This comprehensive review of the factors that affect the harvesting and preparation of oocytes and the management of embryos will allow practitioners to make evidence-based decisions for successful IVF. The book reviews and re-considers the value of strategies and outcomes in the management of fertility and conception rates, centred on the production of oocytes, and successful development of the embryo. Authored by leading experts in the field, chapters engage with treatments and strategies that affect the production of oocytes and embryos, optimizing outcomes in the management of female fertility, conception rates, and live births. This vital guide covers controlled ovarian hyperstimulation, the role of AMH in determining ovarian reserve, and primary stimulation agents and the use of adjuncts. Integral for all clinicians and embryologists working in reproductive medicine units, readers are provided with evidence-based, comprehensive advice and review of all factors affecting the management of oocytes and the embryo that are vital for successful IVF cycles.
A review of the factors involved in the preparation of eggs and embryos that influence the success rate of IVF cycles, allowing practitioners to make evidence-based decisions. Surveying a wide range of strategies to optimize outcomes, centred on the production and management of oocytes, and integral development of the embryo.
Arvustused
'The beauty of this book is that it is very easy to understand and is written in simple English language. It is very useful for a learner working in a subfertility unit, and it would also be helpful as a handbook for clinical use on a daily basis I feel this book would be useful as a guidebook for infertility at all levels.' Tahira Batool Chaudhry, Royal College of Obstetricians and Gynaecologists
Muu info
Comprehensive expert review of factors affecting the preparation of oocytes and embryos for successful IVF.
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vii | |
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Section 1 Oocyte Recruitment |
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1 Physiology of Ovulation |
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1 | (21) |
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2 In Vivo Oocyte Development |
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22 | (14) |
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3 Assessment of Ovarian Reserve |
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36 | (13) |
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Section 2 Stimulation for IVF |
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4 Natural Cycle and Minimal Stimulation IVF |
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49 | (10) |
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5 GnRH Agonists and Antagonists: Which, When and How? |
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59 | (10) |
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Efstratios M. Kolibianakis |
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6 The Gonadotropins in IVF: r-hFSH or u-hFSH, Biosimilars, Regimens, Doses: Which Protocol |
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69 | (11) |
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7 Controlled Ovarian Stimulation Strategies for IVF and Programing Cycles with Steroid Pretreatment |
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80 | (14) |
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8 Monitoring the Stimulated IVF Cycle |
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94 | (27) |
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9 Preventing Ovarian Hyperstimulation Syndrome |
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121 | (6) |
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127 | (14) |
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Section 3 Supplements to Improve Oocytes |
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11 The Use of DHEA to Improve Oocyte Quality |
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141 | (9) |
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12 Implications of Polycystic Ovary Syndrome on Oocyte Quality |
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150 | (5) |
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13 The Use of Melatonin to Improve Oocyte Development |
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155 | (12) |
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14 The Use of LH Supplements to Improve the Response to Ovarian Stimulation |
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167 | (15) |
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15 Growth Hormone as an Adjunct to Controlled Ovarian Hyperstimulation for IVF |
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182 | (9) |
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16 Mitochondrial Transfer Technology for Improving Older Eggs |
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191 | (14) |
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Section 4 Oocyte and Embryo Culture |
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205 | (6) |
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18 Oocyte Banking through Vitrification |
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211 | (13) |
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19 Fertilization and Complete Fertilization Failure in Human IVF |
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224 | (8) |
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20 Physiology and Culture of the Early Human Embryo |
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232 | (13) |
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21 Use of Medium Supplements for Oocyte and Embryo Culture |
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245 | (14) |
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22 Assisted Hatching -- Fresh and Frozen |
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259 | (10) |
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Section 5 Embryo Selection and Transfer |
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23 Assessing Embryo Morphology to Enhance Successful Selection and Transfer |
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269 | (11) |
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24 Evaluation of Embryo Quality: Time-Lapse Imaging to Assess Embryo Morphokinesis |
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280 | (15) |
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25 Metabolomic Screening of Embryos to Enhance Successful Selection and Transfer |
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295 | (10) |
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26 Preimplantation Genetic Screening of Embryos for IVF |
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305 | (9) |
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27 Cleavage-Stage Transfer or Blastocyst Transfer? |
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314 | (13) |
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Evangelos G. Papanikolaou |
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28 Embryo Transfer Technique |
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327 | (13) |
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29 Vitrification of Embryos for IVF |
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340 | (14) |
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30 On the Strategy of "Freezing Only" Embryos |
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354 | (8) |
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31 Fertility Preservation: Eggs, Embryos and Ovarian Tissue, and the Use of GnRH Analogues to Protect Fertility |
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362 | (6) |
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32 Stimulating the Poor Responder |
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368 | (7) |
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| Index |
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375 | |
Gabor Kovacs is a reproductive gynecologist, with nearly forty years of experience in IVF. He is an Honorary Life Member of The International Federation of Fertility Societies (IFFS), Honorary Life Member of The Fertility Society of Australia, and received the Distinguished Alumni Award, Monash University, and Distinguished Service Medal, of The Royal Australian and New Zealand College of Obstetricians and Gynaecologists. He has edited 14 books for Cambridge, and this book is one of a series of four books: How to Improve Preconception Health to Maximize IVF Success (Cambridge, 2018); Male and Sperm Factors that Maximize IVF Success (forthcoming), and How to Prepare the Endometrium to Maximize Implantation Rates and IVF Success (forthcoming). Anthony Rutherford has worked in reproductive medicine since 1985, establishing one of the largest National Health Service IVF units in the UK in Leeds in 1991. Mr Rutherford was one of the first to introduce vaginal ultrasound and the large-scale use of GnRH analogues in IVF protocols into the UK. He has been actively involved nationally with over seventeen years as a Board member of the British Fertility Society, including as past chairman in 2009 to 2011, and in further education through the Royal College of Obstetricians and Gynaecologists. He is a founding member of the British Society of Gynaecological Endoscopy, and currently he is a Board member of the Human fertilization & Embryo Authority, the UK IVF regular. David K. Gardner is a world-renowned embryologist with over thirty-five years' experience. He is a Redmond Barry Distinguished Professor in the School of BioSciences at the University of Melbourne, the Scientific Director of Melbourne IVF, and a Fellow of the Australian Academy of Science. He is the current President of the Alpha, representing Scientists in Reproductive Medicine, and Section Editor of Reproductive BioMedicine Online. He has edited 15 books on human IVF and embryology, is a pioneer of human blastocyst culture, and is one of the most highly cited scientists in reproductive biology and reproductive medicine.
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