cesar A. Arias
Barbara E. Murray
175 Diphtheria and Other Corynebacterial Infections
977(5)
William R. Bishai
John R. Murphy
176 Listeria monocytogenes Infections
982(2)
Elizabeth L. Hohmann
Daniel A. Portnoy
177 Tetanus
984(3)
C. Louise Thwaites
Lam Minh Yen
178 Botulism
987(3)
Susan Maslanka
Agam K. Rao
179 Gas Gangrene and Other Clostridial Infections
990(5)
Amy E. Bryant
Dennis L. Stevens
Section 6: Diseases Caused By Gram-Negative Bacteria
180 Meningococcal Infections
995(8)
Andrew J. Pollard
181 Gonococcal Infections
1003(7)
Sanjay Ram
Peter A. Rice
182 Haemophilus and Moraxella Infections
1010(4)
Timothy F. Murphy
183e Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
1014(1)
Tamar F. Barlam
Dennis L. Kasper
184 Legionella Infections
1014(7)
Victor L. Yu
M. Luisa Pedro-Botet
Yusen E. Lin
185 Pertussis and Other Bordetella Infections
1021(4)
Karina A. Top
Scott A. Halperin
186 Diseases Caused by Gram-Negative Enteric Bacilli
1025(11)
Thomas A. Russo
James R. Johnson
187 Acinetobacter Infections
1036(2)
David L. Paterson
Anton Y. Peleg
188 Helicobacter pylori Infections
1038(4)
John C. Atherton
Martin J. Blaser
189 Infections Due to Pseudomonas Species and Related Organisms
1042(7)
Reuben Ramphal
190 Salmonellosis
1049(6)
David A. Pegues
Samuel I. Miller
191 Shigellosis
1055(3)
Philippe J. Sansonetti
Jean Bergounioux
192 Infections Due to Campylobacter and Related Organisms
1058(3)
Martin J. Blaser
193 Cholera and Other Vibrioses
1061(5)
Matthew K. Waldor
Edward T. Ryan
194e Brucellosis
1066(1)
Nicholas J. Beeching
Michael J. Corbel
195 Tularemia
1066(4)
Richard F. Jacobs
Gordon E. Schutze
196 Plague and Other Yersinia Infections
1070(8)
Michael B. Prentice
197 Bartonella Infections, Including Cat-Scratch Disease
1078(5)
Michael Giladi
Moshe Ephros
198e Donovanosis
1083(1)
Nigel O'Farrell
Section 7: Miscellaneous Bacterial Infections
199 Nocardiosis
1084(4)
Gregory A. Filice
200 Actinomycosis and Whipple's Disease
1088(6)
Thomas A. Russo
201 Infections Due to Mixed Anaerobic Organisms
1094(8)
Ronit Cohen-Poradosu
Dennis L. Kasper
Section 8: Mycobacterial Diseases
202 Tuberculosis
1102(20)
Mario C. Raviglione
203 Leprosy
1122(6)
Robert H. Gelber
204 Nontuberculous Mycobacterial Infections
1128(4)
Steven M. Holland
205e Antimycobacterial Agents
1132(1)
Max R. O'Donnell
Divya Reddy
Jussi J. Saukkonen
Section 9: Spirochetal Diseases
206 Syphilis
1132(8)
Sheila A. Lukehart
207e Endemic Treponematoses
1140(1)
Sheila A. Lukehart
208 Leptospirosis
1140(6)
Rudy A. Hartskeerl
Jiri F.P. Wagenaar
209 Relapsing Fever
1146(3)
Alan G. Barbour
210 Lyme Borreliosis
1149(5)
Allen C. Steere
Section 10: Diseases Caused By Rickettsiae, Mycoplasmas, And Chlamydiae
211 Rickettsial Diseases
1154(9)
David H. Walker
J. Stephen Dumler
Thomas Marrie
212 Infections Due to Mycoplasmas
1163(2)
R. Doug Hardy
213 Chlamydial Infections
1165(9)
Charlotte A. Gaydos
Thomas C. Quinn
Section 11: Viral Diseases: General Considerations
214e Medical Virology
1174(1)
Fred Wang
Elliott Kieff
215e Antiviral Chemotherapy, Excluding Antiretroviral Drugs
1174(1)
Lindsey R. Baden
Raphael Dolin
Section 12: Infections Due To DNA Viruses
216 Herpes Simplex Virus Infections
1175(8)
Lawrence Corey
217 Varicella-Zoster Virus Infections
1183(3)
Richard J. Whitley
218 Epstein-Barr Virus Infections, Including Infectious Mononucleosis
1186(4)
Jeffrey I. Cohen
219 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8*
1190(4)
Camille Nelson Kotton
Martin S. Hirsch
220e Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections
1194(1)
Fred Wang
221 Parvovirus Infections
1195(2)
Kevin E. Brown
222 Human Papillomavirus Infections
1197(5)
Aaron C. Ermel
Darron R. Brown
Section 13: Infections Due To DNA And RNA Respiratory Viruses
223 Common Viral Respiratory Infections
1202(7)
Raphael Dolin
224 Influenza
1209(6)
Yehuda Z. Cohen
Raphael Dolin
Section 14: Infections Due To Human Immunodeficiency Virus And Other Human Retroviruses
225e The Human Retroviruses
1215(1)
Dan L. Longo
Anthony S. Fauci
226 Human Immunodeficiency Virus Disease: AIDS and Related Disorders
1215(70)
Anthony S. Fauci
H. Clifford Lane
Section 15: Infections Due To RNA Viruses
227 Viral Gastroenteritis
1285(4)
Umesh D. Parashar
Roger I. Glass
228 Enterovirus, Parechovirus, and Reovirus Infections
1289(6)
Jeffrey I. Cohen
229 Measles (Rubeola)
1295(4)
Kaitlin Rainwater-Lovett
William J. Moss
230e Rubella (German Measles)
1299(1)
Laura A. Zimmerman
Susan E. Reef
231e Mumps
1299(1)
Steven A. Rubin
Kathryn M. Carbone
232 Rabies and Other Rhabdovirus Infections
1299(5)
Alan C. Jackson
233 Arthropod-Borne and Rodent-Borne Virus Infections
1304(19)
Jens H. Kuhn
Clarence I. Peters
234 Ebolavirus and Marburgvirus Infections
1323(6)
Jens H. Kuhn
Section 16: Fungal Infections
235 Diagnosis and Treatment of Fungal Infections
1329(3)
John E. Edwards Jr
236 Histoplasmosis
1332(2)
Chadi A. Hage
L. Joseph Wheat
237 Coccidioidomycosis
1334(3)
Neil M. Ampel
238 Blastomycosis
1337(2)
Donna C. Sullivan
Rathel L. Nolan III
239 Cryptococcosis
1339(3)
Arturo Casadevall
240 Candidiasis
1342(3)
John E. Edwards Jr
241 Aspergillosis
1345(5)
David W. Denning
242 Mucormycosis
1350(3)
Brad Spellberg
Ashraf S. Ibrahim
243 Superficial Mycoses and Less Common Systemic Mycoses
1353(5)
Carol A. Kauffman
244 Pneumocystis Infections
1358(4)
Henry Masur
Alison Morris
Section 17: Protozoal And Helminthic Infections: General Considerations
245e Laboratory Diagnosis of Parasitic Infections
1362(1)
Sharon L. Reed
Charles E. Davis
246e Agents Used to Treat Parasitic Infections
1363(1)
Thomas A. Moore
Section 18: Protozoal Infections
247 Amebiasis and Infection with Free-Living Amebas
1363(5)
Rosa M. Andrade
Sharon L. Reed
248 Malaria
1368(16)
Nicholas J. White
Joel G. Breman
249 Babesiosis
1384(3)
Edouard G. Vannier
Peter J. Krause
250e Atlas of Blood Smears of Malaria and Babesiosis
1387(1)
Nicholas J. White
Joel G. Breman
251 Leishmaniasis
1387(7)
Shyam Sundar
252 Chagas Disease and African Trypanosomiasis
1394(4)
Louis V. Kirchhoff
Anis Rassi Jr
253 Toxoplasma Infections
1398(7)
Kami Kim
Lloyd H. Kasper
254 Protozoal Intestinal Infections and Trichomoniasis
1405(4)
Peter F. Weller
Section 19: Helminthic Infections
255e Introduction to Helminthic Infections
1409(1)
Peter F. Weller
256 Trichinellosis and Other Tissue Nematode Infections
1410(3)
Peter F. Weller
257 Intestinal Nematode Infections
1413(4)
Peter F. Weller
Thomas B. Nutman
258 Filarial and Related Infections
1417(6)
Thomas B. Nutman
Peter F. Weller
259 Schistosomiasis and Other Trematode Infections
1423(7)
Charles H. King
Adel A.F. Mahmoud
260 Cestode Infections
1430(7)
A. Clinton White Jr
Peter F. Weller
Part 9: Terrorism and Clinical Medicine
261e Microbial Bioterrorism
1437(1)
H. Clifford Lane
Anthony S. Fauci
262e Chemical Terrorism
1437(1)
Charles G. Hurst
Jonathan Newmark
James A. Romano Jr
263e Radiation Terrorism
1437(2)
Christine E. Hill-Kayser
Eli Glatstein
Zelig A. Tochner
Part 10: Disorders of the Cardiovascular System
Section 1: Introduction to Cardiovascular Disorders
264 Approach to the Patient with Possible Cardiovascular Disease
1439(2)
Joseph Loscalzo
265e Basic Biology of the Cardiovascular System
1441(1)
Joseph Loscalzo
Peter Libby
Jonathan A. Epstein
266e Epidemiology of Cardiovascular Disease
1442(1)
Thomas A. Gaziano
J. Michael Gaziano
Section 2: Diagnosis of Cardiovascular Disorders
267 Physical Examination of the Cardiovascular System
1442(28)
Patrick T. O'Gara
Joseph Loscalzo
268 Electrocardiography 145C
Ary L. Goldberger
269e Atlas of Electrocardiography 145S
Ary L. Goldberger
270e Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging 145S
Marcelo F. Di Carli
Raymond Y. Kwong
Scott D. Solomon
271e Atlas of Noninvasive Imaging 146C
Marcelo F. Di Carli
Raymond Y. Kwong
Scott D. Solomon
272 Diagnostic Cardiac Catheterization and Coronary Angiography 146C
Jane A. Leopold
David P. Faxon
Section 3: Disorders Of Rhythm
273e Principles of Electrophysiology 146E
David D. Spragg
Gordon F. Tomaselli
274 The Bradyarrhythmias: Disorders of the Sinoatrial Node 146E
David D. Spragg
Gordon F. Tomaselli
275 The Bradyarrhythmias: Disorders of the Atrioventricular Node
1470(6)
David D. Spragg
Gordon F. Tomaselli
276 Supraventricular Tachyarrhythmias
1476(9)
Gregory F. Michaud
William G. Stevenson
277 Ventricular Arrhythmias
1485(15)
Roy M. John
William G. Stevenson
278e Atlas of Cardiac Arrhythmias 150C
Ary L. Goldberger
Section 4: Disorders Of The Heart
279 Heart Failure: Pathophysiology and Diagnosis
1500(16)
Douglas L. Mann
Murali Chakinala
280 Heart Failure: Management 150i
Mandeep R. Mehra
281 Cardiac Transplantation and Prolonged Assisted Circulation
1516
Sharon A. Hunt
Hari R. Mallidi
282 Congenital Heart Disease in the Adult
1515(20)
Jamil A. Aboulhosn
John S. Child
283 Aortic Valve Disease 152E
Patrick T. O'Gara
Joseph Loscalzo
284 Mitral Valve Disease
1535(16)
Patrick T. O'Gara
Joseph Loscalzo
285 Tricuspid and Pulmonic Valve Disease 154i
Patrick T. O'Gara
Joseph Loscalzo
286 Multiple and Mixed Valvular Heart Disease 155C
Patrick T. O'Gara
Joseph Loscalzo
287 Cardiomyopathy and Myocarditis
1551(20)
Neal K. Lakdawala
Lynne Warner Stevenson
Joseph Loscalzo
288 Pericardial Disease
1571(1)
Eugene Braunwald
289e Tumors and Trauma of the Heart
1571(1)
Eric H. Awtry
Wilson S. Colucci
290e Cardiac Manifestations of Systemic Disease
1571(7)
Eric H. Awtry
Wilson S. Colucci
Section 5: Coronary And Peripheral Vascular Disease
291e The Pathogenesis, Prevention, and Treatment of Atherosclerosis
1578(1)
Peter Libby
292e Atlas of Atherosclerosis
1578(1)
Peter Libby
293 Ischemic Heart Disease
1578(15)
Elliott M. Antman
Joseph Loscalzo
294 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)
1593(6)
Christopher P. Cannon
Eugene Braunwald
295 ST-Segment Elevation Myocardial Infarction
1599(12)
Elliott M. Antman
Joseph Loscalzo
296e Percutaneous Coronary Interventions and Other Interventional Procedures
1611(1)
David P. Faxon
Deepak L. Bhatt
297e Atlas of Percutaneous Revascularization
1611(1)
Jane A. Leopold
Deepak L. Bhatt
David P. Faxon
298 Hypertensive Vascular Disease
1611(16)
Theodore A. Kotchen
299 Renovascular Disease
1627(4)
Stephen C. Textor
300 Deep Venous Thrombosis and Pulmonary Thromboembolism
1631(6)
Samuel Z. Goldhaber
301 Diseases of the Aorta
1637(6)
Mark A. Creager
Joseph Loscalzo
302 Arterial Diseases of the Extremities
1643(7)
Mark A. Creager
Joseph Loscalzo
303 Chronic Venous Disease and Lymphedema
1650(5)
Mark A. Creager
Joseph Loscalzo
304 Pulmonary Hypertension
1655(6)
Aaron B. Waxman
Joseph Loscalzo
Part 11: Disorders of the Respiratory System
Section 1: Diagnosis Of Respiratory Disorders
305 Approach to the Patient with Disease of the Respiratory System
1661(2)
Patricia A. Kritek
Augustine M.K. Choi
306e Disturbances of Respiratory Function
1663(1)
Edward T. Naureckas
Julian Solway
307 Diagnostic Procedures in Respiratory Disease
1663(6)
Anne L. Fuhlbrigge
Augustine M.K. Choi
308e Atlas of Chest Imaging
1669(1)
Patricia A. Kritek
John J. Reilly Jr
Section 2: Diseases Of The Respiratory System
309 Asthma
1669(12)
Peter J. Barnes
310 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
1681(6)
Praveen Akuthota
Michael E. Wechsler
311 Occupational and Environmental Lung Disease
1687(7)
John R. Balmes
Frank E. Speizer
312 Bronchiectasis
1694(3)
Rebecca M. Baron
Miriam Baron Barshak
313 Cystic Fibrosis
1697(3)
Eric J. Sorscher
314 Chronic Obstructive Pulmonary Disease
1700(8)
John J. Reilly Jr.
Edwin K. Silverman
Steven D. Shapiro
315 Interstitial Lung Diseases
1708(8)
Talmadge E. King Jr
316 Disorders of the Pleura
1716(3)
Richard W. Light
317 Disorders of the Mediastinum
1719(1)
Richard W. Light
318 Disorders of Ventilation
1720(3)
John F. McConville
Babak Mokhlesi
Julian Solway
319 Sleep Apnea
1723(4)
Andrew Wellman
Susan Redline
320e Lung Transplantation
1727(2)
Elbert P. Trulock
Part 12: Critical Care Medicine
Section 1: Respiratory Critical Care
321 Approach to the Patient with Critical Illness
1729(7)
John P. Kress
Jesse B. Hall
322 Acute Respiratory Distress Syndrome
1736(4)
Bruce D. Levy
Augustine M.K. Choi
323 Mechanical Ventilatory Support
1740(4)
Bartolome R. Celli
Section 2: Shock And Cardiac Arrest
324 Approach to the Patient with Shock
1744(7)
Ronald V. Maier
325 Severe Sepsis and Septic Shock
1751(8)
Robert S. Munford
326 Cardiogenic Shock and Pulmonary Edema
1759(5)
Judith S. Hochman
David H. Ingbar
327 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
1764(7)
Robert J. Myerburg
Agustin Castellanos
Section 3: Neurologic Critical Care
328 Coma
1771(6)
Allan H. Ropper
329e Examination of the Comatose Patient
1777(1)
S. Andrew Josephson
330 Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy, and Subarachnoid Hemorrhage
1777(10)
J. Claude Hemphill III
Wade S. Smith
Daryl R. Gress
Section 4: Oncologic Emergencies
331 Oncologic Emergencies
1787(12)
Rasim Gucalp
Janice P. Dutcher
Part 13: Disorders of the Kidney and Urinary Tract
332e Cellular and Molecular Biology of the Kidney
1799(1)
Alfred L. George Jr.
Eric G. Neilson
333e Adaptation of the Kidney to Injury
1799(1)
Joseph V. Bonventre
334 Acute Kidney Injury
1799(12)
Sushrut S. Waikar
Joseph V. Bonventre
335 Chronic Kidney Disease
1811(11)
Joanne M. Bargman
Karl Skorecki
336 Dialysis in the Treatment of Renal Failure
1822(3)
Kathleen D. Liu
Glenn M. Chertow
337 Transplantation in the Treatment of Renal Failure
1825(6)
Jamil Azzi
Edgar L. Milford
Mohamed H. Sayegh
Anil Chandraker
338 Glomerular Diseases
1831
Julia B. Lewis
Eric G. Neilson
339 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development
850(1006)
Jing Zhou
Martin R. Pollak
340 Tubulointerstitial Diseases of the Kidney
1856(7)
Laurence H. Beck
David J. Salant
341 Vascular Injury to the Kidney
1863(3)
Nelson Leung
Stephen C. Textor
342 Nephrolithiasis
1866(5)
Gary C. Curhan
343 Urinary Tract Obstruction
1871(4)
Julian L. Seifter
Part 14: Disorders of the Gastrointestinal System
Section 1: Disorders Of The Alimentary Tract
344 Approach to the Patient with Gastrointestinal Disease
1875(5)
William L. Hasler
Chung Owyang
345 Gastrointestinal Endoscopy
1880(20)
Louis Michel Wong Kee Song
Mark Topazian
346e Video Atlas of Gastrointestinal Endoscopy
1900(1)
Louis Michel Wong Kee Song
Mark Topazian
347 Diseases of the Esophagus
1900(11)
Peter J. Kahrilas
Ikuo Hirano
348 Peptic Ulcer Disease and Related Disorders
1911(21)
John Del Valle
349 Disorders of Absorption
1932(14)
Henry J. Binder
350e The Schilling Test
1946(1)
Henry J. Binder
351 Inflammatory Bowel Disease
1947(18)
Sonia Friedman
Richard S. Blumberg
352 Irritable Bowel Syndrome
1965(6)
Chung Owyang
353 Diverticular Disease and Common Anorectal Disorders
1971(7)
Rizwan Ahmed
Susan L. Gearhart
354 Mesenteric Vascular Insufficiency
1978(3)
Rizwan Ahmed
Mahmoud Malas
355 Acute Intestinal Obstruction
1981(4)
Danny O. Jacobs
356 Acute Appendicitis and Peritonitis
1985(4)
Danny O. Jacobs
Section 2: Liver And Biliary Tract Disease
357 Approach to the Patient with Liver Disease
1989(6)
Marc G. Ghany
Jay H. Hoofnagle
358 Evaluation of Liver Function
1995(4)
Daniel S. Pratt
359 The Hyperbilirubinemias
1999(5)
Allan W. Wolkoff
360 Acute Viral Hepatitis
2004(19)
Jules L. Dienstag
361 Toxic and Drug-Induced Hepatitis
2023(8)
William M. Lee
Jules L. Dienstag
362 Chronic Hepatitis
2031(21)
Jules L. Dienstag
363 Alcoholic Liver Disease
2052(2)
Mark E. Mailliard
Michael F. Sorrell
364 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis
2054(4)
Manal F. Abdelmalek
Anna Mae Diehl
365 Cirrhosis and Its Complications
2058(9)
Bruce R. Bacon
366e Atlas of Liver Biopsies
2067(1)
Jules L. Dienstag
Atul K. Bhan
367e Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver
2067(1)
Bruce R. Bacon
368 Liver Transplantation
2067(8)
Raymond T. Chung
Jules L. Dienstag
369 Diseases of the Gallbladder and Bile Ducts
2075(11)
Norton J. Greenberger
Gustav Paumgartner
Section 3: Disorders Of The Pancreas
370 Approach to the Patient with Pancreatic Disease
2086(4)
Darwin L. Conwell
Norton J. Greenberger
Peter A. Banks
371 Acute and Chronic Pancreatitis
2090(13)
Darwin L. Conwell
Peter A. Banks
Norton J. Greenberger
Part 15: Immune-Mediated, Inflammatory, and Rheumatologic Disorders
Section 1: The Immune System In Health And Disease
372e Introduction to the Immune System
2103(1)
Barton F. Haynes
Kelly A. Soderberg
Anthony S. Fauci
373e The Major Histocompatibility Complex
2103(1)
Gerald T. Nepom
374 Primary Immune Deficiency Diseases
2103(10)
Alain Fischer
375e Primary Immunodeficiencies Associated with (or Secondary to) Other Diseases
2113(1)
Alain Fischer
Section 2: Disorders Of Immune-mediated Injury
376 Allergies, Anaphylaxis, and Systemic Mastocytosis
2113(11)
Joshua A. Boyce
K. Frank Austen
377e Autoimmunity and Autoimmune Diseases
2124(1)
Betty Diamond
Peter E. Lipsky
378 Systemic Lupus Erythematosus
2124(10)
Bevra Hannahs Hahn
379 Antiphospholipid Syndrome
2134(2)
Haralampos M. Moutsopoulos
Panayiotis G. Vlachoyiannopoulos
380 Rheumatoid Arthritis
2136(13)
Ankoor Shah
E. William St. Clair
381 Acute Rheumatic Fever
2149(5)
Jonathan R. Carapetis
382 Systemic Sclerosis (Scleroderma) and Related Disorders
2154(12)
John Varga
383 Sjogren's Syndrome
2166(3)
Haralampos M. Moutsopoulos
Athanasios G. Tzioufas
384 The Spondyloarthritides
2169(10)
Joel D. Taurog
John D. Carter
385 The Vasculitis Syndromes
2179(14)
Carol A. Langford
Anthony S. Fauci
386e Atlas of the Vasculitic Syndromes
2193(1)
Carol A. Langford
Anthony S. Fauci
387 Behcet's Syndrome
2194(1)
Haralampos M. Moutsopoulos
388 Polymyositis, Dermatomyositis, and Inclusion Body Myositis
2194(8)
Marinos C. Dalakas
389 Relapsing Polychondritis
2202(3)
Carol A. Langford
390 Sarcoidosis
2205(7)
Robert P. Baughman
Elyse E. Lower
391e IgG4-Related Disease
2212(1)
John H. Stone
392 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases
2212(4)
Daniel L. Kastner
Section 3: Disorders Of The Joints And Adjacent Tissues
393 Approach to Articular and Musculoskeletal Disorders
2216(10)
John J. Cush
394 Osteoarthritis
2226(7)
David T. Felson
395 Gout and Other Crystal-Associated Arthropathies
2233(5)
H. Ralph Schumacher
Lan X. Chen
396 Fibromyalgia
2238(2)
Leslie J. Crofford
397 Arthritis Associated with Systemic Disease, and Other Arthritides
2240(7)
Carol A. Langford
Brian F. Mandell
398 Periarticular Disorders of the Extremities
2247(4)
Carol A. Langford
Part 16: Endocrinology and Metabolism
Section 1: Endocrinology
399 Approach to the Patient with Endocrine Disorders
2251(4)
J. Larry Jameson
400e Mechanisms of Hormone Action
2255(1)
J. Larry Jameson
401e Anterior Pituitary: Physiology of Pituitary Hormones
2255(1)
Shlomo Melmed
J. Larry Jameson
402 Hypopituitarism
2255(6)
Shlomo Melmed
J. Larry Jameson
403 Anterior Pituitary Tumor Syndromes
2261(13)
Shlomo Melmed
J. Larry Jameson
404 Disorders of the Neurohypophysis
2274(9)
Gary L. Robertson
405 Disorders of the Thyroid Gland
2283(26)
J. Larry Jameson
Susan J. Mandel
Anthony P. Weetman
406 Disorders of the Adrenal Cortex
2309(20)
Wiebke Arlt
407 Pheochromocytoma
2329(6)
Hartmut P.H. Neumann
408 Multiple Endocrine Neoplasia
2335(9)
Rajesh V. Thakker
409 Autoimmune Polyendocrine Syndromes
2344(5)
Peter A. Gottlieb
Section 2: Reproductive Endocrinology
410 Disorders of Sex Development
2349(8)
John C. Achermann
J. Larry Jameson
411 Disorders of the Testes and Male Reproductive System
2357(18)
Shalender Bhasin
J. Larry Jameson
412 Disorders of the Female Reproductive System
2375(6)
Janet E. Hall
413 Menopause and Postmenopausal Hormone Therapy
2381(6)
JoAnn E. Manson
Shari S. Bassuk
414 Infertility and Contraception
2387(5)
Janet E. Hall
Section 3: Obesity, Diabetes Mellitus, And Metabolic Syndrome
415e Biology of Obesity
2392(1)
Jeffrey S. Flier
Eleftheria Maratos-Flier
416 Evaluation and Management of Obesity
2392(7)
Robert F. Kushner
417 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology
2399(8)
Alvin C. Powers
418 Diabetes Mellitus: Management and Therapies
2407(15)
Alvin C. Powers
419 Diabetes Mellitus: Complications
2422(8)
Alvin C. Powers
420 Hypoglycemia
2430(5)
Philip E. Cryer
Stephen N. Davis
421 Disorders of Lipoprotein Metabolism
2435(14)
Daniel I. Rader
Helen H. Hobbs
422 The Metabolic Syndrome
2449(5)
Robert H. Eckel
Section 4: Disorders Of Bone And Mineral Metabolism
423 Bone and Mineral Metabolism in Health and Disease
2454(12)
F. Richard Bringhurst
Marie B. Demay
Stephen M. Krane
Henry M. Kronenberg
424 Disorders of the Parathyroid Gland and Calcium Homeostasis
2466(22)
John T. Potts Jr.
Harald Juppner
425 Osteoporosis
2488(16)
Robert Lindsay
Felicia Cosman
426e Paget's Disease and Other Dysplasias of Bone
2504(1)
Murray J. Favus
Tamara J. Vokes
Section 5: Disorders Of Intermediary Metabolism
427 Heritable Disorders of Connective Tissue
2504(10)
Darwin J. Prockop
John F. Bateman
428 Hemochromatosis
2514(5)
Lawrie W. Powell
429 Wilson's Disease
2519(2)
George J. Brewer
430 The Porphyrias
2521(12)
Robert J. Desnick
Manisha Balwani
431e Disorders of Purine and Pyrimidine Metabolism
2533(1)
Christopher M. Burns
Robert L. Wortmann
432e Lysosomal Storage Diseases
2533(1)
Robert J. Hopkin
Gregory A. Grabowski
433e Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
2534(1)
Priya S. Kishnani
Yuan-Tsong Chen
434e Inherited Disorders of Amino Acid Metabolism in Adults
2534(1)
Nicola Longo
435e Inherited Defects of Membrane Transport
2534(1)
Nicola Longo
436e Atlas of Clinical Manifestations of Metabolic Diseases
2534(1)
J. Larry Jameson
Part 17: Neurologic Disorders
Section 1: Diagnosis Of Neurologic Disorders
437 Approach to the Patient with Neurologic Disease
2535(5)
Daniel H. Lowenstein
Joseph B. Martin
Stephen L. Hauser
438e The Neurologic Screening Exam
2540(1)
Daniel H. Lowenstein
439e Video Atlas of the Detailed Neurologic Examination
2540(1)
Martin A. Samuels
440e Neuroimaging in Neurologic Disorders
2540(1)
William P. Dillon
441e Atlas of Neuroimaging
2541(1)
Andre D. Furtado
William P. Dillon
442e Electrodiagnostic Studies of Nervous System Disorders: EEG, Evoked Potentials, and EMG
2541(1)
Michael J. Aminoff
443e Technique of Lumbar Puncture
2541(1)
Elizabeth Robbins
Stephen L. Hauser
444e Biology of Neurologic Diseases
2541(1)
Stephen L. Hauser
Stanley B. Prusiner
M. Flint Beal
Section 2: Diseases Of The Central Nervous System
445 Seizures and Epilepsy
2542(17)
Daniel H. Lowenstein
446 Cerebrovascular Diseases
2559(27)
Wade S. Smith
S. Claiborne Johnston
J. Claude Hemphill III
447 Migraine and Other Primary Headache Disorders
2586(12)
Peter J. Goadsby
Neil H. Raskin
448 Alzheimer's Disease and Other Dementias
2598(11)
William W. Seeley
Bruce L. Miller
449 Parkinson's Disease and Other Movement Disorders
2609(17)
C. Warren Olanow
Anthony H.V. Schapira
Jose A. Obeso
450 Ataxic Disorders
2626(5)
Roger N. Rosenberg
451e Classification of the Spinocerebellar Ataxias
2631(1)
Roger N. Rosenberg
452 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
2631(6)
Robert H. Brown Jr
453e Prion Diseases
2637(1)
Stanley B. Prusiner
Bruce L. Miller
454 Disorders of the Autonomic Nervous System
2637(8)
Phillip A. Low
John W. Engstrom
455 Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders
2645(5)
M. Flint Beal
Stephen L. Hauser
456 Diseases of the Spinal Cord
2650(10)
Stephen L. Hauser
Allan H. Ropper
457e Concussion and Other Traumatic Brain Injuries
2660(1)
Allan H. Ropper
458 Multiple Sclerosis and Other Demyelinating Diseases
2661(13)
Stephen L. Hauser
Douglas S. Goodin
Section 3: Nerve And Muscle Disorders
459 Peripheral Neuropathy
2674(20)
Anthony A. Amato
Richard J. Barohn
460 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies
2694(7)
Stephen L. Hauser
Anthony A. Amato
461 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
2701(6)
Daniel B. Drachman
Anthony A. Amato
462e Muscular Dystrophies and Other Muscle Diseases
2707(1)
Anthony A. Amato
Robert H. Brown Jr
463e Special Issues in Inpatient Neurologic Consultation
2707(1)
S. Andrew Josephson
Martin A. Samuels
Section 4: Chronic Fatigue Syndrome
464e Chronic Fatigue Syndrome
2707(1)
Gijs Bleijenberg
Jos W.M. van der Meer
Section 5: Psychiatric And Addiction Disorders
465e Biology of Psychiatric Disorders
2708(1)
Robert O. Messing
Eric J. Nestler
466 Mental Disorders
2708(15)
Victor I. Reus
467 Alcohol and Alcoholism
2723(5)
Marc A. Schuckit
468e Opioid-Related Disorders
2728(1)
Thomas R. Kosten
Colin N. Haile
469e Cocaine and Other Commonly Abused Drugs
2729(1)
Nancy K. Mello
Jack H. Mendelson
470 Nicotine Addiction
2729(3)
David M. Burns
471e Neuropsychiatric Illnesses in War Veterans
2732(1)
Charles W. Hoge
Part 18: Poisoning, Drug Overdose, and Envenomation
472e Heavy Metal Poisoning
2733(1)
Howard Hu
473e Poisoning and Drug Overdose
2733(1)
Mark B. Mycyk
474 Disorders Caused by Venomous Snakebites and Marine Animal Exposures
2733(11)
Charles Lei
Natalie J. Badowski
Paul S. Auerbach
Robert L. Norris
475 Ectoparasite Infestations and Arthropod Injuries
2744(9)
Richard J. Pollack
Scott A. Norton
Part 19: Disorders Associated with Environmental Exposures
476e Altitude Illness
2753(1)
Buddha Basnyat
Geoffrey Tabin
477e Hyperbaric and Diving Medicine
2753(1)
Michael H. Bennett
Simon J. Mitchell
478e Hypothermia and Frostbite
2753(1)
Daniel F. Danzl
479e Heat-Related Illnesses
2753(1)
Daniel F. Danzl
Appendix: Laboratory Values of Clinical Importance
2754
Alexander Kratz
Michael A. Pesce
Robert C. Basner
Andrew J. Einstein
480e The Clinical Laboratory in Modern Health Care
2770(1)
Anthony A. Killeen
481e Clinical Procedure Tutorial: Central Venous Catheter Placement
2770(1)
Maria A. Yialamas
William E. Corcoran
Gyorgy Frendl
Kurt Fink
482e Clinical Procedure Tutorial: Thoracentesis
2770(1)
Charles A. Morris
Andrea S. Wolf
483e Clinical Procedure Tutorial: Abdominal Paracentesis
2770(1)
Maria A. Yialamas
Anna E. Rutherford
Lindsay King
484e Clinical Procedure Tutorial: Endotracheal Intubation
2770(1)
Charles A. Morris
Emily Page Nelson
485e Clinical Procedures Tutorial: Percutaneous Arterial Blood Gas Sampling
2770(1)
Christian D. Becker
Sean Sadikot
Jeremy Matloff
486e Clinical Procedures Tutorial: Lumbar Puncture
2770
Beth Rapaport
Stephen Krieger
Corey McGraw
Sean Sadikot
Jeremy Matloff
Index
I- 1
Harrison's Manual of Medicine
Contributors
xv
Preface
xvii
Acknowledgments
xix
Section 1: Care Of The Hospitalized Patient
1 Electrolytes/Acid-Base Balance
1(22)
2 Diagnostic Imaging in Internal Medicine
23(3)
3 Procedures Commonly Performed by Internists
26(5)
4 Principles of Critical Care Medicine
31(4)
5 Pain and Its Management
35(5)
6 Assessment of Nutritional Status
40(3)
7 Enteral and Parenteral Nutrition
43(3)
8 Transfusion and Pheresis Therapy
46(2)
9 Palliative and End-of-Life Care
48(9)
Section 2: Medical Emergencies
10 Cardiovascular Collapse and Sudden Death
57(4)
11 Shock
61(4)
12 Sepsis and Septic Shock
65(4)
13 Acute Pulmonary Edema
69(2)
14 Acute Respiratory Distress Syndrome
71(2)
15 Respiratory Failure
73(3)
16 Confusion, Stupor, and Coma
76(6)
17 Stroke
82(9)
18 Subarachnoid Hemorrhage
91(2)
19 Increased Intracranial Pressure and Head Trauma
93(5)
20 Spinal Cord Compression
98(2)
21 Hypoxic-Ischemic Encephalopathy
100(1)
22 Status Epilepticus
101(3)
23 Diabetic Ketoacidosis and Hyperosmolar Coma
104(3)
24 Hypoglycemia
107(2)
25 Oncologic Emergencies
109(5)
26 Anaphylaxis
114(1)
27 Bites, Venoms, Stings, and Marine Poisonings
115(12)
Section 3: Common Patient Presentations
28 Fever, Hyperthermia, and Rash
127(4)
29 Generalized Fatigue
131(4)
30 Weight Loss
135(2)
31 Chest Pain
137(4)
32 Palpitations
141(1)
33 Dyspnea
142(3)
34 Cyanosis
145(1)
35 Cough and Hemoptysis
146(4)
36 Edema
150(4)
37 Abdominal Pain
154(4)
38 Nausea, Vomiting, and Indigestion
158(4)
39 Dysphagia
162(5)
40 Diarrhea, Malabsorption, and Constipation
167(7)
41 Gastrointestinal Bleeding
174(4)
42 Jaundice and Evaluation of Liver Function
178(9)
43 Ascites
187(2)
44 Lymphadenopathy and Splenomegaly
189(5)
45 Anemia and Polycythemia
194(3)
46 Azotemia and Urinary Abnormalities
197(6)
47 Pain and Swelling of Joints
203(4)
48 Back and Neck Pain
207(8)
49 Headache
215(7)
50 Syncope
222(4)
51 Dizziness and Vertigo
226(3)
52 Acute Visual Loss and Double Vision
229(4)
53 Weakness and Paralysis
233(3)
54 Tremor and Movement Disorders
236(3)
55 Aphasia
239(2)
56 Sleep Disorders
241(4)
57 Dysuria and Bladder Pain
245(2)
Section 4: Otolaryngology
58 Sore Throat, Earache, and Upper Respiratory Symptoms
247(8)
Section 5: Dermatology
59 General Examination of the Skin
255(3)
60 Common Skin Conditions
258(7)
Section 6: Hematology And Oncology
61 Examination of Blood Smears and Bone Marrow
265(2)
62 Red Blood Cell Disorders
267(7)
63 Leukocytosis and Leukopenia
274(3)
64 Bleeding and Thrombotic Disorders
277(6)
65 Myeloid Leukemias, Myelodysplasia, and Myeloproliferative Syndromes
283(10)
66 Lymphoid Malignancies
293(12)
67 Skin Cancer
305(3)
68 Head and Neck Cancer
308(2)
69 Lung Cancer
310(6)
70 Breast Cancer
316(5)
71 Tumors of the Gastrointestinal Tract
321(12)
72 Genitourinary Tract Cancer
333(5)
73 Gynecologic Cancer
338(4)
74 Prostate Hyperplasia and Carcinoma
342(3)
75 Cancer of Unknown Primary Site
345(3)
76 Paraneoplastic Endocrine Syndromes
348(4)
77 Neurologic Paraneoplastic Syndromes
352(5)
Section 7: Infectious Diseases
78 Infections Acquired in Health Care Facilities
357(5)
79 Infections in the Immunocompromised Host
362(10)
80 Infective Endocarditis
372(10)
81 Intraabdominal Infections
382(4)
82 Infectious Diarrheas
386(13)
83 Sexually Transmitted and Reproductive Tract Infections
399(16)
84 Infections of the Skin, Soft Tissues, Joints, and Bones
415(7)
85 Pneumococcal Infections
422(3)
86 Staphylococcal Infections
425(9)
87 Streptococcal/Enterococcal Infections, Diphtheria, and Infections Caused by Other Corynebacteria and Related Species
434(9)
88 Meningococcal and Listerial Infections
443(5)
89 Infections Caused by Haemophilus, Bordetella, Moraxella, and HACEK Group Organisms
448(5)
90 Diseases Caused by Gram-Negative Enteric Bacteria and Pseudomonas
453(9)
91 Infections Caused by Miscellaneous Gram-Negative Bacilli
462(7)
92 Anaerobic Infections
469(8)
93 Nocardiosis, Actinomycosis, and Whipple's Disease
477(5)
94 Tuberculosis and Other Mycobacterial Infections
482(12)
95 Lyme Disease and Other Nonsyphilitic Spirochetal Infections
494(6)
96 Rickettsia! Diseases
500(10)
97 Mycoplasma pneumoniae, Legionella Species, and Chlamydia pneumoniae
510(4)
98 Chlamydia trachomatis and C. psittaci
514(2)
99 Herpesvirus Infections
516(9)
100 Cytomegalovirus and Epstein-Barr Virus Infections
525(5)
101 Influenza and Other Viral Respiratory Diseases
530(8)
102 Rubeola, Rubella, Mumps, and Parvovirus Infections
538(5)
103 Enteroviral Infections
543(3)
104 Insect-and Animal-Borne Viral Infections
546(8)
105 HIV Infection and AIDS
554(14)
106 Fungal Infections
568(15)
107 Pneumocystis Infections
583(3)
108 Protozoal Infections
586(13)
109 Helminthic Infections and Ectoparasite
Infestations
599(14)
Section 8: Cardiology
110 Physical Examination of the Heart
613(5)
111 Electrocardiography
618(4)
112 Noninvasive Examination of the Heart
622(5)
113 Congenital Heart Disease in the Adult
627(5)
114 Valvular Heart Disease
632(7)
115 Cardiomyopathies and Myocarditis
639(5)
116 Pericardial Disease
644(5)
117 Hypertension
649(7)
118 Metabolic Syndrome
656(2)
119 ST-Segment Elevation Myocardial Infarction
658(10)
120 Unstable Angina and Non-ST-Elevation Myocardial Infarction
668(4)
121 Chronic Stable Angina
672(5)
122 Bradyarrhythmias
677(2)
123 Tachyarrhythmias
679(8)
124 Heart Failure and Cor Pulmonale
687(6)
125 Diseases of the Aorta
693(3)
126 Peripheral Vascular Disease
696(3)
127 Pulmonary Hypertension
699(6)
Section 9: Pulmonology
128 Respiratory Function and Pulmonary Diagnostic Procedures
705(6)
129 Asthma
711(4)
130 Environmental Lung Diseases
715(3)
131 Chronic Obstructive Pulmonary Disease
718(4)
132 Pneumonia, Bronchiectasis, and Lung Abscess
722(8)
133 Pulmonary Thromboembolism and Deep-Vein Thrombosis
730(4)
134 Interstitial Lung Disease
734(6)
135 Diseases of the Pleura and Mediastinum
740(4)
136 Disorders of Ventilation
744(1)
137 Sleep Apnea
745(2)
Section 10: Nephrology
138 Acute Renal Failure
747(5)
139 Chronic Kidney Disease and Uremia
752(2)
140 Dialysis
754(2)
141 Renal Transplantation
756(3)
142 Glomerular Diseases
759(10)
143 Renal Tubular Disease
769(6)
144 Urinary Tract Infections and Interstitial Cystitis
775(4)
145 Nephrolithiasis
779(3)
146 Urinary Tract Obstruction
782(3)
Section 11: Gastroenterology
147 Peptic Ulcer and Related Disorders
785(5)
148 Inflammatory Bowel Diseases
790(4)
149 Colonic and Anorectal Diseases
794(5)
150 Cholelithiasis, Cholecystitis, and Cholangitis
799(5)
151 Pancreatitis
804(5)
152 Acute Hepatitis
809(7)
153 Chronic Hepatitis
816(10)
154 Cirrhosis and Alcoholic Liver Disease
826(5)
155 Portal Hypertension
831(4)
Section 12: Allergy, Clinical Immunology, And Rheumatology
156 Diseases of Immediate-Type Hypersensitivity
835(5)
157 Primary Immune Deficiency Diseases
840(3)
158 Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Other Connective Tissue Diseases
843(7)
159 Vasculitis
850(4)
160 Ankylosing Spondylitis
854(3)
161 Psoriatic Arthritis
857(2)
162 Reactive Arthritis
859(2)
163 Osteoarthritis
861(2)
164 Gout, Pseudogout, and Related Diseases
863(4)
165 Other Musculoskeletal Disorders
867(3)
166 Sarcoidosis
870(3)
167 Amyloidosis
873(4)
Section 13: Endocrinology And Metabolism
168 Disorders of the Anterior Pituitary and Hypothalamus
877(6)
169 Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone
883(3)
170 Thyroid Gland Disorders
886(9)
171 Adrenal Gland Disorders
895(6)
172 Obesity
901(3)
173 Diabetes Mellitus
904(8)
174 Disorders of the Male Reproductive System
912(5)
175 Disorders of the Female Reproductive System
917(7)
176 Hypercalcemia and Hypocalcemia
924(7)
177 Osteoporosis and Osteomalacia
931(5)
178 Hypercholesterolemia and Hypertriglyceridemia
936(6)
179 Hemochromatosis, Porphyrias, and Wilson's Disease
942(5)
Section 14: Neurology
180 The Neurologic Examination
947(9)
181 Seizures and Epilepsy
956(12)
182 Dementia
968(8)
183 Parkinson's Disease
976(5)
184 Ataxic Disorders
981(3)
185 ALS and Other Motor Neuron Diseases
984(4)
186 Autonomic Nervous System Disorders
988(7)
187 Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders
995(7)
188 Spinal Cord Diseases
1002(6)
189 Tumors of the Nervous System
1008(4)
190 Multiple Sclerosis
1012(8)
191 Acute Meningitis and Encephalitis
1020(11)
192 Chronic and Recurrent Meningitis
1031(9)
193 Peripheral Neuropathies, Including Guillain-Barre Syndrome
1040(10)
194 Myasthenia Gravis
1050(3)
195 Muscle Diseases
1053(10)
Section 15: Psychiatry And Substance Abuse
196 Psychiatric Disorders
1063(8)
197 Psychiatric Medications
1071(8)
198 Eating Disorders
1079(1)
199 Alcohol Use Disorder
1080(4)
200 Narcotic Abuse
1084(3)
Section 16: Disease Prevention And Health Maintenance
201 Routine Disease Screening
1087(5)
202 Cardiovascular Disease Prevention
1092(2)
203 Prevention and Early Detection of Cancer
1094(8)
204 Smoking Cessation
1102(2)
205 Women's Health
1104(3)
Section 17: Adverse Drug Reactions
206 Adverse Drug Reactions
1107(2)
Index
1109
Anthony S. Fauci, MDChief, Laboratory of ImmunoregulationDirector, National Institute of Allergy and Infectious DiseasesNational Institutes of Health. In 2008, Dr. Fauci was awarded the Presidential Medal of Freedom, the Nation's highest civil award.





Dennis L. Kasper, MD, MA (Hon)William Ellery Channing Professor of MedicineProfessor of Microbiology and Molecular GeneticsExecutive Dean for Academic ProgramsHarvard Medical SchoolDirector, Channing LaboratoryDepartment of MedicineBrigham and Womens Hospital





Stephen L. Hauser, MDChairman and Betty Anker Fife ProfessorDepartment of NeurologyUniversity of California, San Francisco





Dan L. Longo, MDScientific DirectorNational Institute on AgingNational Institutes of HealthBethesda, Maryland





Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine; Physician-in-Chief, Brigham and Womens Hospital, Boston, Massachusetts